FDA-filed SPL labeling · retrieved through openFDA

Sodium Phosphate

Sodium Phosphate is a rectal enema used to relieve occasional constipation, usually producing a bowel movement within 1 to 5 minutes.

Brand names VisicolOsmoPrepFerrum PhosphateNatrium Phosphoricum 6x
OTC Forms 2 Routes Oral · Sublingual
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 2 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

At a glance
Linked label effectiveJul 14, 2021
Clinical labels in scope 2
AvailabilityOTC
Earliest approval/marketing year 1940
FDA-listed product records 14
Boxed warningNone found in compared labels
How we combine label and product data →
No current FDA shortage listed · checked Sep 22, 2026
Other forms & routes:
Sodium Phosphate at a glance The quick version — the full detail is in the Patient Information Guide below.
💊
HelloPharmacist Editorial Team Bottom Line
Sodium Phosphate enema is a fast-acting, single-use option for occasional constipation that typically works within 1 to 5 minutes. Stick to one bottle per day and never exceed that — using too much can lead to serious dehydration and other complications. If you have kidney disease, heart problems, or are over 55, talk to your doctor or pharmacist before using it.

📖 Sodium Phosphate: Patient Information Guide

A plain-language walkthrough of Sodium Phosphate — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.

🎯What it's used for

Sodium Phosphate enema is used to relieve occasional constipation in adults and children 2 years and older.

  • Occasional constipation in adults and children 12 and older (standard enema)
  • Occasional constipation in children ages 2 to under 12 (pediatric enema formula only)
💊How it's taken

Sodium Phosphate is given as a rectal enema — one bottle used once per day. Never use more than one enema in any 24-hour period. Children under 2 must not use this product; children ages 2–11 should only use the pediatric version.

  • Remove the protective shield from the tip before inserting
  • Use while lying on your left side with knees bent, or in the knee-chest position
  • Gently insert the tip and squeeze the bottle until nearly empty — you don't need to empty it completely
  • Stay in position until you feel a strong urge to go, usually within 1 to 5 minutes
  • If no urge occurs after 5 minutes, try to empty your bowel anyway
  • Call a doctor right away if no liquid comes out of the rectum within 30 minutes
🤒Side effects — in detail

Most people tolerate this enema well, but watch for these:

  • Rectal discomfort or pressure during insertion
  • Strong, sudden urge to have a bowel movement
  • Thirstiness, dizziness, or nausea
  • Vomiting
  • Urinating less than usual

The last four on that list — especially together — can signal dehydration, which is a serious concern. Stop use and call a doctor if these develop. Rectal bleeding after use also requires immediate medical attention.

⚠️Warnings & precautions
  • One enema per day maximum — using more in 24 hours can cause serious harm, including dangerous changes in your body's fluid and salt balance.
  • Do not use for more than 3 consecutive days without doctor guidance.
  • Do not force the enema tip — this can injure the rectum, especially if you have hemorrhoids.
  • If no liquid returns from the rectum within 30 minutes, call a doctor promptly — dehydration is a real risk.
  • If you already use another sodium phosphate product, do not add this one.
  • People 55 and older, or those with kidney or heart conditions, face greater risk — always check with a doctor first.
🔀What it interacts with

This enema can affect how other medications work, so timing matters:

  • All other medications — take them at least 2 hours before or after using this enema, since laxatives can change how drugs are absorbed
  • Other sodium phosphate products — do not use together; combining them raises the risk of serious side effects

This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.

📋Before taking it
  • Children under 2 years old — do NOT use; this product is not safe for them
  • Children 2 to under 12 — use only the pediatric enema formula, not the adult version
  • Adults 55 and older — higher risk of complications; ask a doctor before use
  • Kidney disease — ask a doctor first; kidneys handle phosphate, so risk is elevated
  • Heart problems — ask a doctor first
  • Dehydration — using this product while already dehydrated is dangerous; check with a doctor
  • Sodium-restricted diet — this product contains sodium; ask a doctor before use
  • Abdominal pain, nausea, or vomiting — these may signal a more serious problem; check with a doctor first
  • Bowel habit changes lasting more than 2 weeks — see a doctor before using a laxative
  • Pregnant or breastfeeding — ask a health professional before use
  • Using laxatives already for more than 3 days — ask a doctor before continuing
🚑If you take too much

If this product is swallowed rather than used rectally, get medical help or contact Poison Control immediately at 1-800-222-1222. Using more than the directed amount rectally can also cause serious harm — including dehydration and dangerous shifts in your body's fluid and electrolyte balance.

📄 Written from Sodium Phosphate’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →

18

Supplements & herbs that interact with Sodium Phosphate

18 supplements and herbal products have documented interactions with Sodium Phosphate in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 1
  • Moderate · 8
  • Minor · 9
Every supplement checked against Sodium Phosphate — ranked by severity The full interaction hub: 1 major · 8 moderate · 9 minor · every one linked to its full report. Check Sodium Phosphate against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

2

Nutrient depletion considerations

Sodium Phosphate has been associated with lower levels of 2 nutrients in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.

See the full Sodium Phosphate nutrient depletion report

Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.

🩺 Pharmacist Counseling Corner

Quick, plain-English answers to the questions patients ask most about Sodium Phosphate — the kind of thing our pharmacy team would talk through with you at the counter.

How quickly will this enema work?
You can usually expect a bowel movement within 1 to 5 minutes of using it — so make sure you're near a bathroom before you start. If you don't feel the urge after 5 minutes, go ahead and try to empty your bowel anyway. If nothing comes out of the rectum within 30 minutes, call your doctor promptly, because staying without a result can put you at risk for dehydration.
Can I use two enemas if one doesn't seem to work?
No — and this is really important. Using more than one enema in a 24-hour period can be genuinely harmful. It can throw off your body's fluid and salt balance in a serious way. If one enema doesn't work, call your doctor rather than reaching for a second bottle.
I have kidney disease. Is it safe for me to use this?
You should talk to your doctor before using this product. Kidney disease and heart problems are both listed as reasons to check in with a doctor first, because this enema can affect your body's fluid and electrolyte balance — and your kidneys play a big role in managing that. Adults 55 and older also need to take that extra step before using it.
I take a few other medications. Should I time this enema around them?
Yes, that's a smart thing to think about. Laxatives — including this enema — can affect how your body absorbs other medications. The general advice is to take your other drugs at least 2 hours before or after using this product. And definitely don't use it if you're already taking another sodium phosphate product. If you're unsure, your pharmacist can help you figure out the timing.
What warning signs should make me stop and call a doctor?
Stop using it and call a doctor right away if you notice rectal bleeding, if you don't have a bowel movement within 30 minutes, or if you feel unusually thirsty, dizzy, or are vomiting — those can all be signs of dehydration. Also, if inserting the tip causes pain or bleeding, stop immediately and seek medical care.
Is this safe to use during pregnancy or while breastfeeding?
The label says to ask a health professional before using it if you're pregnant or breastfeeding. It's worth a quick call to your doctor or midwife before reaching for this one, just to make sure it's appropriate for your situation.
Is Sodium Phosphate available over the counter?
Yes — Sodium Phosphate is available over the counter (without a prescription) in at least some forms, according to its FDA labeling. Follow the package directions and ask your pharmacist if you're unsure which product is right for you.
When was Sodium Phosphate first available?
Sodium Phosphate has been available in the United States since at least 1940, based on FDA approval history (Drugs@FDA) and product marketing records.
Who makes Sodium Phosphate?
Sodium Phosphate is supplied by 9 manufacturers listed in the FDA NDC Directory, including Jost Chemical Co., Avantor Performance Materials, LLC, Sionc Pharmaceuticals Pvt Ltd.

💬 Answers drafted from Sodium Phosphate’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →

🧰 Keep exploring

💊 How Sodium Phosphate comes

Sodium Phosphate is available in 2 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Tablet

By mouth
Brands Ferrum Phosphate
Available strengths 1 strength
2 FDA-listed product records

Sublingual tablet

Under the tongue
Brands Natrium Phosphoricum 6x
Available strengths 1 strength
1 FDA-listed product record

📊 Sodium Phosphate across the U.S. market

How Sodium Phosphate appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

2
Dose forms
9
Manufacturers
2
Brand names
14
FDA-listed product records
1940
First marketed

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Granule (5) · Powder (5) · Crystal (1) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Jost Chemical Co.29%
Avantor Performance Materials, LLC14%
Sionc Pharmaceuticals Pvt Ltd14%
Hyland's7%
Hyland's Inc.7%
Jost Chemical Co7%
Other makers21%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

🔍 Compare Sodium Phosphate products

A representative set of FDA-listed product records for Sodium Phosphate — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Strength Route Manufacturer / Labeler Category Details
💊Sublingual tablet
6 [hp_X] Sublingual Seroyal USA UNAPPROVED HOMEOPATHIC View NDC →
💊Tablet
6 [hp_X] Oral Hyland's UNAPPROVED HOMEOPATHIC View NDC →
6 [hp_X] Oral Hyland's Inc. UNAPPROVED HOMEOPATHIC View NDC →
💊Bulk drug substance
1 kg/kg Avantor Performance Materials, LLC × 2 listings BULK INGREDIENT View NDC →
1 kg/kg Jost Chemical Co BULK INGREDIENT View NDC →
1 kg/kg Jost Chemical Co. × 4 listings BULK INGREDIENT View NDC →
1 kg/kg Jost Chemical Poland Sp Z O O BULK INGREDIENT View NDC →
60 kg/60 kg Sionc Pharmaceuticals Pvt Ltd × 2 listings BULK INGREDIENT View NDC →
1 g/g Spectrum Laboratory Products, Inc. BULK INGREDIENT View NDC →

Showing 14 of 14 products — FDA National Drug Code Directory. See every product, package size and price: browse all 14 Sodium Phosphate NDCs →

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Sodium Phosphate RxCUI 36709 1 dose form · 1 strength
  1. Dose form (SCDF) Oral Tablet RxCUI 375635 In current FDA listings
    Clinical drug / strength (SCD) 1500 MG RxCUI 603011

Look up RxCUI 36709 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

🏷️ Sold under these brand names

Visicol OsmoPrep Ferrum Phosphate Natrium Phosphoricum 6x

🏭 Manufacturers & labelers

Jost Chemical Co. 4 Avantor Performance Materials, LLC 2 Sionc Pharmaceuticals Pvt Ltd 2 Hyland's 1 Hyland's Inc. 1 Jost Chemical Co 1 Jost Chemical Poland Sp Z O O 1 Seroyal USA 1 Spectrum Laboratory Products, Inc. 1

RxNorm drug class

Sodium Phosphate belongs to the Osmotically acting laxatives class.

Drug family (ATC) Osmotically acting laxatives, Enemas, Electrolyte solutions

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

🔬 Where this comes from

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Jul 14, 2021
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Sodium Phosphate.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Sodium Phosphate after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
2
NDC products indexed
14
Distinct labelers/manufacturers represented
9
Linked representative label
Seroyal USA
Linked label effective
Jul 14, 2021
Composite sections available
7
Linked SPL Set ID
22cc1c1e-626f-4a15-e054-00144ff88e88
Linked SPL Document ID
c71d7cd0-09ad-bb0b-e053-2995a90ac703
Open the linked representative label on DailyMed ↗
NDC package records associated with this linked SPL 1

How we combine label and product data

HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 2 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.

For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Seroyal USA is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.

This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.