IBUPROFEN, DIPHENHYDRAMINE HCL 200 mg; 25 mg Capsule, Liquid Filled, 40-count
🆔 Identity & classification
Where does this data come from?
🏷️ RxNorm drug class
This medicine belongs to the Histamine-1 Receptor Antagonist class.
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🏭 Manufacturer & labeler
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🩺 Clinical
Diphenhydramine is used to treat allergy and cold symptoms: sneezing runny nose red, itchy, watery eyes itching of the nose or throat Diphenhydramine is also used to treat insomnia (difficulty falling asleep or staying asleep) in adults, but should not be used to make a child sleepy. Diphenhydramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. Diphenhydramine is also available in combination with other medications. This monograph only includes information about the use of diphenh...
Read the full MedlinePlus article ↗- No — this product is specifically for nights when you have both minor pain AND trouble sleeping at the same time. It's not meant to be used as a plain sleep aid. If you're struggli...
- What exactly is this medicine for — can I just take it to help me sleep?
- Take 2 capsules or caplets at bedtime — whichever form your product comes in. Don't take more than that in 24 hours. If it bothers your stomach, go ahead and take it with food or a...
- How do I take it, and is it okay to take with food?
Patient education
Supplement & herbal interactions
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💊 What it looks like
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🧪 Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.
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UNII H3R47K3TBD
FD&C Blue No. 1 is a synthetic blue dye approved for use in foods and medicines. It serves as a colorant to give the medication its distinctive appearance and help with product identification.
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UNII WZB9127XOA
A synthetic red dye used to color medications and make them easier to identify. It serves as a colorant in tablets, capsules, and liquid formulations.
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UNII 2G86QN327L
Gelatin is a protein derived from animal collagen, commonly used in medicines as a gelling agent and capsule material. It helps create soft or hard capsule shells that hold and release medication, and can also thicken liquid formulations.
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UNII 3WJQ0SDW1A
Polyethylene glycol is a synthetic liquid or solid polymer used in medicines as a solvent, lubricant, and humectant. It helps dissolve active ingredients, reduces friction during manufacturing, and retains moisture in the final product.
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UNII WZH3C48M4T
Potassium hydroxide is a strong alkaline chemical used in medicines to adjust and maintain the pH level of liquid formulations, helping keep the product stable and the active ingredients effective.
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UNII 6O92ICV9RU
A waxy substance derived from sorbitol that helps mix oil and water together in medicines. It's used as an emulsifier to keep ingredients evenly blended and stable.
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UNII 506T60A25R
Sorbitol is a natural sugar alcohol derived from glucose. It serves as a sweetener, humectant, and bulking agent in medications to improve taste and help maintain moisture in the product.
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UNII 059QF0KO0R
Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.
8 inactive ingredients listed in the exact product block matched to this NDC.
Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.
Where does this data come from?
ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.Inactive ingredient FAQ
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💲 Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per mL | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | Not in the retail survey — common for institutional, discontinued, or low-volume packs. | |
| Medicaid paysCMS SDUD · 12 mo | No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data. | |
| Medicare drug plans payPart D · quarterly | No Part D plan price is available for this NDC in our data. | |
Where does this data come from?
🔁 Therapeutic equivalents
| Product | Labeler | Pack | NADAC/unit | TE | Status | Price vs. this |
|---|---|---|---|---|---|---|
| Ibuprofen PM 200 mg/1; 25 mg 00363-0207-11 | WALGREEN | 20 capsules | — | — | FDA listed | — |
| Advil Pm 25 mg/1; 200 mg 00573-0148-06 | Haleon | 40 capsules | — | — | FDA listed | — |
| Advil Pm 25 mg/1; 200 mg 00573-0167-25 | Haleon | 20 capsules | — | — | FDA listed | — |
| Ibuprofen, Diphenhydramine Hcl 200 mg/1; 25 mg 11673-0225-15 | TARGET | 40 capsules | — | — | FDA listed | — |
| Ibuprofen, Diphenhydramine Hcl 200 mg/1; 25 mgthis 11822-0789-04 | Rite | 40 capsules | — | — | FDA listed | — |
| Ibuprofen PM 200 mg/1; 25 mg 30142-0232-15 | KROGER | 40 capsules | — | — | FDA listed | — |
| Ibuprofen PM 200 mg/1; 25 mg 36800-0237-15 | TOP | 40 capsules | — | — | FDA listed | — |
| Ibuprofen PM 200 mg/1; 25 mg 36800-0756-40 | TOP | 40 capsules | — | — | FDA listed | — |
| Ibuprofen PM 200 mg/1; 25 mg 41250-0285-15 | MEIJER | 40 capsules | — | — | FDA listed | — |
| Ibuprofen PM 200 mg/1; 25 mg 42681-0061-01 | Whole | 40 capsules | — | — | FDA listed | — |
| Ibuprofen PM 200 mg/1; 25 mg 49035-0670-15 | Wal-Mart | 40 capsules | — | — | FDA listed | — |
| Diphenhydramine HCl and Ibuprofen 25 mg/1; 200 mg 58602-0717-30 | Aurohealth | 160 capsules | — | — | FDA listed | — |
| Diphenhydramine HCl and Ibuprofen 25 mg/1; 200 mg 58602-0814-10 | Aurohealth | 32 capsules | — | — | FDA listed | — |
| Diphenhydramine HCl and Ibuprofen 25 mg/1; 200 mg 58602-0887-10 | Aurohealth | 32 capsules | — | — | FDA listed | — |
| Ibuprofen PM 200 mg/1; 25 mg 59640-0020-15 | HEB | 40 capsules | — | — | FDA listed | — |
| Ibuprofen PM 200 mg/1; 25 mg 63868-0829-40 | CHAIN | 40 capsules | — | — | FDA listed | — |
| Ibuprofen and Diphenhydramine HCl 200 mg/1; 25 mg 63941-0682-15 | VALU | 40 capsules | — | — | FDA listed | — |
| Ibuprofen PM 200 mg/1; 25 mg 68016-0057-40 | Premier | 40 capsules | — | — | FDA listed | — |
| Ibuprofen, Diphenhydramine Hcl 200 mg/1; 25 mg 69452-0205-04 | Bionpharma | 6 capsules | — | — | FDA listed | — |
| pain relief pm 200 mg/1; 25 mg 69452-0264-22 | Bionpharma | 120 capsules | — | — | FDA listed | — |
| pain relief pm 200 mg/1; 25 mg 69452-0507-78 | Bionpharma | 80 capsules | — | — | FDA listed | — |
| Ibuprofen PM 200 mg/1; 25 mg 69842-0870-15 | CVS | 40 capsules | — | — | FDA listed | — |
| Ibuprofen PM 200 mg/1; 25 mg 69842-0913-40 | CVS | 40 capsules | — | — | FDA listed | — |
Where does this data come from?
⏳ Availability & generic status
This product is an FDA-approved generic. Other versions of the same drug are listed under Therapeutic equivalents, least expensive first.
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🔬 Reported adverse events (FAERS)
Top reported reactions
Reporter sex
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📦 Packaging — all sizes for this product
| Package NDC | Description | Marketing start | Status |
|---|---|---|---|
| 11822-0789-04 You're viewing this | 1 BOTTLE in 1 CARTON (11822-0789-4) / 40 CAPSULE, LIQUID FILLED in 1 BOTTLE | 2020-04-15 | Active |
🧭 About this NDC listing & data coverage
What data is (and isn’t) available for this NDC — tap to expand
| NDC identity (package / product / labeler codes) | ✓ Available |
| Labeler | ✓ Available |
| Product & package description | ✓ Available |
| Marketing category & status | ✓ Available |
| Active ingredient / dosage form / route | ✓ Available |
| FDA label (SPL via DailyMed) | ✓ Available |
| Package photos | ✓ Available |
| Inactive ingredients (structured) | ✓ Available |
| NADAC pharmacy acquisition price (CMS) | — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey. |
| Orange Book / therapeutic-equivalence data | — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope. |
| HCPCS J-code billing crosswalk | — Not published for this NDC Most self-administered / retail products have no J-code — that is normal. |
| Medicaid utilization (CMS SDUD) | — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold. |
Questions about this listing
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📄 FDA label — Drug Facts FDA SPL
🎯 Indications and Usage ▾
Uses ■ for relief of occasional sleeplessness when associated with minor aches and pains ■ helps you fall asleep and stay asleep
⏱️ Dosage and Administration ▾
Directions ■ do not take more than directed ■ adults and children 12 years and over: take 2 capsules at bedtime ■ do not take more than 2 capsules in 24 hours
⚠️ Warnings ▾
Warnings Allergy alert: Ibuprofen may cause a severe allergic reaction, especially in people allergic to aspirin. Symptoms may include: ■ hives ■ facial swelling ■ asthma (wheezing) ■ shock ■ skin reddening ■ rash ■ blisters. If an allergic reaction occurs, stop use and seek medical help right away.
Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you ■ are age 60 or older ■ have had stomach ulcers or bleeding problems ■ take a blood thinning (anticoagulant) or steroid drug ■ take other drugs containing prescription or nonprescription NSAIDs [aspirin, ibuprofen, naproxen, or others] ■ have 3 or more alcoholic drinks every day while using this product ■ take more or for a longer time than directed Heart attack and stroke warning: NSAIDs, except aspirin, increase the risk of heart attack, heart failure, and stroke.
These can be fatal. The risk is higher if you use more than directed or for longer than directed. Do not use ■ if you have ever had an allergic reaction to any other pain reliever/fever reducer ■ unless you have time for a full night’s sleep ■ in children under 12 years of age ■ right before or after heart surgery ■ with any other product containing diphenhydramine, even one used on skin ■ if you have sleeplessness without pain Ask a doctor before use if ■ stomach bleeding warning applies to you ■ you have problems or serious side effects from taking pain relievers or fever reducers ■ you have a history of stomach problems, such as heartburn ■ you have high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma, or had a stroke ■ you are taking a diuretic ■ you have a breathing problem such as emphysema or chronic bronchitis ■ you have glaucoma ■ you have trouble urinating due to an enlarged prostate gland Ask a doctor or pharmacist before use if you are ■ taking sedatives or tranquilizers, or any other sleep-aid ■ under a doctor's care for any continuing medical illness ■ taking any other antihistamines ■ taking aspirin for heart attack or stroke, because ibuprofen may decrease this benefit of aspirin ■ taking any other drug When using this product ■ drowsiness will occur ■ avoid alcoholic drinks ■ do not drive a motor vehicle or operate machinery ■ take with food or milk if stomach upset occurs Stop use and ask a doctor if ■ you experience any of the following signs of stomach bleeding: ■ feel faint ■ vomit blood ■ have bloody or black stools ■ have stomach pain that does not get better ■ you have symptoms of heart problems or stroke: ■ chest pain ■ trouble breathing ■ weakness in one part or side of body ■ slurred speech ■ leg swelling ■ pain gets worse or lasts more than 10 days ■ sleeplessness persists continuously for more than 2 weeks.
Insomnia may be a symptom of a serious underlying medical illness ■ redness or swelling is present in the painful area ■ any new symptoms appear If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use ibuprofen during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery. Keep out of reach of children.
In case of overdose, get medical help or contact a Poison Control Center right away.
📦 Storage and Handling ▾
Other information ■ each capsule contains: potassium 20 mg ■ read all warnings and directions before use. Keep carton. ■ store at 20° to 25°C (68° to 77°F) ■ avoid excessive heat above 40°C (104°F) ■ protect from light
🧪 Active Ingredient ▾
Active ingredients (in each capsule) Diphenhydramine hydrochloride 25 mg Solubilized ibuprofen equal to 200 mg ibuprofen (NSAID) * (present as the free acid and potassium salt) * nonsteroidal anti-inflammatory drug
🧪 Inactive Ingredients ▾
Inactive ingredients FD&C blue #1, FD&C red #40, gelatin, pharmaceutical ink, polyethylene glycol, potassium hydroxide, purified water, sorbitan, sorbitol
🎯 Purpose ▾
Purposes Nighttime sleep-aid Pain reliever