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Dietary supplement

Wild Lettuce Ingredients & Drug Interactions

by Red Moon Herbs

Wild Lettuce label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Wild Lettuce against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Wild Lettuce is a dietary supplement by Red Moon Herbs with 1 active ingredient. Its ingredients are commonly taken for insomnia and trouble sleeping, anxiety and restlessness, pain relief.Based on those ingredients, 393 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Wild Lettuce Flowering Top Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Wild Lettuce by Red Moon Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Wild Lettuce by Red Moon Herbs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Wild Lettuce by Red Moon Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.
  • “EXTRACT” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

This product contains one active ingredient: wild lettuce flowering top extract, a liquid made from the flowering tops of the wild lettuce plant. The extract is suspended in water and alcohol.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Wild Lettuce product and its label doesn't state a use — see Wild Lettuce's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The data we hold doesn't include effectiveness ratings for wild lettuce, so we can't tell you from our records whether it works for any particular purpose.

The evidence, ingredient by ingredient Wild Lettuce

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Wild lettuce seems generally well tolerated when you use a mature, properly harvested product at standard doses. However, the safety data on this herb is limited.

Large amounts — or prematurely harvested wild lettuce — have been linked to sweating, faster breathing and heart rate, dilated pupils, dizziness, ringing in the ears, vision problems, pressure in the head, drowsiness, restlessness, slowed breathing, and in rare cases coma or death. Topically, it can trigger contact dermatitis in people who are sensitive to it.

There isn't enough safety information to use wild lettuce during pregnancy or while breastfeeding, so it's best avoided in both cases. If you're pregnant or nursing and considering this product, talk it over with your doctor or pharmacist.

Side effects, ingredient by ingredient Wild Lettuce

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Wild Lettuce.
  • The most serious interaction on file is rated Moderate.
  • For scale: 393 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking if you use any sedating medications (like sleep aids, anti-anxiety drugs, or opioids) or anticholinergic drugs (like antihistamines, some antidepressants, or urinary antispasmodics). The interaction checker on this page can help you look up your specific medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Wild Lettuce by Red Moon Herbs may be worth considering if you're interested in herbal relaxation support and you don't take sedating medications or anticholinergic drugs. Since the safety data is limited and large doses carry real risks, start low and talk with your own doctor or pharmacist before adding it to your routine — especially if you're on any prescription medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Wild Lettuce, straight from the product label.

Brand Red Moon Herbs
Barcode (UPC) 857999002443
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Dec 21, 2024
DSLD ID 319336
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Children (All), Infants/Baby (0 - 1 Year), Seniors/Mature (>50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Wild Lettuce by Red Moon Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
25 Drop(s)
Maximum serving Sizes:
75 Drop(s)
UPC/BARCODE
857999002443
IngredientAmount% DV
EXTRACT0 NP--
Wild Lettuce Flowering Top Extract0 NP--

Other ingredients: Water, Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Shake well. Take 25-75 drops 1-3 times daily in a little water.

General Statements

Red Moon Herbs Est. 1994

Still made the wise woman way

FDA Statement of Identity

Dietary Supplement

Formula

Fresh Appalachian Extracts for the whole family

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Wild Lettuce by Red Moon Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Wild Lettuce label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Wild Lettuce by Red Moon Herbs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size25 Drop(s) Dosage formLiquid Amounts shown are per serving.

EXTRACT

0 NP per serving

Other (inactive) ingredients: Water, Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Wild Lettuce by Red Moon Herbs Drug Interactions

Want to check YOUR meds against Wild Lettuce?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
393Drugs
393 Moderate

Ingredients driving the most interactions

Wild Lettuce Flowering Top Extract 393

Individual Drug Interactions

The ingredients in Wild Lettuce interact with 393 drugs. Click any drug to see the details.

1 of the 1 ingredient in Wild Lettuce interact with drugs. Each result below shows which ingredient is responsible. Wild Lettuce Flowering Top Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Wild Lettuce with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Wild Lettuce Flowering Top Extract2 drug types · 393 drugs

Anticholinergic Drugs

Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug. If it does, it appears to be in very low amounts. Nevertheless, there have been case reports of individuals consuming large amounts of wild lettuce experiencing anticholinergic-related side effects, such as constipation, dry mouth, dizziness, and sweating. Therefore, if you are already taking a drug with anticholinergic effects, you should be cautious about combining it with wild lettuce as the risk of side effects may be increased.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.

Likelihood Possible Evidence D
Wild Lettuce Flowering Top Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Wild Lettuce, from the product label.

Red Moon Herbs

See all Red Moon Herbs products
Name
Red Moon Herbs
City
Asheville
State
NC
Phone Number
888-929-0777
Web Address
redmoonherbs.com
Pharmacist Counseling Corner

Wild Lettuce by Red Moon Herbs: Common Questions

Does Wild Lettuce by Red Moon Herbs interact with any medications?
Yes. Based on its ingredients, Wild Lettuce has a known interaction with 393 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Wild Lettuce contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
No, there isn't enough safety information, so it's best avoided during pregnancy. Talk with your doctor or pharmacist about what's right for you.
Can I take this while breastfeeding?
No, there's no reliable safety data for breastfeeding, so you should avoid it. If you're interested in using an herbal product while nursing, check with your own doctor or pharmacist first.
What are the most common side effects?
When you use properly harvested wild lettuce at normal doses, it's generally well tolerated. If you apply it to your skin, contact dermatitis (an irritant rash) can happen in people sensitive to it. Large doses carry more serious risks like dizziness, drowsiness, or rapid heart rate.
Will this make me drowsy?
Large amounts of wild lettuce can cause drowsiness. If you're also taking sedating medications like sleep aids or anti-anxiety drugs, the effect could add up. Check with your pharmacist or doctor before combining them.
What does wild lettuce extract actually do?
The data we hold doesn't include effectiveness ratings for this herb, so I can't tell you from our records what it's intended to do or whether research backs that up.
Is this the same as eating wild lettuce?
This is a concentrated extract, so it's more potent than the whole plant. That also means the risks of side effects at high doses are real, so stick to the label directions.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Wild Lettuce is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Wild Lettuce label
Go deeper

The Full Monographs Behind Wild Lettuce’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Wild Lettuce

Interacts with 393 drugs

Wild lettuce is a traditional herb used mainly for sleep, anxiety, and pain, but solid human research supporting these uses is very limited. Because its safety is not well studied, it should...

Read the full Wild Lettuce monograph →
Sources

Sources & How We Checked

Wild Lettuce's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Wild Lettuce 5 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Besharat S, Besharat M, Jabbari A. Wild lettuce (Lactuca virosa) toxicity. BMJ Case Rep. 2009;2009. pii: bcr06.2008.0134.
  5. Mullins ME, Horowitz BZ. The case of the salad shooters: intravenous injection of wild lettuce extract. Vet Hum Toxicol. 1998;40(5):290-1.

See these in context on the Wild Lettuce monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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