Home › NDC Lookup › Ingredients › Carduus Marianus, Cynara Scolymus, Solid... › 70964-0001-01
Advance Plus Carduus Marianus, Cynara Scolymus, Solidago Virgaurea, Taraxacum Officinale, Benzoicum Acidum, Berberis Vulgaris, Bryonia (Alba), Cantharis, Carduus Benedictus, Ceanothus Americanus, Chelidonium Majus, Chionanthus Virginica, Cinchona Officinalis, Dioscore 3 [hp_X]/mL; 3 [hp_X]/mL; 3 [hp_X]/mL; 3 [hp_X]/mL; 15 [hp_X]/mL; 15 [hp_X]/mL; 15 [hp_X]/mL Spray, 30 mL — NDC 70964-0001-01 package photo
Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.

Advance Plus Carduus Marianus, Cynara Scolymus, Solidago Virgaurea, Taraxacum Officinale, Benzoicum Acidum, Berberis Vulgaris, Bryonia (Alba), Cantharis, Carduus Benedictus, Ceanothus Americanus, Chelidonium Majus, Chionanthus Virginica, Cinchona Officinalis, Dioscore 3 [hp_X]/mL; 3 [hp_X]/mL; 3 [hp_X]/mL; 3 [hp_X]/mL; 15 [hp_X]/mL; 15 [hp_X]/mL; 15 [hp_X]/mL Spray, 30 mL — NDC 70964-0001-1 (Billing 70964-0001-01)

by VitaminMed, LLC · 30 mL in 1 BOTTLE, SPRAY

This is a package of 30 mL of Advance Plus Carduus Marianus, Cynara Scolymus, Solidago Virgaurea, Taraxacum Officinale, Benzoicum Acidum, Berberis Vulgaris, Bryonia (Alba), Cantharis, Carduus Benedictus, Ceanothus Americanus, Chelidonium Majus, Chionanthus Virginica, Cinchona Officinalis, Dioscore 3 [hp_X]/mL; 3 [hp_X]/mL; 3 [hp_X]/mL; 3 [hp_X]/mL; 15 [hp_X]/mL; 15 [hp_X]/mL; 15 [hp_X]/mL Spray from VitaminMed, LLC, marketed since Dec 2016 and currently FDA-listed. It is this product's only package size.

NDC 70964-0001-01
🏷️ FDA NDC (as labeled) 70964-0001-1 billing pads the package segment with a zero
OTC On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 8, 2026 · this listing last changed Oct 8, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

NDC database record

One package, one record: these facts belong to NDC 70964-0001-1 alone.

Record
FDA NDC Directory package listing · Human OTC drug
Code segments
70964 labeler · 0001 product · 1 package
Package marketed since
Mar 3, 2017
Sample package
No — commercial package
Listing certified through
Dec 31, 2027
Barcode (UPC)
0744309189461
FDA record last changed
Oct 8, 2026

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 70964-0001-1
Product NDC 70964-0001
11-digit billing NDC 70964000101
UNII U946SH95EE, B71UA545DE, 5405K23S50, 39981FM375, 8SKN0B0MIM, 1TH8Q20J0U +12 more
UPC 0744309189461
SPL Set ID 97824fb3-e2b4-4807-943b-88e26b211bf1
Established class (EPC) Nitrogen Binding Agent; Non-Standardized Food Allergenic Extract; Non-Standardized Plant Allergenic Extract
Mechanism of action Ammonium Ion Binding Activity
Physiologic effect Increased Histamine Release; Cell-mediated Immunity; Increased IgG Production
Chemical class Allergens; Dietary Proteins; Plant Proteins; Food Additives; Seed Storage Proteins
DEA schedule Non-controlled
Marketing category UNAPPROVED HOMEOPATHIC
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2016-12-08
Route ORAL
Dosage form SPRAY
Substance MILK THISTLE; CYNARA SCOLYMUS LEAF; SOLIDAGO VIRGAUREA FLOWERING TOP; TARAXACUM OFFICINALE; BENZOIC ACID; BERBERIS VULGARIS ROOT BARK; BRYONIA ALBA ROOT; LYTTA VESICATORIA; CENTAUREA BENEDICTA; CEANOTHUS AMERICANUS LEAF; CHELIDONIUM MAJUS WHOLE; CHIONANTH
Why two NDCs? The FDA registers this code as 70964-0001-1 — a 5-4-1 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the package segment → 70964-0001-01. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

Clinical

🧪 What is this product?

Advance Plus Carduus Marianus is an unapproved homeopathic oral spray containing multiple plant extracts, including milk thistle, artichoke leaf, goldenrod, dandelion, and barberry root bark, among others. In homeopathic practice, these ingredients are traditionally used in combinations aimed at supporting liver and digestive function. Homeopathic products are marketed based on traditional use rather than FDA evaluation for effectiveness. The potencies and formulation listed reflect homeopathic preparation methods.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer mLPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
70964-0001-01 You're viewing this Main listing 30 mL in 1 BOTTLE, SPRAY 2017-03-03 — Active

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Advance Plus 3 [hp_X]/mL; 3 [hp_X]/mL; 3 [hp_X]/mL; 3 [hp_X]/mL; 15 [hp_X]/mL; 15 [hp_X]/mL; 15 [hp_X]/mLthis 70964-0001-01 VitaminMed, 30 ml — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2016
On the market since
Dec 2016
📍
2026
Currently FDA-listed
10 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII 3K9958V90M
    A liquid solvent derived from fermentation or chemical synthesis. In medicines, alcohol dissolves active ingredients, helps preserve the product, and improves how the body absorbs certain drugs.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.

2 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesCane alcohol USP, purified water USP.

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerVitaminMed, LLC
Labeler code70964
First marketedDec 2016
Product typeHuman Otc Drug
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose 📄 Keep Out of Reach of Children 📄 Questions or Comments 📄 Package Label / Principal Display Panel
🎯 Indications and Usage 15 words ▾

USES: ■ Improves liver, kidney and colon functions. ■ Reduces symptoms associated with toxic conditions.

⏱️ Dosage and Administration 39 words ▾

DIRECTIONS: Adults and children 12 years and older, hold nozzle 1" from mouth, spray twice and swallow at bedtime, or use as directed by your healthcare practitioner. Consult a physician for use in children under 12 years of age.

⚠️ Warnings 68 words ▾

WARNINGS: Stop use and ask a doctor if symptoms worsen or persist for more than a few days. If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. Do not use if tamper evident seal is broken or missing. Keep tightly closed in a cool, dry place.

🧪 Active Ingredient 64 words ▾

ACTIVE INGREDIENTS: (in each spray) Benzoicum Acidum 15X, Berberis Vulgaris 15X, Bryonia 15X, Cantharis 15X, Carduus Benedictus 15X, Carduus Marianus 3X, Ceanothus Americanus 15X, Chelidonium Majus 15X, Chionanthus Virginica 15X, Cinchona Officinalis 15X, Cynara Scolymus 3X, Dioscorea Villosa 15X, Dolichos Pruriens 15X, Iris Versicolor 15X, Juniperus Communis 15X, Nux Vomica 15X, Ptelea Trifoliata 15X, Solidago Virgaurea 3X, Taraxacum Officinale 3X, 15X, Uricum Acidum 15X.

🧪 Inactive Ingredients 8 words ▾

INACTIVE INGREDIENTS: Cane alcohol USP, purified water USP.

🎯 Purpose 104 words ▾

PURPOSE: Benzoicum Acidum – Toxin elimination, Berberis Vulgaris – Liver function, Bryonia – Liver detox support, Cantharis – Bladder inflammation relief, Carduus Benedictus – Gastrointestinal health, Carduus Marianus – Liver function support, Ceanothus Americanus – Spleen support, Chelidonium Majus – Liver drainage, Chionanthus Virginica – Gallbladder support, Cinchona Officinalis – General detoxification, Cynara Scolymus – Liver drainage, Dioscorea Villosa – Digestive support, Dolichos Pruriens – Digestive support, Iris Versicolor – Pancreas health, Juniperus Communis – Kidney drainage, Nux Vomica - Detoxification, Ptelea Trifoliata – Liver detox, Solidago Virgaurea – Kidney support, Taraxacum Officinale – Liver and Kidney detox, Uricum Acidum – Uric acid metabolism

📄 Keep Out of Reach of Children 21 words ▾

KEEP OUT OF REACH OF CHILDREN: In case of overdose, get medical help or contact a Poison Control Center right away.

📄 Questions or Comments 21 words ▾

QUESTIONS: Distributed by: VitaminMed 1231 South Myrtle Ave. Clearwater, FL 33756 www.vitaminmed.com Call: 800-949-7875 Monday - Friday 9:00am - 5:00pm Eastern

📄 Package Label / Principal Display Panel 18 words ▾

PACKABE LABEL DISPLAY: M VitaminMed NDC# 70964-0001-1 Advance Plus Homeopathic Medicine 1 FL OZ. 30 ML Advance Plus

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

About this NDC listing & data coverage

Over-the-counter (OTC) product Homeopathic listing

About homeopathic listings

Advance Plus Carduus Marianus, Cynara Scolymus, Solidago Virgaurea, Taraxacum Officinale, Benzoicum Acidum, Berberis Vulgaris, Bryonia (Alba), Cantharis, Carduus Benedictus, Ceanothus Americanus, Chelidonium Majus, Chionanthus Virginica, Cinchona Officinalis, Dioscore 3 [hp_X]/mL; 3 [hp_X]/mL; 3 [hp_X]/mL; 3 [hp_X]/mL; 15 [hp_X]/mL; 15 [hp_X]/mL; 15 [hp_X]/mL SPRAY is listed under the homeopathic marketing category. An NDC listing in this category does not by itself establish FDA approval, and FDA does not evaluate homeopathic products for effectiveness. This page reports the listing data as published.

What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Unapproved Homeopathic". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by VitaminMed, LLC. Listing status can change — the directory data on this page refreshes weekly.
Who lists this product with the FDA?
VitaminMed, LLC is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
← 70957-0020-01 · Organic 70966-0001-01 · Dasami →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.