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Dietary supplement

Vitamin K2 MK-4 (Menatetrenone) 5 mg Ingredients & Drug Interactions

by Carlson

Vitamin K2 MK-4 (Menatetrenone) 5 mg label
See full label image
Capsule Category: Vitamin
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Vitamin K2 MK-4 (Menatetrenone) 5 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Vitamin K2 MK-4 (Menatetrenone) 5 mg is a dietary supplement by Carlson with 1 active ingredient. Its ingredients are commonly taken for supporting normal blood clotting, bone health, heart and vascular health.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin K2. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Vitamin K2 MK-4 (Menatetrenone) 5 mg by Carlson

Ask about any prescription or over-the-counter medication and we check it for interactions with Vitamin K2 MK-4 (Menatetrenone) 5 mg by Carlson — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Vitamin K2 MK-4 (Menatetrenone) 5 mg by Carlson

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Vitamin K2 (as menatetrenone, or MK-4) at 5 mg per capsule. Vitamin K2 is a fat-soluble vitamin that plays a role in bone health and clotting factor function.

The capsule also contains inactive ingredients (microcrystalline cellulose, magnesium stearate, silicon dioxide, and beef gelatin) that serve as binders and the capsule shell.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Bone support and cardiovascular function.
  • We looked for evidence on: Cardiovascular disease (CVD), Osteoporosis, Hemorrhagic disease, Vitamin K-dependent clotting factors deficiency (VKCFD), Warfarin anticoagulation, Bone density — and 2 related terms.
  • The strongest evidence on file: Vitamin K is rated "Effective" for Hemorrhagic disease (Natural Medicines).
  • Also on file: Vitamin K is rated "Effective" for Warfarin anticoagulation, Vitamin K-dependent clotting factors deficiency (VKCFD).
  • Also on file: Vitamin K is rated "Possibly Effective" for Osteoporosis.

Vitamin K2 is considered effective for treating vitamin K deficiency and conditions tied to clotting factor problems, including hypoprothrombinemia and hemorrhagic disease. For bone health and osteoporosis, the evidence is less established—it's rated possibly effective, meaning more research is needed to confirm a real benefit at this dose.

The evidence, ingredient by ingredient Vitamin K

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin K from food and most supplements is generally well tolerated in healthy people. When taken by mouth, the most common side effects are mild gastrointestinal ones: nausea, stomach upset, abdominal pain, and diarrhea.

The safety data indicates this product is likely safe in pregnancy and breastfeeding, though standard practice is to check with your doctor before starting any supplement during those times.

Side effects, ingredient by ingredient Vitamin K

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin K.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Blood thinners (anticoagulants)—especially warfarin—need to be discussed with your doctor before you add this product. Vitamin K can reduce how well these drugs work and increase your clot risk.

If you take any anticoagulant, clear it first with your provider.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a straightforward, single-ingredient vitamin K2 product—useful if you have a vitamin K deficiency or your doctor recommends it for bone support. The critical point: if you're on warfarin or any blood thinner, talk with your doctor or pharmacist before taking it, because vitamin K can make those drugs less effective.

For everyone else, check your medications on this page and discuss any questions with your own healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vitamin K2 MK-4 (Menatetrenone) 5 mg, straight from the product label.

Brand Carlson
Barcode (UPC) 088395010019
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Mar 24, 2020
DSLD ID 216184
Product type Vitamin
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vitamin K2 MK-4 (Menatetrenone) 5 mg by Carlson, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
180
UPC/BARCODE
088395010019
IngredientAmount% DV
Vitamin K25 mg--

Other ingredients: Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide, Beef Gelatin Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Formulation

Bone support Cardiovascular function Optimal wellness

Gluten-free No artificial preservatives

Research suggests Vitamin K2 as MK-4 (menatetrenone) promotes healthy bones and cardiovascular system function.

Potency & quality guaranteed An FDA regulated facility

Precautions

Warning: Vitamin K can antagonize the effect of anticoagulants, including Warfarin. Do not take this product if you are taking Warfarin without first consulting with your physician. Do not use during pregnancy or breastfeeding.

Formula

A single capsule provides 5 mg of MK-4.

Suggested/Recommended/Usage/Directions

Directions: Adults: take one capsule daily at mealtime.

Storage

Keep bottle tightly closed. Store away from heat and moisture.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Vitamin K2 MK-4 (Menatetrenone) 5 mg by Carlson label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Vitamin K2 MK-4 (Menatetrenone) 5 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Vitamin K2 MK-4 (Menatetrenone) 5 mg by Carlson

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.

Vitamin K2

Interacts with
2 drugs
5 mg per serving Form: MK-4

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but suppl...

Vitamin K2 monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide, Beef Gelatin Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vitamin K2 MK-4 (Menatetrenone) 5 mg by Carlson Drug Interactions

Want to check YOUR meds against Vitamin K2 MK-4 (Menatetrenone) 5 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Major

Ingredients driving the most interactions

Vitamin K2 2

Individual Drug Interactions

The ingredients in Vitamin K2 MK-4 (Menatetrenone) 5 mg interact with 2 drugs. Click any drug to see the details.

1 of the 1 ingredient in Vitamin K2 MK-4 (Menatetrenone) 5 mg interact with drugs. Each result below shows which ingredient is responsible. Vitamin K2

Each ingredient & the kinds of drugs it affects

For each ingredient in Vitamin K2 MK-4 (Menatetrenone) 5 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin K21 drug type · 2 drugs

Warfarin (Coumadin)

Vitamin K can antagonize and reverse the therapeutic effects of warfarin.
Vitamin K antagonizes the effects of warfarin. Excessive vitamin K intake, either from supplements or from changes in the diet, can reduce the anticoagulant effect of warfarin.

Likelihood Likely Evidence C
Vitamin K2 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Vitamin K2 MK-4 (Menatetrenone) 5 mg, from the product label.

Carlson

See all Carlson products
Name
Carlson Division of J.R. Carlson Laboratories, Inc.
City
Arlington Heights
State
IL
ZipCode
60004
Phone Number
888-234-5656
Web Address
www.carlsonlabs.com
Pharmacist Counseling Corner

Vitamin K2 MK-4 (Menatetrenone) 5 mg by Carlson: Common Questions

Does Vitamin K2 MK-4 (Menatetrenone) 5 mg by Carlson interact with any medications?
Yes. Based on its ingredients, Vitamin K2 MK-4 (Menatetrenone) 5 mg has a known interaction with 2 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vitamin K2 MK-4 (Menatetrenone) 5 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does Vitamin K2 do?
Vitamin K2 (MK-4) supports your body's clotting factors—proteins that help blood clot properly—and plays a role in bone health. It's used to treat vitamin K deficiency and related bleeding disorders, and some evidence suggests it may support bone strength, though more research is needed.
Can I take this if I'm pregnant or breastfeeding?
The safety data rates Vitamin K2 as likely safe during pregnancy and breastfeeding. That said, it's smart to discuss any supplement with your doctor during these times to make sure it fits your personal situation.
What side effects might I notice?
Most people tolerate it well. If you do experience side effects, they're usually mild and digestive: nausea, stomach upset, abdominal pain, or diarrhea. Serious reactions are very rare.
Is this the same as Vitamin K1?
No. This product contains Vitamin K2 (specifically MK-4, or menatetrenone), which is different from Vitamin K1. They have different roles in your body and different dietary sources, though both are important forms of vitamin K.
Does this product have any fillers or binders?
Yes. Besides the active vitamin K2, the capsule contains microcrystalline cellulose (a binder), magnesium stearate, silicon dioxide, and a beef gelatin capsule. These are standard inactive ingredients that help hold the supplement together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Vitamin K2 MK-4 (Menatetrenone) 5 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vitamin K2 MK-4 (Menatetrenone) 5 mg label
Go deeper

The Full Monographs Behind Vitamin K2 MK-4 (Menatetrenone) 5 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin K

Interacts with 2 drugs

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but supplements are sometimes used for deficiency...

Read the full Vitamin K monograph →
Sources

Sources & How We Checked

Vitamin K2 MK-4 (Menatetrenone) 5 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin K 11 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  3. Crowther MA, Ageno W, Garcia D, et al. Oral vitamin K versus placebo to correct excessive anticoagulation in patients receiving warfarin: a randomized trial. Ann Intern Med. 2009;150(5):293-300. PubMed
  4. Dietary vitamin K guidance: an effective strategy for stable control of oral anticoagulation? Nutr Rev. 2010;68(3):178-81. PubMed
  5. Kim JS, Nafziger AN, Gaedigk A, et al. Effects of oral vitamin K on S- and R-warfarin pharmacokinetics and pharmacodynamics: enhanced safety of warfarin as a CYP2C9 probe. J Clin Pharmacol. 2001 Jul;41(7):715-22. PubMed
  6. Riegert-Johnson, D. L. and Volcheck, G. W. The incidence of anaphylaxis following intravenous phytonadione (vitamin K1): a 5-year retrospective review. Ann.Allergy Asthma Immunol. 2002;89(4):400-406. PubMed
  7. Dezee, K. J., Shimeall, W. T., Douglas, K. M., Shumway, N. M., and O'malley, P. G. Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis. Arch.Intern.Med. 2-27-2006;166(4):391-397. DOI
  8. Dentali, F., Ageno, W., and Crowther, M. Treatment of coumarin-associated coagulopathy: a systematic review and proposed treatment algorithms. J.Thromb.Haemost. 2006;4(9):1853-1863. PubMed
  9. Caluwé R, Vandecasteele S, Van Vlem B, Vermeer C, De Vriese AS. Vitamin K2 supplementation in haemodialysis patients: a randomized dose-finding study. Nephrol Dial Transplant. 2014;29(7):1385-90.
  10. Huang ZB, Wan SL, Lu YJ, Ning L, Liu C, Fan SW. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials. Osteoporos Int. 2015;26(3):1175-86. PubMed
  11. Hunnali CR, Devi U, Kitchanan S, Sethuraman G. Three Different Regimens for Vitamin K Birth Prophylaxis in Infants Born Preterm: A Randomized Clinical Trial. J Pediatr 2023;255:98-104. PubMed

See these in context on the Vitamin K monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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