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Dietary supplement

Vitamin K12 Ingredients & Drug Interactions

by CHK Nutrition

Vitamin K12 label
See full label image
Capsule Category: Vitamin
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Vitamin K12 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Vitamin K12 is a dietary supplement by CHK Nutrition with 1 active ingredient. Its ingredients are commonly taken for supporting normal blood clotting, bone health, heart and vascular health.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are MenaquinGold Vitamin K2. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Vitamin K12 by CHK Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Vitamin K12 by CHK Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Vitamin K12 by CHK Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: MenaquinGold Vitamin K2. Vitamin K is a fat-soluble vitamin your body uses to make proteins that support blood clotting and bone health.

The capsule itself is made from vegetarian cellulose, with cellulose, magnesium stearate, and silica as inactive ingredients to help hold the capsule together.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: supports bone building and healthy arteries.
  • We looked for evidence on: Cardiovascular disease (CVD), Hemorrhagic disease, Hypoprothrombinemia, Osteoporosis, Vitamin K-dependent clotting factors deficiency (VKCFD), Warfarin anticoagulation — and 4 related terms.
  • The strongest evidence on file: Vitamin K is rated "Effective" for Hemorrhagic disease (Natural Medicines).
  • Also on file: Vitamin K is rated "Effective" for Hypoprothrombinemia, Warfarin anticoagulation, Vitamin K-dependent clotting factors deficiency (VKCFD).
  • Also on file: Vitamin K is rated "Possibly Effective" for Osteoporosis.

Vitamin K2 is effective for treating vitamin K deficiency conditions, including low blood clotting factors (hypoprothrombinemia and vitamin K-dependent clotting factors deficiency) and hemorrhagic disease. For osteoporosis, the evidence is possibly effective — meaning it may help, but more research is needed to confirm the benefit.

The evidence, ingredient by ingredient Vitamin K

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Taken by mouth, vitamin K is generally well tolerated. The most common side effects are mild: nausea, diarrhea, stomach upset, and abdominal pain.

These are typically infrequent. The safety notes advise that normal dietary amounts are fine, but you should check with your doctor before taking supplements — especially if you take warfarin or other blood thinners.

Side effects, ingredient by ingredient Vitamin K

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin K.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist if you take warfarin (Coumadin) or any other blood thinner medication. Vitamin K can reduce how well these drugs work.

Altogether, these interactions span 2 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

If you're deficient in vitamin K or have a clotting disorder, this supplement may help. If you take warfarin or other blood thinners, talk to your pharmacist or doctor first — vitamin K can interfere with how these work.

For anyone else, it's generally well tolerated; just watch for mild stomach upset.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vitamin K12, straight from the product label.

Brand CHK Nutrition
Barcode (UPC) 787500021222
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jun 24, 2020
DSLD ID 228639
Product type Vitamin
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vitamin K12 by CHK Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
UPC/BARCODE
787500021222
IngredientAmount% DV
MenaquinGold Vitamin K245 mcg38%

Other ingredients: Vegetarian Capsule, Cellulose, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Contains no salt, dairy, wheat, gluten, soy, preservatives, artificial colors or flavors.

Natural color variations may occur in this product.

All natural source Supports bone building and healthy arteries

Quality and potency guaranteed

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, adults take one (1) vegetarian capsule daily at mealtime, or as directed by a health care professional.

Storage

Store in a cool, dry place and away from direct light.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Keep out of reach of children.

General Statements

New day. Fresh start. Better health.

FDA Statement of Identity

Dietary Supplement

Formula

Vitamin K2 (menaquinone) is an all-natural form of Vitamin K that is much more biologically active than the more common form, Vitamin K1 (phylloquinone). Vitamin K2 increases the body's formation of osteocalcin, which helps calcium is critical to the growth and strength of bones. Vitamin K2 also increases the formation of protein (matrix GLA-protein) which regulates the amount of calcium present in arterial walls. This helps maintain the elasticity and overall health of arteries.

Brand IP Statement(s)

MenaquinGold is a registered trademark of Viridis Biopharma Pvt. Ltd.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Vitamin K12 by CHK Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Vitamin K12 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Vitamin K12 by CHK Nutrition

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.

MenaquinGold Vitamin K2

Interacts with
2 drugs
45 mcg per serving Form: Menaquinone-7

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but suppl...

MenaquinGold Vitamin K2 monograph & interactions

Other (inactive) ingredients: Vegetarian Capsule, Cellulose, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vitamin K12 by CHK Nutrition Drug Interactions

Want to check YOUR meds against Vitamin K12?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

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2Drugs
2 Major

Ingredients driving the most interactions

MenaquinGold Vitamin K2 2

Individual Drug Interactions

The ingredients in Vitamin K12 interact with 2 drugs. Click any drug to see the details.

1 of the 1 ingredient in Vitamin K12 interact with drugs. Each result below shows which ingredient is responsible. MenaquinGold Vitamin K2

Each ingredient & the kinds of drugs it affects

For each ingredient in Vitamin K12 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

MenaquinGold Vitamin K21 drug type · 2 drugs

Warfarin (Coumadin)

Vitamin K can antagonize and reverse the therapeutic effects of warfarin.
Vitamin K antagonizes the effects of warfarin. Excessive vitamin K intake, either from supplements or from changes in the diet, can reduce the anticoagulant effect of warfarin.

Likelihood Likely Evidence C
MenaquinGold Vitamin K2 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Vitamin K12, from the product label.

CHK Nutrition

See all CHK Nutrition products
Name
CHK Nutrition
Street Address
3930 E Calvary Rd
City
Duluth
State
MN
ZipCode
55803
Phone Number
877-538-8388
Pharmacist Counseling Corner

Vitamin K12 by CHK Nutrition: Common Questions

Does Vitamin K12 by CHK Nutrition interact with any medications?
Yes. Based on its ingredients, Vitamin K12 has a known interaction with 2 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vitamin K12 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on warfarin?
Not without talking to your doctor first. Vitamin K can reverse warfarin's blood-thinning effects, which could raise your clot risk. Your doctor may adjust your warfarin dose or advise against this supplement.
What are the side effects?
Taken by mouth, the most common are nausea, diarrhea, stomach upset, and abdominal pain. These are usually mild and infrequent. Serious side effects are very rare.
Is it safe during pregnancy?
Yes — vitamin K2 is rated as likely safe during pregnancy and while breastfeeding. That said, any supplement decision during pregnancy should involve your obstetrician.
What is vitamin K2, and what does it do?
Vitamin K2 is a form of vitamin K, a nutrient your body needs to make proteins for blood clotting and bone health. This product uses MenaquinGold, a specific form of K2.
Does this product contain fillers?
The capsule contains vegetarian cellulose, and the formula includes cellulose, magnesium stearate, and silica — all standard inactive ingredients to make the capsule stable and easy to swallow.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Vitamin K12 is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vitamin K12 label
Go deeper

The Full Monographs Behind Vitamin K12’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin K

Interacts with 2 drugs

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but supplements are sometimes used for deficiency...

Read the full Vitamin K monograph →
Sources

Sources & How We Checked

Vitamin K12's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin K 11 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  3. Crowther MA, Ageno W, Garcia D, et al. Oral vitamin K versus placebo to correct excessive anticoagulation in patients receiving warfarin: a randomized trial. Ann Intern Med. 2009;150(5):293-300. PubMed
  4. Dietary vitamin K guidance: an effective strategy for stable control of oral anticoagulation? Nutr Rev. 2010;68(3):178-81. PubMed
  5. Kim JS, Nafziger AN, Gaedigk A, et al. Effects of oral vitamin K on S- and R-warfarin pharmacokinetics and pharmacodynamics: enhanced safety of warfarin as a CYP2C9 probe. J Clin Pharmacol. 2001 Jul;41(7):715-22. PubMed
  6. Riegert-Johnson, D. L. and Volcheck, G. W. The incidence of anaphylaxis following intravenous phytonadione (vitamin K1): a 5-year retrospective review. Ann.Allergy Asthma Immunol. 2002;89(4):400-406. PubMed
  7. Dezee, K. J., Shimeall, W. T., Douglas, K. M., Shumway, N. M., and O'malley, P. G. Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis. Arch.Intern.Med. 2-27-2006;166(4):391-397. DOI
  8. Dentali, F., Ageno, W., and Crowther, M. Treatment of coumarin-associated coagulopathy: a systematic review and proposed treatment algorithms. J.Thromb.Haemost. 2006;4(9):1853-1863. PubMed
  9. Caluwé R, Vandecasteele S, Van Vlem B, Vermeer C, De Vriese AS. Vitamin K2 supplementation in haemodialysis patients: a randomized dose-finding study. Nephrol Dial Transplant. 2014;29(7):1385-90.
  10. Huang ZB, Wan SL, Lu YJ, Ning L, Liu C, Fan SW. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials. Osteoporos Int. 2015;26(3):1175-86. PubMed
  11. Hunnali CR, Devi U, Kitchanan S, Sethuraman G. Three Different Regimens for Vitamin K Birth Prophylaxis in Infants Born Preterm: A Randomized Clinical Trial. J Pediatr 2023;255:98-104. PubMed

See these in context on the Vitamin K monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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