Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Vitamin K-2 Ingredients & Drug Interactions

by GNC Preventive Nutrition

Vitamin K-2 label
See full label image
Softgel Capsule Category: Vitamin
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Vitamin K-2 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Vitamin K-2 is a dietary supplement by GNC Preventive Nutrition with 1 active ingredient. Its ingredients are commonly taken for supporting normal blood clotting, bone health, heart and vascular health.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin K-2. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Vitamin K-2 by GNC Preventive Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Vitamin K-2 by GNC Preventive Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Vitamin K-2 by GNC Preventive Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: vitamin K-2 in softgel form. Vitamin K is a fat-soluble vitamin your body uses to make proteins that control blood clotting and support bone health.

The softgel also contains several inactive ingredients — soybean oil, gelatin, glycerin, caramel color, and titanium dioxide — that help deliver and preserve the vitamin.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: bone health.
  • We looked for evidence on: Osteoporosis, bone density, fracture prevention, skeletal health.
  • The strongest evidence on file: Vitamin K is rated "Possibly Effective" for Osteoporosis (Natural Medicines).

Vitamin K-2 is rated effective for correcting certain clotting deficiencies — hypoprothrombinemia (low blood-clotting proteins), vitamin K-dependent clotting factor deficiency, and hemorrhagic disease (abnormal bleeding). It's also rated effective for managing warfarin anticoagulation in medical settings.

For bone health and osteoporosis, the evidence is rated possibly effective — promising, but not yet conclusive in our data.

The evidence, ingredient by ingredient Vitamin K

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Taken by mouth, vitamin K-2 is generally well tolerated in healthy people. The most common side effects are mild gastrointestinal ones — nausea, diarrhea, stomach upset, and abdominal pain.

These are usually mild to moderate and not severe. For pregnancy and breastfeeding, vitamin K-2 is rated likely safe.

That said, normal dietary amounts are fine, but before you add a supplement, check with your doctor — especially if you're on warfarin or any other blood thinner.

Side effects, ingredient by ingredient Vitamin K

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin K.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before using this product if you take warfarin (Coumadin) or any other blood thinner (anticoagulant). Vitamin K-2 can reverse the effect of these medications, putting you at risk.

We also hold data showing one additional anticoagulant medication is affected — use the search tool below to confirm your exact drugs aren't on that list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Vitamin K-2 is a straightforward supplement for people who need to support their clotting or bone health and aren't on blood thinners. If you take warfarin or another anticoagulant, you need to talk with your doctor or pharmacist before starting this product — the interaction is real and serious.

For everyone else, side effects are usually just mild stomach upset.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 26, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vitamin K-2, straight from the product label.

Brand GNC Preventive Nutrition
Barcode (UPC) 048107102401
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Oct 26, 2011
DSLD ID 843
Product type Vitamin
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vitamin K-2 by GNC Preventive Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
048107102401
IngredientAmount% DV
Vitamin K-2100 mcg125%

Other ingredients: Soybean Oil, Gelatin, Glycerin, Caramel color, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

DIETARY SUPPLEMENT

Precautions

KEEP OUT OF REACH OF CHILDREN.

WARNING: Do not use if pregnant, nursing or are allergic or contraindicated to aspirin. If you are taking aspirin or blood thinning or other medication, consult your healthcare professional before using this product. Discontinue use two weeks prior to surgery, or if upset stomach occurs.

Storage

Store in a cool, dry place.

General Statements

BONE

For more information:

Good for the bone-building process* Features 100 mcg of superior vitamin K-2 menaquinone-7

NEW

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General

CODE 096821 AMG

Suggested/Recommended/Usage/Directions

DIRECTIONS: As a dietary supplement, take one softgel capsule daily.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Vitamin K-2 by GNC Preventive Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Vitamin K-2 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Vitamin K-2 by GNC Preventive Nutrition

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Vitamin K-2

Interacts with
2 drugs
100 mcg per serving Form: Menaquinone-7

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but suppl...

Vitamin K-2 monograph & interactions

Other (inactive) ingredients: Soybean Oil, Gelatin, Glycerin, Caramel color, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vitamin K-2 by GNC Preventive Nutrition Drug Interactions

Want to check YOUR meds against Vitamin K-2?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Major

Ingredients driving the most interactions

Vitamin K-2 2

Individual Drug Interactions

The ingredients in Vitamin K-2 interact with 2 drugs. Click any drug to see the details.

1 of the 1 ingredient in Vitamin K-2 interact with drugs. Each result below shows which ingredient is responsible. Vitamin K-2

Each ingredient & the kinds of drugs it affects

For each ingredient in Vitamin K-2 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin K-21 drug type · 2 drugs

Warfarin (Coumadin)

Vitamin K can antagonize and reverse the therapeutic effects of warfarin.
Vitamin K antagonizes the effects of warfarin. Excessive vitamin K intake, either from supplements or from changes in the diet, can reduce the anticoagulant effect of warfarin.

Likelihood Likely Evidence C
Vitamin K-2 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Vitamin K-2, from the product label.

GNC Preventive Nutrition

See all GNC Preventive Nutrition products
Name
General Nutrition Corporation
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
gnc.com
Pharmacist Counseling Corner

Vitamin K-2 by GNC Preventive Nutrition: Common Questions

Does Vitamin K-2 by GNC Preventive Nutrition interact with any medications?
Yes. Based on its ingredients, Vitamin K-2 has a known interaction with 2 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vitamin K-2 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this hurt if I'm taking warfarin?
Yes — this is a serious interaction. Vitamin K-2 can block warfarin's ability to thin your blood, which defeats the purpose of taking it. You must talk with your doctor before starting any vitamin K supplement if you're on warfarin.
What side effects should I expect?
Most people have none, but some experience mild stomach upset — nausea, diarrhea, or abdominal pain. These are usually not serious and often pass.
Is vitamin K-2 safe during pregnancy?
Vitamin K-2 is rated likely safe in pregnancy. Normal dietary amounts are fine; if you're considering a supplement, check with your doctor or pharmacist first, especially if you take any blood-thinning medications.
What is vitamin K-2 actually for?
Your body uses it to make proteins that control blood clotting and support bone strength. This product is effective for treating certain clotting deficiencies and helping manage warfarin therapy under medical supervision; for bone health, the evidence is still being built.
Does this product have fillers?
It contains inactive ingredients — soybean oil, gelatin, glycerin, caramel color, and titanium dioxide — that help form and color the softgel capsule.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Vitamin K-2 is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vitamin K-2 label
Go deeper

The Full Monographs Behind Vitamin K-2’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin K

Interacts with 2 drugs

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but supplements are sometimes used for deficiency...

Read the full Vitamin K monograph →
Sources

Sources & How We Checked

Vitamin K-2's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin K 11 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  3. Crowther MA, Ageno W, Garcia D, et al. Oral vitamin K versus placebo to correct excessive anticoagulation in patients receiving warfarin: a randomized trial. Ann Intern Med. 2009;150(5):293-300. PubMed
  4. Dietary vitamin K guidance: an effective strategy for stable control of oral anticoagulation? Nutr Rev. 2010;68(3):178-81. PubMed
  5. Kim JS, Nafziger AN, Gaedigk A, et al. Effects of oral vitamin K on S- and R-warfarin pharmacokinetics and pharmacodynamics: enhanced safety of warfarin as a CYP2C9 probe. J Clin Pharmacol. 2001 Jul;41(7):715-22. PubMed
  6. Riegert-Johnson, D. L. and Volcheck, G. W. The incidence of anaphylaxis following intravenous phytonadione (vitamin K1): a 5-year retrospective review. Ann.Allergy Asthma Immunol. 2002;89(4):400-406. PubMed
  7. Dezee, K. J., Shimeall, W. T., Douglas, K. M., Shumway, N. M., and O'malley, P. G. Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis. Arch.Intern.Med. 2-27-2006;166(4):391-397. DOI
  8. Dentali, F., Ageno, W., and Crowther, M. Treatment of coumarin-associated coagulopathy: a systematic review and proposed treatment algorithms. J.Thromb.Haemost. 2006;4(9):1853-1863. PubMed
  9. Caluwé R, Vandecasteele S, Van Vlem B, Vermeer C, De Vriese AS. Vitamin K2 supplementation in haemodialysis patients: a randomized dose-finding study. Nephrol Dial Transplant. 2014;29(7):1385-90.
  10. Huang ZB, Wan SL, Lu YJ, Ning L, Liu C, Fan SW. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials. Osteoporos Int. 2015;26(3):1175-86. PubMed
  11. Hunnali CR, Devi U, Kitchanan S, Sethuraman G. Three Different Regimens for Vitamin K Birth Prophylaxis in Infants Born Preterm: A Randomized Clinical Trial. J Pediatr 2023;255:98-104. PubMed

See these in context on the Vitamin K monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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