Major interaction on record — check this product against your medications before combining. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Vegan Vitamin K2 Ingredients & Drug Interactions

by NatureWise

Vegan Vitamin K2 label
See full label image
Softgel Capsule Category: Vitamin
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Vegan Vitamin K2 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Vegan Vitamin K2 is a dietary supplement by NatureWise with 2 active ingredients. Its ingredients are commonly taken for supporting normal blood clotting, bone health, heart and vascular health.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin K2. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Vegan Vitamin K2 by NatureWise

Ask about any prescription or over-the-counter medication and we check it for interactions with Vegan Vitamin K2 by NatureWise — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Vegan Vitamin K2 by NatureWise

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients, both vitamin K2. Vitamin K is a fat-soluble vitamin your body needs to make clotting factors — proteins that help your blood clot — and to support bone health.

The supplement is delivered in a softgel capsule with inactive ingredients including tapioca starch gel, glycerin, purified water, and extra virgin olive oil.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: blood clotting and bone health.
  • We looked for evidence on: Hemorrhagic disease, Hypoprothrombinemia, Intraventricular hemorrhage, Osteoporosis, Vitamin K-dependent clotting factors deficiency (VKCFD), Warfarin anticoagulation — and 4 related terms.
  • The strongest evidence on file: Vitamin K is rated "Effective" for Hemorrhagic disease (Natural Medicines).
  • Also on file: Vitamin K is rated "Effective" for Hypoprothrombinemia, Warfarin anticoagulation, Vitamin K-dependent clotting factors deficiency (VKCFD).
  • Also on file: Vitamin K is rated "Possibly Effective" for Osteoporosis.

Vitamin K2 is effective for preventing and treating vitamin K deficiency states, including hypoprothrombinemia (abnormally low clotting protein levels), vitamin K-dependent clotting factor deficiency, and hemorrhagic disease. It is also rated possibly effective for osteoporosis.

The data on file does not establish effectiveness for other uses.

The evidence, ingredient by ingredient Vitamin K

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Taken by mouth, vitamin K is generally well tolerated in healthy people. The most common side effects are mild gastrointestinal effects — nausea, stomach upset, abdominal pain, and diarrhea — reported in a small number of users.

Vitamin K is rated likely safe in pregnancy and lactation. Check with your doctor before taking supplements, as normal dietary amounts are appropriate for most people but supplement use warrants professional guidance.

Side effects, ingredient by ingredient Vitamin K

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin K.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check warfarin (Coumadin) and other blood thinners (anticoagulants) with your pharmacist before you start. Vitamin K can reduce their effectiveness, which is a major concern.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a straight vitamin K2 supplement useful if you have a documented deficiency or your doctor recommends it for bone health. If you take warfarin or any blood thinner, you must talk to your pharmacist or doctor before starting — vitamin K directly interferes with how these medications work.

For anyone else, a quick medication check is still a good idea.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vegan Vitamin K2, straight from the product label.

Brand NatureWise
Barcode (UPC) 855724007596
Net contents 90 Vegetarian Softgel(s)
Market status On market
Date entered into DSLD Mar 25, 2025
DSLD ID 327761
Product type Vitamin
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vegan Vitamin K2 by NatureWise, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Softgel(s)
Maximum serving Sizes:
1 Vegetarian Softgel(s)
Servings per container
90
UPC/BARCODE
855724007596
IngredientAmount% DV
Vitamin K2500 mcg417%
Vitamin K2100 mcg83%

Other ingredients: Tapioca Starchgel, Modified, Glycerin, Water, Purified, Extra Virgin Olive Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Vegan

Gluten free Dairy free

Supports calcium uptake and bone mineralization

This product does not contain: wheat, gluten, dairy, eggs, tree nuts, peanuts, fish, shellfish, yeast, soy, fillers, or binders.

Suggested/Recommended/Usage/Directions

Suggested use: Adults take 1 softgel daily with food, or as recommended by your healthcare provider.

Precautions

Discontinue use 2 weeks prior to surgery. NatureWise vitamin K2 should always be taken in conjunction with a healthy diet and regular exercise program.

Caution: As with any dietary supplement, you should consult your healthcare provider before use, especially if pregnant, nursing, have a medical condition, taking medications, or have known adverse reactions or allergies.

Caution: As with any dietary supplement, you should consult your healthcare provider before use, especially if pregnant, nursing, have a medical condition, taking medications, or have known adverse reactions or allergies.

Warning: Contains vitamin K2.

Warfarin statement: Do not use with Warfarin (coumadin) unless under the care of a physician

Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

Formula

100 mcg MK-7 + 500 mcg MK-4 The human body uses vitamin K to produce a protein called prothrombin, which plays an essential role in blood clotting and helps maintain bone mineral density. Vitamin K2 promotes heart health by preventing calcium buildup in the blood vessels, and its antioxidant properties help protect cells from free radical damage. It also supports energy production and normal blood glucose levels. Menaquinone-7, a subtype of vitamin K2, is the most bioavailable of the menaquinones and has demonstrated the greatest bone building benefits.

MK-7 & MK-4 Formulated with VitaMK7, the most advanced vitamin K2 Menaquinone-7

General Statements

To learn more about NatureWise vitamin K2 and our other great products, please visit us at naturewise.com.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

VitaMK7 is a trademark of Gnosis.

Copyright 2022 NatureWise. All Rights Reserved.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Vegan Vitamin K2 by NatureWise label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Vegan Vitamin K2 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Vegan Vitamin K2 by NatureWise

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Softgel(s) Dosage formSoftgel Capsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin K2

Interacts with
2 drugs
500 mcg per serving Form: Menaquinone-4

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but suppl...

Vitamin K2 monograph & interactions

Vitamin K2

Interacts with
2 drugs
100 mcg per serving Form: VitaMK7

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but suppl...

Vitamin K2 monograph & interactions

Other (inactive) ingredients: Tapioca Starchgel, Modified, Glycerin, Water, Purified, Extra Virgin Olive Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vegan Vitamin K2 by NatureWise Drug Interactions

Want to check YOUR meds against Vegan Vitamin K2?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Major

Ingredients driving the most interactions

Vitamin K2 2

Individual Drug Interactions

The ingredients in Vegan Vitamin K2 interact with 2 drugs. Click any drug to see the details.

1 of the 2 ingredients in Vegan Vitamin K2 interact with drugs. Each result below shows which ingredient is responsible. Vitamin K2

Each ingredient & the kinds of drugs it affects

For each ingredient in Vegan Vitamin K2 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin K21 drug type · 2 drugs

Warfarin (Coumadin)

Vitamin K can antagonize and reverse the therapeutic effects of warfarin.
Vitamin K antagonizes the effects of warfarin. Excessive vitamin K intake, either from supplements or from changes in the diet, can reduce the anticoagulant effect of warfarin.

Likelihood Likely Evidence C
Vitamin K2 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Vegan Vitamin K2, from the product label.

NatureWise

See all NatureWise products
Name
NatureWise
City
Costa Mesa
State
CA
ZipCode
92626
Phone Number
800-510-7207
Web Address
naturewise.com
Pharmacist Counseling Corner

Vegan Vitamin K2 by NatureWise: Common Questions

Does Vegan Vitamin K2 by NatureWise interact with any medications?
Yes. Based on its ingredients, Vegan Vitamin K2 has a known interaction with 2 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vegan Vitamin K2 contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on warfarin?
No, not without talking to your doctor first. Vitamin K directly reduces how well warfarin works, which can raise your clot risk. Your doctor may be able to adjust your dose or monitor you more closely, but you need that conversation before you start the supplement.
What are the side effects?
Taken by mouth, vitamin K most commonly causes mild gastrointestinal effects like nausea, stomach upset, abdominal pain, or diarrhea. These are reported in a small number of users and are generally mild to moderate.
Is it safe during pregnancy and breastfeeding?
Yes, vitamin K is rated likely safe in pregnancy and lactation. That said, any supplement use during these times is worth discussing with your doctor for personalized advice.
What does vitamin K2 actually do in my body?
Vitamin K is needed to make clotting factors — proteins that help your blood clot — and to support bone health. It's a fat-soluble vitamin, which is why this softgel formulation includes olive oil to help your body absorb it.
Does this product have fillers?
Yes. The inactive ingredients are tapioca starch gel, glycerin, purified water, and extra virgin olive oil — these are the excipients that make up the softgel capsule.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Vegan Vitamin K2 is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vegan Vitamin K2 label
Go deeper

The Full Monographs Behind Vegan Vitamin K2’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin K

Interacts with 2 drugs

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but supplements are sometimes used for deficiency...

Read the full Vitamin K monograph →
Sources

Sources & How We Checked

Vegan Vitamin K2's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin K 11 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  3. Crowther MA, Ageno W, Garcia D, et al. Oral vitamin K versus placebo to correct excessive anticoagulation in patients receiving warfarin: a randomized trial. Ann Intern Med. 2009;150(5):293-300. PubMed
  4. Dietary vitamin K guidance: an effective strategy for stable control of oral anticoagulation? Nutr Rev. 2010;68(3):178-81. PubMed
  5. Kim JS, Nafziger AN, Gaedigk A, et al. Effects of oral vitamin K on S- and R-warfarin pharmacokinetics and pharmacodynamics: enhanced safety of warfarin as a CYP2C9 probe. J Clin Pharmacol. 2001 Jul;41(7):715-22. PubMed
  6. Riegert-Johnson, D. L. and Volcheck, G. W. The incidence of anaphylaxis following intravenous phytonadione (vitamin K1): a 5-year retrospective review. Ann.Allergy Asthma Immunol. 2002;89(4):400-406. PubMed
  7. Dezee, K. J., Shimeall, W. T., Douglas, K. M., Shumway, N. M., and O'malley, P. G. Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis. Arch.Intern.Med. 2-27-2006;166(4):391-397. DOI
  8. Dentali, F., Ageno, W., and Crowther, M. Treatment of coumarin-associated coagulopathy: a systematic review and proposed treatment algorithms. J.Thromb.Haemost. 2006;4(9):1853-1863. PubMed
  9. Caluwé R, Vandecasteele S, Van Vlem B, Vermeer C, De Vriese AS. Vitamin K2 supplementation in haemodialysis patients: a randomized dose-finding study. Nephrol Dial Transplant. 2014;29(7):1385-90.
  10. Huang ZB, Wan SL, Lu YJ, Ning L, Liu C, Fan SW. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials. Osteoporos Int. 2015;26(3):1175-86. PubMed
  11. Hunnali CR, Devi U, Kitchanan S, Sethuraman G. Three Different Regimens for Vitamin K Birth Prophylaxis in Infants Born Preterm: A Randomized Clinical Trial. J Pediatr 2023;255:98-104. PubMed

See these in context on the Vitamin K monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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