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Dietary supplement

Vitamin K2 45 mcg Ingredients & Drug Interactions

by Nutri-Rich

Vitamin K2 45 mcg label
See full label image
Softgel Capsule Category: Vitamin
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Vitamin K2 45 mcg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Vitamin K2 45 mcg is a dietary supplement by Nutri-Rich with 1 active ingredient. Its ingredients are commonly taken for supporting normal blood clotting, bone health, heart and vascular health.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin K-2. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Vitamin K2 45 mcg by Nutri-Rich

Ask about any prescription or over-the-counter medication and we check it for interactions with Vitamin K2 45 mcg by Nutri-Rich — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Vitamin K2 45 mcg by Nutri-Rich

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Vitamin K-2 at 45 micrograms per softgel. Vitamin K is a fat-soluble nutrient your body uses to make clotting proteins and support bone health.

The softgel also contains inactive ingredients — extra virgin olive oil, gelatin, glycerin, purified water, and carob — that help deliver and preserve the vitamin.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports healthy arteries and strong bones.
  • We looked for evidence on: Cardiovascular disease (CVD), Osteoporosis, Stroke, Bone density, Arterial calcification, Vascular health.
  • The strongest evidence on file: Vitamin K is rated "Possibly Effective" for Osteoporosis (Natural Medicines).
  • Also on file: Vitamin K is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD), Stroke.

Vitamin K-2 is effective for treating vitamin K deficiency and related clotting disorders, including hypoprothrombinemia and vitamin K-dependent clotting factor deficiency. It's also effective for managing bleeding disorders and for correcting problems caused by excessive warfarin use.

For osteoporosis, the evidence is less complete — it's rated possibly effective, meaning the data suggests a benefit but isn't conclusive yet.

The evidence, ingredient by ingredient Vitamin K

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin K taken by mouth is generally well tolerated in healthy people at typical dietary and supplement doses. The most common side effects are mild gastrointestinal — nausea, stomach upset, abdominal pain, and diarrhea.

The safety data advises checking with your doctor before taking supplements, though normal dietary amounts are fine. This product is rated likely safe in pregnancy and lactation, but talk with your healthcare provider about your individual situation.

Side effects, ingredient by ingredient Vitamin K

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin K.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start this product, double-check if you're taking warfarin (Coumadin) or any blood thinner — Vitamin K-2 can reduce its effectiveness at a Major level of concern. Use the medication search tool below with your exact drugs to see if there are any other interactions specific to you.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Vitamin K-2 is a straightforward supplement for people who need to support clotting function or bone health. If you take warfarin or any other blood thinner, you must check with your pharmacist first — this product can interfere with how those medications work.

Anyone else should have a brief conversation with their provider before starting, just to be sure it fits your health picture.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vitamin K2 45 mcg, straight from the product label.

Brand Nutri-Rich
Barcode (UPC) 619176100812
Net contents 90 Softgel(s)
Market status On market
Date entered into DSLD Apr 25, 2018
DSLD ID 176554
Product type Vitamin
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vitamin K2 45 mcg by Nutri-Rich, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
90
UPC/BARCODE
619176100812
IngredientAmount% DV
Vitamin K-245 mcg56%

Other ingredients: extra virgin Olive Oil, Gelatin, Glycerin, purified Water, Carob

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Vitamin K2 supports healthy arteries and works synergistically with calcium for strong bones. It is not synethesized by our bodies and typically deficient in our diets.

Third-party quality tested NSF GMP certified facility

Made in the USA

Supports arterial health and strong bones.

Formula

We use a soy-free form that is naturally fermented and blend it with extra virgin Olive Oil for extra health benefits.

Vitamin K2 45mcg Vitamin K2 as MK-7

Superior MK-7 form is natural and easily absorbed.

Formulation

We use a soy-free form that is naturally fermented and blend it with extra virgin Olive Oil for extra health benefits.

Sugar free Gluten free No artificial additives Non-GMO

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Take 1 softgel daily.

Precautions

Note: If you take anticoagulants such as warfarin, please consult your physician before use. If you are pregnant, nursing, or taking any medications, consult your physician before use.

Store in a cool, dry place, away from the reach of children.

Storage

Store in a cool, dry place, away from the reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any diseases.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Vitamin K2 45 mcg by Nutri-Rich label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Vitamin K2 45 mcg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Vitamin K2 45 mcg by Nutri-Rich

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container90 Amounts shown are per serving.

Vitamin K-2

Interacts with
2 drugs
45 mcg per serving Form: Menaquinone-7

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but suppl...

Vitamin K-2 monograph & interactions

Other (inactive) ingredients: Extra virgin Olive Oil, Gelatin, Glycerin, Purified Water, Carob. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vitamin K2 45 mcg by Nutri-Rich Drug Interactions

Want to check YOUR meds against Vitamin K2 45 mcg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Major

Ingredients driving the most interactions

Vitamin K-2 2

Individual Drug Interactions

The ingredients in Vitamin K2 45 mcg interact with 2 drugs. Click any drug to see the details.

1 of the 1 ingredient in Vitamin K2 45 mcg interact with drugs. Each result below shows which ingredient is responsible. Vitamin K-2

Each ingredient & the kinds of drugs it affects

For each ingredient in Vitamin K2 45 mcg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin K-21 drug type · 2 drugs

Warfarin (Coumadin)

Vitamin K can antagonize and reverse the therapeutic effects of warfarin.
Vitamin K antagonizes the effects of warfarin. Excessive vitamin K intake, either from supplements or from changes in the diet, can reduce the anticoagulant effect of warfarin.

Likelihood Likely Evidence C
Vitamin K-2 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Vitamin K2 45 mcg, from the product label.

Nutri-Rich

See all Nutri-Rich products
Name
Nutri-Rich
Street Address
2307 Moore Avenue
City
Fullerton
State
CA
ZipCode
92833
Phone Number
1 855 200 8985
Web Address
www.nutri-rich.com
Pharmacist Counseling Corner

Vitamin K2 45 mcg by Nutri-Rich: Common Questions

Does Vitamin K2 45 mcg by Nutri-Rich interact with any medications?
Yes. Based on its ingredients, Vitamin K2 45 mcg has a known interaction with 2 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vitamin K2 45 mcg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this vitamin K supplement interfere with my blood thinner?
Yes — if you take warfarin (Coumadin), this product is a Major concern. Vitamin K can weaken warfarin's blood-thinning effect. Check with your pharmacist or doctor before taking it. That conversation is essential for your safety.
What side effects should I expect?
Vitamin K taken by mouth is generally well tolerated. The most common side effects are mild gastrointestinal ones: nausea, stomach upset, abdominal pain, and diarrhea. Serious side effects are very rare when taken by mouth.
Does this work for osteoporosis?
The evidence suggests vitamin K may help with bone health, but it's rated possibly effective — meaning the data is promising but not yet conclusive. Talk with your doctor about whether it makes sense for your situation.
Is it safe to take while I'm pregnant or breastfeeding?
This product is rated likely safe during pregnancy and lactation. That said, every pregnancy is unique — talk with your provider about whether it's right for you and your situation.
What exactly is in each softgel?
The active ingredient is vitamin K-2 at 45 micrograms. The softgel also contains olive oil, gelatin, glycerin, water, and carob to hold it together and preserve it — these are inactive ingredients that just help deliver the vitamin.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Vitamin K2 45 mcg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vitamin K2 45 mcg label
Go deeper

The Full Monographs Behind Vitamin K2 45 mcg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin K

Interacts with 2 drugs

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but supplements are sometimes used for deficiency...

Read the full Vitamin K monograph →
Sources

Sources & How We Checked

Vitamin K2 45 mcg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin K 11 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  3. Crowther MA, Ageno W, Garcia D, et al. Oral vitamin K versus placebo to correct excessive anticoagulation in patients receiving warfarin: a randomized trial. Ann Intern Med. 2009;150(5):293-300. PubMed
  4. Dietary vitamin K guidance: an effective strategy for stable control of oral anticoagulation? Nutr Rev. 2010;68(3):178-81. PubMed
  5. Kim JS, Nafziger AN, Gaedigk A, et al. Effects of oral vitamin K on S- and R-warfarin pharmacokinetics and pharmacodynamics: enhanced safety of warfarin as a CYP2C9 probe. J Clin Pharmacol. 2001 Jul;41(7):715-22. PubMed
  6. Riegert-Johnson, D. L. and Volcheck, G. W. The incidence of anaphylaxis following intravenous phytonadione (vitamin K1): a 5-year retrospective review. Ann.Allergy Asthma Immunol. 2002;89(4):400-406. PubMed
  7. Dezee, K. J., Shimeall, W. T., Douglas, K. M., Shumway, N. M., and O'malley, P. G. Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis. Arch.Intern.Med. 2-27-2006;166(4):391-397. DOI
  8. Dentali, F., Ageno, W., and Crowther, M. Treatment of coumarin-associated coagulopathy: a systematic review and proposed treatment algorithms. J.Thromb.Haemost. 2006;4(9):1853-1863. PubMed
  9. Caluwé R, Vandecasteele S, Van Vlem B, Vermeer C, De Vriese AS. Vitamin K2 supplementation in haemodialysis patients: a randomized dose-finding study. Nephrol Dial Transplant. 2014;29(7):1385-90.
  10. Huang ZB, Wan SL, Lu YJ, Ning L, Liu C, Fan SW. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials. Osteoporos Int. 2015;26(3):1175-86. PubMed
  11. Hunnali CR, Devi U, Kitchanan S, Sethuraman G. Three Different Regimens for Vitamin K Birth Prophylaxis in Infants Born Preterm: A Randomized Clinical Trial. J Pediatr 2023;255:98-104. PubMed

See these in context on the Vitamin K monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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