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Topricin Aesculus hippocastanum, Arnica montana, Belladonna, Crotalus horridus, Echinacea, Graphites, Heloderma, Lachesis mutus, Naja tripudians, Rhus toxicodendron, Ruta graveolens 6 [hp_X]/170g; 6 [hp_X]/170g; 8 [hp_X]/170g; 6 [hp_X]/170g; 6 [hp_X]/170g; 8 [hp_X]/170g; 8 [hp_X]/1 Cream, 113 g — NDC 61500-5527-04 package photo

Topricin Aesculus hippocastanum, Arnica montana, Belladonna, Crotalus horridus, Echinacea, Graphites, Heloderma, Lachesis mutus, Naja tripudians, Rhus toxicodendron, Ruta graveolens 6 [hp_X]/170g; 6 [hp_X]/170g; 8 [hp_X]/170g; 6 [hp_X]/170g; 6 [hp_X]/170g; 8 [hp_X]/170g; 8 [hp_X]/1 Cream, 113 g

by Topical BioMedics, Inc. · 113 g in 1 JAR (61500-5527-4)
NDC 61500-5527-04
🏷️ FDA NDC (as labeled) 61500-5527-4 billing pads the package segment with a zero
This package
Contains113 g Pack sizes7 compare ↓
Also comes in: 21 g 61500-5527-01 57 g 61500-5527-02 170 g 61500-5527-05 227 g 61500-5527-08 454 g 61500-5527-06 907 g 61500-5527-03
OTC On market Non-controlled
🗂️ Data synced Sep 17, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

🆔 Identity & classification

FDA NDC (as labeled) 61500-5527-4
Product NDC 61500-5527
11-digit billing NDC 61500552704
UNII KK0Z92II8M, O80TY208ZW, YHA2XLJ956, VB06AV5US8, 4QQN74LH4O, O9M1UQ4YIO +5 more
UPC 0609863034346
SPL Set ID 53f5778f-ab62-4dda-9bd9-8cc7fdd69d1e
DEA schedule Non-controlled
Marketing category UNAPPROVED HOMEOPATHIC
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2016-04-01
Route TOPICAL
Dosage form CREAM
Substance AESCULUS HIPPOCASTANUM FLOWER; ARNICA MONTANA; CROTALUS HORRIDUS HORRIDUS VENOM; ECHINACEA ANGUSTIFOLIA; GRAPHITE; HELODERMA HORRIDUM VENOM; LACHESIS MUTA VENOM; NAJA NAJA VENOM; RUTA GRAVEOLENS FLOWERING TOP; ATROPA BELLADONNA; TOXICODENDRON PUBESCENS LE
Why two NDCs? The FDA registers this code as 61500-5527-4 — a 5-4-1 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the package segment → 61500-5527-04. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

🏭 Manufacturer & labeler

LabelerTopical BioMedics, Inc.
Labeler code61500
First marketedApr 2016
Product typeHuman Otc Drug
Portfolio2 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

🩺 Clinical

🧪 What is this product?

Topricin is a homeopathic cream applied to the skin that contains multiple plant and animal-derived ingredients traditionally used in homeopathic practice for minor skin and soft tissue concerns. The formula includes arnica, echinacea, and ruta, which are commonly selected in homeopathy for bruising and minor trauma, as well as belladonna and other botanical and zoological substances included in classical homeopathic preparations. This is an unapproved homeopathic product marketed based on homeopathic tradition and is not evaluated by the FDA for effectiveness or safety.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

🧪 Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII UPY805K99W
    A synthetic compound derived from caprylic acid that works as a preservative and antimicrobial agent to help prevent bacterial and fungal growth in the medicine.
  • UNII 59TL3WG5CO
    A synthetic polymer made by crosslinking acrylic acid with allyl sucrose. It thickens liquids, forms gels, and helps control how fast the medicine is released in your body.
  • UNII 936JST6JCN
    Cetyl alcohol is a waxy, fatty substance derived from plant or animal sources. It acts as an emulsifier and thickener in medicines, helping blend oil and water components and giving products a smooth, creamy texture.
  • UNII PDC6A3C0OX
    Glycerin is a clear, thick liquid derived from plant oils or fats. It acts as a humectant to retain moisture, a sweetener, and a solvent in medications.
  • UNII TM2TZD4G4A
    A plant-derived oily substance used as an emulsifier and solubilizer in medicines. It helps blend water and oil-based ingredients together and improves how the body absorbs certain active drugs.
  • UNII 230OU9XXE4
    A waxy substance made from glycerin and stearic acid that acts as an emulsifier to blend oily and watery ingredients together. It also helps thicken and stabilize the medicine's texture.
  • UNII FM8D1RE2VP
    A plant-based oil that has been chemically hardened to stay solid at room temperature. It works as a binder and lubricant to hold tablet ingredients together and help them release properly during digestion.
  • UNII 0RE8K4LNJS
    Isopropyl myristate is an oily liquid made from coconut or palm oil. It's used in medicines as an emollient and penetration enhancer to help the medicine absorb through skin or improve spreadability in topical products.
  • UNII 1DI56QDM62
    A natural fatty substance from soybeans that helps mix oil and water-based ingredients together. It acts as an emulsifier and lubricant in medicines to improve texture and help the product break down properly in your body.
  • UNII C9H2L21V7U
    A fat derived from coconut or palm oil containing shorter fatty acid chains. It serves as a solvent and carrier to help dissolve or suspend active ingredients, improving absorption and stability in liquid formulations.
  • UNII YD01N1999R
    A waxy substance made from polyethylene glycol and stearic acid. It helps mix oil and water-based ingredients together and serves as an emulsifier and solubilizer in liquid and semi-solid medicines.
  • UNII 55X04QC32I
    A strong alkaline chemical used to adjust and maintain the pH balance of liquid medicines. It helps keep the medicine stable and ensures it stays effective during storage.
  • UNII 53J3F32P58
    A synthetic detergent derived from stearic acid, a fatty substance. It helps dissolve or distribute oil-based ingredients evenly throughout the medicine, acting as an emulsifier and solubilizer in tablets and capsules.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.

14 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesInactive Ingredients: Water/Aqua/Eau, Caprylic/Capric Triglyceride, Isopropyl Myristate, Glycerin, Glyceryl Monostearate SE, Steareth-20, Hydrogenated Vegetable Oil, Caprylhydroxamic Acid, Glyceryl Caprylate, Cetyl Alcohol, Carbomer, Sodium Hydroxide *Inactive ingredients derived from natural sources

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

💲 Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer gPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Try another pack size: 21 g 57 g 170 g 227 g 454 g 907 g
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

🔁 Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Topricin 6 [hp_X]/170g; 6 [hp_X]/170g; 8 [hp_X]/170g; 6 [hp_X]/170g; 6 [hp_X]/170g; 8 [hp_X]/170g; 8 [hp_X]this 61500-5527-04 Topical 113 g — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

⏳ Availability & generic status

🏛️
2016
On the market since
Apr 2016
📍
2026
Currently FDA-listed
10 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

🔬 Reported adverse events (FAERS)

Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for Topricin (this brand).

Top reported reactions

Fatigue5
Asthenia4
Balance Disorder4
Disorientation4
Dyspnoea4
Insomnia4
Abdominal Pain3

Reporter sex

10 reports
Male · 20%
Female · 80%

Serious outcomes

Disabling5
Hospitalization3
Reports over time (by year) — tap or hover for the count & year
2019 2021 2023 2026 1 0
Most recent year is provisional (FAERS lags ~3 months).
Where does this data come from?
Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.

📦 Packaging — all sizes for this product

Package NDCDescription Marketing startStatus
61500-5527-01 21 g in 1 TUBE (61500-5527-1) 2016-04-05 Active
61500-5527-02 57 g in 1 TUBE (61500-5527-2) 2016-04-01 Active
61500-5527-03 907 g in 1 BOTTLE, PUMP (61500-5527-3) 2016-04-01 Active
61500-5527-04 You're viewing this 113 g in 1 JAR (61500-5527-4) 2016-04-01 Active
61500-5527-05 170 g in 1 TUBE (61500-5527-5) 2016-04-01 Active
61500-5527-06 454 g in 1 BOTTLE (61500-5527-6) 2016-04-01 Active
61500-5527-08 227 g in 1 BOTTLE (61500-5527-8) 2016-04-01 Active

You're viewing one of 7 pack sizes for this product.

Pack size FAQ

What quantity is in NDC 61500-5527-04?
NDC 61500-5527-04 contains 113 g — 113 g in 1 jar.
What is the difference between NDC 61500-5527-04 and NDC 61500-5527-01?
Both are Topricin Aesculus hippocastanum, Arnica montana, Belladonna, Crotalus horridus, Echinacea, Graphites, Heloderma, Lachesis mutus, Naja tripudians, Rhus toxicodendron, Ruta graveolens 6 [hp_X]/170g; 6 [hp_X]/170g; 8 [hp_X]/170g; 6 [hp_X]/170g; 6 [hp_X]/170g; 8 [hp_X]/170g; 8 [hp_X]/1 Cream — the drug itself is identical. NDC 61500-5527-04 is the 113 g package, while NDC 61500-5527-01 is the 21 g package.
What NDC number is used to bill for this package of Topricin Aesculus hippocastanum, Arnica montana, Belladonna, Crotalus horridus, Echinacea, Graphites, Heloderma, Lachesis mutus, Naja tripudians, Rhus toxicodendron, Ruta graveolens 6 [hp_X]/170g; 6 [hp_X]/170g; 8 [hp_X]/170g; 6 [hp_X]/170g; 6 [hp_X]/170g; 8 [hp_X]/170g; 8 [hp_X]/1 Cream?
Bill NDC 61500-5527-04 — the 11-digit billing format is 61500552704. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

🧭 About this NDC listing & data coverage

Over-the-counter (OTC) product Homeopathic listing

About homeopathic listings

Topricin Aesculus hippocastanum, Arnica montana, Belladonna, Crotalus horridus, Echinacea, Graphites, Heloderma, Lachesis mutus, Naja tripudians, Rhus toxicodendron, Ruta graveolens 6 [hp_X]/170g; 6 [hp_X]/170g; 8 [hp_X]/170g; 6 [hp_X]/170g; 6 [hp_X]/170g; 8 [hp_X]/170g; 8 [hp_X]/1 CREAM is listed under the homeopathic marketing category. An NDC listing in this category does not by itself establish FDA approval, and FDA does not evaluate homeopathic products for effectiveness. This page reports the listing data as published.

What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Unapproved Homeopathic". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The FDA registers it as 61500-5527-4, which is what is printed on the packaging and shown on DailyMed. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero: 61500-5527-04, written without dashes as 61500552704. The Identity section at the top of this page lists every form of this code.
What do the three segments of this NDC mean?
In 61500-5527-04, the first segment (61500) is the labeler code FDA assigned to Topical BioMedics, Inc.; the middle segment (5527) identifies this specific product — its ingredient, strength, and dosage form; and the last segment (04) identifies this exact package size and type. Together they name one specific package of one specific product.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by Topical BioMedics, Inc.. Listing status can change — the directory data on this page refreshes weekly.
Does this product come in other package sizes?
Yes — the FDA directory lists 6 other package presentations of this same product, including 21 g (61500-5527-01), 57 g (61500-5527-02), 170 g (61500-5527-05). Each has its own NDC and its own page — see the package list near the top of this page.
Who lists this product with the FDA?
Topical BioMedics, Inc. is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.

📄 FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose
🎯 Indications and Usage 159 words ▾

Uses Rapid, soothing relief of pain, stiffness, tingling, or burning nerve pain associated with: Arthritis and other joint pain and discomfort Fibromyalgia Carpal Tunnel Syndrome and other types of nerve pain Pains & muscle cramps of the back, neck, shoulder, legs, hands & feet Sports injuries (muscle pulls & soreness, impact, sprains, dislocations) Repetitive motion injuries, such as bursitis, tendonitis and sciatica First Aid for simple trauma (bruises, minor burns, cuts, scrapes & strains Purpose Relieves pain in the lower back, hip and spine Treats pain of impact, falling injuries and contusion to muscles and joints Treats muscle spasms night leg cramps Relief of impact injuries & deep muscle bruising Relieves sharp stitching pain in joints & muscles Relieves skin conditions Relief of burning pain in the hands and feet Relief of sciatic pain and carpal tunnel Relieves nerve injury pain Pain relief of muscle cramping, joint and post-surgical pain Relief of injuries to the knee, shin and elbow

⏱️ Dosage and Administration 52 words ▾

Directions Generously apply 3-4 times daily or more often if needed, 3 inches on and around affected area. Massage in until absorbed, re-apply before bedtime and in the morning. Use before and after sports work outs and other phys9ical acrivities. Apply immediately for acute trauma injuries (sprain, strain, bruise, and impact injuries).

⚠️ Warnings 98 words ▾

Warnings For external use only. Do not apply in eyes. Ask doctor or pharmacist before using if you are taking a presciption medication.

Ask doctor or pharmacist before using if you are pregnant or nursing. Keep all medicines out of reach of children . Use only as directed, see doctor if pain persists for more than 3 days or worsens, if new symptoms occur, or if redness or swelling are present because these could be signs of a more serious condition.

Before considering any self help regimen always consult your doctor, especially if you are taking prescription medication.

🧪 Active Ingredient 31 words ▾

Active Ingredients Aesculus hippocastanum 6X Arnica montana 6X Belladona 6X Crotalus horridus 8X Echinacea 6X Graphites 6X Heloderma 8X Lachesis mutus 8X Naja tripudians 8X Rhus toxicodendron 6X Ruta graveolens 6X

🧪 Inactive Ingredients 32 words ▾

Inactive Ingredients Inactive Ingredients: Water/Aqua/Eau, Caprylic/Capric Triglyceride, Isopropyl Myristate, Glycerin, Glyceryl Monostearate SE, Steareth-20, Hydrogenated Vegetable Oil, Caprylhydroxamic Acid, Glyceryl Caprylate, Cetyl Alcohol, Carbomer, Sodium Hydroxide *Inactive ingredients derived from natural sources

🎯 Purpose 85 words ▾

Purpose Relieves pain in the lower back, hip and spine Treats pain of impact, falling injuries and contusion to muscles and joints Treats muscle spasms night leg cramps Relief of impact injuries & deep muscle bruising Relieves sharp stitching pain in joints & muscles Relieves skin conditions Relief of burning pain in the hands and feet Relief of sciatic pain and carpal tunnel Relieves nerve injury pain Pain relief of muscle cramping, joint and post-surgical pain Relief of injuries to the knee, shin and elbow

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗
← 61481-3008-01 · Wilc 61500-5547-00 · Topical →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.