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Eversmile IPR Glide 2.7% Sodium Fluoride Gel 27 mg/mL Gel — NDC 72655-0400-01 package photo
Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.

Eversmile IPR Glide 2.7% Sodium Fluoride Gel 27 mg/mL Gel — NDC 72655-400-01 (Billing 72655-0400-01)

by Everbrands, Inc. dba Everpure, Inc. · 1 SYRINGE, PLASTIC in 1 BOX / 4 mL in 1 SYRINGE, PLASTIC

This is a package of Eversmile IPR Glide 2.7% Sodium Fluoride Gel 27 mg/mL Gel from Everbrands, Inc. dba Everpure, Inc., marketed since Apr 2026 and currently FDA-listed. It is the main listing for this product, which comes in 2 package sizes.

NDC 72655-0400-01
🏷️ FDA NDC (as labeled) 72655-400-01 billing pads the product segment with a zero
This package
Contains4 mL in 1 syringe, plastic Pack sizes2 compare ↓
Main listing for product 72655-400 · Also comes in: 1 mL 72655-400-02
Rx only On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 72655-400-01
Product NDC 72655-400
11-digit billing NDC 72655040001
RxCUI 2740863
UNII 8ZYQ1474W7
SPL Set ID 15f79f56-c8ba-434b-a839-f969a1758b9f
DEA schedule Non-controlled
Marketing category UNAPPROVED DRUG OTHER
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2026-04-10
Route DENTAL
Dosage form GEL
Substance SODIUM FLUORIDE
Quick answers
  • RxCUI (RxNorm): 2740863
Why two NDCs? The FDA registers this code as 72655-400-01 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 72655-0400-01. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

RxNorm drug class

This medicine belongs to the Caries prophylactic agents class.

Drug family (ATC) Caries prophylactic agents, Fluoride
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

Clinical

📖 About the active ingredient: Sodium Fluoride MedlinePlus · NLM
General information about the ingredient itself — the description of this specific product follows below.

Fluoride is used to prevent tooth decay. It is taken up by teeth and helps to strengthen teeth, resist acid, and block the cavity-forming action of bacteria. Fluoride usually is prescribed for children and adults whose homes have water that is not fluoridated (already has fluoride added). This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Read the full MedlinePlus article ↗
🧪 What is this product?

Eversmile IPR Glide is a dental gel containing sodium fluoride at a concentration of 27 mg/mL. Applied topically to the teeth, sodium fluoride is commonly used in dental products to help strengthen tooth enamel and reduce tooth decay. This product is an unapproved drug and is marketed without an approved FDA application.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer gPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Try another pack size: 1 mL
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
72655-0400-01 You're viewing this Main listing 1 SYRINGE, PLASTIC in 1 BOX / 4 mL in 1 SYRINGE, PLASTIC 2026-04-10 — Active
72655-0400-02 72655-400-02 1 SYRINGE, PLASTIC in 1 BOX / 1 mL in 1 SYRINGE, PLASTIC 2026-04-10 — Active

Pack size FAQ

What quantity is in this package?
This package is listed by the FDA — 1 syringe, plastic in 1 box / 4 ml in 1 syringe, plastic.
What NDC number is used to bill for this package of Eversmile IPR Glide 2.7% Sodium Fluoride Gel 27 mg/mL Gel?
Use the 11-digit billing form listed in the identifiers section of this page. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Eversmile IPR Glide 27 mg/mLthis 72655-0400-01 Everbrands, 1 syringe — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2026
On the market since
Apr 2026
📍
2026
Currently FDA-listed
listed with the FDA
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

What it looks like

FlavorMint
One label can cover several strengths, so colors may be combined — always confirm a loose pill against the dispensed prescription label or a pharmacist.
Where does this data come from?
Physical description (imprint, shape, color, scoring, coating) from this product’s FDA Structured Product Labeling (SPL), mirrored from DailyMed / openFDA.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII PDC6A3C0OX
    Glycerin is a clear, thick liquid derived from plant oils or fats. It acts as a humectant to retain moisture, a sweetener, and a solvent in medications.
  • UNII I2N4ZF9233
    Hydroxyethyl cellulose is a thickening agent made from plant cellulose. It increases the viscosity of liquid medicines and helps create a smooth, uniform texture in gels and topical formulations.
  • UNII AV092KU4JH
    A natural oil extracted from peppermint plants. It's used as a flavoring agent to mask bitter tastes and add a refreshing mint flavor to medicines, making them easier to take.
  • UNII 6DC9Q167V3
    Propylene glycol is a clear liquid derived from petroleum or vegetable sources. It acts as a solvent, humectant, and preservative in medicines, helping dissolve active ingredients and maintain product stability.
  • UNII Z8IX2SC1OH
    Propylparaben is a chemical preservative used to prevent bacterial and fungal growth in medicines and personal care products. It helps extend shelf life and maintain product safety during storage.
  • UNII OJ245FE5EU
    Sodium benzoate is a salt derived from benzoic acid, a preservative. It's added to medicines to prevent growth of bacteria, fungi, and other microorganisms that could spoil the product.
  • UNII 96K6UQ3ZD4
    Sucralose is a synthetic sweetener made from sugar. It's added to medicines to improve taste without adding calories, helping make bitter or unpleasant-tasting drugs easier to take.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.

8 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesInactive Ingredients: Water, glycerin, hydroxyethyl cellulose, propylene glycol, sucralose, mint oil, sodium benzoate, propylparaben.

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerEverbrands, Inc. dba Everpure, Inc.
Labeler code72655
First marketedApr 2026
Product typeHuman Prescription Drug
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

Full prescribing information FDA SPL

The complete FDA label for this product — the official prescribing information, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings and Cautions 📦 How Supplied / Storage and Handling 🧪 Inactive Ingredients 📋 Description 📄 Package Label / Principal Display Panel
🎯 Indications and Usage 9 words ▾

INDICATIONS Indications: To prevent dental caries and strengthen enamel.

⏱️ Dosage and Administration 164 words ▾

DIRECTIONS Directions For Use: IPR procedure: Dispense IPR Glide directly to the interproximal tooth surfaces or to IPR cutting instruments. Perform IPR procedure and replenish IPR Glide as needed. Rinse teeth with water.

Inform patient not to swallow IPR Glide. In-Office Post IPR Renewal: Rinse teeth with water, air dry and apply IPR Glide directly to teeth surfaces where IPR was performed. Have patient spit out excess IPR Glide and inform patient to keep surfaces dry for 30 minutes avoiding food and liquids.

Aligners may be worn to prevent saliva contamination. At-home Post IPR Renewal: Apply IPR Glide inside of aligners at the location where IPR was performed. Your dentist can use a marker and indicate where to apply the IPR Glide.

Place aligners in mouth and wipe off any excess IPR Glide using a tissue. Allow IPR Glide to remain on teeth for 5-10 minutes, then remove aligners and spit out any excess. Keep surfaces dry for 30 minutes avoiding food and liquids.

⚠️ Warnings and Cautions 52 words ▾

PRECAUTIONS/WARNINGS Precautions/Warnings: Store above 25°C/77°F. Keep out of reach of children. Read directions carefully before using. Do not swallow. If a large dose is ingested (more than 1/4 oz), contact poison control and seek medical help immediately. Do not use if nursing, pregnant, or allergic to fluoride or any listed inactive ingredient.

📦 How Supplied / Storage and Handling 16 words ▾

HOW SUPPLIED 4mL in plastic syringe. Mint: NDC 72655-400-01 1mL in plastic syringe. Mint: NDC 72655-400-02

🧪 Inactive Ingredients 16 words ▾

INACTIVE INGREDIENTS Inactive Ingredients: Water, glycerin, hydroxyethyl cellulose, propylene glycol, sucralose, mint oil, sodium benzoate, propylparaben.

📋 Description 10 words ▾

DESCRIPTION Rx ONLY 2.7% Neutral Sodium Fluoride IMPROVES INTERPROXIMAL REDUCTION

📄 Package Label / Principal Display Panel 57 words ▾

IPR GLIDE™ Labeling ----------------------------------------------------- DURING AND AFTER IPR GLIDE™ LUBRICATES & STRENGTHENS ENAMEL Rx ONLY 2.7% Neutral Sodium Fluoride 4ml (0.13 fl oz) Manufactured By EverBrands, Inc. 11791 Monarch St Garden Grove, CA 92841 iprglide.com eversmilewhite.com (855) 595-2999 [email protected] 4mL 1mL res IPR GLide 4 ml Box IPR GLide 4 ml syringe IPR GLide 1 ml syringe

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

About this NDC listing & data coverage

Finished prescription product Marketed without an FDA application

Listed without an FDA application

This product's marketing category indicates it is marketed without an approved FDA application (no NDA, ANDA, or BLA on file). Having an NDC does not by itself establish FDA approval — the NDC Directory is a listing system, not an approval decision. Approval-linked data such as Orange Book therapeutic-equivalence ratings therefore does not apply.

What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Unapproved Drug Other". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by Everbrands, Inc. dba Everpure, Inc.. Listing status can change — the directory data on this page refreshes weekly.
Does this product come in other package sizes?
Yes — the FDA directory lists 1 other package presentation of this same product, including 1 syringe (72655-0400-02). Each has its own NDC and its own page — see the package list near the top of this page.
Who lists this product with the FDA?
Everbrands, Inc. dba Everpure, Inc. is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as a prescription product, so it is dispensed under a prescriber's order. Your pharmacist can tell you whether any over-the-counter forms of the same medication exist.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
← 72655-0300-01 · Everbrands, 72655-0500-01 · Everbrands, →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.