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Upside Down Pain Relief Benzocaine, Glycerin 20 mg/g; 20 mg/g Aerosol, Spray, 1 canister — NDC 72705-0300-01 package photo

Upside Down Pain Relief Benzocaine, Glycerin 20 mg/g; 20 mg/g Aerosol, Spray, 1 canister

by Fridababy, LLC · 1 CANISTER in 1 CARTON (72705-300-01) / 99.2 g in 1 CANISTER
NDC 72705-0300-01
🏷️ FDA NDC (as labeled) 72705-300-01 billing pads the product segment with a zero
OTC On market Non-controlled
🗂️ Data synced Sep 17, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

🆔 Identity & classification

FDA NDC (as labeled) 72705-300-01
Product NDC 72705-300
11-digit billing NDC 72705030001
UNII PDC6A3C0OX, U3RSY48JW5
Application # M015
SPL Set ID 31c2cd25-1fec-5ec5-e063-6394a90a24b4
Established class (EPC) Non-Standardized Chemical Allergen; Standardized Chemical Allergen
Physiologic effect Increased Histamine Release; Cell-mediated Immunity; Increased IgG Production
Chemical class Allergens; Glycerol
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2025-08-15
Route TOPICAL
Dosage form AEROSOL, SPRAY
Substance GLYCERIN; BENZOCAINE
Why two NDCs? The FDA registers this code as 72705-300-01 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 72705-0300-01. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

🏭 Manufacturer & labeler

LabelerFridababy, LLC
FDA applicationM015 (OTC MONOGRAPH DRUG)
Labeler code72705
First marketedAug 2025
Product typeHuman Otc Drug
Portfolio11 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

🩺 Clinical

🧪 What is this product?

Upside Down Pain Relief is an over-the-counter topical spray containing benzocaine and glycerin. Benzocaine is a local anesthetic commonly used in products meant to numb minor pain and irritation on skin surfaces. Glycerin functions as a skin conditioning agent and humectant in topical preparations. This spray is marketed as an OTC monograph drug, meaning it follows established FDA guidelines for its category rather than individual product approval.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

🧪 Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII 7528N5H79B
    A liquid solvent derived from grain fermentation. In medicines, it dissolves active ingredients, helps preserve the product, and improves how the body absorbs the drug.
  • UNII RUE8E6T4NB
    Aloe vera leaf juice is a clear gel extracted from aloe vera plant leaves. It's used in medicines as a lubricant, emollient, and preservative to soothe skin contact and help keep the product stable.
  • UNII 2968PHW8QP
    A weak organic acid derived from citrus fruits or made through fermentation. It works as a buffer to control pH, a preservative to extend shelf life, and a flavoring agent in medications.
  • UNII AM13FS69BX
    Dimethyl ether is a gas that becomes liquid when pressurized. It's used in medicines as a propellant to help deliver the active ingredient from aerosol containers, similar to how spray cans work.
  • UNII T7S323PKJS
    Hamamelis virginiana is an extract from the witch hazel plant. In medications, it's used as an astringent and skin-soothing agent to help reduce irritation and provide a mild drying effect in topical formulations.
  • UNII 5655G9Y8AQ
    A synthetic liquid polymer used as a solvent and humectant in medications. It helps dissolve active ingredients, maintain moisture in the formulation, and improve how the medicine flows and is absorbed.
  • UNII 1VPU26JZZ4
    Potassium sorbate is a salt derived from sorbic acid, a naturally occurring preservative. It prevents growth of mold, yeast, and some bacteria, extending the medicine's shelf life.
  • UNII 1827NY57O3
    A synthetic liquid derived from propylene glycol, used as a solvent and humectant to keep medicines moisturized and improve their consistency in liquid or semi-solid formulations.
  • UNII OJ245FE5EU
    Sodium benzoate is a salt derived from benzoic acid, a preservative. It's added to medicines to prevent growth of bacteria, fungi, and other microorganisms that could spoil the product.

9 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesaloe barbadensis leaf juice, citric acid, dimethyl ether, dipropylene glycol, ethanol, polyethylene glycol, potassium sorbate, PPG-3 methyl ether, sodium benzoate, witch hazel extract

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

💲 Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer mLPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

🔁 Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Upside Down Pain Relief 20 mg/g; 20 mg/gthis 72705-0300-01 Fridababy, 1 canister — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

⏳ Availability & generic status

🏛️
2025
On the market since
Aug 2025
📍
2026
Currently FDA-listed
1 year listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

📦 Packaging — all sizes for this product

Package NDCDescription Marketing startStatus
72705-0300-01 You're viewing this 1 CANISTER in 1 CARTON (72705-300-01) / 99.2 g in 1 CANISTER 2025-08-15 Active

🧭 About this NDC listing & data coverage

Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The FDA registers it as 72705-300-01, which is what is printed on the packaging and shown on DailyMed. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero: 72705-0300-01, written without dashes as 72705030001. The Identity section at the top of this page lists every form of this code.
What do the three segments of this NDC mean?
In 72705-0300-01, the first segment (72705) is the labeler code FDA assigned to Fridababy, LLC; the middle segment (0300) identifies this specific product — its ingredient, strength, and dosage form; and the last segment (01) identifies this exact package size and type. Together they name one specific package of one specific product.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by Fridababy, LLC. Listing status can change — the directory data on this page refreshes weekly.
Who lists this product with the FDA?
Fridababy, LLC is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.

📄 FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🧪 Inactive Ingredients 🎯 Purpose
🎯 Indications and Usage 15 words ▾

Uses ■ Helps relieve discomfort in the perianal area. ■ Temporarily protects inflamed perianal skin.

⏱️ Dosage and Administration 58 words ▾

Directions Adults: •When practical, cleanse the affected area with mild soap and warm water, and rinse thoroughly. •Gently pat dry before use. •Hold the can upside-down and point spray nozzle 6 to 12 inches from affected area. •Apply externally up to 6 times daily or after each bowel movement. Children under 12 years of age: consult a doctor.

⚠️ Warnings 190 words ▾

Warnings For extemal use only FLAMMABLE. Do not use near heat, flame, or fire or wlile smoking. When using this product ■ Use only as directed. ■ Do not exceed recommended daily dosage unless directed by a doctor. ■ Intentional misuse by deliberately concentrating or inhaling the contents can be hmmful or fatal. ■ Do not put this product into the rectum by using fingers or any mechanical device or applicator.

Stop use and ask a doctor if ■ Condition worsens or does not improve within 7 days. ■ Bleeding occurs ■ Certain persons can develop allergic reactions to ingredients in this product. If the symptoms being treated does not subside or if redness, irritation, swelling, pain, or other syptoms develop or increase, discontinue use and consult a doctor. ■ Avoid spaying in eyes. ■ Contents under pressure. Do not puncture or incinerate. ■ Do not store at temperature above 120ºF.

Keep out of reach of children. ■ If swallowed, get medical help or contact a Poison Control Cerier right away. Keep out of reach of children. •If swallowed, get medical help or contact a Poison Control Center right away.

🧪 Inactive Ingredients 25 words ▾

Inactive Ingredients aloe barbadensis leaf juice, citric acid, dimethyl ether, dipropylene glycol, ethanol, polyethylene glycol, potassium sorbate, PPG-3 methyl ether, sodium benzoate, witch hazel extract

🎯 Purpose 4 words ▾

Purpose Local anesthetic Protectant

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗
← 72705-0251-02 · Fridababy, 72705-0420-01 · Fridababy, →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.