No known drug interactions for the matched ingredients — not a guarantee none exist. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Vegetarian Enzyme Ingredients & Drug Interactions

by Douglas Laboratories

Tablet Or Pill Category: Non-nutrient/non-botanical
No known interaction
The interaction bottom line No known interaction

Vegetarian Enzyme is a dietary supplement by Douglas Laboratories with 4 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of Vegetarian Enzyme by Douglas Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • “Vegetarian Enzyme Concentrate” is listed as a grouped ingredient — the label gives one combined amount (450 mg) without saying how much of each component you get.

This product contains 4 active ingredients: three digestive enzymes (Amylase, Protease, and Lipase) plus Cellulase, along with a vegetarian enzyme concentrate blend. The enzymes work to break down carbohydrates, proteins, fats, and plant fiber in food.

The tablet also contains several inactive ingredients — cellulose, hydroxypropylcellulose, croscarmellose sodium, stearic acid, vegetable stearate, and silica — which are fillers, binders, and flow agents typical in tablet manufacturing.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Digestive enzyme blend support.
  • We looked for evidence on: Dyspepsia, Indigestion, Bloating and gas, Fat digestion.
  • The closest evidence on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).

The evidence for Lipase is not established for the conditions studied in our data — inflammatory bowel disease and dyspepsia both carry a rating of insufficient reliable evidence. We hold no effectiveness ratings for Amylase, Protease, or Cellulase.

If you're considering this product for a specific digestive concern, talk to your pharmacist about what the research actually supports.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Lipase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Protease and Lipase are generally well tolerated in most adults, though some people report digestive upset or allergic reactions. Protease exposure — even occupational airborne contact — has rarely triggered allergic rhinitis (nasal and eye inflammation) or asthma in case reports.

Lipase has not been thoroughly studied for safety outcomes; no adverse effects have been reported in adults, but the data is limited. For pregnancy: safety data on supplemental Protease and Lipase is thin or absent, so both should be used only if your doctor advises it.

For breastfeeding: the same applies — check with your healthcare provider first. Do not give this product to premature infants; lipase has caused serious gastrointestinal harm in that population.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Lipase

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 2 matched ingredients has a documented medication interaction on file.

No interactions are documented in our data for the ingredients we could check. If you take any medications, use the search tool on this page to verify, or ask your pharmacist.

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.

This is a straightforward enzyme blend with no known drug interactions for the ingredients we could verify. It's generally well tolerated by healthy adults, but digestive enzyme supplements aren't yet proven for common conditions like bloating or indigestion.

If you're pregnant, breastfeeding, or have a serious digestive condition, talk to your pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vegetarian Enzyme, straight from the product label.

Brand Douglas Laboratories
Barcode (UPC) 310539704868
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Feb 23, 2016
DSLD ID 56455
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vegetarian Enzyme by Douglas Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
30
UPC/BARCODE
310539704868
IngredientAmount% DV
Amylase4200 DU--
Protease250 SAPU--
Lipase2400 LU--
Cellulase600 CU--
Vegetarian Enzyme Concentrate450 mg--

Other ingredients: Cellulose, Hydroxypropylcellulose, Croscarmellose Sodium, Stearic Acid, Vegetable Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

~ 1 Alpha Amylase Dextrinizing Unit ~ 2 Spectrophotometric Acid Protease Unit ~ 3 Lipase Unit ~ 4 Cellulase Unit

Vegetarian Enzyme is a special blend of plant enzymes.

Formulation

This product contains no animal products.

This product contains NO yeast, wheat gluten, soy protein, milk/dairy, corn, sodium, sugar, starch, artificial coloring, preservatives or flavoring.

Non-Animal

Suggested/Recommended/Usage/Directions

Suggested Usage: As a dietary supplement, adults take 1 to 2 tablets 3 times daily with meals, or as directed by your healthcare professional.

Precautions

KEEP OUT OF REACH OF CHILDREN.

Tamper resistant package, do not use if outer seal is missing.

Storage

For optimal storage conditions, store in a cool, dry place. (59(0)-77(0)F/15(0)-25(0)C) (35-65% relative humidity)

General

Formula #7048

FDA Statement of Identity

A Dietary Supplement

See for yourself

Vegetarian Enzyme by Douglas Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Vegetarian Enzyme by Douglas Laboratories

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vegetarian Enzyme Concentrate

450 mg per serving

Other (inactive) ingredients: Cellulose, Hydroxypropylcellulose, Croscarmellose Sodium, Stearic Acid, Vegetable Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vegetarian Enzyme by Douglas Laboratories Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Vegetarian Enzyme. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Vegetarian Enzyme, from the product label.

Douglas Laboratories

See all Douglas Laboratories products
Name
Douglas Laboratories
Street Address
600 Boyce Road
City
Pittsburgh
State
PA
ZipCode
15205
Phone Number
1.800.245.4440
Web Address
www.douglaslabs.com
Pharmacist Counseling Corner

Vegetarian Enzyme by Douglas Laboratories: Common Questions

Does Vegetarian Enzyme by Douglas Laboratories interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Vegetarian Enzyme. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Vegetarian Enzyme contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
Safety data on these enzymes during pregnancy is limited. Both Protease and Lipase should be used only if your doctor advises it. Talk with your healthcare provider about whether it's right for you.
Is it safe to breastfeed while taking this?
There isn't enough safety data on Protease and Lipase during breastfeeding to recommend use without medical advice. Check with your healthcare provider first.
What are these enzymes supposed to do?
Digestive enzymes break down food: Amylase works on carbohydrates, Protease on proteins, Lipase on fats, and Cellulase on plant fiber. The idea is to help your digestive system process food more efficiently.
Does this product actually work for bloating or indigestion?
We don't have evidence that lipase — one of the main enzymes — is reliably effective for bloating, indigestion, or inflammatory bowel disease. The proof just isn't strong enough in our data.
Can this cause allergic reactions?
Yes, allergic reactions are possible, though uncommon. Protease exposure has rarely triggered allergic rhinitis or asthma, even from airborne contact in occupational settings. If you have a history of allergies or asthma, mention that to your pharmacist.
Can I give this to my premature infant?
No. Lipase has caused serious gastrointestinal problems in premature infants, including abdominal distension, bleeding, and a higher rate of a serious inflammation of the intestines (necrotizing enterocolitis). Do not give this product to premature babies.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Vegetarian Enzyme is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vegetarian Enzyme label
Sources

Sources & How We Checked

Vegetarian Enzyme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring