FDA-filed SPL labeling · retrieved through openFDA

Nitrous Oxide

Brand names Nitrous Oxide Oxygen MixNitrous Oxide Sedara
Rx Form 1 Route Respiratory (inhalation)
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 46 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

At a glance
Linked label effectiveMar 24, 2026
Clinical labels in scope ⓘ46
AvailabilityRx
Earliest approval/marketing year ⓘ1954
FDA-listed product records ⓘ137
Boxed warningNone found in compared labels
How we combine label and product data →
✓No current FDA shortage listed · checked Sep 18, 2026

❓ Nitrous Oxide: frequently asked questions

Common questions about Nitrous Oxide, answered from its official FDA-filed labeling.

Is Nitrous Oxide available over the counter? ▾
Nitrous Oxide is dispensed by prescription according to its FDA labeling, so it isn't sold over the counter. Your prescriber and pharmacist will determine if it's appropriate for you.
When was Nitrous Oxide first available? ▾
Nitrous Oxide has been available in the United States since at least 1954, based on FDA approval history (Drugs@FDA) and product marketing records.
Who makes Nitrous Oxide? ▾
Nitrous Oxide is supplied by 55 manufacturers listed in the FDA NDC Directory, including Roberts Oxygen Company, Inc., Linde Gas & Equipment Inc., Machine & Welding Supply Company dba Arc3 Gases South.

💬 Answers drafted from Nitrous Oxide’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →

🧰 Keep exploring

🌿Drug & Supplement CheckerNitrous Oxide vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Nitrous Oxide NDCs & costs 🅰️Browse Drugs A–ZLook up any medication

💊 How Nitrous Oxide comes

Nitrous Oxide is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

📊 Nitrous Oxide across the U.S. market

How Nitrous Oxide appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

1
Dose forms ⓘ
55
Manufacturers
3
Brand names
137
FDA-listed product records ⓘ
1954
First marketed ⓘ
Roberts Oxygen Company, Inc.6%
Linde Gas & Equipment Inc.3%
Machine & Welding Supply Company dba Arc3 Gases South3%
General Air Service & Supply Co3%
General Welding Supply Corp.3%
Helget Gas Products3%
Other makers81%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

🔍 Compare Nitrous Oxide products

A representative set of FDA-listed product records for Nitrous Oxide — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 137 of 137 products — FDA National Drug Code Directory. See every product, package size and price: browse all 137 Nitrous Oxide NDCs →

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Nitrous Oxide RxCUI 7486 1 dose form · 5 strengths
  1. Dose form (SCDF) Gas for Inhalation RxCUI 385093 In current FDA listings
    Clinical drug / strength (SCD) 90 % RxCUI 347107 99 % RxCUI 312022 99.2 % RxCUI 347166 99.5 % RxCUI 347046 100 % RxCUI 347126

Look up RxCUI 7486 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

🏷️ Sold under these brand names

Nitrous Oxide Oxygen Mix Nitrous Oxide Sedara

🏭 Manufacturers & labelers

Roberts Oxygen Company, Inc. 7 Linde Gas & Equipment Inc. 4 Machine & Welding Supply Company dba Arc3 Gases South 3 General Air Service & Supply Co 3 General Welding Supply Corp. 3 Helget Gas Products 3 Holston Gases, Inc 3 ILMO Products Company 3 Keen Compressed Gas Co. Inc. 3 Lessors, Incorporated 3 AGL Welding Supply Co., Inc. 3 Westair Gases & Equipment, Inc. 3 Matheson Tri-Gas, Inc. 3 Maverick Oxygen & Respiratory Equipment, Llc 3 Medical-technical Gases, Inc. 3 Metro Welding Supply Corporation 3 Norco, Inc 3 Nexair, Llc 3 Nitrous Oxide 3 Nitrous Oxide of Canada 3 DuPuy Oxygen & Supply Company, Inc. 3 Aero All Gas Company 3 Spectrum Gas Products, Inc 3 Air Source Industries 3

…and 16 more on the FDA NDC directory.

RxNorm drug class

Nitrous Oxide belongs to the Other general anesthetics class.

Drug family (ATC) Other general anesthetics

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

🔬 Where this comes from

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Mar 24, 2026
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Nitrous Oxide.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Nitrous Oxide after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
46
NDC products indexed
137
Distinct labelers/manufacturers represented
55
Linked representative label ⓘ
Mitchell Welding Supply
Linked label effective
Mar 24, 2026
Linked SPL Set ID
70476a79-2b72-22c0-e053-2a91aa0a4c10
Linked SPL Document ID
4dc96074-509e-baa8-e063-6294a90a5aab
Open the linked representative label on DailyMed ↗

How we combine label and product data

HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 46 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.

For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Mitchell Welding Supply is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.

This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.