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Dietary supplement

Water-Soluble Pumpkin Seed Extract With Soy Isoflavones Ingredients & Drug Interactions

by Life Extension

Water-Soluble Pumpkin Seed Extract With Soy Isoflavones label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Water-Soluble Pumpkin Seed Extract With Soy Isoflavones against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Water-Soluble Pumpkin Seed Extract With Soy Isoflavones is a dietary supplement by Life Extension with 2 active ingredients. Its ingredients are commonly taken for benign prostatic hyperplasia (bph) symptoms, overactive bladder, eye and skin health (vitamin a source).Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are water-soluble Pumpkin extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Water-Soluble Pumpkin Seed Extract With Soy Isoflavones by Life Extension

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HelloPharmacist Scorecard of Water-Soluble Pumpkin Seed Extract With Soy Isoflavones by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Go Less Powder Blend” is a proprietary blend — the label gives one combined amount (312 mg) without saying how much of each component you get.

This product contains 2 active ingredients. Water-soluble pumpkin extract is the primary component — it's derived from pumpkin seeds and is used to address urinary and prostate concerns.

The second active is a soy isoflavone extract called SoyLife. The capsule also contains several inactive ingredients (rice flour, maltodextrin, stearic acid, silica, magnesium stearate, and vegetable cellulose) that act as fillers and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support for urinary and prostate health.
  • We looked for evidence on: Benign prostatic hyperplasia (BPH), Overactive bladder.
  • The strongest evidence on file: Pumpkin is rated "Possibly Effective" for Benign prostatic hyperplasia (BPH) (Natural Medicines).
  • Also on file: Pumpkin is rated "Insufficient Reliable Evidence To Rate" for Overactive bladder.

The pumpkin extract in this product is rated possibly effective for benign prostatic hyperplasia (BPH) — enlarged prostate in men. For other uses listed on the label — including hair loss, interstitial cystitis (bladder pain), parasite infection, and urinary tract infections — the evidence we hold is insufficient to rate whether it works.

The soy isoflavone ingredient has no effectiveness ratings on file.

The evidence, ingredient by ingredient Pumpkin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pumpkin as a food is well tolerated. Concentrated seed supplements are generally well tolerated in adults, though mild abdominal discomfort, diarrhea, nausea, and vomiting occur in some users; anaphylaxis is rare.

There are two historical case reports of substantial hair loss 1–3 weeks after consuming bitter-tasting pumpkin or squash — attributed to high levels of cucurbitacin, a compound found in wild pumpkins. Pregnancy safety data is not on file; breastfeeding safety has not been well studied for concentrated pumpkin supplements.

Talk with your doctor or pharmacist about whether this product is right for you during pregnancy or while nursing.

Side effects, ingredient by ingredient Pumpkin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pumpkin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take lithium, check with your doctor or pharmacist before using this product — the pumpkin extract may reduce how your body clears lithium and raise its level. We could not check the soy isoflavone ingredient for interactions, so use the medication search tool on this page to confirm your other drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with benign prostate enlargement if the pumpkin extract proves effective for you. If you take lithium, you'll need to check with your doctor or pharmacist before starting — the pumpkin content may affect how your body handles it.

Generally well tolerated, though stomach upset can occur. Run your medications through the checker on this page and discuss it with your own healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Water-Soluble Pumpkin Seed Extract With Soy Isoflavones, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870121060
Net contents 60 Vegetarian Capsules
Market status On market
Date entered into DSLD Nov 25, 2011
DSLD ID 2512
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Water-Soluble Pumpkin Seed Extract With Soy Isoflavones by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
UPC/BARCODE
737870121060
IngredientAmount% DV
Go Less Powder Blend312 mg--
water-soluble Pumpkin extract0 NP--
SoyLife Soy extract0 NP--

Other ingredients: Rice Flour, Maltodextrin, Stearic Acid, Silica, Magnesium Stearate, Vegetable Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

and SoyLife(R) are trademarks of Frutarom Netherlands BV.

For Longer Life(R)

Precautions

Contains soybeans. Contains corn and rice.

- DO NOT EXCEED RECOMMENDED DOSE.

- Do not purchase if outer seal is broken or damaged.

CAUTION: Persons with estrogen dependent cancers should consult a healthcare professional before beginning a soy regimen.

WARNINGS: - KEEP OUT OF REACH OF CHILDREN.

- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Formulation

This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), tree nuts, wheat, yeast, or gluten. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.

Seals/Symbols

Go-Less(TM)

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

DIRECTIONS: Take one (1) capsule three times daily for the first two weeks. After two weeks, reduce to two (2) capsules daily or as recommended by a healthcare practitioner. This product can be taken with or without food.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General

01210A Rev. 9/08

General Statements

For optimal potency use by: Lot No.:

Read the entire label and follow directions carefully prior to use.

Supports Healthy Bladder Function*

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Water-Soluble Pumpkin Seed Extract With Soy Isoflavones by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Water-Soluble Pumpkin Seed Extract With Soy Isoflavones label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Water-Soluble Pumpkin Seed Extract With Soy Isoflavones by Life Extension

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Go Less Powder Blend

312 mg per serving

Other (inactive) ingredients: Rice Flour, Maltodextrin, Stearic Acid, Silica, Magnesium Stearate, Vegetable Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Water-Soluble Pumpkin Seed Extract With Soy Isoflavones by Life Extension Drug Interactions

Want to check YOUR meds against Water-Soluble Pumpkin Seed Extract With Soy Isoflavones?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1Drugs
1 Moderate

Ingredients driving the most interactions

water-soluble Pumpkin extract 1

Individual Drug Interactions

The ingredients in Water-Soluble Pumpkin Seed Extract With Soy Isoflavones interact with 1 drug. Click any drug to see the details.

1 of the 2 ingredients in Water-Soluble Pumpkin Seed Extract With Soy Isoflavones interact with drugs. Each result below shows which ingredient is responsible. water-soluble Pumpkin extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Water-Soluble Pumpkin Seed Extract With Soy Isoflavones with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

water-soluble Pumpkin extract1 drug type · 1 drug

Lithium

Pumpkin might reduce excretion and increase levels of lithium.
Pumpkin is thought to have diuretic properties. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
water-soluble Pumpkin extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Water-Soluble Pumpkin Seed Extract With Soy Isoflavones, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
FL
ZipCode
33309
Phone Number
1-800-544-4440
Web Address
http://www.lef.org
Pharmacist Counseling Corner

Water-Soluble Pumpkin Seed Extract With Soy Isoflavones by Life Extension: Common Questions

Does Water-Soluble Pumpkin Seed Extract With Soy Isoflavones by Life Extension interact with any medications?
Yes. Based on its ingredients, Water-Soluble Pumpkin Seed Extract With Soy Isoflavones has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Water-Soluble Pumpkin Seed Extract With Soy Isoflavones contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is this product supposed to do?
It's designed to support urinary and prostate health. The pumpkin extract is possibly effective for benign prostatic hyperplasia (BPH), the enlarged prostate common in older men. For other uses like hair loss or UTI prevention, we don't have solid evidence in our data that it works.
What side effects might I get?
Most people tolerate it fine. Some report mild abdominal discomfort, diarrhea, nausea, or vomiting. Very rarely, anaphylaxis has been reported. There are also two old case reports of hair loss after eating bitter-tasting pumpkin or squash, thought to be from a toxin in wild varieties — not typical commercial pumpkin.
Is it safe while breastfeeding?
Safety during breastfeeding hasn't been well studied for concentrated pumpkin supplements. Pumpkin as a food is fine, but we don't have enough data on the extract form. Talk with your doctor or pharmacist for personalized advice.
Can I take it if I'm pregnant?
We don't have pregnancy safety data on file for this product. Pumpkin as food is fine, but concentrated supplements are different — check with your doctor or pharmacist before using it during pregnancy.
Why can't you check one of the ingredients for interactions?
The soy isoflavone extract — the SoyLife ingredient — doesn't have a monograph in our data, so we have no interaction information for it. That doesn't mean it doesn't interact; it means we haven't checked it. Use the medication search tool on this page to look up your specific drugs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Water-Soluble Pumpkin Seed Extract With Soy Isoflavones is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Water-Soluble Pumpkin Seed Extract With Soy Isoflavones label
Go deeper

The Full Monographs Behind Water-Soluble Pumpkin Seed Extract With Soy Isoflavones’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pumpkin

Interacts with 1 drug

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The evidence for these uses is limited and...

Read the full Pumpkin monograph →
Sources

Sources & How We Checked

Water-Soluble Pumpkin Seed Extract With Soy Isoflavones's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pumpkin 5 references
  1. Marks L, Partin AW, Epstein JI, et al. Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia. J Urol 2000;163:1451-6. DOI
  2. Cho YH, Lee SY, Jeong DW, et al. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evid Based Complement Alternat Med 2014;2014:549721. PubMed
  3. Vahlensieck W, Theurer C, Pfitzer E, Patz B, Banik N, Engelmann U. Effects of pumpkin seed in men with lower urinary tract symptoms due to benign prostatic hyperplasia in the one-year, randomized, placebo-controlled GRANU study. Urol Int 2015;94(3):286-95 PubMed
  4. Assouly P. Hair loss associated with cucurbit poisoning. JAMA Dermatol. 2018 May 1;154(5):617-618. PubMed
  5. Gawryjolek J, Ludwig H, Zbikowska-Götz M, Bartuzi Z, Krogulska A. Anaphylaxis after consumption of pumpkin seeds in a 2-y-old child tolerant to its pulp: A case study. Nutrition 2021;89:111272. PubMed

See these in context on the Pumpkin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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