No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

Zi Su Ye Ingredients & Drug Interactions

by Herbal Terra

Liquid Category: Botanical
No known interaction
The interaction bottom line No known interaction

Zi Su Ye is a dietary supplement by Herbal Terra with 1 active ingredient. Its ingredients are commonly taken for seasonal and food allergies, asthma and airway inflammation, atopic dermatitis (eczema).We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of Zi Su Ye by Herbal Terra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: a dried leaf liquid extract of Zi Su Ye, also called perilla (Folium perillae). Perilla is a plant used in traditional herbalism and appears in Asian cuisines as a food.

The product also contains menstruum, which is the liquid base used to extract and deliver the herb.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Seasonal allergies and respiratory inflammation support.
  • We looked for evidence on: Allergic rhinitis (hay fever), Asthma, Cough, Atopic dermatitis, Airway inflammation.
  • The closest evidence on file: Perilla is rated "Insufficient Reliable Evidence To Rate" for Allergic rhinitis (hay fever) (Natural Medicines).
  • Also on file: Perilla is rated "Insufficient Reliable Evidence To Rate" for Asthma, Cough.

The effectiveness of perilla for age-related cognitive decline, allergic rhinitis (hay fever), asthma, osteoporosis, cancer, and headache hasn't been established in the data we hold. Each of these uses is rated as having insufficient reliable evidence, which means there's not enough solid research to say whether it works.

The evidence, ingredient by ingredient Perilla

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Perilla is generally well tolerated when eaten as a food, but supplement-strength products haven't been well studied, so we don't have a complete picture of how safe they are at higher doses. The most common side effect from topical use is dermatitis (skin irritation).

A rare but serious concern is anaphylaxis (a severe allergic reaction) — many cases have been reported in people who consumed perilla seeds, likely tied to a component called oleosin. Breathing in smoke from roasted perilla seeds has also triggered occupational asthma in some people.

Because there isn't enough safety data, the facts advise against medicinal amounts during pregnancy and while breastfeeding — talk with your doctor or pharmacist about whether this product is right for you in those situations.

Side effects, ingredient by ingredient Perilla

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented for the ingredient we could check. Always verify your exact medications with the tool on this page before starting.

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. No medication interactions are currently documented, and safety information is well characterized.

Perilla is a traditional herb, but we don't have strong evidence it works for any of the conditions listed here, and supplement-strength products are not well studied. If you're interested in trying it, know that serious allergic reactions are rare but documented.

Talk to your pharmacist if you're pregnant, breastfeeding, or have a history of allergies to plants in the mint family.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Zi Su Ye, straight from the product label.

Brand Herbal Terra
Barcode (UPC) 0606595864913
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Sep 25, 2020
DSLD ID 234430
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic, Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Zi Su Ye by Herbal Terra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
0606595864913
IngredientAmount% DV
certified organic Zi Su Ye (Folium perillae) dried leaf liquid extract970 mg--

Other ingredients: Menstruum

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Direction Shake well before use. Adults take up to 30 drops (1 mL, one full squeeze of the dropper bulb) in 3-4 fl. oz of juice or water up to 4 times a day. We recommend to seek expert medical advice before taking this or any other herbal supplements.

FDA Disclaimer Statement

Notice This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Manufactured in the USA in an FDA registered facility

Sugar free

Dried herb/menstruum ratio: 1:3 Expertly extracted Laboratory tested 330 mg/1 mL Premium product Super concentrated liquid herbal extract

Non GMO

No artificial ingredients, GMO, gluten, color additives, fillers, preservatives or binders. Natural Gluten Free

Precautions

Caution May have contraindications.

Do not use if you are allergic to any ingredients.

Consult a physician before using during pregnancy, if nursing, or if you are on any medications.

Keep out of the reach of children.

Storage

Store in a cool, dry, dark place.

Formula

Folium perillae

FDA Statement of Identity

Herbal Supplement

Seals/Symbols

Made in USA Made in an FDA registered facility Natural Gluten Free

See for yourself

Zi Su Ye by Herbal Terra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Zi Su Ye by Herbal Terra

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

970 mg per serving

Perilla is an Asian mint-family plant used in cooking and traditional medicine, mainly for allergy, breathing, and digestive complaints. Most human ev...

Certified organic Zi Su Ye (Folium perillae) dried leaf liquid extract monograph & interactions

Other (inactive) ingredients: Menstruum. These complete the product’s ingredient list but are not active constituents.

Interaction report

Zi Su Ye by Herbal Terra Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Zi Su Ye. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Zi Su Ye, from the product label.

Herbal Terra

See all Herbal Terra products
Name
Herbal Terra
Pharmacist Counseling Corner

Zi Su Ye by Herbal Terra: Common Questions

Does Zi Su Ye by Herbal Terra interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Zi Su Ye. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Zi Su Ye contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is Zi Su Ye?
Zi Su Ye is the dried leaf of perilla, a plant used in traditional herbalism and found in some Asian foods. This product is a liquid extract of that leaf.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety data to know either way. The facts advise against medicinal amounts in both cases. Talk with your doctor or pharmacist about what's right for you.
What are the side effects?
Perilla is generally well tolerated, and skin irritation is the most commonly reported topical side effect. Rarely, people have had severe allergic reactions (anaphylaxis) after eating perilla seeds, and some people have developed asthma from inhaling smoke from roasted seeds.
Does this actually work for any of the conditions listed?
Not according to the evidence we hold. Perilla hasn't been studied enough to say whether it helps with cognitive decline, hay fever, asthma, bone health, cancer, or headache.
Is perilla safe as a supplement?
Perilla is generally well tolerated as a food, but supplement-strength products haven't been well studied, so we don't know as much about safety at higher doses. If you have allergies to plants in the mint family, be cautious.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Zi Su Ye is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Zi Su Ye label
Go deeper

The Full Monographs Behind Zi Su Ye’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Zi Su Ye's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Perilla 4 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Kanzaki, T. and Kimura, S. Occupational allergic contact dermatitis from Perilla frutescens (shiso). Contact Dermatitis 1992;26(1):55-56.
  3. Yu H, Qiu JF, Ma LJ, Hu YJ, Li P, Wan JB. Phytochemical and phytopharmacological review of Perilla frutescens L. (Labiatae), a traditional edible-medicinal herb in China. Food Chem Toxicol 2017;108(Pt B):375-91. PubMed
  4. Jeong K, Lee SY, Jeon SA, et al. Clinical and immunological characterization of perilla seed allergy in children. J Investig Allergol Clin Immunol 2021. PubMed

See these in context on the Perilla monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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