Inactive ingredients by manufacturer

Tapentadol inactive ingredients by manufacturer

Wondering whether your Tapentadol has lactose, gluten, soy, a dye or gelatin in it? The medicine is the same, but the fillers, coatings and colors differ from one company to the next. This page shows what each Tapentadol product's FDA label lists, so you can find a version that leaves out what you avoid and ask your pharmacist for it by its NDC.

We have read the FDA labels of 26 of the 26 current Tapentadol products on the market today, from 6 companies listing it with the FDA, and lined them up side by side.

Dr. Brian Staiger, PharmD, BCPS
Curated and coded by Dr. Brian Staiger, PharmD, BCPS, clinical pharmacist. The ingredient groups this page checks for (what counts as a gluten source, a synthetic dye, soy and so on) are his classification; the lists themselves are the manufacturers' own FDA labels. Updated October 6, 2026. Rebuilt daily from the FDA directory; labels re-read when the FDA publishes a new version.

Ask about your bottle

Is there something in your Tapentadol? Ask in plain words.

Name the company, strength or the NDC on your bottle and the ingredient you avoid. The answer comes only from the FDA labels on this page.

Answers are drawn from the FDA label data on this page and checked against it. They are not medical advice: confirm with your pharmacist before relying on them.

The short answer

Which Tapentadol products list lactose, a gluten source, soy, dyes or gelatin?

  1. LactoseDiffers by manufacturer

    12 of 26 checked products list lactose; 14 do not. See which products do not list it

  2. Wheat or gluten sourceNo checked product

    No checked Tapentadol product lists a wheat or gluten source.

  3. SoyNo checked product

    No checked Tapentadol product lists soy.

  4. Synthetic dyesDiffers by manufacturer

    10 of 26 checked products list synthetic dyes; 16 do not. See which products do not list it

  5. GelatinNo checked product

    No checked Tapentadol product lists gelatin.

Also listed by some products: Titanium dioxide 25 of 26 Carmine or shellac 10 of 26 Propylene glycol 11 of 26 PEG or polysorbate 25 of 26

Find a version without it

Every current Tapentadol product and what its label lists

Hide products that list:

Tapentadol 50 mg extended-release tablet 2 companies Titanium dioxide 2 Carmine or shellac 2 Propylene glycol 2 Polyethylene glycol or polysorbate 2
CompanyListsInactive ingredients on the label
CollegiumNDC 24510-0058-01 Titanium dioxide Carmine or shellac Propylene glycol Polyethylene glycol or polysorbate
Show 9 ingredients

.ALPHA.-TOCOPHEROL, FERROSOFERRIC OXIDE, HYPROMELLOSE, UNSPECIFIED, POLYETHYLENE GLYCOL, UNSPECIFIED, POLYVINYL ALCOHOL, UNSPECIFIED, PROPYLENE GLYCOL, SHELLAC, TALC, TITANIUM DIOXIDE
HikmaNDC 00054-0936-21 Titanium dioxide Carmine or shellac Propylene glycol Polyethylene glycol or polysorbate
Show 9 ingredients

.ALPHA.-TOCOPHEROL, FERROSOFERRIC OXIDE, HYPROMELLOSE, UNSPECIFIED, POLYETHYLENE GLYCOL, UNSPECIFIED, POLYVINYL ALCOHOL, UNSPECIFIED, PROPYLENE GLYCOL, SHELLAC, TALC, TITANIUM DIOXIDE
Tapentadol 50 mg tablet 5 companies Lactose 4 Titanium dioxide 5 Polyethylene glycol or polysorbate 5
CompanyListsInactive ingredients on the label
AvKARENDC 73190-0081-01 Lactose Titanium dioxide Polyethylene glycol or polysorbate
Show 11 ingredients

CROSCARMELLOSE SODIUM, FERRIC OXIDE RED, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE 101, MICROCRYSTALLINE CELLULOSE 102, POLYETHYLENE GLYCOL 3350, POLYVINYL ALCOHOL, UNSPECIFIED, POVIDONE K30, TALC, TITANIUM DIOXIDE
CollegiumNDC 24510-0050-01 Lactose Titanium dioxide Polyethylene glycol or polysorbate
Show 10 ingredients

ALUMINUM OXIDE, CROSCARMELLOSE SODIUM, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, POLYETHYLENE GLYCOL, UNSPECIFIED, POLYVINYL ALCOHOL, UNSPECIFIED, POVIDONE, UNSPECIFIED, TALC, TITANIUM DIOXIDE
EpicNDC 42806-0626-01 Titanium dioxide Polyethylene glycol or polysorbate
Show 10 ingredients

CARAMEL, COPOVIDONE K25-31, CROSCARMELLOSE SODIUM, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, POLYETHYLENE GLYCOL 4000, POLYVINYL ALCOHOL, UNSPECIFIED, SILICON DIOXIDE, TALC, TITANIUM DIOXIDE
HikmaNDC 00054-0942-25 Lactose Titanium dioxide Polyethylene glycol or polysorbate
Show 10 ingredients

ALUMINUM OXIDE, CROSCARMELLOSE SODIUM, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, POLYETHYLENE GLYCOL, UNSPECIFIED, POLYVINYL ALCOHOL, UNSPECIFIED, POVIDONE, UNSPECIFIED, TALC, TITANIUM DIOXIDE
NovadozNDC 72205-0369-91 Lactose Titanium dioxide Polyethylene glycol or polysorbate
Show 11 ingredients

CROSCARMELLOSE SODIUM, FERRIC OXIDE RED, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE 101, MICROCRYSTALLINE CELLULOSE 102, POLYETHYLENE GLYCOL 3350, POLYVINYL ALCOHOL, UNSPECIFIED, POVIDONE K30, TALC, TITANIUM DIOXIDE
Tapentadol 75 mg tablet 5 companies Lactose 4 Titanium dioxide 5 Polyethylene glycol or polysorbate 5 Synthetic dyes 1
CompanyListsInactive ingredients on the label
AvKARENDC 73190-0082-01 Lactose Titanium dioxide Polyethylene glycol or polysorbate
Show 11 ingredients

CROSCARMELLOSE SODIUM, FERRIC OXIDE RED, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE 101, MICROCRYSTALLINE CELLULOSE 102, POLYETHYLENE GLYCOL 3350, POLYVINYL ALCOHOL, UNSPECIFIED, POVIDONE K30, TALC, TITANIUM DIOXIDE
CollegiumNDC 24510-0075-01 Lactose Titanium dioxide Polyethylene glycol or polysorbate
Show 10 ingredients

ALUMINUM OXIDE, CROSCARMELLOSE SODIUM, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, POLYETHYLENE GLYCOL, UNSPECIFIED, POLYVINYL ALCOHOL, UNSPECIFIED, POVIDONE, UNSPECIFIED, TALC, TITANIUM DIOXIDE
EpicNDC 42806-0627-01 Synthetic dyes Titanium dioxide Polyethylene glycol or polysorbate
Show 11 ingredients

COPOVIDONE K25-31, CROSCARMELLOSE SODIUM, D&C YELLOW NO. 10, FD&C RED NO. 40, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, POLYETHYLENE GLYCOL 4000, POLYVINYL ALCOHOL, UNSPECIFIED, SILICON DIOXIDE, TALC, TITANIUM DIOXIDE
HikmaNDC 00054-0943-25 Lactose Titanium dioxide Polyethylene glycol or polysorbate
Show 10 ingredients

ALUMINUM OXIDE, CROSCARMELLOSE SODIUM, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, POLYETHYLENE GLYCOL, UNSPECIFIED, POLYVINYL ALCOHOL, UNSPECIFIED, POVIDONE, UNSPECIFIED, TALC, TITANIUM DIOXIDE
NovadozNDC 72205-0370-91 Lactose Titanium dioxide Polyethylene glycol or polysorbate
Show 11 ingredients

CROSCARMELLOSE SODIUM, FERRIC OXIDE RED, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE 101, MICROCRYSTALLINE CELLULOSE 102, POLYETHYLENE GLYCOL 3350, POLYVINYL ALCOHOL, UNSPECIFIED, POVIDONE K30, TALC, TITANIUM DIOXIDE
Tapentadol 100 mg extended-release tablet 2 companies Synthetic dyes 2 Titanium dioxide 2 Carmine or shellac 2 Propylene glycol 2 Polyethylene glycol or polysorbate 2
CompanyListsInactive ingredients on the label
CollegiumNDC 24510-0116-01 Synthetic dyes Titanium dioxide Carmine or shellac Propylene glycol Polyethylene glycol or polysorbate
Show 11 ingredients

.ALPHA.-TOCOPHEROL, ALUMINUM OXIDE, FD&C BLUE NO. 2, FERROSOFERRIC OXIDE, HYPROMELLOSE, UNSPECIFIED, POLYETHYLENE GLYCOL, UNSPECIFIED, POLYVINYL ALCOHOL, UNSPECIFIED, PROPYLENE GLYCOL, SHELLAC, TALC, TITANIUM DIOXIDE
HikmaNDC 00054-0937-21 Synthetic dyes Titanium dioxide Carmine or shellac Propylene glycol Polyethylene glycol or polysorbate
Show 11 ingredients

.ALPHA.-TOCOPHEROL, ALUMINUM OXIDE, FD&C BLUE NO. 2, FERROSOFERRIC OXIDE, HYPROMELLOSE, UNSPECIFIED, POLYETHYLENE GLYCOL, UNSPECIFIED, POLYVINYL ALCOHOL, UNSPECIFIED, PROPYLENE GLYCOL, SHELLAC, TALC, TITANIUM DIOXIDE
Tapentadol 100 mg tablet 5 companies Lactose 4 Titanium dioxide 5 Polyethylene glycol or polysorbate 5 Synthetic dyes 1
CompanyListsInactive ingredients on the label
AvKARENDC 73190-0083-01 Lactose Titanium dioxide Polyethylene glycol or polysorbate
Show 11 ingredients

CROSCARMELLOSE SODIUM, FERRIC OXIDE RED, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE 101, MICROCRYSTALLINE CELLULOSE 102, POLYETHYLENE GLYCOL 3350, POLYVINYL ALCOHOL, UNSPECIFIED, POVIDONE K30, TALC, TITANIUM DIOXIDE
CollegiumNDC 24510-0100-01 Lactose Titanium dioxide Polyethylene glycol or polysorbate
Show 10 ingredients

ALUMINUM OXIDE, CROSCARMELLOSE SODIUM, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, POLYETHYLENE GLYCOL, UNSPECIFIED, POLYVINYL ALCOHOL, UNSPECIFIED, POVIDONE, UNSPECIFIED, TALC, TITANIUM DIOXIDE
EpicNDC 42806-0628-01 Synthetic dyes Titanium dioxide Polyethylene glycol or polysorbate
Show 11 ingredients

COPOVIDONE K25-31, CROSCARMELLOSE SODIUM, FD&C RED NO. 40, FD&C YELLOW NO. 6, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, POLYETHYLENE GLYCOL 4000, POLYVINYL ALCOHOL, UNSPECIFIED, SILICON DIOXIDE, TALC, TITANIUM DIOXIDE
HikmaNDC 00054-0945-25 Lactose Titanium dioxide Polyethylene glycol or polysorbate
Show 10 ingredients

ALUMINUM OXIDE, CROSCARMELLOSE SODIUM, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, POLYETHYLENE GLYCOL, UNSPECIFIED, POLYVINYL ALCOHOL, UNSPECIFIED, POVIDONE, UNSPECIFIED, TALC, TITANIUM DIOXIDE
NovadozNDC 72205-0371-91 Lactose Titanium dioxide Polyethylene glycol or polysorbate
Show 11 ingredients

CROSCARMELLOSE SODIUM, FERRIC OXIDE RED, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE 101, MICROCRYSTALLINE CELLULOSE 102, POLYETHYLENE GLYCOL 3350, POLYVINYL ALCOHOL, UNSPECIFIED, POVIDONE K30, TALC, TITANIUM DIOXIDE
Tapentadol 150 mg extended-release tablet 2 companies Synthetic dyes 2 Titanium dioxide 2 Carmine or shellac 2 Propylene glycol 2 Polyethylene glycol or polysorbate 2
CompanyListsInactive ingredients on the label
CollegiumNDC 24510-0174-01 Synthetic dyes Titanium dioxide Carmine or shellac Propylene glycol Polyethylene glycol or polysorbate
Show 12 ingredients

.ALPHA.-TOCOPHEROL, ALUMINUM OXIDE, FD&C BLUE NO. 2, FERRIC OXIDE YELLOW, FERROSOFERRIC OXIDE, HYPROMELLOSE, UNSPECIFIED, POLYETHYLENE GLYCOL, UNSPECIFIED, POLYVINYL ALCOHOL, UNSPECIFIED, PROPYLENE GLYCOL, SHELLAC, TALC, TITANIUM DIOXIDE
HikmaNDC 00054-0938-21 Synthetic dyes Titanium dioxide Carmine or shellac Propylene glycol Polyethylene glycol or polysorbate
Show 12 ingredients

.ALPHA.-TOCOPHEROL, ALUMINUM OXIDE, FD&C BLUE NO. 2, FERRIC OXIDE YELLOW, FERROSOFERRIC OXIDE, HYPROMELLOSE, UNSPECIFIED, POLYETHYLENE GLYCOL, UNSPECIFIED, POLYVINYL ALCOHOL, UNSPECIFIED, PROPYLENE GLYCOL, SHELLAC, TALC, TITANIUM DIOXIDE
Tapentadol 200 mg extended-release tablet 2 companies Synthetic dyes 2 Titanium dioxide 2 Carmine or shellac 2 Propylene glycol 2 Polyethylene glycol or polysorbate 2
CompanyListsInactive ingredients on the label
CollegiumNDC 24510-0232-01 Synthetic dyes Titanium dioxide Carmine or shellac Propylene glycol Polyethylene glycol or polysorbate
Show 11 ingredients

.ALPHA.-TOCOPHEROL, ALUMINUM OXIDE, FD&C BLUE NO. 2, FERROSOFERRIC OXIDE, HYPROMELLOSE, UNSPECIFIED, POLYETHYLENE GLYCOL, UNSPECIFIED, POLYVINYL ALCOHOL, UNSPECIFIED, PROPYLENE GLYCOL, SHELLAC, TALC, TITANIUM DIOXIDE
HikmaNDC 00054-0939-21 Synthetic dyes Titanium dioxide Carmine or shellac Propylene glycol Polyethylene glycol or polysorbate
Show 11 ingredients

.ALPHA.-TOCOPHEROL, ALUMINUM OXIDE, FD&C BLUE NO. 2, FERROSOFERRIC OXIDE, HYPROMELLOSE, UNSPECIFIED, POLYETHYLENE GLYCOL, UNSPECIFIED, POLYVINYL ALCOHOL, UNSPECIFIED, PROPYLENE GLYCOL, SHELLAC, TALC, TITANIUM DIOXIDE
Tapentadol 250 mg extended-release tablet 2 companies Synthetic dyes 2 Titanium dioxide 2 Carmine or shellac 2 Propylene glycol 2 Polyethylene glycol or polysorbate 2
CompanyListsInactive ingredients on the label
CollegiumNDC 24510-0291-01 Synthetic dyes Titanium dioxide Carmine or shellac Propylene glycol Polyethylene glycol or polysorbate
Show 11 ingredients

.ALPHA.-TOCOPHEROL, ALUMINUM OXIDE, FD&C BLUE NO. 2, FERROSOFERRIC OXIDE, HYPROMELLOSE, UNSPECIFIED, POLYETHYLENE GLYCOL, UNSPECIFIED, POLYVINYL ALCOHOL, UNSPECIFIED, PROPYLENE GLYCOL, SHELLAC, TALC, TITANIUM DIOXIDE
HikmaNDC 00054-0940-21 Synthetic dyes Titanium dioxide Carmine or shellac Propylene glycol Polyethylene glycol or polysorbate
Show 11 ingredients

.ALPHA.-TOCOPHEROL, ALUMINUM OXIDE, FD&C BLUE NO. 2, FERROSOFERRIC OXIDE, HYPROMELLOSE, UNSPECIFIED, POLYETHYLENE GLYCOL, UNSPECIFIED, POLYVINYL ALCOHOL, UNSPECIFIED, PROPYLENE GLYCOL, SHELLAC, TALC, TITANIUM DIOXIDE
Tapentadol 20 mg/mL oral solution 1 company Propylene glycol 1
CompanyListsInactive ingredients on the label
ANINDC 70954-0801-10 Propylene glycol
Show 5 ingredients

ANHYDROUS CITRIC ACID, PROPYLENE GLYCOL, SODIUM HYDROXIDE, SUCRALOSE, WATER

A product with none of these listed is not certified to be without them: the label says what the manufacturer declared, and the source of a starch or a flavor is often not stated. The companies are the FDA's labelers, which include repackagers and distributors selling another company's product under their own label. The NDC opens the product's own page, with the full label and its inactive-ingredient notes.

Tapentadol without lactose

Lactose: milk sugar; a concern with lactose intolerance or a milk allergy. 12 of 26 checked products list lactose; 14 do not.

Show which Tapentadol products list lactose and which do not, by product and company

Does not list lactose

Lists lactose

Tapentadol without synthetic dyes

Synthetic dyes: FD&C or D&C colorants and their aluminum lakes. 10 of 26 checked products list synthetic dyes; 16 do not.

Show which Tapentadol products list synthetic dyes and which do not, by product and company

Does not list synthetic dyes

Lists synthetic dyes

Tapentadol without titanium dioxide

Titanium dioxide: A white colorant some people choose to avoid. 25 of 26 checked products list titanium dioxide; 1 does not.

Show which Tapentadol products list titanium dioxide and which do not, by product and company

Does not list titanium dioxide

Lists titanium dioxide

Tapentadol without carmine or shellac

Carmine or shellac: insect-derived red colorant or coating glaze. 10 of 26 checked products list carmine or shellac; 16 do not.

Show which Tapentadol products list carmine or shellac and which do not, by product and company

Does not list carmine or shellac

Lists carmine or shellac

Tapentadol without propylene glycol

Propylene glycol: A solvent in liquids and capsules; a concern in kidney disease, for infants, and at high doses. 11 of 26 checked products list propylene glycol; 15 do not.

Show which Tapentadol products list propylene glycol and which do not, by product and company

Does not list propylene glycol

Lists propylene glycol

Tapentadol without polyethylene glycol or polysorbate

Polyethylene glycol or polysorbate: PEG, macrogol or polysorbate; a rare cause of allergic reactions. 25 of 26 checked products list polyethylene glycol or polysorbate; 1 does not.

Show which Tapentadol products list polyethylene glycol or polysorbate and which do not, by product and company

Does not list polyethylene glycol or polysorbate

Lists polyethylene glycol or polysorbate

At the pharmacy counter

How to use this at the pharmacy counter

  1. Pick the company whose list suits you and copy the NDC from the table. Many pharmacies order from wholesalers that carry several companies' versions and can request a particular one if you ask before the prescription is filled; some buy from one contracted source only, and a few insurance plans cover only certain NDCs, so ask the pharmacist to check.
  2. Treat "does not list" as exactly that. The label is what the manufacturer declared; a flavor or a starch may have an unstated source, and lines change. For celiac disease or a serious allergy, ask the manufacturer's medical information line for a written statement about the lot you have.
  3. Check the bottle each refill. A different company usually means a different shape, color and inactive-ingredient list; the pharmacist can tell you who made it, and the two-NDC comparison shows the difference line by line.
  4. If you need one company's version kept constant, ask your prescriber to write that company or the NDC on the prescription and tell the pharmacy you need it held. Rules vary by state and plan, so confirm with the pharmacist.
Ask Dr. Staiger which Tapentadol product suits you →

Common questions about Tapentadol inactive ingredients

Is Tapentadol gluten-free?
This page cannot certify any Tapentadol product gluten-free; it reports what each label declares. Of the 26 products checked, none lists a wheat, barley, rye or gluten ingredient, and none lists a starch without a stated source. If you have celiac disease, ask the manufacturer's medical information line for a written gluten statement for the lot you have.
Does Tapentadol contain lactose?
12 of 26 checked Tapentadol products list lactose; 14 do not: ANI (20 mg/mL oral solution), Collegium (50 mg extended-release tablet, 100 mg extended-release tablet and 150 mg extended-release tablet and 2 more), Epic (50 mg tablet, 75 mg tablet and 100 mg tablet) and Hikma (50 mg extended-release tablet, 100 mg extended-release tablet and 150 mg extended-release tablet and 2 more). The lactose in a tablet or capsule is a small amount, but people with a milk allergy or a strong intolerance often prefer a version that does not list it.
Does Tapentadol contain soy?
No checked Tapentadol product lists a soy ingredient (soybean oil or soy lecithin) on its label. Soy lecithin is the usual form and the amount is small, but people with a soy allergy often prefer a version that does not list it.
Is there a dye-free Tapentadol?
10 of 26 checked Tapentadol products list a synthetic dye (an FD&C or D&C colorant); 16 do not: ANI (20 mg/mL oral solution), AvKARE (50 mg tablet, 75 mg tablet and 100 mg tablet), Collegium (50 mg extended-release tablet, 50 mg tablet and 75 mg tablet and 1 more) and Epic (50 mg tablet) and 2 other companies. Colorants often differ by strength within one company's line, so compare the lists above strength by strength.
Does Tapentadol contain gelatin?
No checked Tapentadol product lists gelatin on its label. Gelatin is usually bovine or porcine and the label rarely says which; for kosher, halal or vegetarian needs, ask the manufacturer.
Why do the inactive ingredients differ between manufacturers?
A generic must match the brand's active ingredient, strength, dose form and how it is absorbed; its fillers, binders, coatings and colorants are the manufacturer's own choice. That is why one Tapentadol product can list lactose and a dye while another from a different company lists neither.
Can my pharmacy give me a specific manufacturer's version?
Often, if you ask before the prescription is filled: many pharmacies order from wholesalers that carry several companies' versions and can request a particular one. Some pharmacies buy a generic from one contracted source only, and a few insurance plans cover only certain NDCs, so ask the pharmacist to check. Give them the NDC from this page; the company name alone is often enough.
How current is this list?
The products are the ones in the FDA's current NDC directory as of October 6, 2026. The list is rebuilt every day, the FDA directory is re-imported every week, and each inactive-ingredient list is the manufacturer's FDA label as our label sync last read it, re-read when the FDA publishes a new version. Formulations change, so check the label on your own bottle and ask your pharmacist if a refill looks different.

Sources: the products are the finished Tapentadol products in the FDA's current NDC directory (openFDA), as of October 6, 2026; each inactive-ingredient list is the manufacturer's FDA Structured Product Label via DailyMed, as our label sync last read it. The concern groups are HelloPharmacist's classification of the names the label declares. Educational information only, not medical advice; confirm with your pharmacist before relying on a list. ← Back to the Tapentadol guide