Major interaction on record — check this product against your medications before combining. Based on 3 of 7 ingredients. Check your meds →
Dietary supplement

Xtreme Shock Watermelon Ingredients & Drug Interactions

by ANSI Advanced Nutrient Science

Xtreme Shock Watermelon label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Xtreme Shock Watermelon against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Xtreme Shock Watermelon is a dietary supplement by ANSI Advanced Nutrient Science with 7 active ingredients. Its ingredients are commonly taken for mental focus and alertness, coping with stress, fatigue and sleep loss.Based on those ingredients, 701 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are USP Caffeine, GlutaZorb, L-Tyrosine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Xtreme Shock Watermelon by ANSI Advanced Nutrient Science

Ask about any prescription or over-the-counter medication and we check it for interactions with Xtreme Shock Watermelon by ANSI Advanced Nutrient Science — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Xtreme Shock Watermelon by ANSI Advanced Nutrient Science

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 8 active ingredients.
  • “Endonine” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Xtreme Shock Proprietary Blend” is a proprietary blend — the label gives one combined amount (5,550 mg) without saying how much of each component you get.

Xtreme Shock Watermelon contains 8 active ingredients designed for workout support. L-Tyrosine is an amino acid thought to help with focus and mental clarity.

Beta-Alanine is included for possible athletic performance benefits, though it commonly causes a harmless tingling sensation in the skin. Carnosine, Glutamine (branded here as GlutaZorb), and Arginine Malate are amino acids and amino acid compounds meant to support muscle function and recovery.

The product also includes caffeine (USP grade) for mental alertness and athletic performance. Two proprietary blends — Xtreme Shock Proprietary Blend and Carnosine ATP Synthesizer — and a creatine derivative (KreAlkalyn) round out the formula.

Several inactive ingredients including maltodextrin, citric acid, and sucralose are added as fillers and sweeteners.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: pre-workout performance and athletic endurance.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Exercise-induced muscle soreness, Exercise-induced muscle breakdown, Fatigue, Mental alertness — and 4 related terms.
  • The strongest evidence on file: Caffeine is rated "Likely Effective" for Athletic performance (Natural Medicines).
  • Also on file: Caffeine is rated "Likely Effective" for Mental alertness.
  • Also on file: Tyrosine is rated "Possibly Effective" for Cognitive function.

Evidence for this product's ingredients is mixed. Caffeine is well established for boosting mental alertness and is likely effective for athletic performance.

Beta-alanine and L-tyrosine are possibly effective for athletic performance, though tyrosine is also only possibly effective for cognitive function and memory. Glutamine is possibly effective for postoperative recovery and HIV-related wasting.

Carnosine and the other ingredients lack solid evidence — the data shows insufficient reliable evidence to rate them for cognitive decline, athletic performance, or most other uses. Overall, the strongest case is for caffeine and beta-alanine in athletic settings, but the full product's effectiveness for any specific goal is not well established in the data we hold.

The evidence, ingredient by ingredient Tyrosine Glutamine Caffeine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these ingredients are generally well tolerated at normal doses in healthy adults. Caffeine is well tolerated in moderate amounts but can cause anxiety, insomnia, nausea, tremors, and restlessness — and rarely, stroke.

Beta-alanine commonly causes a dose-dependent pins-and-needles sensation (paresthesia) on the scalp and body that typically lasts about an hour; this is harmless but can feel strange. L-Tyrosine, carnosine, and glutamine may cause gastrointestinal symptoms like nausea, heartburn, bloating, and diarrhea.

Glutamine has rarely been linked to dizziness and, in two cases, mania in people with bipolar disorder. None of these ingredients have strong safety data for long-term high-dose use.

Pregnancy and breastfeeding safety varies by ingredient: beta-alanine and carnosine should be avoided (not enough safety data); glutamine is likely safe in pregnancy but safety is uncertain while breastfeeding; and caffeine safety in pregnancy depends on how much — ask your doctor about safe limits. L-Tyrosine, arginine malate, and other ingredients lack pregnancy/breastfeeding data on file.

Side effects, ingredient by ingredient Tyrosine Glutamine Caffeine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Glutamine, Caffeine, Tyrosine, Carnosine.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; diabetes medications; lithium; Parkinson's medications.
  • For scale: 701 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before starting if you take ephedrine (a Major interaction risk), seizure medications like phenobarbital or carbamazepine, Parkinson's disease medication (levodopa), thyroid hormones, diabetes medications, blood-pressure or heart medications, antipsychotics like clozapine, sedatives like pentobarbital, vasodilators like dipyridamole (especially before a stress test), quinolone antibiotics, or acid-reflux drugs like cimetidine. No interactions are documented in our data for arginine malate, KreAlkalyn, or aminoglycine, but we could not check those ingredients.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a caffeinated pre-workout powder aimed at athletic performance and mental focus. It's not for you if you take ephedrine, seizure medications, certain antipsychotics, or diabetes drugs without checking first — the interactions can be serious.

If you're pregnant, breastfeeding, or have kidney or liver disease, talk to your pharmacist or doctor before use. Run your medications through the checker on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Xtreme Shock Watermelon, straight from the product label.

Brand ANSI Advanced Nutrient Science
Barcode (UPC) 689570404113
Net contents 8.8 oz.; 250 g
Market status On market
Date entered into DSLD Nov 25, 2011
DSLD ID 2487
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Xtreme Shock Watermelon by ANSI Advanced Nutrient Science, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5.55 Gram(s)
Maximum serving Sizes:
16.65 Gram(s)
Servings per container
45
UPC/BARCODE
689570404113
IngredientAmount% DV
L-Tyrosine0 NP--
Beta-Alanine0 NP--
Arginine Malate0 NP--
Endonine0 NP--
Carnosine ATP Synthesizer0 NP--
Xtreme Shock Proprietary Blend5550 mg--
KreAlkalyn0 NP--
GlutaZorb0 NP--
USP Caffeine0 NP--
Aminoglycine0 NP--

Other ingredients: Maltodextrin, Citric Acid, Silica, Natural Flavors, Beet, Sucralose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

Day 1 - 2: 1 Scoop Day 3 - 4: 1 - 2 Scoops Day 5+: 1 - 3 Scoops

Directions for use: See Chart Below: Xtreme Shock Pre Workout Formula is so Xtreme we recommend for the first 5 days start off with 1 Scoop (5.55g) on days 1 and 2. For Days 3 and 4, 1-2 Scoops and Days 5 and beyond 1-3 Scoops. 1 Scoop, use 4 - 6 oz. cold water. 2 Scoops, use 8 - 12 oz. cold water. 3 Scoops, use 12 - 16 oz. cold water.

Precautions

KEEP OUT OF REACH OF CHILDREN.

Do not take this product if you are pregnant or nursing.

Always consult a physician before starting any diet or exercise program.

Consult a health care professional before using this product if you have heart disease, thyroid disease, diabetes, high blood pressure, depression or other psychiatric condition, glaucoma, difficulty in urinating, prostate enlargement, or seizure disorder, if you are using a monoamine oxidase inhibitor (MAOI) or any other prescription drug, or you are using an over-the-counter drug containing ephedrine, psuedoephedrine or phenylpropanolamine (ingredients found in certain allergy, asthma, cough/cold and weight control products).

Discontinue use and call a health care professional immediately if you experience rapid heartbeat, tremors, dizziness, severe headache, shortness of breath, or similar symptoms.

DO NOT Exceed 3 Scoops in any 24 hour period.

Do not use during strenuous activity in high temperature conditions.

Do not use with alcohol.

Exceeding recommended serving will not improve results and may cause serious adverse health effects.

Limit the use of caffeine containing medications, food, and beverages while taking this product.

NOTE: Three scoops contains 300 mg of caffeine, limit the use of caffeinated products while taking this supplement. May cause flush and/or body tingle sensation. (Feel it Work!)

This product is not suitable for sleep.

WARNING: Not intended for the use by anyone under the age of 18.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

STORE IN COOL, DRY PLACE.

General Statements

45 Ultra Concentrated Take Your Next Workout To The “Xtreme” Xtreme Pump* Xtreme Strength* Xtreme Vascularity* Xtreme Energy* Xtreme Stamina* Xtreme Recovery* Xtreme Focus*

All-in-One Pre-Workout Formula

Enhanced with

FEEL THE RUSH IN 15 MINUTES!

The Most Xplosive Beta-Alanine / Nitric Oxide Muscle Energy & Strength Activator

WATERMELON Naturally Flavored

Brand IP Statement(s)

Kre-Alkalyn(R) & GlutaZorb(R) are trademarks of All American Pharmaceutical. Kre-Alkayn(R) is protected by US Patent 6,399,661. Other patents pending. Glutazorb(R) is patent pending.

Formulation

ZERO SUGAR

Seals/Symbols

ANSi(R) ADVANCED NUTRIENT SCIENCE

GLUTAZORB

U.S. PATENT #6,399,661 KRE-ALKALYN(R) +Ph-Correct Creatine(TM)

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Xtreme Shock Watermelon by ANSI Advanced Nutrient Science label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Xtreme Shock Watermelon label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Xtreme Shock Watermelon by ANSI Advanced Nutrient Science

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size5.55 Gram(s) Dosage formPowder Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Xtreme Shock Proprietary Blend

5550 mg per serving

Other (inactive) ingredients: Maltodextrin, Citric Acid, Silica, Natural Flavors, Beet, Sucralose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Xtreme Shock Watermelon by ANSI Advanced Nutrient Science Drug Interactions

Want to check YOUR meds against Xtreme Shock Watermelon?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
701Drugs
8 Major 613 Moderate 80 Minor

Ingredients driving the most interactions

USP Caffeine 655
GlutaZorb 50
L-Tyrosine 21

Individual Drug Interactions

The ingredients in Xtreme Shock Watermelon interact with 701 drugs. Click any drug to see the details.

3 of the 7 ingredients in Xtreme Shock Watermelon interact with drugs. Each result below shows which ingredient is responsible. USP Caffeine GlutaZorb L-Tyrosine

Each ingredient & the kinds of drugs it affects

For each ingredient in Xtreme Shock Watermelon with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

USP Caffeine41 drug types · 655 drugs

Ephedrine

Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Use of ephedrine with caffeine can increase the risk of stimulatory adverse effects. There is evidence that using ephedrine with caffeine might increase the risk of serious life-threatening or debilitating adverse effects such as hypertension, myocardial infarction, stroke, seizures, and death.

Likelihood Probable Evidence D
Adenosine (Adenocard)

Theoretically, caffeine might decrease the vasodilatory effects of adenosine and interfere with its use prior to stress testing.
Some evidence shows that caffeine is a competitive inhibitor of adenosine and can reduce the vasodilatory effects of adenosine in humans. However, other research shows that caffeine does not seem to affect supplemental adenosine because high interstitial levels of adenosine overcome the antagonistic effects of caffeine. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. However, methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Possible Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, caffeine may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Caffeine is reported to have antiplatelet activity. Theoretically, it might increase the risk of bleeding when used concomitantly with these agents; however, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Beta-Adrenergic Agonists

Theoretically, large amounts of caffeine might increase the cardiac inotropic effects of beta-agonists.

Likelihood Probable Evidence D
Carbamazepine (Tegretol)

Theoretically, caffeine might reduce the effects of carbamazepine and increase the risk for convulsions.
Animal research suggests that taking caffeine can lower the anticonvulsant effects of carbamazepine and can induce seizures when taken in doses above 400 mg/kg. Human research has shown that taking caffeine 300 mg in three divided doses along with carbamazepine 200 mg reduces the bioavailability of carbamazepine by 32% and prolongs the plasma half-life of carbamazepine 2-fold in healthy individuals.

Likelihood Possible Evidence D
Cimetidine (Tagamet)

Theoretically, cimetidine might increase the levels and adverse effects of caffeine.
Cimetidine decreases the rate of caffeine clearance by 31% to 42%.

Likelihood Likely Evidence B
Clozapine (Clozaril)

Caffeine might increase the levels and adverse effects of clozapine and acutely exacerbate psychotic symptoms.
Caffeine might increase the effects and toxicity of clozapine. Caffeine doses of 400-1000 mg per day inhibit clozapine metabolism. Clozapine is metabolized by cytochrome P450 1A2 (CYP1A2). Although researchers speculate that caffeine might inhibit CYP1A2, there is no reliable evidence that caffeine affects CYP1A2. There is also speculation that genetic factors might make some patients more sensitive to an interaction between clozapine and caffeine. In one case report, severe, life-threatening clozapine toxicity and multiorgan system failure occurred in a patient with schizophrenia stabilized on clozapine who consumed caffeine 600 mg daily.

Likelihood Possible Evidence B
Dipyridamole (Persantine)

Theoretically, caffeine might decrease the vasodilatory effects of dipyridamole and interfere with its use prior to stress testing.
Caffeine inhibits dipyridamole-induced vasodilation. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. Methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Probable Evidence B
Disulfiram (Antabuse)

Theoretically, disulfiram use might increase the levels and adverse effects of caffeine.
Disulfiram decreases the rate of caffeine clearance.

Likelihood Probable Evidence B
Diuretic Drugs

Theoretically, using caffeine with diuretic drugs might increase the risk of hypokalemia.
Caffeine, especially in excessive amounts, can reduce potassium levels due to stimulation of the sodium-potassium pump. Diuretics can also cause lower potassium levels.

Likelihood Possible Evidence D
Estrogens

Theoretically, estrogens might increase the levels and adverse effects of caffeine.
Estrogen inhibits caffeine metabolism.

Likelihood Probable Evidence B
Ethosuximide (Zarontin)

Theoretically, caffeine might reduce the effects of ethosuximide and increase the risk for convulsions.
Animal research suggests that caffeine 92.4 mg/kg can decrease the anticonvulsant activity of ethosuximide. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Felbamate (Felbatol)

Theoretically, caffeine might reduce the effects of felbamate and increase the risk for convulsions.
Animal research suggests that a high dose of caffeine 161.7 mg/kg can decreases the anticonvulsant activity of felbamate. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Flutamide (Eulexin)

Theoretically, caffeine might increase the levels and adverse effects of flutamide.
In vitro evidence suggests that caffeine can inhibit the metabolism of flutamide. However, this effect has not been reported in humans.

Likelihood Probable Evidence D
Fluvoxamine (Luvox)

Theoretically, fluvoxamine might increase the levels and adverse effects of caffeine.
Fluvoxamine reduces caffeine metabolism.

Likelihood Probable Evidence D
Lithium

Abrupt caffeine withdrawal might increase the levels and adverse effects of lithium.
Caffeine has diuretic activity. When abruptly discontinued, caffeine may alter the clearance of lithium. There are two case reports of lithium tremor that worsened upon abrupt coffee withdrawal and 6 case reports of elevated serum lithium levels after reducing or eliminating caffeine intake. In one case, a male with schizoaffective disorder stabilized on lithium had an elevated lithium level after reducing his caffeine intake by 87%. At a later date, he increased his caffeine intake by 6-fold, resulting in a subtherapeutic lithium level and a recurrence of psychiatric symptoms.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Caffeine has been shown to inhibit monoamine oxidase (MAO) A and B in laboratory studies. Concomitant intake of large amounts of caffeine with MAOIs might precipitate a hypertensive crisis. In a case report, a patient that consumed 10-12 cups of caffeinated coffee and took the MAOI tranylcypromine presented with severe hypertension. Hypertension was resolved after the patient switched to drinking decaffeinated coffee.

Likelihood Possible Evidence D
Nicotine

Theoretically, concomitant use might increase the risk of hypertension.
Concomitant use of caffeine and nicotine has been shown to have additive cardiovascular effects, including increased heart rate and blood pressure. Blood pressure was increased by 10.8/12.4 mmHg when the agents were used concomitantly.

Likelihood Probable Evidence B
Pentobarbital (Nembutal)

Theoretically, caffeine might decrease the effects of pentobarbital.
Caffeine might negate the hypnotic effects of pentobarbital.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

Theoretically, caffeine might reduce the effects of phenobarbital and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenobarbital. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Phenylpropanolamine

Theoretically, phenylpropanolamine might increase the risk of hypertension, as well as the levels and adverse effects of caffeine.
Concomitant use of phenylpropanolamine and caffeine might cause an additive increase in blood pressure. Phenylpropanolamine also seems to increase caffeine serum levels.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, caffeine might reduce the effects of phenytoin and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenytoin. The effect does not seem to be related to the seizure threshold-lowering effects of caffeine. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Pioglitazone (Actos)

Theoretically, caffeine might increase the levels and clinical effects of pioglitazone.
Animal research suggests that caffeine can modestly increase the maximum concentration, area under the curve, and half-life of pioglitazone, and also reduce its clearance. This increased the antidiabetic effects of pioglitazone. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.
Quinolones (also called fluoroquinolones) can decrease caffeine clearance by inhibiting cytochrome P450 1A2 (CYP1A2) enzyme.

Likelihood Probable Evidence B
Riluzole (Rilutek)

Theoretically, concomitant use might increase the levels and adverse effects of both caffeine and riluzole.
Caffeine and riluzole are both metabolized by cytochrome P450 1A2 (CYP1A2), and concomitant use might reduce the metabolism of one or both agents.

Likelihood Possible Evidence D
USP Caffeine full monograph & all 41 interactions

GlutaZorb1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
GlutaZorb full monograph & interactions

L-Tyrosine2 drug types · 21 drugs

Levodopa

Theoretically, tyrosine might decrease the effectiveness of levodopa.
Tyrosine and levodopa compete for absorption in the proximal duodenum by the large neutral amino acid (LNAA) transport system. Advise patients to separate doses of tyrosine and levodopa by at least 2 hours.

Likelihood Probable Evidence D
Thyroid Hormone

Theoretically, tyrosine might have additive effects with thyroid hormone medications.
Tyrosine is a precursor to thyroxine and might increase levels of thyroid hormones.

Likelihood Probable Evidence D
L-Tyrosine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Xtreme Shock Watermelon, from the product label.

ANSI Advanced Nutrient Science

See all ANSI Advanced Nutrient Science products
Web Address
www.nutrientscience.com
Pharmacist Counseling Corner

Xtreme Shock Watermelon by ANSI Advanced Nutrient Science: Common Questions

Does Xtreme Shock Watermelon by ANSI Advanced Nutrient Science interact with any medications?
Yes. Based on its ingredients, Xtreme Shock Watermelon has a known interaction with 701 medications, including 8 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Xtreme Shock Watermelon contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's the tingling I might feel from this product?
That's likely from beta-alanine, one of the active ingredients. It causes a harmless, dose-dependent pins-and-needles sensation (paresthesia) on the scalp and body that usually starts within 20 minutes and lasts about an hour. It's more noticeable at higher doses and isn't dangerous — just unusual.
Will this help my athletic performance?
Beta-alanine and caffeine are possibly or likely effective for athletic performance in the data we hold. L-tyrosine is only possibly ineffective for athletic performance. The other ingredients lack solid evidence. You'll get the most support from the caffeine and beta-alanine, but results vary.
Can I take this if I'm pregnant?
Not without talking to your doctor first. Beta-alanine and carnosine should be avoided during pregnancy (not enough safety data). Caffeine can be used in pregnancy but only at safe limits set by your doctor. The safety data for most other ingredients isn't on file.
What side effects might I experience?
The most common are from caffeine — anxiety, insomnia, nausea, tremors, and restlessness. Beta-alanine causes tingling (harmless). L-tyrosine, carnosine, and glutamine may cause nausea, heartburn, bloating, or diarrhea. High doses increase the risk of side effects.
Can I take this with my blood pressure medication?
That depends on which one. Caffeine can interact with several cardiovascular drugs, and L-tyrosine can affect thyroid hormones. Check your exact medication on the interaction checker below before you start — don't assume it's safe.
Is this safe for long-term daily use?
The long-term safety data for these ingredients at high doses are limited. Most studies look at short-term use. Talk to your pharmacist about how often and for how long it's appropriate for you to use this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Xtreme Shock Watermelon is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Xtreme Shock Watermelon label
Go deeper

The Full Monographs Behind Xtreme Shock Watermelon’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tyrosine

Interacts with 21 drugs

L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performance during short-term stress, sleep loss,...

Read the full Tyrosine monograph → Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph → Herb & supplement monograph

Caffeine

Interacts with 655 drugs

Caffeine is a natural stimulant found in coffee, tea, and many other plants and products. In moderate amounts it can boost alertness and reduce tiredness for most healthy adults, but too muc...

Read the full Caffeine monograph →
Sources

Sources & How We Checked

Xtreme Shock Watermelon's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 269 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tyrosine 4 references
  1. Meyer JS, Welch KM, Deshmukh VD, et al. Neurotransmitter precursor amino acids in the treatment of multi-infarct dementia and Alzheimer's disease. J Amer Geriat Soc 1977;25:289-98.
  2. DiPiro JT, Talbert RL, Yee GC, et al; eds. Pharmacotherapy: A pathophysiologic approach. 4th ed. Stamford, CT: Appleton & Lange, 1999.
  3. Wood DR, Reimherr FW, Wender PH. Amino acid precursors for the treatment of attention deficit disorder, residual type. Psychopharmacol Bull 1985;21:146-9.
  4. van Spronsen FJ, van Rijn M, Bekhof J. Phenylketonuria: tyrosine supplementation in phenylalanine-restricted diets. Am J Clin Nutr 2001;73:153-7. PubMed

See these in context on the Tyrosine monograph →

Beta-alanine 13 references
  1. Harris RC, Tallon MJ, Dunnett M, et al. The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis. Amino Acids 2006;30:279-89.
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See these in context on the Caffeine monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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