FDA-filed SPL labeling · retrieved through openFDA

Adenine / Anhydrous Citric Acid / Dextrose / Monobasic / Monohydrate / Sodium Phosphate / Trisodium

CPDA-1 (Citrate Phosphate Dextrose Adenine) is a sterile anticoagulant solution used in blood collection bag systems to preserve whole blood and blood components for transfusion use.

Drug classes Calculi Dissolution Agent
Rx Form 1 Route Intravenous
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 3 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

At a glance
Linked label effectiveOct 10, 2024
Clinical labels in scope 3
AvailabilityRx
Earliest approval/marketing year 2009
FDA-listed product records 3
Boxed warningNone found in compared labels
How we combine label and product data →
No current FDA shortage listed · checked Sep 18, 2026
Adenine / Anhydrous Citric Acid / Dextrose / Monobasic / Monohydrate / Sodium Phosphate / Trisodium at a glance The quick version — the full detail is in the Patient Information Guide below.
💊
HelloPharmacist Editorial Team Bottom Line
CPDA-1 blood bag systems are professional-use medical devices used in blood banks and collection centers to collect and preserve whole blood and its components — they are not medications patients take themselves. All handling must follow strict institutional protocols and aseptic technique. These products require a prescription and are not intended for direct intravenous infusion.

📖 Adenine / Anhydrous Citric Acid / Dextrose / Monobasic / Monohydrate / Sodium Phosphate / Trisodium: Patient Information Guide

A plain-language walkthrough of Adenine / Anhydrous Citric Acid / Dextrose / Monobasic / Monohydrate / Sodium Phosphate / Trisodium — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.

🎯What it's used for

CPDA-1 (Citrate Phosphate Dextrose Adenine) solution is used exclusively in professional blood collection settings — not as a medication taken by patients.

  • TERUFLEX Blood Anticoagulant CPDA-1 (all products): Collection, processing, and preservation of whole blood and blood components for transfusion
  • TERUFLEX Blood Anticoagulant CPDA-1 for Collection of 450mL of Blood: Designed specifically for collecting 450 mL (±10%) of whole blood
  • TERUFLEX BLOOD with Diversion Blood Sampling Arm 70 mL CPDA-1 and teruflex blood bag system with diversion blood sampling arm 70 ml cpda-1: Include an integral diversion pouch to collect donor blood samples for laboratory testing before the main unit is collected
  • All TERUFLEX CPDA-1 products support further processing into components such as red blood cells, platelets, and plasma using standard blood bank techniques
  • Not intended for direct intravenous infusion into any patient
💊How it's taken

These are professional-use blood collection systems, not medications dosed by patients. Trained blood bank staff use the TERUFLEX CPDA-1 bag system to collect whole blood (450 mL ±10% or 500 mL ±10% depending on the product), following institutional standard operating procedures. The anticoagulant solution inside the bag acts during and after collection to keep blood from clotting. After collection, blood components must be separated and stored according to strict time and temperature requirements — for example, red blood cells are stored at 1–6°C for up to 35 days.

🤒Side effects — in detail

Side effects are not listed in the FDA label for this blood collection system, as it is a professional-use device — not a drug taken by patients.

⚠️Warnings & precautions
  • Inspect before every use: Do not use the bag if the solution is cloudy, contains particles, or if the bag shows any signs of leaking.
  • Storage: Keep at room temperature (15–30°C / 59–86°F). Never expose to excessive heat, direct sunlight, or freezing temperatures.
  • Infection control: Human blood carries potential infectious agents. Always follow institutional protocols to protect both donors and staff.
  • Aseptic technique required: All steps must be performed using sterile methods to prevent contamination of the blood supply.
  • Needle safety: Never touch the needle after removing its cover. Use approved needle safety devices.
  • Dielectric tube sealer caution: Do not use one to seal tubing while the needle is still in the donor's arm unless the device is specifically cleared for that use.
  • AGELESS oxygen absorber packet: This packet is inside the blister package, generates heat when opened, and should never be opened. Dispose of it with the blister tray only — not with flammable waste.
📋Before taking it
  • This product is for use only by trained healthcare and blood bank professionals — not for patient self-use
  • Requires a prescription (Rx only)
  • Only use if the solution appears clear and free of particles
  • Do not use if the bag set shows any leaks
  • Handle the AGELESS oxygen absorber packet with care — it generates heat and should not be opened
  • Follow all institutional procedures for handling human blood to prevent exposure to infectious agents
📦How to store it

Room Temperature (15-30°C/59-86°F). Avoid excessive heat and direct sunlight. Protect from freezing.

📄 Written from Adenine / Anhydrous Citric Acid / Dextrose / Monobasic / Monohydrate / Sodium Phosphate / Trisodium’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →

🩺 Pharmacist Counseling Corner

Quick, plain-English answers to the questions patients ask most about Adenine / Anhydrous Citric Acid / Dextrose / Monobasic / Monohydrate / Sodium Phosphate / Trisodium — the kind of thing our pharmacy team would talk through with you at the counter.

Is this something a patient takes as a medication?
No — CPDA-1 is not a drug you take yourself. It's the anticoagulant preservative solution inside a blood collection bag used at blood banks and donation centers. Trained healthcare professionals use it to collect your whole blood, keep it from clotting, and preserve it so it can be processed and eventually given to someone who needs a transfusion.
Why does the blood bag contain all those ingredients — citric acid, dextrose, adenine, and phosphate?
Each ingredient plays a role in keeping donated blood usable. Citrate (from citric acid) prevents clotting. Dextrose (a sugar) gives red blood cells energy to stay alive during storage. Phosphate helps maintain the right chemical balance. Adenine supports red blood cell survival so the blood remains safe for transfusion for up to 35 days when stored at the right temperature.
What is the diversion pouch on some of the TERUFLEX bags for?
The diversion pouch captures the very first bit of blood drawn during a donation — usually about 35 mL. That first portion can sometimes carry small amounts of skin bacteria from the needle insertion site. By diverting it into a separate pouch for lab testing, the main blood collection bag stays cleaner and safer for the person who will eventually receive the transfusion.
How long can blood collected in a CPDA-1 bag be stored?
Red blood cells collected in a CPDA-1 bag can be stored between 1–6°C for up to 35 days. Platelets have a much shorter shelf life and must be kept at 20–24°C with continuous gentle mixing. Plasma intended for transfusion must be frozen within specific time windows after collection. Your blood bank follows strict protocols for all of this.
Is there anything I need to know as a blood donor about the bag being used to collect my blood?
The main things to know: the bag and its solution are sterile and inspected before use, the needle is handled with strict safety measures, and your blood is mixed with the anticoagulant solution right away to keep it from clotting. The whole process follows your donation center's standard operating procedures designed to protect both you and the person who will receive your donation.
What should blood bank staff watch out for when using these bags?
Staff should always inspect the bag for leaks and check that the solution is clear before use. The bags should be stored at room temperature — never frozen or left in heat or direct sunlight. Strict sterile technique is required throughout, and all institutional infection control procedures must be followed when handling human blood. The AGELESS oxygen absorber packet inside the packaging should not be opened — it generates heat and should be discarded with the blister tray.
Is Adenine / Anhydrous Citric Acid / Dextrose / Monobasic / Monohydrate / Sodium Phosphate / Trisodium available over the counter?
Adenine / Anhydrous Citric Acid / Dextrose / Monobasic / Monohydrate / Sodium Phosphate / Trisodium is dispensed by prescription according to its FDA labeling, so it isn't sold over the counter. Your prescriber and pharmacist will determine if it's appropriate for you.
When was Adenine / Anhydrous Citric Acid / Dextrose / Monobasic / Monohydrate / Sodium Phosphate / Trisodium first available?
Adenine / Anhydrous Citric Acid / Dextrose / Monobasic / Monohydrate / Sodium Phosphate / Trisodium has been available in the United States since at least 2009, based on FDA approval history (Drugs@FDA) and product marketing records.

💬 Answers drafted from Adenine / Anhydrous Citric Acid / Dextrose / Monobasic / Monohydrate / Sodium Phosphate / Trisodium’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →

🧰 Keep exploring

💊 How Adenine / Anhydrous Citric Acid / Dextrose / Monobasic / Monohydrate / Sodium Phosphate / Trisodium comes

Adenine / Anhydrous Citric Acid / Dextrose / Monobasic / Monohydrate / Sodium Phosphate / Trisodium is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Injection

Into a vein
Brands TERUFLEX Blood Anticoagulant Citrate Phosphate Dextrose Adenine (CPDA-1) for Collection of 450mL of Blood teruflex blood bag system with diversion blood sampling arm 70 ml cpda-1 TERUFLEX BLOOD with Diversion Blood Sampling Arm 70 mL CPDA-1
How this form is used
What it may be used for
  • TERUFLEX Blood Anticoagulant CPDA-1 products are used for the collection, processing, and preservation of whole blood and blood components
  • TERUFLEX BLOOD with Diversion Blood Sampling Arm 70 mL CPDA-1 and the teruflex blood bag system with diversion blood sampling arm 70 ml cpda-1 include an integral diversion pouch to obtain donor blood samples for laboratory testing before the main collection begins
  • TERUFLEX Blood Anticoagulant CPDA-1 for Collection of 450mL of Blood is designed for collection of 450 mL (±10%) of whole blood
  • These products are not intended for direct intravenous infusion into a patient
Important instructions
  • TERUFLEX CPDA-1 blood bag systems must be used following institutional standard operating procedures and aseptic technique
  • TERUFLEX BLOOD with Diversion Blood Sampling Arm: close the white clamp below the diversion pouch before starting phlebotomy, and do not collect donor test samples until the tubing between the 'Y' and the diversion pouch is permanently sealed
  • Mix blood with the anticoagulant solution in the collection bag continuously during and immediately after collection to prevent clotting
  • Store CPDA-1 Red Blood Cells (or Whole Blood) between 1–6°C for up to 35 days after collection
Available strengths 1 strength
3 FDA-listed product records

📊 Adenine / Anhydrous Citric Acid / Dextrose / Monobasic / Monohydrate / Sodium Phosphate / Trisodium across the U.S. market

How Adenine / Anhydrous Citric Acid / Dextrose / Monobasic / Monohydrate / Sodium Phosphate / Trisodium appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

1
Dose forms
1
Manufacturers
3
Brand names
3
FDA-listed product records
2009
First marketed

🔍 Compare Adenine / Anhydrous Citric Acid / Dextrose / Monobasic / Monohydrate / Sodium Phosphate / Trisodium products

A representative set of FDA-listed product records for Adenine / Anhydrous Citric Acid / Dextrose / Monobasic / Monohydrate / Sodium Phosphate / Trisodium — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Strength Route Manufacturer / Labeler Category Details
💊Injection
ANHYDROUS CITRIC ACID 2.99 g/1000 mL; TRISODIUM CITRATE DIHYDRATE 26.3 g/1000 mL; SODIUM PHOSPHATE, MONOBASIC, MONOHYDRATE 2.22 g/1000 mL; DEXTROSE MONOHYDRATE 31.9 g/1000 mL; ADENINE 0.275 g/1000 mL Intravenous Terumo Corporation × 3 listings NDA View NDC →

Showing 3 of 3 products — FDA National Drug Code Directory. See every product, package size and price: browse all 3 Adenine / Anhydrous Citric Acid / Dextrose / Monobasic / Monohydrate / Sodium Phosphate / Trisodium NDCs →

🏷️ Sold under these brand names

teruflex blood bag system with diversion blood sampling arm 70 ml cpda-1 TERUFLEX Blood Anticoagulant Citrate Phosphate Dextrose Adenine (CPDA-1) for Collection of 450mL of Blood TERUFLEX BLOOD with Diversion Blood Sampling Arm 70 mL CPDA-1

🏭 Manufacturers & labelers

Terumo Corporation 3

🔬 Where this comes from

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Oct 10, 2024
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Adenine / Anhydrous Citric Acid / Dextrose / Monobasic / Monohydrate / Sodium Phosphate / Trisodium.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Adenine / Anhydrous Citric Acid / Dextrose / Monobasic / Monohydrate / Sodium Phosphate / Trisodium after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
3
NDC products indexed
3
Distinct labelers/manufacturers represented
1
Linked representative label
Terumo Corporation
Linked label effective
Oct 10, 2024
Composite sections available
8
Linked SPL Set ID
86b3a329-c83f-4977-92f5-0e9dfe1872d7
Linked SPL Document ID
f4ad452e-9aff-4985-a0e4-f8ca3d3cc6c1
Open the linked representative label on DailyMed ↗

How we combine label and product data

HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 3 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.

For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Terumo Corporation is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.

This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.