Interactions on record — worth a quick check against your medications. Based on 10 of 14 ingredients. Check your meds →
Dietary supplement

VRM3 Micro Ingredients & Drug Interactions

by Systemic Formulas Bio Challenge

VRM3 Micro label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking VRM3 Micro against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

VRM3 Micro is a dietary supplement by Systemic Formulas Bio Challenge with 14 active ingredients. Its ingredients are commonly taken for inflammation and swelling, sinus and nasal congestion, digestion support.Based on those ingredients, 1,170 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pomegranate, Valerian, Maracuja. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against VRM3 Micro by Systemic Formulas Bio Challenge

Ask about any prescription or over-the-counter medication and we check it for interactions with VRM3 Micro by Systemic Formulas Bio Challenge — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of VRM3 Micro by Systemic Formulas Bio Challenge

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 14 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1,500 mg) without saying how much of each component you get.

VRM3 Micro contains 14 ingredients total, including a proprietary blend with several identified components. The active ingredients we know about are bromelain (an enzyme from pineapple), pomegranate (fruit extract), valerian (root), black walnut (hull or leaf), kamala (a traditional botanical), maracuja, wild geranium, carrapicho, star anise, bistort, wormseed oil, and yerba santa.

The product also contains two inactive ingredients — cellulose and leucine — which are filler and binding materials.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: intestinal tract health and microscopic organism elimination.
  • We looked for evidence on: Intestinal parasite infection, Intestinal parasites, Intestinal worms, Parasite cleanse.
  • The closest evidence on file: Wormseed is rated "Insufficient Reliable Evidence To Rate" for Intestinal parasite infection (Natural Medicines).

The effectiveness evidence for most of these ingredients is either limited or not established in the data we hold. Pomegranate has possibly effective evidence for high blood pressure (hypertension) but is considered possibly ineffective for high cholesterol (hyperlipidemia).

Valerian is possibly effective for insomnia. Bromelain, black walnut, kamala, wormseed, and yerba santa all lack reliable evidence for their intended uses in clinical trials.

Star anise and bistort have no effectiveness ratings in our data. The evidence for this product's overall purpose isn't established from the ingredient profile alone.

The evidence, ingredient by ingredient Bromelain Pomegranate Valerian Black Walnut Kamala Passion Flower Star Anise Bistort

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 10 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 9 of 10.
  • General safety write-ups exist for 10 of 10.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Several ingredients here need caution or should be avoided depending on your situation. Bromelain is generally well tolerated short-term but long-term safety is not well studied; it can cause diarrhea, flatulence, headache, and stomach upset orally.

Some people may have allergic reactions. Pomegranate fruit and juice in food amounts are generally safe, but concentrated extracts should be used with caution due to limited safety data.

Valerian is well tolerated short-term but can cause drowsiness, dizziness, headache, and vivid dreams; rare cases of liver damage have been reported, and abruptly stopping it after long use can cause withdrawal symptoms like anxiety and insomnia, so taper slowly. Black walnut's nut is well tolerated, but the leaf, bark, and hull contain tannins that may upset the stomach.

Wormseed oil is unsafe at medicinal doses — concentrated amounts can cause serious poisoning with seizures, muscle twitching, kidney problems, and even death. Star anise in food amounts is safe, but concentrated tea has been linked to neurological problems like seizures and jitteriness.

Yerba santa and kamala have limited safety data.

Side effects, ingredient by ingredient Bromelain Pomegranate Valerian Black Walnut Kamala Passion Flower Star Anise Bistort

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 10 matched ingredients can interact with medications — Pomegranate, Yerba Santa, Valerian, Passion Flower, Bromelain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; lithium.
  • For scale: 1,171 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before taking VRM3 Micro if you use blood thinners or antiplatelet drugs (Major), blood pressure medications, sedatives or sleep aids, ACE inhibitors, drugs metabolized by your liver via CYP2D6 or CYP2C9 pathways, warfarin, or lithium (all Moderate severity). Valerian also interacts with alcohol, so avoid combining them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product contains ingredients with documented interactions affecting more than 1,100 individual medications, so checking your exact prescriptions is essential before starting it. If you take blood thinners, blood pressure medications, sedatives, anxiety drugs, lithium, or any CYP enzyme-metabolized medications, talk with your pharmacist first.

People pregnant or breastfeeding should avoid this product — several ingredients are unsafe or lack adequate safety data. Consider it only after confirming all your medications are clear.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 10 of 14 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about VRM3 Micro, straight from the product label.

Brand Systemic Formulas Bio Challenge
Barcode (UPC) 635585049313
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Jun 25, 2013
DSLD ID 22221
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for VRM3 Micro by Systemic Formulas Bio Challenge, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
UPC/BARCODE
635585049313
IngredientAmount% DV
Proprietary Blend1500 mg--
Bromelain0 NP--
Pomegranate0 NP--
Valerian0 NP--
Black Walnut0 NP--
Kamala0 NP--
Maracuja0 NP--
Wild Geranium0 NP--
Carrapicho0 NP--
Erva Tostao0 NP--
Anis Estrelado0 NP--
Bistort0 NP--
Wormseed Oil0 NP--
Jalapa0 NP--
Yerba Santa0 NP--

Other ingredients: Cellulose, Leucine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Pregnant women/children: consult with health practitioner before use.

Pregnant women/children: consult with health practitioner before use.

Keep away from Heat, Sunlight and Children.

Storage

Keep away from Heat, Sunlight and Children.

Seals/Symbols

veg

General

#493 G/12

General Statements

Assures good health in the intestinal tract by suppporting microscopic organism elimination.

SOLD THROUGH PROFESSIONALS

MADE IN U.S.A.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, or prevent any diseases.

Suggested/Recommended/Usage/Directions

DIRECTIONS FOR NUTRITIONAL USE: 1-3 capsules at bedtime for 30-75 days, or as directed. For the most part, four bottles may be needed to complete the program. Increase the amount of liquids you drink each day while taking this product.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

VRM3 Micro by Systemic Formulas Bio Challenge label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

VRM3 Micro label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in VRM3 Micro by Systemic Formulas Bio Challenge

These are the 14 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

1500 mg per serving

Other (inactive) ingredients: Cellulose, Leucine. These complete the product’s ingredient list but are not active constituents.

Interaction report

VRM3 Micro by Systemic Formulas Bio Challenge Drug Interactions

Want to check YOUR meds against VRM3 Micro?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,170Drugs
683 Moderate 487 Minor

Ingredients driving the most interactions

Pomegranate 922
Valerian 902
Maracuja 836
Bromelain 141
Yerba Santa 1

Individual Drug Interactions

The ingredients in VRM3 Micro interact with 1,170 drugs. Click any drug to see the details.

5 of the 14 ingredients in VRM3 Micro interact with drugs. Each result below shows which ingredient is responsible. Pomegranate Valerian Maracuja Bromelain Yerba Santa

Each ingredient & the kinds of drugs it affects

For each ingredient in VRM3 Micro with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Pomegranate9 drug types · 922 drugs

Ace Inhibitors (Aceis)

Theoretically, taking pomegranate with ACEIs might increase the risk of adverse effects.
Pomegranate juice is thought to have ACE inhibitor-like effects.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Consuming pomegranate juice can modestly lower blood pressure.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
In vitro, pomegranate juice inhibits CYP2D6. However, the clinical significance of this potential interaction in humans is not known.

Likelihood Possible Evidence D
Rosuvastatin (Crestor)

Theoretically, taking pomegranate with rosuvastatin might increase the risk of adverse effects.
In one case, a patient taking rosuvastatin 5 mg every other day in combination with ezetimibe 10 mg daily developed rhabdomyolysis after drinking pomegranate juice 200 mL twice weekly for 3 weeks. This patient had a history of elevated creatine kinase levels while not receiving any statin treatment. This suggests a possible underlying myopathy and predisposition to rhabdomyolysis.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, pomegranate might increase warfarin levels and increase the risk of bleeding. Also, discontinuing regular consumption of pomegranate juice might decrease warfarin levels.
In one case report, a patient had a stable, therapeutic bleeding time, as measured by international normalized ratio (INR), while taking warfarin in combination with pomegranate juice 2-3 times per week. The patient became subtherapeutic within about 10 days after discontinuing pomegranate juice, which required a warfarin dose increase. In another case report, a patient with a stable INR for over one year presented with an INR of 14. The patient noted no changes to medications or diet but did report consuming around 3 liters of pomegranate juice over the previous week. The patient's INR stabilized upon moderation of pomegranate juice consumption. The mechanism of this potential interaction is unclear.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, taking pomegranate with carbamazepine might increase the risk of adverse effects, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice may inhibit cytochrome P450 3A4 (CYP3A4) metabolism of carbamazepine and increase levels of carbamazepine by 1.5 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP3A4, but might not inhibit hepatic CYP3A4. However, some human research suggests that pomegranate does not significantly inhibit CYP3A4 drug metabolism in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2C9.
Some animal and in vitro research shows that pomegranate juice inhibits intestinal, but not hepatic, CYP2C9 isoenzyme activity. However, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Pomegranate contains several polyphenols that have individually been shown to inhibit CYP3A4. However, there is contradictory evidence about the effect of whole pomegranate juice on CYP3A4 activity. In vitro, pomegranate juice significantly inhibits the CYP3A4 enzyme, with comparable inhibition to grapefruit juice. In an animal model, pomegranate juice inhibits CYP3A4 metabolism of carbamazepine and increases levels of carbamazepine by 1.5 times; however, in human volunteers, drinking a single glass of pomegranate juice 240 mL or taking 200 mL daily for 2 weeks does not significantly affect levels of the CYP3A4 substrate midazolam after oral or intravenous administration. Another study in healthy volunteers shows that consuming pomegranate juice 300 mL three times daily for three days also does not significantly affect levels of simvastatin, a CYP3A4 substrate This suggests that pomegranate is unlikely to significantly affect levels of CYP3A4 substrates in humans.

Likelihood Unlikely Evidence B
Tolbutamide (Orinase)

Theoretically, pomegranate might increase levels of tolbutamide, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice inhibits the cytochrome P450 2C9 (CYP2C9) metabolism of tolbutamide. Pomegranate juice increased tolbutamide levels by 1.2 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP2C9, but might not inhibit hepatic CYP2C9. Despite this evidence, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans. This interaction does not appear to be clinically significant in humans.

Likelihood Unlikely Evidence D
Pomegranate full monograph & interactions

Valerian6 drug types · 902 drugs

Alcohol (Ethanol)

Valerian can have additive sedative effects when used concomitantly with alcohol.
Valerian has sedative effects. Theoretically, valerian might have an additive sedative effect when combined with alcohol. Excessive sedation has been reported in an alcohol-abusing individual who took valerian and Gingko biloba. However, the potential interaction between valerian and alcohol has been disputed in other research. Limited evidence suggests that a combination of valerian 160 mg and lemon balm 80 mg (Euvegal) does not cause further deterioration in reaction ability and reaction rate when taken with alcohol as compared to the effects of alcohol alone.

Likelihood Possible Evidence B
Alprazolam (Xanax)

Valerian can have additive sedative effects when used with alprazolam. Also, valerian in high doses might modestly increase alprazolam levels, though this is not likely to be clinically significant.
Valerian has sedative effects. Theoretically, valerian might cause additive sedation when combined with alprazolam. Also, a small pharmacokinetic study shows that taking valerian extract 1000 mg daily (providing 11 mg valerenic acid) might increase alprazolam levels by about 19%. This might be due to valerian's mild inhibition of cytochrome P450 3A4 (CYP3A4). Despite being statistically significant, this increase is not likely to be clinically significant.

Likelihood Possible Evidence B
Cns Depressants

Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Theoretically, concomitant use of valerian and drugs with sedative and anesthetic properties may cause additive therapeutic and adverse effects.

Likelihood Possible Evidence D
Glucuronidated Drugs

Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
In vitro research shows that methanolic valerian extract and valerenic acid might competitively inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1) and UGT2B7.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Although some in vitro evidence suggests that valerian affects CYP2D6, clinical pharmacokinetic (PK) studies show that valerian is unlikely to affect the CYP2D6 enzyme. In one PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days did not affect the metabolism of dextromethorphan, a CYP2D6 substrate. In another PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of debrisoquine, an accepted CYP2D6 probe-substrate.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Although some in vitro evidence suggests that valerian extract might inhibit or induce CYP3A4, clinical pharmacokinetic (PK) studies show that valerian does not have a clinically significant effect on the CYP3A4 enzyme. In one PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of midazolam, an accepted CYP3A4 probe-substrate. In another PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days modestly increases levels of alprazolam, a CYP3A4 substrate, suggesting mild inhibition of CYP3A4. However, this mild inhibition is unlikely to be clinically relevant.

Likelihood Possible Evidence B
Valerian full monograph & interactions

Maracuja3 drug types · 836 drugs

Cns Depressants

Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Research in animals and humans shows that passion flower has sedative effects which can be additive when used with sedative medications like lorazepam.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
In vitro research suggests that passion flower can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.

Likelihood Possible Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
In vitro research shows that the passion flower constituents apigenin and vitexin inhibit OATP2B1 and OATP1A2. This inhibition may be dose-dependent. One specific high-flavonoid passion flower extract (Valverde) seems to inhibit OATP2B1 and OATP1A2, while another extract with a lower flavonoid concentration (Arkocaps) shows less potent inhibition. OATPs are responsible for the uptake of drugs and other compounds into the body; however, the specific activities of OATP2B1 and OATP1A2 are not well characterized.

Likelihood Possible Evidence D
Maracuja full monograph & interactions

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B
Bromelain full monograph & interactions

Yerba Santa1 drug type · 1 drug

Lithium

Yerba santa is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, yerba santa might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Yerba Santa full monograph & interactions
The maker

Brand information

Manufacturer and brand details for VRM3 Micro, from the product label.

Systemic Formulas Bio Challenge

Name
Systemic Formulas Inc.
Street Address
P.O. Box 1516
City
Ogden
State
UT
ZipCode
84402
Web Address
systemicformulas.com
Pharmacist Counseling Corner

VRM3 Micro by Systemic Formulas Bio Challenge: Common Questions

Does VRM3 Micro by Systemic Formulas Bio Challenge interact with any medications?
Yes. Based on its ingredients, VRM3 Micro has a known interaction with 1,170 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
VRM3 Micro contains 14 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant?
No. Bromelain, valerian, black walnut, kamala, and wormseed are all unsafe or best avoided in pregnancy. Star anise and yerba santa likely have limited safety data in pregnancy. Talk with your doctor or pharmacist — this product is not recommended if you're expecting.
Can I breastfeed while taking this?
The safety data advises against it. Bromelain, valerian, black walnut, kamala, wormseed, star anise, yerba santa, and bistort all lack adequate safety information for breastfeeding mothers. Check with your pharmacist or doctor about what's safe for nursing.
Does bromelain really thin the blood?
Bromelain has antiplatelet effects — meaning it may reduce how sticky your blood cells are — which can increase bleeding risk if you're already on a blood thinner or antiplatelet drug like aspirin. There's one case report of minor bruising when someone took it with naproxen. It's a real concern if you take bleeding-risk medications.
What side effects might I experience?
The most common side effects from these ingredients are digestive — diarrhea, flatulence, stomach upset, and nausea, mainly from bromelain and pomegranate. Valerian commonly causes drowsiness, dizziness, headache, and vivid dreams. Wormseed oil at medicinal doses is unsafe and can cause serious toxicity. Other side effects depend on which ingredient affects you.
Can I use this long-term?
Long-term safety is not well studied for most of these ingredients. Bromelain, valerian, black walnut, and yerba santa all have limited long-term safety data. Valerian used long-term and then stopped suddenly can cause withdrawal symptoms like anxiety and insomnia, so you'd need to taper it slowly. Check with your pharmacist about your timeline.
What if I'm allergic to pineapple or tree nuts?
Bromelain is an enzyme from pineapple, so if you're allergic to pineapple, avoid this product. Black walnut is a tree nut — people with tree nut allergies can have serious reactions. Let your pharmacist know about any nut or pineapple allergies before using this.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

VRM3 Micro label
Go deeper

The Full Monographs Behind VRM3 Micro’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bromelain

Interacts with 141 drugs

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early studies are promising, but the overall evi...

Read the full Bromelain monograph → Herb & supplement monograph

Pomegranate

Interacts with 922 drugs

Pomegranate is a nutrient-rich fruit that is high in antioxidants and is widely enjoyed as food and juice. Early research suggests it may support heart health and blood pressure, but the evi...

Read the full Pomegranate monograph → Herb & supplement monograph

Valerian

Interacts with 902 drugs

Valerian is an herb whose root is widely used as a natural sleep aid and for calming nerves. The evidence is mixed and often weak, so it may help some people sleep but does not work reliably...

Read the full Valerian monograph → Herb & supplement monograph

Black Walnut

Black walnut is a tree whose green hulls are traditionally used as a natural antiparasitic and digestive remedy, but solid human evidence for these uses is lacking. It contains a compound ca...

Read the full Black Walnut monograph → Herb & supplement monograph

Kamala

Kamala is a red powder from the fruit of the Mallotus philippensis tree, used in traditional medicine mainly to expel intestinal worms and as a dye. Modern human evidence for its safety and...

Read the full Kamala monograph → Herb & supplement monograph

Passion Flower

Interacts with 836 drugs

Passion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restlessness, but the evidence is limited and mo...

Read the full Passion Flower monograph → Herb & supplement monograph

Star Anise

Star anise (Illicium verum) is a star-shaped spice widely used in cooking and traditional medicine, mostly for digestive and respiratory complaints. Human evidence for health benefits is lim...

Read the full Star Anise monograph → Herb & supplement monograph

Bistort

Bistort is a traditional herb whose root is rich in tannins and has long been used for diarrhea, sore throat, and minor wounds. Modern human studies are very limited, so its true effectivene...

Read the full Bistort monograph → Herb & supplement monograph

Wormseed

Wormseed (also called epazote) is a strong-smelling herb traditionally used to expel intestinal worms and to flavor food. Its essential oil is potentially toxic and has caused serious poison...

Read the full Wormseed monograph → Herb & supplement monograph

Yerba Santa

Interacts with 1 drug

Yerba Santa is an aromatic shrub from the western United States and Mexico that has long been used in folk medicine for coughs, congestion, and other respiratory complaints. Modern scientifi...

Read the full Yerba Santa monograph →
Sources

Sources & How We Checked

VRM3 Micro's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 117 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
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Pomegranate 27 references
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Valerian 37 references
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See these in context on the Valerian monograph →

Black Walnut 3 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Food and Drug Administration. Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA); Public Law 108-282, Title II. Accessed on May 19, 2021. Available at: https://www.fda.gov/food/food-allergensgluten-free-guidance-documents-regulatory-infor

See these in context on the Black Walnut monograph →

Passion Flower 19 references
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  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
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  5. Farnsworth N, Bingel A, Cordell G, et al. Potential value of plants as sources of new antifertility agents I. J Pharm Sci 1975;64:535-98. DOI
  6. Mori A, Hasegawa K, Murasaki M, et al. Clinical evaluation of Passiflamin (passiflora extract) on neurosis - multicenter double blind study in comparison with mexazolam. Rinsho Hyoka (Clinical Evaluation) 1993;21:383-440.
  7. Miyasaka LS, Atallah AN, Soares BG. Passiflora for anxiety disorder. Cochrane Database Syst Rev 2007;(1):CD004518. DOI
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  11. Smith, G. W., Chalmers, T. M., and Nuki, G. Vasculitis associated with herbal preparation containing Passiflora extract. Br J Rheumatol. 1993;32(1):87-88.
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  13. Nojoumi M, Ghaeli P, Salimi S, Sharifi A, Raisi F. Effects of Passion Flower Extract, as an Add-On Treatment to Sertraline, on Reaction Time in Patients ?with Generalized Anxiety Disorder: A Double-Blind Placebo-Controlled Study. Iran J Psychiatry. 2016;1
  14. Rokhtabnak F, Ghodraty MR, Kholdebarin A, et al. Comparing the Effect of Preoperative Administration of Melatonin and Passiflora incarnata on Postoperative Cognitive Disorders in Adult Patients Undergoing Elective Surgery. Anesth Pain Med. 2016;7(1):e4123 PubMed
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See these in context on the Passion Flower monograph →

Star Anise 10 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
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Bistort 1 reference
  1. Herbs at a Glance — NIH NCCIH Source

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Wormseed 1 reference
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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