No known drug interactions for the matched ingredients — not a guarantee none exist. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Vegetarian Enzyme Ingredients & Drug Interactions

by Douglas Laboratories

Tablet Or Pill Category: Non-nutrient/non-botanical
No known interaction
The interaction bottom line No known interaction

Vegetarian Enzyme is a dietary supplement by Douglas Laboratories with 4 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of Vegetarian Enzyme by Douglas Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Vegetarian Enzyme Concentrate” is listed as a grouped ingredient — the label gives one combined amount (450 mg) without saying how much of each component you get.

Vegetarian Enzyme contains four active ingredients: amylase, protease, lipase, and cellulase. These are digestive enzymes—proteins that help break down carbohydrates, proteins, fats, and plant fiber in your food so your body can absorb them.

The product also contains several inactive ingredients (microcrystalline cellulose, hydroxypropyl cellulose, stearic acid, croscarmellose sodium, vegetable stearate, and silica) that form the tablet and help it dissolve.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: digestive enzyme support.
  • We looked for evidence on: Dyspepsia, indigestion, bloating, fat digestion.
  • The closest evidence on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).

The evidence we hold doesn't establish that lipase works for inflammatory bowel disease (IBD), indigestion (dyspepsia), or prematurity—the data is insufficient to rate it. We have no effectiveness ratings for amylase, protease, or cellulase.

If you're considering this product for a specific digestive concern, talk with your pharmacist about whether the science supports it for your situation.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Lipase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Protease and lipase are generally well tolerated in adults but may cause digestive upset or allergic reactions in some people. Rarely, occupational exposure to airborne protease can trigger allergic rhinitis or asthma; this is mainly a concern for industrial workers, not supplement users.

Lipase is not recommended in pregnancy or while breastfeeding without medical advice—the safety data is limited. Protease should be avoided in pregnancy unless your doctor prescribes it.

If you have serious digestive conditions, check with your healthcare provider before starting.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Lipase

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 2 matched ingredients has a documented medication interaction on file.

No interactions are documented in our data for the ingredients we could check. That said, we have no data on amylase or cellulase, so mention those names to your pharmacist if you take any medications.

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.

This product is a straightforward digestive enzyme blend that's generally well tolerated by most adults. If you're pregnant or breastfeeding, have a serious digestive disorder, or take any medications, talk with your pharmacist or doctor first.

Run your exact medications through the checker on this page before you begin.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vegetarian Enzyme, straight from the product label.

Brand Douglas Laboratories
Barcode (UPC) 310539002285
Net contents 120 Tablet(s)
Market status On market
Date entered into DSLD Feb 25, 2021
DSLD ID 245429
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vegetarian Enzyme by Douglas Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
60
UPC/BARCODE
310539002285
IngredientAmount% DV
Amylase0 NP--
Protease0 NP--
Lipase0 NP--
Cellulase0 NP--
Vegetarian Enzyme Concentrate450 mg--

Other ingredients: Microcrystalline Cellulose, Hydroxypropyl Cellulose, Coating, Stearic Acid, Croscarmellose Sodium, Vegetable Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: As a dietary supplement, adults take 2 tablets with each meal, or as directed by your health professional.

Precautions

Warning: If you are pregnant, nursing, have any health condition or taking any medication, consult your health professional before using this product.

Keep out of the reach of children.

Use only if safety seal is intact.

Storage

Store in a cool, dry place.

Formulation

Gluten-free, Non-GMO

Digestive health

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity. Scan to learn about our manufacturing excellence

FDA Statement of Identity

Dietary Supplement

See for yourself

Vegetarian Enzyme by Douglas Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Vegetarian Enzyme by Douglas Laboratories

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vegetarian Enzyme Concentrate

450 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Hydroxypropyl Cellulose, Coating, Stearic Acid, Croscarmellose Sodium, Vegetable Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vegetarian Enzyme by Douglas Laboratories Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Vegetarian Enzyme. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Vegetarian Enzyme, from the product label.

Douglas Laboratories

See all Douglas Laboratories products
Name
Douglas Laboratories
Street Address
600 Boyce Road
City
Pittsburgh
State
PA
ZipCode
15205
Phone Number
1.800.245.4440
Web Address
www.douglaslabs.com
Pharmacist Counseling Corner

Vegetarian Enzyme by Douglas Laboratories: Common Questions

Does Vegetarian Enzyme by Douglas Laboratories interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Vegetarian Enzyme. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Vegetarian Enzyme contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
Protease should be avoided in pregnancy unless your doctor prescribes it. Lipase has limited safety data in pregnancy, so use it only if your doctor advises. Talk with your healthcare provider or pharmacist before starting.
Is it safe while breastfeeding?
There's little safety data on protease or supplemental lipase during breastfeeding. Use isn't recommended without medical advice. Check with your healthcare provider first.
What are the side effects?
Protease and lipase are generally well tolerated, but some people experience digestive upset. Rarely, people exposed to airborne protease (mainly in occupational settings) have had allergic reactions like nasal congestion or asthma. Serious side effects are uncommon.
Does this work for indigestion or IBS?
We hold insufficient evidence to say whether lipase helps indigestion or inflammatory bowel disease. Talk with your pharmacist about whether a digestive enzyme is right for your symptoms.
Should I take this if I have a digestive disorder?
If you have a serious digestive condition, use this product only under medical guidance. Your doctor can tell you whether a digestive enzyme supplement fits your treatment plan.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Vegetarian Enzyme is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vegetarian Enzyme label
Sources

Sources & How We Checked

Vegetarian Enzyme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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