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I.C. Ivy Block ZINC ACETATE 1 mg/mL Lotion, 5 mL — NDC 59555-0200-01 package photo

I.C. Ivy Block ZINC ACETATE 1 mg/mL Lotion, 5 mL

by R & R Lotion, Inc · 5 mL in 1 PACKET (59555-200-01)
NDC 59555-0200-01
🏷️ FDA NDC (as labeled) 59555-200-01 billing pads the product segment with a zero
This package
Contains5 mL Pack sizes10 compare ↓
Also comes in: 4 ml 59555-0200-16 7 ml 59555-0200-17 50 ml 59555-0200-03 59 ml 59555-0200-04 118 ml 59555-0200-07 236 ml 59555-0200-08 473 ml 59555-0200-09 946 ml 59555-0200-10 3785 ml 59555-0200-11
OTC On market Non-controlled
🗂️ Data synced Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

🆔 Identity & classification

FDA NDC (as labeled) 59555-200-01
Product NDC 59555-200
11-digit billing NDC 59555020001
UNII FM5526K07A
Application # M016
SPL Set ID db263f4a-56a1-432c-b2e8-2a9bdd3ff129
Established class (EPC) Copper Absorption Inhibitor
Physiologic effect Decreased Copper Ion Absorption
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2021-07-13
Route TOPICAL
Dosage form LOTION
Substance ZINC ACETATE
Why two NDCs? The FDA registers this code as 59555-200-01 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 59555-0200-01. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

🏭 Manufacturer & labeler

LabelerR & R Lotion, Inc
FDA applicationM016 (OTC MONOGRAPH DRUG)
Labeler code59555
First marketedJul 2021
Product typeHuman Otc Drug
Portfolio13 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

🩺 Clinical

🧪 What is this product?

I.C. Ivy Block is an over-the-counter lotion applied to the skin, marketed under FDA's OTC monograph rules for its category. It contains zinc acetate, an astringent mineral salt typically used in topical products to help dry out oily skin and reduce minor skin irritation. This lotion is commonly used as a protective barrier before potential exposure to plants like poison ivy, oak, or sumac.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

💊 What it looks like

Color White
One label can cover several strengths, so colors may be combined — always confirm a loose pill against the dispensed prescription label or a pharmacist.
Where does this data come from?
Physical description (imprint, shape, color, scoring, coating) from this product’s FDA Structured Product Labeling (SPL), mirrored from DailyMed / openFDA.

🧪 Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII RUE8E6T4NB
    Aloe vera leaf juice is a clear gel extracted from aloe vera plant leaves. It's used in medicines as a lubricant, emollient, and preservative to soothe skin contact and help keep the product stable.
  • UNII A3N5ZCN45C
    Bentonite is a naturally occurring clay mineral used in medicines as a binder and absorbent. It helps hold tablet ingredients together and can absorb moisture or unwanted substances in the formulation.
  • UNII E4F12ROE70
    A refined mineral oil derived from crude petroleum containing 13 to 14 carbon chains. It acts as a solvent, emollient, and carrier in topical formulations to help dissolve active ingredients and improve product texture and spreadability.
  • UNII 2968PHW8QP
    A weak organic acid derived from citrus fruits or made through fermentation. It works as a buffer to control pH, a preservative to extend shelf life, and a flavoring agent in medications.
  • UNII 0THT5PCI0R
    A silicone-based liquid that helps distribute active ingredients evenly throughout topical products. It acts as a solvent and emollient, allowing medicines to spread smoothly on skin while improving texture and absorption.
  • UNII 92RU3N3Y1O
    Dimethicone is a silicone-based oil that acts as an anti-foaming agent and lubricant in medicines. It reduces gas bubbles in liquid formulations and helps coat and protect the stomach lining when ingested.
  • UNII 7FLD91C86K
    Edetate disodium is a chemical compound that binds and removes certain metal ions. In medicines, it acts as a preservative and stabilizer by preventing metals like calcium from interfering with the product's shelf life and consistency.
  • UNII 147D247K3P
    Ethylhexylglycerin is a synthetic preservative used to prevent bacteria and mold from growing in medicines and personal care products. It helps keep the product safe and stable throughout its shelf life.
  • UNII PDC6A3C0OX
    Glycerin is a clear, thick liquid derived from plant oils or fats. It acts as a humectant to retain moisture, a sweetener, and a solvent in medications.
  • UNII NT00Y05A2V
    A liquid extract from witch hazel plant leaves and twigs. It's used in topical products as an astringent agent and to help deliver other active ingredients into the skin.
  • UNII Z95S6G8201
    A synthetic surfactant derived from lauryl alcohol and ethylene oxide. It helps dissolve and mix oily and watery ingredients in liquid formulations, and may improve how the medicine spreads or is absorbed.
  • UNII 6M3P64V0NC
    A fine powder made from magnesium, aluminum, and silicon compounds. It absorbs moisture and helps keep medicine ingredients from clumping or separating, so the product stays stable and flows smoothly during manufacturing.
  • UNII HIE492ZZ3T
    Phenoxyethanol is a synthetic preservative and antimicrobial agent used to prevent bacterial and fungal growth in medicines and cosmetic products, extending shelf life and maintaining product safety.
  • UNII E2KR9C9V2I
    Polyacrylamide is a synthetic polymer used as a thickening agent and binder in medications. It helps create the proper texture and hold ingredients together in the formulation.
  • UNII FZ989GH94E
    Povidone is a synthetic polymer made from a plastic-like material. It acts as a binder to hold tablet ingredients together and as a disintegrant to help the tablet break apart in your stomach so the medicine can be absorbed.
  • UNII 8D08K3S51E
    Propylene carbonate is a clear liquid solvent derived from propylene. It helps dissolve or suspend active ingredients in liquid medicines and can improve how well the product flows and mixes.
  • UNII BE5VYX4VP8
    Quaternium-90 is a synthetic antimicrobial preservative derived from ammonium compounds. It prevents bacterial and fungal growth in liquid medicines and personal care products to extend shelf life.

17 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesDi Water, Cyclopentasiloxane (and) Quaternium - 90 Bentonite (and) Trifluoromethyl C1-4 Alkyl Dimethicone (and) Propylene Carbonate, Bentonite, Dimethicone, Polyacrylamide (and) c13-14 Isoparaffin (and) Laureth-7, Glycerin, Magnesium Aluminum Silicate, Phenoxyethanol (and) Ethylhexlglycerin, PVP, Aloe Barbadensis Leaf Juice, Disodium EDTA, Hamamelis Virginiana (Witch Hazel) Water (and) Phenoxyethanol, Citric Acid

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

💲 Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer gPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Try another pack size: 4 ml 7 ml 50 ml 59 ml 118 ml 236 ml 473 ml 946 ml 3785 ml
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

🔁 Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
I.C. Ivy Block 1 mg/mLthis 59555-0200-01 R 5 ml — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

⏳ Availability & generic status

🏛️
2021
On the market since
Jul 2021
📍
2026
Currently FDA-listed
5 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

🔬 Reported adverse events (FAERS)

Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for I.C. Ivy Block (this brand).

Top reported reactions

Fatigue25
Diarrhoea24
Pyrexia20
Condition Aggravated18
Nausea17
Arthralgia16
Malaise15

Reporter sex

418 reports

Serious outcomes

Death36
Disabling4
Reports over time (by year) — tap or hover for the count & year
2019 2021 2023 2026 38 0
Most recent year is provisional (FAERS lags ~3 months).
Where does this data come from?
Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.

📦 Packaging — all sizes for this product

Package NDCDescription Marketing startStatus
59555-0200-01 You're viewing this 5 mL in 1 PACKET (59555-200-01) 2021-09-21 Active
59555-0200-03 50 mL in 1 BOTTLE, PUMP (59555-200-03) 2021-09-21 Active
59555-0200-04 59 mL in 1 BOTTLE, DISPENSING (59555-200-04) 2021-09-21 Active
59555-0200-07 118 mL in 1 BOTTLE, DISPENSING (59555-200-07) 2021-09-21 Active
59555-0200-08 236 mL in 1 BOTTLE, DISPENSING (59555-200-08) 2021-09-21 Active
59555-0200-10 946 mL in 1 BOTTLE, PUMP (59555-200-10) 2021-09-21 Active
59555-0200-11 3785 mL in 1 BOTTLE, PLASTIC (59555-200-11) 2021-09-21 Active
59555-0200-16 4 mL in 1 PACKET (59555-200-16) 2021-09-21 Active
59555-0200-09 473 mL in 1 BOTTLE, PUMP (59555-200-09) 2021-07-13 Active
59555-0200-17 7 mL in 1 PACKET (59555-200-17) 2021-07-13 Active

You're viewing one of 10 pack sizes for this product.

Pack size FAQ

What quantity is in NDC 59555-0200-01?
NDC 59555-0200-01 contains 5 mL — 5 ml in 1 packet.
What is the difference between NDC 59555-0200-01 and NDC 59555-0200-16?
Both are I.C. Ivy Block ZINC ACETATE 1 mg/mL Lotion — the drug itself is identical. NDC 59555-0200-01 is the 5 mL package, while NDC 59555-0200-16 is the 4 ml package.
What NDC number is used to bill for this package of I.C. Ivy Block ZINC ACETATE 1 mg/mL Lotion?
Bill NDC 59555-0200-01 — the 11-digit billing format is 59555020001. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

🧭 About this NDC listing & data coverage

Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The FDA registers it as 59555-200-01, which is what is printed on the packaging and shown on DailyMed. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero: 59555-0200-01, written without dashes as 59555020001. The Identity section at the top of this page lists every form of this code.
What do the three segments of this NDC mean?
In 59555-0200-01, the first segment (59555) is the labeler code FDA assigned to R & R Lotion, Inc; the middle segment (0200) identifies this specific product — its ingredient, strength, and dosage form; and the last segment (01) identifies this exact package size and type. Together they name one specific package of one specific product.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by R & R Lotion, Inc. Listing status can change — the directory data on this page refreshes weekly.
Does this product come in other package sizes?
Yes — the FDA directory lists 9 other package presentations of this same product, including 4 ml (59555-0200-16), 7 ml (59555-0200-17), 50 ml (59555-0200-03). Each has its own NDC and its own page — see the package list near the top of this page.
Who lists this product with the FDA?
R & R Lotion, Inc is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.

📄 FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 📦 Storage and Handling 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose
🎯 Indications and Usage 6 words ▾

Uses Poison Ivy, Oak, Sumac Protectant

⏱️ Dosage and Administration 49 words ▾

Directions Shake well before use Apply 15 minutes before exposure Apply generously to dry, exposed skin Allow to dry Apply every 4 hours for continued protection or sooner if needed After possible exposure with skin irritants, remove using IC Ivy Cleanser Children under 2 year - ask a doctor.

⚠️ Warnings 67 words ▾

Warnings For external use only - When using this product do not get into eyes If contact occurs, rinse eyes thoroughly with water Stop use and ask a doctor if condition worsens Symptoms last more than 7 days or clear up and occur again within a few days Keep out of reach of children If swallowed, get medical help or contact a Poison Control Center right away.

📦 Storage and Handling 7 words ▾

Other Information Protect from excessive heat (48°C/120°F)

🧪 Active Ingredient 5 words ▾

Active Ingredients Zinc Acetate 0.1%

🧪 Inactive Ingredients 49 words ▾

Inactive Ingredients Di Water, Cyclopentasiloxane (and) Quaternium - 90 Bentonite (and) Trifluoromethyl C1-4 Alkyl Dimethicone (and) Propylene Carbonate, Bentonite, Dimethicone, Polyacrylamide (and) c13-14 Isoparaffin (and) Laureth-7, Glycerin, Magnesium Aluminum Silicate, Phenoxyethanol (and) Ethylhexlglycerin, PVP, Aloe Barbadensis Leaf Juice, Disodium EDTA, Hamamelis Virginiana (Witch Hazel) Water (and) Phenoxyethanol, Citric Acid

🎯 Purpose 3 words ▾

Purpose Skin Protectant

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗
← 59555-0117-01 · R 59555-0303-04 · R →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.