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Dietary supplement

Wild Lettuce Ingredients & Drug Interactions

by Earthborn Elements

Wild Lettuce label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Wild Lettuce against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Wild Lettuce is a dietary supplement by Earthborn Elements with 1 active ingredient. Its ingredients are commonly taken for insomnia and trouble sleeping, anxiety and restlessness, pain relief.Based on those ingredients, 393 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactuca virosa. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Wild Lettuce by Earthborn Elements

Ask about any prescription or over-the-counter medication and we check it for interactions with Wild Lettuce by Earthborn Elements — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Wild Lettuce by Earthborn Elements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Lactuca virosa, commonly called wild lettuce. It's a plant extract traditionally used as a herbal remedy, though we hold no established effectiveness ratings for it in our data.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Wild Lettuce product and its label doesn't state a use — see Wild Lettuce's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We don't have effectiveness ratings on file for wild lettuce, so the evidence for what it's meant to do isn't established in our data. If you're considering this for a specific condition, your pharmacist or doctor can help you figure out whether there's research backing its use.

The evidence, ingredient by ingredient Wild Lettuce

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Wild lettuce has limited human safety data. High doses have been linked to side effects, and large amounts—or prematurely harvested wild lettuce—can cause sweating, rapid heartbeat, dizziness, ringing in the ears, vision problems, head pressure, drowsiness, agitation, breathing depression, and in severe cases, coma or death.

Topically, it may cause contact dermatitis (skin irritation). The safety data advises against use during pregnancy and breastfeeding.

There isn't enough reliable information to know whether it's safe at any dose in either situation, so talk with your doctor or pharmacist for personalized guidance.

Side effects, ingredient by ingredient Wild Lettuce

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Wild Lettuce.
  • The most serious interaction on file is rated Moderate.
  • For scale: 393 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, check whether you're on any CNS depressants (sedatives, sleep aids, certain pain relievers, or drugs that slow brain activity) or anticholinergic medications (which affect nerve signals). Both categories have Moderate-severity interaction concerns with wild lettuce.

Use the search tool below with your medication names to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Wild lettuce is a herbal product with limited safety information and no established effectiveness ratings in our data. It interacts with sedatives and anticholinergic medications, so if you take any prescription or over-the-counter drugs—especially sleep aids or pain relievers—check them against the interaction tool first.

Talk to your pharmacist before starting, especially if you're pregnant, breastfeeding, or taking regular medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Wild Lettuce, straight from the product label.

Brand Earthborn Elements
Net contents 200 Capsule(s)
Market status On market
Date entered into DSLD Dec 21, 2024
DSLD ID 319679
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Wild Lettuce by Earthborn Elements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
200
IngredientAmount% DV
Lactuca virosa400 mg--

Other ingredients: Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1 capsule daily, preferably with meals. Take with at least 8 oz of liquid.

Precautions

If pregnant, nursing, or taking medications, consult your physician.

General Statements

Questions? Concerns? Scan this code with your phone's camera to chat with us online and get 20% coupon for your next Amazon Earthborn Elements order!

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Wild Lettuce by Earthborn Elements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Wild Lettuce label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Wild Lettuce by Earthborn Elements

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container200 Amounts shown are per serving.

Lactuca virosa

Interacts with
393 drugs
400 mg per serving Form: Lactuca virosa, Lactuca virosa

Wild lettuce is a traditional herb used mainly for sleep, anxiety, and pain, but solid human research supporting these uses is very limited. Because i...

Lactuca virosa monograph & interactions

Other (inactive) ingredients: Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Wild Lettuce by Earthborn Elements Drug Interactions

Want to check YOUR meds against Wild Lettuce?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
393Drugs
393 Moderate

Ingredients driving the most interactions

Lactuca virosa 393

Individual Drug Interactions

The ingredients in Wild Lettuce interact with 393 drugs. Click any drug to see the details.

1 of the 1 ingredient in Wild Lettuce interact with drugs. Each result below shows which ingredient is responsible. Lactuca virosa

Each ingredient & the kinds of drugs it affects

For each ingredient in Wild Lettuce with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactuca virosa2 drug types · 393 drugs

Anticholinergic Drugs

Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug. If it does, it appears to be in very low amounts. Nevertheless, there have been case reports of individuals consuming large amounts of wild lettuce experiencing anticholinergic-related side effects, such as constipation, dry mouth, dizziness, and sweating. Therefore, if you are already taking a drug with anticholinergic effects, you should be cautious about combining it with wild lettuce as the risk of side effects may be increased.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.

Likelihood Possible Evidence D
Lactuca virosa full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Wild Lettuce, from the product label.

Earthborn Elements

See all Earthborn Elements products
Name
Earthborn Elements
Street Address
9450 SW Gemini Dr #49936
City
Beaverton
State
Oregon
ZipCode
97008
Web Address
Earthbornelements.com
Pharmacist Counseling Corner

Wild Lettuce by Earthborn Elements: Common Questions

Does Wild Lettuce by Earthborn Elements interact with any medications?
Yes. Based on its ingredients, Wild Lettuce has a known interaction with 393 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Wild Lettuce contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take wild lettuce if I'm pregnant?
The safety data advises against it. There isn't enough reliable information to know whether it's safe during pregnancy, so talk with your doctor or pharmacist before using it.
Can I take wild lettuce while breastfeeding?
No, avoid it. There is no reliable safety data on wild lettuce during breastfeeding, so it's best to skip it if you're nursing.
What side effects can wild lettuce cause?
Large doses or prematurely harvested wild lettuce can cause sweating, rapid heartbeat, dizziness, ringing in the ears, vision problems, head pressure, drowsiness, and agitation. In rare severe cases, it's been linked to breathing depression, coma, and death. Topically, it may cause skin irritation.
What are the main interactions I should watch for?
The two main concerns are with sedatives and sleep aids (which could cause extra drowsiness) and anticholinergic drugs (which may cause constipation, dry mouth, or dizziness). Check your exact medications with the tool on this page.
Does this product have any fillers or extra ingredients?
The capsule itself is made from gelatin. Beyond that, it contains only the wild lettuce extract.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Wild Lettuce is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Wild Lettuce label
Go deeper

The Full Monographs Behind Wild Lettuce’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Wild Lettuce

Interacts with 393 drugs

Wild lettuce is a traditional herb used mainly for sleep, anxiety, and pain, but solid human research supporting these uses is very limited. Because its safety is not well studied, it should...

Read the full Wild Lettuce monograph →
Sources

Sources & How We Checked

Wild Lettuce's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Wild Lettuce 5 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Besharat S, Besharat M, Jabbari A. Wild lettuce (Lactuca virosa) toxicity. BMJ Case Rep. 2009;2009. pii: bcr06.2008.0134.
  5. Mullins ME, Horowitz BZ. The case of the salad shooters: intravenous injection of wild lettuce extract. Vet Hum Toxicol. 1998;40(5):290-1.

See these in context on the Wild Lettuce monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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