Yohimbe Extract Ingredients & Drug Interactions
by Herbadiet
What is this page for?
First and foremost: checking Yohimbe Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Yohimbe Extract is a dietary supplement by Herbadiet with 1 active ingredient. Its ingredients are commonly taken for erectile dysfunction, low sex drive, sexual performance.Based on those ingredients, 1,125 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Yohimbe Bark Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Yohimbe Extract by Herbadiet
Ask about any prescription or over-the-counter medication and we check it for interactions with Yohimbe Extract by Herbadiet — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Yohimbe Extract by Herbadiet
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains a single active ingredient: yohimbe bark extract. The extract's main active compound is yohimbine, which acts as an alpha-2 adrenergic antagonist—meaning it affects how certain nerve signals work in your body, particularly those that control blood pressure and heart rate.
The capsule itself is made from vegetable cellulose.
Does it work?
Not established
The evidence we hold doesn't establish that yohimbe works for any of the uses it's marketed for. Studies on obesity, orthostatic low blood pressure (dizziness on standing), and antidepressant-induced sexual dysfunction all show insufficient reliable evidence to rate whether it actually helps.
Fatigue is in the same category. That doesn't mean it doesn't work—just that the data we have doesn't support a clear claim.
How safe is it?
Well-documented data
Yohimbe carries real safety concerns you should know about. It can cause serious heart and blood pressure effects, and because supplement potency varies widely between products, you can't be sure exactly how much yohimbine you're getting in each dose.
Common side effects from yohimbine include anxiety, agitation, sweating, diarrhea, flushing, headache, high blood pressure, increased urination, nausea, rapid heart rate, tremors, dizziness, and vomiting—and these tend to get worse at higher doses. Rare but serious effects include hypertensive crisis (dangerously high blood pressure), heart rhythm problems, and chest discomfort.
Yohimbe is considered unsafe in pregnancy because it may affect the uterus. Breastfeeding safety hasn't been established, so it should be avoided then as well.
Talk to your pharmacist or doctor before starting this supplement, especially if you have heart disease, high blood pressure, or anxiety.
Meds to double-check
Major interaction found
Before taking this product, check with your pharmacist if you take MAOIs (an older class of antidepressant)—this is a Major severity interaction. Also double-check if you take blood pressure medications, antidepressants (especially tricyclic or tricyclic-like types), stimulants, phenothiazines (older psychiatric drugs), or any medication your liver breaks down through CYP2D6 or CYP3A4 enzymes.
Your pharmacist can tell you if your current drugs fall into any of these categories.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.
Yohimbe extract is a single-ingredient supplement with limited evidence for the conditions it claims to address. The major concern is its serious interactions with antidepressants, blood pressure medications, and other drugs, plus its unpredictable strength and risk of raising blood pressure and heart rate.
If you're on any prescription medication, check it against this product with our tool before you buy. Pregnancy and breastfeeding are off-limits.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 18, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Yohimbe Extract, straight from the product label.
| Brand | Herbadiet |
|---|---|
| Barcode (UPC) | 880417474867 |
| Net contents | 60 V-Cap(s) |
| Market status | On market |
| Date entered into DSLD | Dec 18, 2021 |
| DSLD ID | 258253 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult Male (18-50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Yohimbe Extract by Herbadiet, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Yohimbe Bark Extract | 30 mg | -- |
Other ingredients: Vegetable Cellulose Shell
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Yohimbe is an ever-green tree native to Western Africa, where its bark has long been thought to boost libido. Herbadiet delivers the benefits of this centuries old herb in an easy-to-use dietary supplement. Herbadiet's full spectrum Yohimbe extract provides a complete approach for sexual wellness.
Formulation
Enhances energy & stamina Enhances libido Promotes sexual health
Natural color variation may occur in this product
100% natural Men health
Non-GMO
Suitable for vegetarians and vegans
Free Of preservatives, binders, gluten, artificial ingredients, dairy, soy, wheat, yeast
Every batch 3rd party lab tested
FDA Disclaimer Statement
These statements have not been evaluated by FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Precautions
Do not use if seal under the cap is broken or missing. Dietary supplement shouldn't be used as a substitute for a varied diet
Caution: If you are pregnant, breast feeding, or taking medications, consult your doctor before use.
Discontinue use and consult your doctor if any adverse reactions occur.
Keep out of reach of children.
Not for medicinal use
Storage
Store in cool, dry place
Seals/Symbols
fssai Lic. No.: 20817018000147 Vcaps Plus GMP Good Manufacturing Practice Quality Product
General Statements
1% for the planet
License Number: 10018064001315
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions for Use: Take 1 capsule daily, atleast 1 hour before activity or as directed by your physician.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Yohimbe Extract by Herbadiet label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Yohimbe Extract by Herbadiet
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Yohimbe Bark Extract
Interacts with1,125 drugs
Yohimbe is a West African tree bark that contains yohimbine, a compound mainly promoted for erectile dysfunction and as an aphrodisiac. A prescription...
Yohimbe Bark Extract monograph & interactionsOther (inactive) ingredients: Vegetable Cellulose Shell. These complete the product’s ingredient list but are not active constituents.
Yohimbe Extract by Herbadiet Drug Interactions
HelloPharmacist Interaction Report
Yohimbe Extract by Herbadiet contains yohimbine, which interacts with a number of medications, some seriously.
The most serious concern is with MAOIs (monoamine oxidase inhibitors), a class of older antidepressants. Yohimbine has MAO inhibitory effects of its own; combining them can cause additive effects and potentially dangerous interactions.
Read the full breakdown — every affected drug type, severity by severity
Yohimbe also interacts with blood pressure medications (antihypertensive drugs), stimulants, and tricyclic antidepressants (TCAs)—a different class of older antidepressants. With blood pressure medications and stimulants, yohimbine can raise blood pressure and cause additive stimulant effects.
With TCAs, a small clinical trial showed that intravenous yohimbine caused severe anxiety, agitation, and tremor in patients already taking these drugs.
Additionally, yohimbe affects how your liver metabolizes certain medications through its interaction with liver enzymes (CYP2D6 and CYP3A4), potentially raising levels of drugs broken down by those pathways. It also interacts with phenothiazines (older psychiatric medications).
Altogether, these interactions span 1,113 individual medications.
If you take any prescription medication—especially any antidepressant, blood pressure drug, or stimulant—run it through the checker on this page before you start yohimbe.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Yohimbe Extract?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Yohimbe Extract interact with 1,125 drugs. Click any drug to see the details.
1 of the 1 ingredient in Yohimbe Extract interact with drugs. Each result below shows which ingredient is responsible. Yohimbe Bark Extract
Acetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Yohimbe Extract — through 1 ingredient. Tap an ingredient for the detail:
Yohimbe Bark ExtractStimulant Drugs, Cytochrome P450 2d6 (cyp2d6) Inhibitors +3 Moderate
Interaction Summary
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Read the full Yohimbe Bark Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Yohimbe Extract — through 1 ingredient. Tap an ingredient for the detail:
Yohimbe Bark ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 2d6 (cyp2d6) Inhibitors +3 Moderate
Interaction Summary
Theoretically, yohimbe might increase the levels and adverse effects of CYP2D6 substrates.
Read the full Yohimbe Bark Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Yohimbe Extract — through 1 ingredient. Tap an ingredient for the detail:
Yohimbe Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Yohimbe Bark Extract + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Yohimbe Extract — through 1 ingredient. Tap an ingredient for the detail:
Yohimbe Bark ExtractStimulant Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Read the full Yohimbe Bark Extract + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Yohimbe Extract — through 1 ingredient. Tap an ingredient for the detail:
Yohimbe Bark ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Inhibitors +2 Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Yohimbe Bark Extract + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Yohimbe Extract — through 1 ingredient. Tap an ingredient for the detail:
Yohimbe Bark ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Yohimbe Bark Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Yohimbe Extract — through 1 ingredient. Tap an ingredient for the detail:
Yohimbe Bark ExtractCytochrome P450 2d6 (cyp2d6) Inhibitors, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
CYP2D6 inhibitors may increase the levels and adverse effects of yohimbine, a constituent of yohimbe.
Read the full Yohimbe Bark Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with Yohimbe Extract — through 1 ingredient. Tap an ingredient for the detail:
Yohimbe Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Inhibitors +2 Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Yohimbe Bark Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with Yohimbe Extract — through 1 ingredient. Tap an ingredient for the detail:
Yohimbe Bark ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Yohimbe Bark Extract + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, Chlorzoxazone, CodeineAcetazone Forte C8, Parafon Forte C8
How Acetaminophen, Chlorzoxazone, Codeine interacts with Yohimbe Extract — through 1 ingredient. Tap an ingredient for the detail:
Yohimbe Bark ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Yohimbe Bark Extract + Acetaminophen, Chlorzoxazone, Codeine interactionAcetaminophen, CodeineTylenol No.3, Tylenol w/ Codeine
How Acetaminophen, Codeine interacts with Yohimbe Extract — through 1 ingredient. Tap an ingredient for the detail:
Yohimbe Bark ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, yohimbe might increase the levels and adverse effects of CYP2D6 substrates.
Read the full Yohimbe Bark Extract + Acetaminophen, Codeine interactionAcetaminophen, Codeine, DoxylamineMersyndol
How Acetaminophen, Codeine, Doxylamine interacts with Yohimbe Extract — through 1 ingredient. Tap an ingredient for the detail:
Yohimbe Bark ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Yohimbe Bark Extract + Acetaminophen, Codeine, Doxylamine interactionAcetaminophen, Codeine, MethocarbamolAcetaminophen, Codeine, Methocarbamol, Robaxacet 8
How Acetaminophen, Codeine, Methocarbamol interacts with Yohimbe Extract — through 1 ingredient. Tap an ingredient for the detail:
Yohimbe Bark ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, yohimbe might increase the levels and adverse effects of CYP2D6 substrates.
Read the full Yohimbe Bark Extract + Acetaminophen, Codeine, Methocarbamol interactionAcetaminophen, Dexbrompheniramine, PseudoephedrineSinadrin Plus
How Acetaminophen, Dexbrompheniramine, Pseudoephedrine interacts with Yohimbe Extract — through 1 ingredient. Tap an ingredient for the detail:
Yohimbe Bark ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Stimulant Drugs Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Yohimbe Bark Extract + Acetaminophen, Dexbrompheniramine, Pseudoephedrine interactionAcetaminophen, DextromethorphanTylenol Cough Ex Strength
How Acetaminophen, Dextromethorphan interacts with Yohimbe Extract — through 1 ingredient. Tap an ingredient for the detail:
Yohimbe Bark ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, yohimbe might increase the levels and adverse effects of CYP2D6 substrates.
Read the full Yohimbe Bark Extract + Acetaminophen, Dextromethorphan interactionAcetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
How Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interacts with Yohimbe Extract — through 1 ingredient. Tap an ingredient for the detail:
Yohimbe Bark ExtractStimulant Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Read the full Yohimbe Bark Extract + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylephrineConar-A
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interacts with Yohimbe Extract — through 1 ingredient. Tap an ingredient for the detail:
Yohimbe Bark ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Yohimbe Bark Extract + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylpropanolamineAnatuss
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interacts with Yohimbe Extract — through 1 ingredient. Tap an ingredient for the detail:
Yohimbe Bark ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Yohimbe Bark Extract + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PseudoephedrineRobitussin Cold, Severe Cold, Suphedrine Cold/Cough
How Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interacts with Yohimbe Extract — through 1 ingredient. Tap an ingredient for the detail:
Yohimbe Bark ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Yohimbe Bark Extract + Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineTheracaps
How Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interacts with Yohimbe Extract — through 1 ingredient. Tap an ingredient for the detail:
Yohimbe Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Yohimbe Bark Extract + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAcetaminophen, Dextromethorphan, PseudoephedrineAlka-Seltzer PLUS Flu Liquid Gels, Non Aspirin Cold Caps, Tylenol Cold, Tylenol Flu Daytime Ex Strength, Tylenol Flu Ex Strength
How Acetaminophen, Dextromethorphan, Pseudoephedrine interacts with Yohimbe Extract — through 1 ingredient. Tap an ingredient for the detail:
Yohimbe Bark ExtractStimulant Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Read the full Yohimbe Bark Extract + Acetaminophen, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Dichloralantipyrine, IsomethepteneAmidrine, Midchlor, Migquin, Migratine
How Acetaminophen, Dichloralantipyrine, Isometheptene interacts with Yohimbe Extract — through 1 ingredient. Tap an ingredient for the detail:
Yohimbe Bark ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Stimulant Drugs Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Yohimbe Bark Extract + Acetaminophen, Dichloralantipyrine, Isometheptene interactionAcetaminophen, Dichloralphenazone, IsomethepteneMidrin
How Acetaminophen, Dichloralphenazone, Isometheptene interacts with Yohimbe Extract — through 1 ingredient. Tap an ingredient for the detail:
Yohimbe Bark ExtractStimulant Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Read the full Yohimbe Bark Extract + Acetaminophen, Dichloralphenazone, Isometheptene interactionAcetaminophen, Dichlorophenazone, IsometheptaneIsocom
How Acetaminophen, Dichlorophenazone, Isometheptane interacts with Yohimbe Extract — through 1 ingredient. Tap an ingredient for the detail:
Yohimbe Bark ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Stimulant Drugs Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Yohimbe Bark Extract + Acetaminophen, Dichlorophenazone, Isometheptane interactionAcetaminophen, DiphenhydramineTylenol PM, Tylenol PM Ex Strength
How Acetaminophen, Diphenhydramine interacts with Yohimbe Extract — through 1 ingredient. Tap an ingredient for the detail:
Yohimbe Bark ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Inhibitors Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Yohimbe Bark Extract + Acetaminophen, Diphenhydramine interactionAcetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief
How Acetaminophen, Diphenhydramine, Pseudoephedrine interacts with Yohimbe Extract — through 1 ingredient. Tap an ingredient for the detail:
Yohimbe Bark ExtractCytochrome P450 2d6 (cyp2d6) Inhibitors, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
CYP2D6 inhibitors may increase the levels and adverse effects of yohimbine, a constituent of yohimbe.
Read the full Yohimbe Bark Extract + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionAcetaminophen, Doxylamine, PseudoephedrineEx Strength Tylenol Sinus Nighttime
How Acetaminophen, Doxylamine, Pseudoephedrine interacts with Yohimbe Extract — through 1 ingredient. Tap an ingredient for the detail:
Yohimbe Bark ExtractStimulant Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Read the full Yohimbe Bark Extract + Acetaminophen, Doxylamine, Pseudoephedrine interactionAcetaminophen, HydrocodoneAnexsia, Anodynos DHC, Azdone, Co-Gesic, Doucet, Lorcet +9 more
How Acetaminophen, Hydrocodone interacts with Yohimbe Extract — through 1 ingredient. Tap an ingredient for the detail:
Yohimbe Bark ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Yohimbe Bark Extract + Acetaminophen, Hydrocodone interactionAcetaminophen, MeperidineDemerol APAP
How Acetaminophen, Meperidine interacts with Yohimbe Extract — through 1 ingredient. Tap an ingredient for the detail:
Yohimbe Bark ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Yohimbe Bark Extract + Acetaminophen, Meperidine interactionAcetaminophen, OxycodonePercocet, Roxicet, Tylox, Xartemis XR
How Acetaminophen, Oxycodone interacts with Yohimbe Extract — through 1 ingredient. Tap an ingredient for the detail:
Yohimbe Bark ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Yohimbe Bark Extract + Acetaminophen, Oxycodone interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Yohimbe Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Yohimbe Bark Extract
Monoamine Oxidase Inhibitors (Maois)
Concomitant use of MAOIs with yohimbe can result in additive effects.
Yohimbine, a constituent of yohimbe, has MAO inhibitory effects. At high doses, yohimbine is a non-selective inhibitor of MAO.
Antihypertensive Drugs
Theoretically, yohimbe might reduce the effects of antihypertensive drugs.
Yohimbine, a constituent of yohimbe, is an alpha-2 adrenoceptor antagonist and has been reported to increase blood pressure in clinical research. Theoretically, concomitant use of yohimbe and antihypertensive drugs can interfere with blood pressure control.
Clonidine (Catapres)
Theoretically, yohimbe might precipitate clonidine withdrawal.
Chronic clonidine use can downregulate alpha-2 adrenoreceptors. Animal research and one human case report suggest that concomitant administration of yohimbine, an alpha-2 adrenoceptor antagonist, may precipitate clonidine withdrawal and lead to sympathomimetic toxicity, including hypertensive crisis.
Cytochrome P450 2D6 (Cyp2D6) Inhibitors
CYP2D6 inhibitors may increase the levels and adverse effects of yohimbine, a constituent of yohimbe.
In vitro and clinical research shows that the yohimbe bark constituent, yohimbine, is metabolized by CYP2D6 isoenzymes. Paroxetine, a cytochrome P450 (CYP) 2D6 inhibitor, increases the maximum serum concentration of yohimbine and reduces the clearance of yohimbine compared to yohimbine alone in patients who are extensive CYP2D6 metabolizers..
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, yohimbe might increase the levels and adverse effects of CYP2D6 substrates.
In vitro research suggests that yohimbine, a constituent of yohimbe bark, inhibits CYP2D6 enzyme activity.
Cytochrome P450 3A4 (Cyp3A4) Inhibitors
Theoretically, CYP3A4 inhibitors might increase the levels and adverse effects of yohimbine, a constituent of yohimbe bark.
In vitro and clinical research shows that the yohimbe bark constituent, yohimbine, is metabolized by CYP3A4 enzymes. Theoretically, drugs that inhibit CYP3A4 might increase the levels and adverse effects of yohimbine.
Paroxetine (Paxil)
Paroxetine decreases the clearance of yohimbine and may increase its effects.
Paroxetine, a cytochrome P450 (CYP) 2D6 inhibitor, increases the maximum serum concentration of yohimbine by about 350% and reduces the clearance of yohimbine by about 80% compared to yohimbine alone in patients who are extensive CYP2D6 metabolizers. No significant changes in pharmacokinetic parameters of yohimbine were observed with coadministration of paroxetine in patients who are poor CYP2D6 metabolizers.
Phenothiazines
Theoretically, using yohimbine with phenothiazines might have additive effects.
Yohimbine, a constituent of yohimbe, has alpha-2 adrenergic antagonist effects. Theoretically, combining it with phenothiazines can cause additive alpha-2 adrenergic antagonism.
Stimulant Drugs
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Yohimbine, a constituent of yohimbe, has sympathomimetic effects and increases blood pressure in a dose-dependent manner. Theoretically, taking yohimbe with stimulant drugs can have additive stimulant and hypertensive effects.
Tricyclic Antidepressants (Tcas)
Theoretically, taking yohimbe with TCAs can increase adverse effects.
A small clinical study in patients taking TCAs for at least 4 weeks shows that receiving doses of intravenous yohimbine 2.5-20 mg daily for up to 7 days precipitates severe anxiety, agitation, and tremor. The effects of yohimbe bark itself are unclear; oral yohimbe bark contains 0.6% to 1.38% yohimbine, but it is unclear how much is absorbed.
Anticoagulant/Antiplatelet Drugs
Theoretically, combining yohimbe bark with antiplatelet or anticoagulant drugs might have additive effects; however, this has not been reported in clinical research.
Research in healthy adults shows that taking yohimbine, a constituent of yohimbe bark, in doses of 8 mg or more, seems to inhibit platelet aggregation in vitro by binding to the alpha-2 adrenoceptor. The effects of yohimbe bark itself are unclear; yohimbe bark contains 0.6% to 1.38% yohimbine, but it is unclear how much is absorbed.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that yohimbe extract induces CYP1A2 enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that yohimbe extract induces CYP3A4 enzymes.
Brand information
Manufacturer and brand details for Yohimbe Extract, from the product label.
Herbadiet
See all Herbadiet products- Name
- Arkure Health Care
- City
- Haryana
- State
- India
- Web Address
- www.herbadiet.in
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The Full Monographs Behind Yohimbe Extract’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Yohimbe Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 66 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Yohimbe 66 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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