Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Vitamin K1 1% Ingredients & Drug Interactions

by BulkSupplements.com

Vitamin K1 1% label
See full label image
Powder Category: Vitamin
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Vitamin K1 1% against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Vitamin K1 1% is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for supporting normal blood clotting, bone health, heart and vascular health.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin K1. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Vitamin K1 1% by BulkSupplements.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Vitamin K1 1% by BulkSupplements.com — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Vitamin K1 1% by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: vitamin K1 (phytonadione), a fat-soluble vitamin that plays a central role in blood clotting. Your body uses it to activate several proteins that form clots and stop bleeding.

It's also involved in bone metabolism. The powder form includes maltodextrin as an inactive ingredient (a binder and flow agent).

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Supporting normal blood clotting and bone health.
  • We looked for evidence on: Hemorrhagic disease, Hypoprothrombinemia, Intraventricular hemorrhage, Vitamin K-dependent clotting factors deficiency (VKCFD), Warfarin anticoagulation, Osteoporosis — and 3 related terms.
  • The strongest evidence on file: Vitamin K is rated "Effective" for Hemorrhagic disease (Natural Medicines).
  • Also on file: Vitamin K is rated "Effective" for Hypoprothrombinemia, Warfarin anticoagulation, Vitamin K-dependent clotting factors deficiency (VKCFD).
  • Also on file: Vitamin K is rated "Possibly Effective" for Osteoporosis.

Vitamin K1 is effective for treating vitamin K deficiency conditions, including low levels of vitamin K-dependent clotting factors, hypoprothrombinemia (a disorder affecting clotting proteins), and hemorrhagic disease (abnormal bleeding). It's also effective for managing warfarin anticoagulation when dose adjustment is needed.

For osteoporosis, the evidence suggests it may help, though more research is needed.

The evidence, ingredient by ingredient Vitamin K

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Taken by mouth, vitamin K1 is generally well tolerated in most people. The most common side effects are mild: nausea, diarrhea, and stomach upset — occurring in a small number of people who take it orally.

The safety notes advise that normal dietary amounts are fine, but you should check with your doctor or pharmacist before adding a supplement to your routine. During pregnancy and lactation, vitamin K1 is rated as likely safe.

However, the data here applies to the supplement itself — not to any specific medical use in pregnancy — so talk with your provider about whether it's right for your situation.

Side effects, ingredient by ingredient Vitamin K

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin K.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Blood thinners — especially warfarin (Coumadin) — are the key concern with vitamin K1. If you take warfarin, this supplement can reduce its ability to prevent clots.

Check your exact medications with the tool on this page before starting.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Vitamin K1 is useful if you have a vitamin K deficiency or bleeding disorder, or if your doctor has directed you to use it. If you take warfarin or any blood thinner, do not start this supplement without checking with your pharmacist or doctor first — it can interfere with how well your medication works.

For everyone else, run your medications through the checker below before you buy.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vitamin K1 1%, straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X001B5T26H
Net contents 250 Gram(s); 8.8 Ounce(s)
Market status On market
Date entered into DSLD Apr 23, 2024
DSLD ID 311791
Product type Vitamin
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vitamin K1 1% by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
10 mg
Maximum serving Sizes:
10 mg
Servings per container
25000
UPC/BARCODE
X001B5T26H
IngredientAmount% DV
Vitamin K1100 mcg83%

Other ingredients: Maltodextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

BulkSupplements.com Clean & pure bulk supplements

Formulation

Free of: Soy, dairy, yeast, gluten, added sugars

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 10 mg once daily with food, or as directed by a physician.

General Statements

Use an accurate milligram scale to measure.

New

Storage

Contents are sold by weight, not volume. Settling may occur. Store in a dry, cool, dark place.

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Vitamin K1 1% by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Vitamin K1 1% label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Vitamin K1 1% by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size10 mg Dosage formPowder Servings per container25000 Amounts shown are per serving.

Vitamin K1

Interacts with
2 drugs
100 mcg per serving

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but suppl...

Vitamin K1 monograph & interactions

Other (inactive) ingredients: Maltodextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vitamin K1 1% by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Vitamin K1 1%?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Major

Ingredients driving the most interactions

Vitamin K1 2

Individual Drug Interactions

The ingredients in Vitamin K1 1% interact with 2 drugs. Click any drug to see the details.

1 of the 1 ingredient in Vitamin K1 1% interact with drugs. Each result below shows which ingredient is responsible. Vitamin K1

Each ingredient & the kinds of drugs it affects

For each ingredient in Vitamin K1 1% with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin K11 drug type · 2 drugs

Warfarin (Coumadin)

Vitamin K can antagonize and reverse the therapeutic effects of warfarin.
Vitamin K antagonizes the effects of warfarin. Excessive vitamin K intake, either from supplements or from changes in the diet, can reduce the anticoagulant effect of warfarin.

Likelihood Likely Evidence C
Vitamin K1 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Vitamin K1 1%, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
bulksupplements.com
Pharmacist Counseling Corner

Vitamin K1 1% by BulkSupplements.com: Common Questions

Does Vitamin K1 1% by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Vitamin K1 1% has a known interaction with 2 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vitamin K1 1% contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does vitamin K1 do?
Vitamin K1 helps your body make proteins that form blood clots and stop bleeding. It's also involved in bone health. Your body needs it for normal clotting, and deficiencies can cause excessive bleeding or bruising.
Can I take this if I'm on warfarin?
No — not without talking to your doctor or pharmacist first. Vitamin K1 can reduce how well warfarin works at preventing clots. If you're already on warfarin, any change in vitamin K intake needs to be managed with your provider.
What are the side effects?
Taken by mouth, vitamin K1 is usually mild and well tolerated. The most common side effects are nausea, diarrhea, and stomach upset. Serious side effects are very rare.
Is it safe in pregnancy?
Vitamin K1 is rated as likely safe during pregnancy and breastfeeding. That said, any supplement use in pregnancy should be discussed with your doctor to make sure it's right for your situation.
What's in this powder besides vitamin K1?
The powder contains maltodextrin, which is an inactive ingredient used as a binder and flow agent. It helps the powder mix and stay stable.
Does it really work for osteoporosis?
The evidence suggests vitamin K1 may help with bone health, but the research isn't conclusive yet. It's rated as possibly effective for osteoporosis, meaning more studies are needed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Vitamin K1 1% is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vitamin K1 1% label
Go deeper

The Full Monographs Behind Vitamin K1 1%’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin K

Interacts with 2 drugs

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but supplements are sometimes used for deficiency...

Read the full Vitamin K monograph →
Sources

Sources & How We Checked

Vitamin K1 1%'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin K 11 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  3. Crowther MA, Ageno W, Garcia D, et al. Oral vitamin K versus placebo to correct excessive anticoagulation in patients receiving warfarin: a randomized trial. Ann Intern Med. 2009;150(5):293-300. PubMed
  4. Dietary vitamin K guidance: an effective strategy for stable control of oral anticoagulation? Nutr Rev. 2010;68(3):178-81. PubMed
  5. Kim JS, Nafziger AN, Gaedigk A, et al. Effects of oral vitamin K on S- and R-warfarin pharmacokinetics and pharmacodynamics: enhanced safety of warfarin as a CYP2C9 probe. J Clin Pharmacol. 2001 Jul;41(7):715-22. PubMed
  6. Riegert-Johnson, D. L. and Volcheck, G. W. The incidence of anaphylaxis following intravenous phytonadione (vitamin K1): a 5-year retrospective review. Ann.Allergy Asthma Immunol. 2002;89(4):400-406. PubMed
  7. Dezee, K. J., Shimeall, W. T., Douglas, K. M., Shumway, N. M., and O'malley, P. G. Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis. Arch.Intern.Med. 2-27-2006;166(4):391-397. DOI
  8. Dentali, F., Ageno, W., and Crowther, M. Treatment of coumarin-associated coagulopathy: a systematic review and proposed treatment algorithms. J.Thromb.Haemost. 2006;4(9):1853-1863. PubMed
  9. Caluwé R, Vandecasteele S, Van Vlem B, Vermeer C, De Vriese AS. Vitamin K2 supplementation in haemodialysis patients: a randomized dose-finding study. Nephrol Dial Transplant. 2014;29(7):1385-90.
  10. Huang ZB, Wan SL, Lu YJ, Ning L, Liu C, Fan SW. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials. Osteoporos Int. 2015;26(3):1175-86. PubMed
  11. Hunnali CR, Devi U, Kitchanan S, Sethuraman G. Three Different Regimens for Vitamin K Birth Prophylaxis in Infants Born Preterm: A Randomized Clinical Trial. J Pediatr 2023;255:98-104. PubMed

See these in context on the Vitamin K monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team