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Dietary supplement

Water Pill Ingredients & Drug Interactions

by Swanson

Water Pill label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Water Pill against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Water Pill is a dietary supplement by Swanson with 2 active ingredients. Its ingredients are commonly taken for varicose veins and chronic venous insufficiency, hemorrhoids, easy bruising and fragile capillaries.Based on those ingredients, 552 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Yellow Sweet Clover, Rutin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Water Pill by Swanson

Ask about any prescription or over-the-counter medication and we check it for interactions with Water Pill by Swanson — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Water Pill by Swanson

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Water Pill contains 2 active ingredients: rutin and yellow sweet clover. Rutin is a plant compound; yellow sweet clover is an herb.

Both are traditionally used to support circulation and reduce swelling, though the evidence backing these uses is not yet established. The capsule also contains microcrystalline cellulose, gelatin, magnesium stearate, and silica as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: leg swelling and circulation support.
  • We looked for evidence on: Varicose veins, Chronic venous insufficiency (CVI), Hemorrhoids, Postoperative swelling, Lymphedema, Bruises — and 3 related terms.
  • The closest evidence on file: Sweet Clover is rated "Insufficient Reliable Evidence To Rate" for Chronic venous insufficiency (CVI) (Natural Medicines).
  • Also on file: Sweet Clover is rated "Insufficient Reliable Evidence To Rate" for Hemorrhoids, Bruises, Postoperative swelling.
  • Also on file: Rutin is rated "Insufficient Reliable Evidence To Rate" for Hemorrhoids, Lymphedema, Varicose veins.

The evidence for both active ingredients in this product is insufficient to rate their effectiveness. Rutin has been studied for aging skin, autism spectrum disorder, inflammatory bowel disease, diabetes, exercise-induced respiratory infections, and hemorrhoids, but reliable evidence is lacking for all of them.

Yellow sweet clover has been studied for chronic venous insufficiency, diabetic neuropathy, hemorrhoids, and postoperative pain, but again, the evidence is not yet established. We don't hold data showing these ingredients work for the purposes Water Pill is marketed for.

The evidence, ingredient by ingredient Rutin Sweet Clover

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Rutin is generally well tolerated in food and short-term supplement use, though long-term safety data are limited. The safety data for supplement doses of rutin are not robust enough to recommend it without medical advice; you should talk with your doctor before using it.

Some people report headache, flushing, or rashes from rutin. Yellow sweet clover is generally used in small amounts and is generally well tolerated, but its coumarin content can affect bleeding and liver function — large amounts have caused liver injury and a bleeding disorder in case reports.

Both ingredients carry safety concerns in pregnancy and breastfeeding (see below).

Side effects, ingredient by ingredient Rutin Sweet Clover

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Sweet Clover, Rutin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 553 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Water Pill, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs — yellow sweet clover may increase bleeding risk (Moderate severity). Also flag any antidiabetes medication, since rutin may raise hypoglycemia risk, and any drug known to stress the liver, since yellow sweet clover's coumarin content carries a liver toxicity risk.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Water Pill is marketed as a diuretic support supplement, but neither ingredient has established evidence for this use in the data we hold. More importantly, if you take blood thinners, antidiabetes drugs, or medications that affect the liver, you need to clear this product with your own doctor or pharmacist first — the interactions are real and potentially serious.

Even in people with no medications, the long-term safety of these ingredients is not well documented.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Water Pill, straight from the product label.

Brand Swanson
Barcode (UPC) 087614022215
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 308817
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Water Pill by Swanson, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
087614022215
IngredientAmount% DV
Rutin200 mg--
Yellow Sweet Clover40 mg--

Other ingredients: Microcrystalline Cellulose, Gelatin, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Total wellness for mind, body & home Unsurpassed purity & potency 100% money back guaranteed

Circulatory health 2-in-1 formula

Brand IP Statement(s)

Swanson Science-backed quality since 1969

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take two capsules one to two times per day with water.

Precautions

Warning: For adults only. Keep out of reach of children.

Do not take this product if you are pregnant or nursing. Consult your healthcare provider before use if you are taking medication blood-thinning medication or if you have or have had a blood coagulation disorder.

Discontinue use two weeks prior to surgery. Do not use if seal is broken.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Herbal Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Water Pill by Swanson label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Water Pill label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Water Pill by Swanson

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Rutin

Interacts with
86 drugs
200 mg per serving

Rutin is a plant flavonoid (often taken from buckwheat or citrus) that people use mainly for blood vessel and circulation problems like varicose veins...

Rutin monograph & interactions

Yellow Sweet Clover

Interacts with
480 drugs
40 mg per serving Form: Coumarin

Sweet clover is a traditional European herb most often promoted for vein problems and leg swelling, but high-quality human evidence is limited. It con...

Yellow Sweet Clover monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Gelatin, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Water Pill by Swanson Drug Interactions

Want to check YOUR meds against Water Pill?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
552Drugs
552 Moderate

Ingredients driving the most interactions

Yellow Sweet Clover 480
Rutin 86

Individual Drug Interactions

The ingredients in Water Pill interact with 552 drugs. Click any drug to see the details.

2 of the 2 ingredients in Water Pill interact with drugs. Each result below shows which ingredient is responsible. Yellow Sweet Clover Rutin

Each ingredient & the kinds of drugs it affects

For each ingredient in Water Pill with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Yellow Sweet Clover2 drug types · 480 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fresh sweet clover might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Fresh sweet clover contains coumarinic acids, which are converted to free coumarins during drying. Dicoumarol, which has anticoagulant activity, also has been found in some sweet clover preparations and can be formed if fresh sweet clover is allowed to spoil.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use of sweet clover with hepatoxic drugs might increase the risk of hepatotoxicity.
Orally, large amounts of sweet clover can cause transient liver injury in susceptible individuals, possibly due to coumarin content. In one case report, a patient with multiple sclerosis developed jaundiced palms and a slight elevation in serum alanine aminotransferase (ALT) after taking sweet clover containing coumarin 10 mg daily for 3 years. Two weeks after starting therapy with subcutaneous interferon (IFN)-beta 1b, aspartate transaminase (AST) and ALT levels increased to 7 and 17 times the upper limit of normal, respectively. Levels normalized after discontinuation of both products. Subsequent use of IFN-beta 1a alone, without sweet clover, resulted in only a very slight increase in AST.

Likelihood Possible Evidence D
Yellow Sweet Clover full monograph & interactions

Rutin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking rutin with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that rutin has hypoglycemic effects.

Likelihood Possible Evidence D
Rutin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Water Pill, from the product label.

Swanson

See all Swanson products
Name
Swanson Health Products
City
Fargo
State
ND
ZipCode
58104
Phone Number
1-800-437-4148
Web Address
swanson.com
Pharmacist Counseling Corner

Water Pill by Swanson: Common Questions

Does Water Pill by Swanson interact with any medications?
Yes. Based on its ingredients, Water Pill has a known interaction with 552 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Water Pill contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Water Pill if I'm pregnant?
Rutin is likely safe in pregnancy. Yellow sweet clover does not have enough safety data in pregnancy — the facts advise against supplement doses. Talk with your doctor or pharmacist about your specific situation before taking this product.
What's rutin, and what is it supposed to do?
Rutin is a plant compound found in foods. In this product, it's intended to support circulation or reduce swelling, but we don't hold evidence that it works for these purposes. Animal studies suggest it may lower blood sugar, which is why it can interact with antidiabetes drugs.
What's yellow sweet clover?
Yellow sweet clover is an herb traditionally used to support vein health and reduce swelling. It contains coumarin, a compound with blood-thinning properties — which is why it can interact with anticoagulants and increase liver stress in some people.
What side effects might I experience?
Rutin may cause headache, flushing, or rashes in some people. Yellow sweet clover rarely causes headache, and large amounts can cause liver injury or bleeding problems — as seen in case reports. Most people tolerate small amounts without symptoms.
Is this product safe to take long-term?
Long-term safety data for both ingredients are limited. Rutin has been studied mostly short-term, and yellow sweet clover's coumarin content raises concerns about liver and bleeding effects with prolonged use. Talk with your doctor about how long it's safe for you to take this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Water Pill label
Go deeper

The Full Monographs Behind Water Pill’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Rutin

Interacts with 86 drugs

Rutin is a plant flavonoid (often taken from buckwheat or citrus) that people use mainly for blood vessel and circulation problems like varicose veins and hemorrhoids. The evidence is limite...

Read the full Rutin monograph → Herb & supplement monograph

Sweet Clover

Interacts with 480 drugs

Sweet clover is a traditional European herb most often promoted for vein problems and leg swelling, but high-quality human evidence is limited. It contains coumarin, which can become dangero...

Read the full Sweet Clover monograph →
Sources

Sources & How We Checked

Water Pill's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Rutin 2 references
  1. Mehta DK (Ex Ed). British National Formulary, Number 37. British Medical Association and Royal Pharmaceutical Society of Great Britain: London, England, March 1999.
  2. Sun C, Wang L, Sun J, Wang Z, Tang Z. Hypoglycemic and hypolipidemic effects of rutin on hyperglycemic rats. J Tradit Chin Med. 2020;40(4):640-645.

See these in context on the Rutin monograph →

Sweet Clover 6 references
  1. Monographs on the medicinal uses of plant drugs. Exeter, UK: European Scientific Co-op Phytother, 1997.
  2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  3. Wichtl MW. Herbal Drugs and Phytopharmaceuticals. Ed. N.M. Bisset. Stuttgart: Medpharm GmbH Scientific Publishers, 1994.
  4. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  5. Hogan RP III. Hemorrhagic diathesis caused by drinking an herbal tea. JAMA 1983;249:2679-80. DOI
  6. Tamura S, Warabi Y, Matsubara S. Severe liver dysfunction possibly caused by the combination of interferon beta-1b therapy and melilot (sweet clover) supplement. J Clin Pharm Ther 2012;37(6):724-5. PubMed

See these in context on the Sweet Clover monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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