Bayer Headache Aspirin and caffeine 500 mg; 32.5 mg Tablet, 50-count — NDC 0280-0064-02 (Billing 00280-0064-02)
This is a package of 50 tablets of Bayer Headache Aspirin and caffeine 500 mg; 32.5 mg Tablet from Bayer HealthCare LLC., marketed since Apr 2021 and currently FDA-listed.
NDC database record
One package, one record: these facts belong to NDC 0280-0064-02 alone.
- Record
- FDA NDC Directory package listing · Human OTC drug
- Code segments
- 0280 labeler · 0064 product · 02 package
- Package marketed since
- Apr 28, 2021
- Sample package
- No — commercial package
- Listing certified through
- Dec 31, 2026
- Barcode (UPC)
- 0312843592186
- FDA record last changed
- Oct 1, 2026
Identity & classification
Regulatory identifiers FDA, NLM and CMS codes for this package
- RxCUI (RxNorm): 702316
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 5, 2026
- RxNorm (NLM RxNav) · catalog refreshed Oct 1, 2026
- Medi-Span GPI (licensed)
- First Databank (licensed) · refreshed Oct 1, 2026
RxNorm drug class
This medicine belongs to the Platelet Aggregation Inhibitor class.
Where does this data come from?
- RxClass (NLM) · catalog refreshed Oct 1, 2026
Clinical
This is an over-the-counter tablet taken by mouth that combines aspirin with caffeine. Aspirin is a nonsteroidal anti-inflammatory drug typically used to relieve minor pain and reduce fever. Caffeine is a central nervous system stimulant commonly included in pain-relief products to enhance their effectiveness. This combination is marketed as an OTC monograph product, meaning it follows the FDA's established rules for this category of pain reliever.
Patient education
Supplement & herbal interactions
Where does this data come from?
- MedlinePlus (NLM) · refreshed Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 5, 2026
Ask a licensed pharmacist directly — free, answered by our team.
Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per each | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | Not in the retail survey — common for institutional, discontinued, or low-volume packs. | |
| Medicaid paysCMS SDUD · 12 mo | No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data. | |
| Medicare drug plans payPart D · quarterly | No Part D plan price is available for this NDC in our data. | |
Where does this data come from?
- CMS NADAC weekly file
- CMS ASP pricing files · refreshed Sep 20, 2026
- CMS Medicaid State Drug Utilization Data · refreshed Oct 5, 2026
- CMS Part D plan pricing files · refreshed Sep 24, 2026
- VA National Acquisition Center price file
Packaging — all sizes for this product
| Package NDC | Description | Marketing start | Marketing end | Status |
|---|---|---|---|---|
| 00280-0064-01 0280-0064-01 Main listing | 1 BOTTLE in 1 CARTON / 100 TABLET in 1 BOTTLE | 2021-04-28 | — | Active |
| 00280-0064-02 You're viewing this | 1 BOTTLE in 1 CARTON / 50 TABLET in 1 BOTTLE | 2021-04-28 | — | Active |
Pack size FAQ
What quantity is in this package?
How does this package differ from NDC 00280-0064-01?
What NDC number is used to bill for this package of Bayer Headache Aspirin and caffeine 500 mg; 32.5 mg Tablet?
Therapeutic equivalents
| Product | Labeler | Pack | NADAC/unit | TE | Status | Price vs. this |
|---|---|---|---|---|---|---|
| Bayer Headache 500 mg/1; 32.5 mgthis 00280-0064-02 | Bayer | 50 tablets | — | — | FDA listed | — |
| Aspirina Cafeina 32.5 mg/1; 500 mg 00280-0162-01 | Bayer | 24 tablets | — | — | FDA listed | — |
| Bayer Back and Body Extra Strength 35.5 mg/1; 500 mg 00280-2150-02 | Bayer | 200 tablets | — | — | FDA listed | — |
| pain relief back and body EXTRA STRENGTH 500 mg/1; 32.5 mg 11822-4130-02 | Rite | 100 tablets | — | — | FDA listed | — |
| Back and Body 500 mg/1; 32.5 mg 30142-0654-12 | Kroger | 100 tablets | — | — | FDA listed | — |
| Back and Body Extra Strength 500 mg/1; 32.5 mg 41250-0143-12 | Meijer | 100 tablets | — | — | FDA listed | — |
| Green Guard Extra Strength Pain Relief 500 mg/1; 32.5 mg 47682-0048-80 | Unifirst | 2 tablets | — | — | FDA listed | — |
| Medi First Pain Ache 500 mg/1; 32.5 mg 47682-0821-36 | Unifirst | 2 tablets | — | — | FDA listed | — |
| Medi First Plus Pain Ache 500 mg/1; 32.5 mg 47682-0921-36 | Unifirst | 2 tablets | — | — | FDA listed | — |
| Back and Body Extra Strength 500 mg/1; 32.5 mg 50844-0413-08 | L.N.K. | 24 tablets | — | — | FDA listed | — |
| AeroTab Pain Reliever 500 mg/1; 32.5 mg 55305-0135-01 | Aero | 2 tablets | — | — | FDA listed | — |
| Back and Body Extra Strength 500 mg/1; 32.5 mg 55910-0134-15 | DOLGENCORP, | 50 tablets | — | — | FDA listed | — |
| Back and Body Extra Strength 500 mg/1; 32.5 mg 59779-0143-12 | CVS | 100 tablets | — | — | FDA listed | — |
| Back and Body Pain Relief 500 mg/1; 32.5 mg 67091-0430-50 | WinCo | 50 tablets | — | — | FDA listed | — |
| Back and Body Extra Strength 500 mg/1; 32.5 mg 70000-0127-01 | Cardinal | 50 tablets | — | — | Discontinued | — |
| Thompson XS Pain Ache 32.5 mg/1; 500 mg 73408-0821-80 | Thompson | 2 tablets | — | — | FDA listed | — |
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 1, 2026
- FDA Orange Book · refreshed Oct 3, 2026
- CMS NADAC weekly file
Availability & generic status
We did not find an FDA-approved generic match for this exact strength, form and route.
Where does this data come from?
- FDA Orange Book · refreshed Oct 3, 2026
What it looks like
Where does this data come from?
- FDA label on DailyMed · label index refreshed Oct 5, 2026
Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.
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UNII R12CBM0EIZ
A natural wax derived from a Brazilian palm tree, used as a coating and polish on tablets and capsules. It creates a smooth, shiny finish that protects the medicine and improves appearance.
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UNII 2S42T2808B
A synthetic red dye used as a colorant to give the medicine its red color. It helps make pills or liquids visually distinct and easier to identify.
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UNII CQ3XH3DET6
D&C Yellow No. 10 Aluminum Lake is a yellow colorant made by combining a dye with aluminum salts. It's used in medicines to add color for product identification and visual appeal.
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UNII 3NXW29V3WO
Hypromellose is a plant-based thickener made from cellulose. It's used in medicines as a binder to hold ingredients together, a coating for tablets, and a thickener for liquids.
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UNII SMD1X3XO9M
Powdered cellulose is a fine, plant-based powder made from purified wood fibers. In medicines, it acts as a filler to add bulk and volume, and helps tablets or capsules hold together during manufacturing and storage.
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UNII 6DC9Q167V3
Propylene glycol is a clear liquid derived from petroleum or vegetable sources. It acts as a solvent, humectant, and preservative in medicines, helping dissolve active ingredients and maintain product stability.
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UNII 46N107B71O
Shellac is a natural resin secreted by the lac beetle. It's used as a coating on tablets and capsules to control how quickly the medicine dissolves and to improve appearance and stability.
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UNII O8232NY3SJ
A plant-based carbohydrate derived from corn kernels. It acts as a filler to add bulk, a binder to hold ingredients together, and a disintegrant to help the tablet break apart in your stomach for absorption.
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UNII 15FIX9V2JP
Titanium dioxide is a bright white mineral powder commonly used as a colorant and opacifying agent. It makes pills and tablets white or lighter in color and helps make coatings non-transparent.
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UNII XHX3C3X673
Triacetin is a clear, oily liquid made from glycerin and acetic acid. It works as a plasticizer and solvent in medicines, helping soften coatings and improve how liquids mix together in formulations.
10 inactive ingredients listed in the exact product block matched to this NDC.
Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.
Where does this data come from?
ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.- FDA label on DailyMed · label index refreshed Oct 5, 2026
- FDA openFDA NDC Directory · synced Oct 1, 2026
Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
Why might an inactive ingredient be missing?
Can inactive ingredients matter?
Manufacturer & labeler
More NDCs from Bayer HealthCare LLC. labeler code 00280
- Alka-Seltzer Cool Action Extra Strength ReliefChews Mint Calcium Carbonate 750 mg Tablet, Chewable NDC 0280-0058-30
- Alka-Seltzer Ultra Strength Heartburn ReliefChews Strawberry and Orange Calcium Carbonate 1000 mg Tablet, Chewable NDC 0280-0059-50
- Alka-Seltzer Plus Cold Sparkling Original PowerFast Fizz aspirin, chlorpheniramine maleate, phenylephrine bitartrate 325 mg; 2 mg; 7.8 mg Tablet, Effervescent NDC 0280-0060-01
- Alka-Seltzer Plus Maximum Strength Cough, Mucus and Congestion Powermax acetaminophen, dextromethorphan hydrobromide, guaifenesin, phenylephrine hydrochloride 200 mg; 325 mg; 10 mg; 5 mg Capsule, Liquid Filled NDC 0280-0061-01
- Alka-Seltzer Plus Maximum Strength Cough, Mucus and Congestion Day and Night acetaminophen, dextromethorphan hydrobromide, doxylamine succinate, guaifenesin, phenylephrine hydrochloride Kit NDC 0280-0062-01
- AleveX camphor and menthol 5.5 mg/g; 16 mg/g Lotion NDC 0280-0063-01
- Astepro Allergy Azelastine HCl 205.5 ug Spray, Metered NDC 0280-0065-01
- Children Astepro Allergy Azelastine HCl 205.5 ug Spray, Metered NDC 0280-0066-01
- Alka-Seltzer Plus Severe Cold Night PowerFast Fizz aspirin, doxylamine succinate, dextromethorphan hydrobromide, phenylephrine bitartrate 325 mg; 6.25 mg; 10 mg; 7.8 mg Tablet, Effervescent NDC 0280-0068-01
- Alka-Seltzer Plus Severe Cold PowerFast Fizz Day and Night aspirin, dextromethorphan hydrobromide, phenylephrine bitartrate Kit NDC 0280-0069-01
- Midol Bloat Relief pamabrom 50 mg Tablet NDC 0280-0070-01
- docusate sodium 100 mg Capsule NDC 0280-0071-01
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 1, 2026
- Drugs@FDA
FDA label — Drug Facts FDA SPL
🎯 Indications and Usage ▾
Uses Uses temporarily relieves minor aches and pains due to: headache toothache colds muscle pain minor pain of arthritis temporarily reduces fever
⏱️ Dosage and Administration ▾
Directions ● drink a full glass of water with each dose ● adults and children 12 years and over: take 2 caplets every 6 hours not to exceed 8 caplets in 24 hours ● children under 12 years: consult a doctor
⚠️ Warnings ▾
Warnings Reye’s syndrome : Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product. When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness. Allergy alert : Aspirin may cause a severe allergic reaction which may include: • hives • facial swelling • asthma (wheezing) • shock Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding.
The chance is higher if you ● are age 60 or older ● have had stomach ulcers or bleeding problems ● take a blood thinning (anticoagulant) or steroid drug ● take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) ● have 3 or more alcoholic drinks every day while using this product ● take more or for a longer time than directed Do not use ● if you are allergic to aspirin or any other pain reliever/fever reducer ● if you have ever had an allergic reaction to this product or any of its Ingredients Ask a doctor before use if ● stomach bleeding warning applies to you ● you have a history of stomach problems, such as heartburn ● you have high blood pressure, heart disease, liver cirrhosis, or kidney disease ● you are taking a diuretic ● you have asthma Ask a doctor or pharmacist before use if you are taking a prescription drug for ● gout ● diabetes ● arthritis Stop use and ask a doctor if an allergic reaction occurs.
Seek medical help right away. you experience any of the following signs of stomach bleeding: feel faint vomit blood have bloody or black stools have stomach pain that does not get better pain gets worse or lasts more than 10 days fever gets worse or lasts more than 3 days redness or swelling is present new symptoms occur ringing in the ears or a loss of hearing occurs If pregnant or breast-feeding, ask a health professional before use . It is especially important not to use aspirin during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.
Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.
🧪 Active Ingredient ▾
Active ingredients (in each caplet) Purpose Aspirin 500 mg (NSAID)*………………………...................Pain reliever/fever reducer Caffeine 32.5 mg……………………………….....................Pain reliever aid *nonsteroidal anti-inflammatory drug
🧪 Inactive Ingredients ▾
Inactive ingredients carnauba wax, corn starch, D&C red #30 aluminum lake, D&C yellow #10 aluminum lake, hypromellose, powdered cellulose, propylene glycol, shellac, titanium dioxide, triacetin
📄 Do Not Use ▾
Do not use ● if you are allergic to aspirin or any other pain reliever/fever reducer ● if you have ever had an allergic reaction to this product or any of its Ingredients
📄 Ask a Doctor Before Use If ▾
Ask a doctor before use if ● stomach bleeding warning applies to you ● you have a history of stomach problems, such as heartburn ● you have high blood pressure, heart disease, liver cirrhosis, or kidney disease ● you are taking a diuretic ● you have asthma
Stop use and ask a doctor if an allergic reaction occurs. Seek medical help right away. you experience any of the following signs of stomach bleeding: feel faint vomit blood have bloody or black stools have stomach pain that does not get better pain gets worse or lasts more than 10 days fever gets worse or lasts more than 3 days redness or swelling is present new symptoms occur ringing in the ears or a loss of hearing occurs
📄 Ask a Doctor or Pharmacist Before Use If ▾
Ask a doctor or pharmacist before use if you are taking a prescription drug for ● gout ● diabetes ● arthritis
🤰 If Pregnant or Breast-Feeding ▾
If pregnant or breast-feeding, ask a health professional before use . It is especially important not to use aspirin during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.
📄 Keep Out of Reach of Children ▾
Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.
📄 Other Information ▾
Other information ● save carton for full directions and warnings ● Store at room temperature. Avoid excessive heat above 40ºC (104ºF).
📄 Questions or Comments ▾
Questions or comments? 1-800-331-4536 (Mon-Fri 9AM - 5PM EST)
📄 Package Label / Principal Display Panel ▾
Package Display 50 Count Carton Bayer® ASPIRIN (NSAID)/PAIN RELIEVER/FEVER REDUCER CAFFEINE/PAIN RELIEVER AID Headache FAST RELIEF AT THE SITE OF PAIN 50 COATED CAPLETS 500 MG Carton 50 count
Reported adverse events (FAERS)
Top reported reactions
Reporter sex
Serious outcomes
Where does this data come from?
About this NDC listing & data coverage
What data is (and isn’t) available for this NDC — tap to expand
| NDC identity (package / product / labeler codes) | ✓ Available |
| Labeler | ✓ Available |
| Product & package description | ✓ Available |
| Marketing category & status | ✓ Available |
| Active ingredient / dosage form / route | ✓ Available |
| FDA label (SPL via DailyMed) | ✓ Available |
| Package photos | ✓ Available |
| Inactive ingredients (structured) | ✓ Available |
| NADAC pharmacy acquisition price (CMS) | — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey. |
| Orange Book / therapeutic-equivalence data | — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope. |
| HCPCS J-code billing crosswalk | — Not published for this NDC Most self-administered / retail products have no J-code — that is normal. |
| Medicaid utilization (CMS SDUD) | — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold. |