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Likewise Facial Moisturizer - Sun Protectant SPF 50 Normal to Oily Skin OCTINOXATE, OCTISALATE, ZINC OXIDE 75 mg/mL; 50 mg/mL; 111.6 mg/mL Cream — NDC 76229-0345-03 package photo

Likewise Facial Moisturizer - Sun Protectant SPF 50 Normal to Oily Skin OCTINOXATE, OCTISALATE, ZINC OXIDE 75 mg/mL; 50 mg/mL; 111.6 mg/mL Cream

by Likewise Incorporated · 1 BOTTLE in 1 PACKAGE (76229-345-03) / 50 mL in 1 BOTTLE
NDC 76229-0345-03
🏷️ FDA NDC (as labeled) 76229-345-03 billing pads the product segment with a zero
OTC On market Non-controlled
🗂️ Data synced Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

🆔 Identity & classification

FDA NDC (as labeled) 76229-345-03
Product NDC 76229-345
11-digit billing NDC 76229034503
UNII 4Y5P7MUD51, 4X49Y0596W, SOI2LOH54Z
Application # M020
SPL Set ID 97bd2033-2cf0-4e5d-81e2-c453a1e3a65e
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2011-06-20
Route TOPICAL
Dosage form CREAM
Substance OCTINOXATE; OCTISALATE; ZINC OXIDE
Why two NDCs? The FDA registers this code as 76229-345-03 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 76229-0345-03. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

🏭 Manufacturer & labeler

LabelerLikewise Incorporated
FDA applicationM020 (OTC MONOGRAPH DRUG)
Labeler code76229
First marketedJun 2011
Product typeHuman Otc Drug
Portfolio4 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

🩺 Clinical

🧪 What is this product?

Likewise Facial Moisturizer is a topical cream that combines moisturizing and sun protection in one product intended for normal to oily skin. It contains three active sunscreen ingredients: octinoxate and octisalate, which are organic UV filters that absorb ultraviolet light, and zinc oxide, an inorganic UV filter that reflects and scatters UV rays. This is an over-the-counter monograph product, meaning it is marketed under FDA's established guidelines for sunscreen formulations rather than as an individually approved application. The SPF 50 rating indicates the product's sun protection level.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

🧪 Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII TR046Y3K1G
    A liquid alcohol derived from petroleum or plant sources. It acts as a solvent and humectant in medicines, helping dissolve active ingredients and retain moisture in the formulation.
  • UNII 76A0JE0FKJ
    Adipic acid is an organic compound used in medicines as a buffer and pH regulator. It helps maintain the proper acidity level in the product to keep it stable and improve how the body absorbs the active ingredient.
  • UNII F2VW3D43YT
    Azelaic acid is a naturally occurring compound that acts as a preservative and antimicrobial agent in medications. It helps prevent bacterial and fungal growth, extending the product's shelf life and stability.
  • UNII 3XUS85K0RA
    Butylene glycol is a clear liquid derived from petroleum or plants that acts as a humectant, solvent, and preservative booster in medicines. It helps keep formulations stable, dissolve active ingredients, and maintain moisture in topical products.
  • UNII 00YIU5438U
    Caprylyl glycol is a clear liquid derived from coconut oil. In medicines, it acts as a humectant to retain moisture, a preservative booster to prevent microbial growth, and a solvent to help dissolve or mix other ingredients.
  • UNII K679OBS311
    Carboxymethylcellulose sodium is a plant-derived thickening agent made from cellulose. In medicines, it acts as a binder to hold ingredients together, a disintegrant to help the tablet break apart, or a thickener in liquids.
  • UNII OP1R32D61U
    Microcrystalline cellulose is a purified form of cellulose, a natural fiber from plant sources. It acts as a binder and filler in tablets and capsules, helping hold ingredients together and give the medicine its shape and size.
  • UNII I670DAL4SZ
    A preservative that fights bacteria and fungi. It keeps medicines and topical products stable and safe from microbial contamination during storage and use.
  • UNII 92RU3N3Y1O
    Dimethicone is a silicone-based oil that acts as an anti-foaming agent and lubricant in medicines. It reduces gas bubbles in liquid formulations and helps coat and protect the stomach lining when ingested.
  • UNII MP1J8420LU
    A salt derived from edetic acid that binds to trace metals in medicines. It serves as a chelating agent and preservative to prevent metal-catalyzed breakdown of the drug and extend shelf life.
  • UNII DH2M523P0H
    Genistein is a naturally occurring plant compound often derived from soy. In medications, it may serve as an antioxidant to help protect the drug's stability and prevent degradation over time.
  • UNII PDC6A3C0OX
    Glycerin is a clear, thick liquid derived from plant oils or fats. It acts as a humectant to retain moisture, a sweetener, and a solvent in medications.
  • UNII 230OU9XXE4
    A waxy substance made from glycerin and stearic acid that acts as an emulsifier to blend oily and watery ingredients together. It also helps thicken and stabilize the medicine's texture.
  • UNII 51FI676N6F
    A nucleic acid derived from herring fish sperm. It's used in some formulations as a binder or structural agent to help hold ingredients together and improve tablet or capsule integrity.
  • UNII YCZ8EM144Q
    A fat derived from palm oil that has been chemically treated to make it more stable. It acts as a binder and lubricant in tablets and capsules, helping hold ingredients together and prevent sticking during manufacturing.
  • UNII 2NX48Z0A9G
    Icodextrin is a glucose polymer derived from starch. It acts as a thickening agent and osmotic agent in medicines, helping to control texture and absorption in formulations like eye drops or injectable solutions.
  • UNII VYT2JA85NH
    A plant extract from cogon grass roots used in some formulations. It may serve as a natural filler, thickening agent, or ingredient to help bind tablet components together.
  • UNII C9H2L21V7U
    A fat derived from coconut or palm oil containing shorter fatty acid chains. It serves as a solvent and carrier to help dissolve or suspend active ingredients, improving absorption and stability in liquid formulations.
  • UNII TIX5482832
    A plant-derived powder from moringa seeds, used in formulations as a natural binder and thickening agent to help hold ingredients together and achieve the desired texture or consistency.
  • UNII QI80HXD6S5
    Neopentyl glycol is a synthetic alcohol compound used as a humectant and solvent in medicines. It helps retain moisture and improve the stability and texture of liquid or semi-solid formulations.
  • UNII 25X51I8RD4
    Niacinamide is a form of vitamin B3, a water-soluble nutrient. In medicines, it may be added as a nutritional supplement or to support skin health, though its primary role here is as an active ingredient rather than a traditional inactive filler.
  • UNII YD01N1999R
    A waxy substance made from polyethylene glycol and stearic acid. It helps mix oil and water-based ingredients together and serves as an emulsifier and solubilizer in liquid and semi-solid medicines.
  • UNII B697894SGQ
    Polyethylene glycol 400 is a clear, thick liquid made from petroleum-derived polymers. It acts as a solvent and humectant in medicines, helping dissolve active ingredients and retain moisture in the formulation.
  • UNII 0R4AQI398X
    Rye is a cereal grain used as a filler and binder in medications. It helps give tablets and capsules their structure and holds ingredients together.
  • UNII 452VLY9402
    Serine is an amino acid, a building block of proteins. In medications, it functions as a buffering agent and stabilizer to help maintain the product's pH balance and protect active ingredients during storage.
  • UNII C269C4G2ZQ
    Sodium alginate is a natural thickener and gelling agent derived from seaweed. In medicines, it acts as a binder to hold ingredients together, a thickener to adjust texture, and a disintegrant to help the tablet or capsule break apart for absorption.
  • UNII H5BJH23Z9A
    A natural polymer extracted from porcine (pig) cartilage tissue. It acts as a binder to hold tablet ingredients together and may improve the product's texture and consistency during manufacturing.
  • UNII 1Q73Q2JULR
    Sodium citrate is a salt derived from citric acid. It works as a buffer to maintain the medicine's pH level and may also help improve taste or act as a preservative in the formulation.
  • UNII R0ZB2556P8
    Tocopherol is a form of vitamin E derived from plant oils. It acts as an antioxidant in medicines to prevent oils and fats from breaking down and spoiling during storage.
  • UNII A8OE252M6L
    A synthetic fatty substance made from plant or mineral oils. It works as a lubricant and emollient in medicines, helping pills slide smoothly during manufacturing and improving how the product feels or spreads.
  • UNII FY36J270ES
    A synthetic chemical compound used as a plasticizer in film coatings. It makes tablet or capsule coatings flexible and durable so they don't crack or break during handling and storage.
  • UNII LDC331P08E
    A silicone-based compound that acts as a glidant and flow agent in solid medications. It reduces friction between powder particles, helping the medicine flow smoothly during manufacturing and tablet compression.
  • UNII 7L6DL16P1T
    Tropolone is a naturally occurring organic compound used in medicines as a preservative and antimicrobial agent to help prevent bacterial and fungal growth in the product.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.
  • UNII TTV12P4NEE
    Xanthan gum is a thickening and stabilizing ingredient made from fermented corn or other sugars. It's added to medicines to improve texture, prevent separation of liquids and solids, and help the product stay consistent.

35 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesInactive ingredients Water, Caprylic/Capric Triglyceride, C15-19 Alkane, Butylene Glycol, Tridecyl Stearate, Neopentyl Glycol, Dicaprylate/Dicaprate, Caprylyl Methicone, Diethylhexyl Sebacate, Glyceryl Stearate, Peg-100 Stearate, Hydrogenated Dimer Dilinoleyl/Dimethylcarbonate Copolymer, Acrylates/C12-22 Alkyl Methacrylate Copolymer, Acrylates Crosspolymer, Potassium CetylPhosphate, Dimethicone, Hydrogenated Palm Glycerides, Polyhydroxystearic Acid, Triethoxycaprylylsilane, Fragrance, Glycerin, Xanthan Gum, Tridecyl Trimellitate, Atelocollagen, Carbomer, Microcrystalline Cellulose, Cellulose Gum, Moringa Pterygosperma Seed Extract, Secale Cereale (Rye) Seed Extract, Dextrin, Imperata Cylindrica Root Extract, Peg-8, Tetrasodium EDTA, Chlorphenesin, Algin, Sodium Citrate, Serine, Adipic Acid/Neopentyl Glycol Crosspolymer, Amodimethicone, Hydroxypropyl Methylcellulose, VP/VA Copolymer, 1,2-Hexanediol, Caprylyl Glycol, Tropolone, Azelaic Acid, Lecithin, Sodium Chondroitin Sulfate, Tocopheryl Acetate, Niacinamide, Ascorbyl Tetraisopalmitate, Tocopherol, DNA, Genistein, Ethylbisiminomethylguaiacol Manganese Chloride.

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

💲 Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer gPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

🔁 Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Likewise Hand Moisturizer - Sun Protectant SPF 50 75 mg/mL; 50 mg/mL; 111.6 mg/mL 76229-0123-01 Likewise 1 bottle — — FDA listed —
Likewise Facial Moisturizer - Sun Protectant SPF 50 Normal to Oily Skin 75 mg/mL; 50 mg/mL; 111.6 mg/mLthis 76229-0345-03 Likewise 1 bottle — — FDA listed —
Likewise Facial Moisturizer - Sun Protectant SPF 50 Normal to Dry Skin 75 mg/mL; 50 mg/mL; 111.6 mg/mL 76229-0456-04 Likewise 1 bottle — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

⏳ Availability & generic status

🏛️
2011
On the market since
Jun 2011
📍
2026
Currently FDA-listed
15 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

🔬 Reported adverse events (FAERS)

Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for OCTINOXATE, OCTISALATE, ZINC OXIDE — the ingredient across all brands.

Top reported reactions

Chemical Burn1
Dehydration1
Expired Product Administered1
Facial Pain1
Feeling Abnormal1
Hypersensitivity1
Hypophagia1

Reporter sex

2 reports
Male · 50%
Female · 50%
Where does this data come from?
Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.

📦 Packaging — all sizes for this product

Package NDCDescription Marketing startStatus
76229-0345-03 You're viewing this 1 BOTTLE in 1 PACKAGE (76229-345-03) / 50 mL in 1 BOTTLE 2017-12-30 Active

🧭 About this NDC listing & data coverage

Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The FDA registers it as 76229-345-03, which is what is printed on the packaging and shown on DailyMed. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero: 76229-0345-03, written without dashes as 76229034503. The Identity section at the top of this page lists every form of this code.
What do the three segments of this NDC mean?
In 76229-0345-03, the first segment (76229) is the labeler code FDA assigned to Likewise Incorporated; the middle segment (0345) identifies this specific product — its ingredient, strength, and dosage form; and the last segment (03) identifies this exact package size and type. Together they name one specific package of one specific product.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by Likewise Incorporated. Listing status can change — the directory data on this page refreshes weekly.
Who lists this product with the FDA?
Likewise Incorporated is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.

📄 FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose 📋 Description
🎯 Indications and Usage 21 words ▾

Uses Helps prevent sunburn Higher SPF provides more protection Retains SPF after 40 minutes of activity in water or vigorous sweating.

⏱️ Dosage and Administration 22 words ▾

Directions - Apply daily 15 minutes before sun exposure and as needed - Children under 6 months of age: ask a doctor.

⚠️ Warnings 5 words ▾

Warnings For external use only

🧪 Active Ingredient 9 words ▾

Active Ingredients..............Purpose Octinoxate 7.50%............Sunscreen Octisalate 5.00%.............Sunscreen Zinc Oxide 11.16%..........Sunscreen

🧪 Inactive Ingredients 105 words ▾

Inactive ingredients Water, Caprylic/Capric Triglyceride, C15-19 Alkane, Butylene Glycol, Tridecyl Stearate, Neopentyl Glycol, Dicaprylate/Dicaprate, Caprylyl Methicone, Diethylhexyl Sebacate, Glyceryl Stearate, Peg-100 Stearate, Hydrogenated Dimer Dilinoleyl/Dimethylcarbonate Copolymer, Acrylates/C12-22 Alkyl Methacrylate Copolymer, Acrylates Crosspolymer, Potassium CetylPhosphate, Dimethicone, Hydrogenated Palm Glycerides, Polyhydroxystearic Acid, Triethoxycaprylylsilane, Fragrance, Glycerin, Xanthan Gum, Tridecyl Trimellitate, Atelocollagen, Carbomer, Microcrystalline Cellulose, Cellulose Gum, Moringa Pterygosperma Seed Extract, Secale Cereale (Rye) Seed Extract, Dextrin, Imperata Cylindrica Root Extract, Peg-8, Tetrasodium EDTA, Chlorphenesin, Algin, Sodium Citrate, Serine, Adipic Acid/Neopentyl Glycol Crosspolymer, Amodimethicone, Hydroxypropyl Methylcellulose, VP/VA Copolymer, 1,2-Hexanediol, Caprylyl Glycol, Tropolone, Azelaic Acid, Lecithin, Sodium Chondroitin Sulfate, Tocopheryl Acetate, Niacinamide, Ascorbyl Tetraisopalmitate, Tocopherol, DNA, Genistein, Ethylbisiminomethylguaiacol Manganese Chloride.

🎯 Purpose 24 words ▾

Uses - Helps prevent sunburn - Higher SPF provides more protection - Retains SPF after 40 minutes of activity in water or vigorous sweating.

📋 Description 89 words ▾

protect hydrate renew . . . . . . . NORMAL TO OILY SKIN Daily moisturizer + Sunscreen Dermatologist developed Toner balances skin and controls blemishes with Azelaic Acid and Niacimide Anti-aging antioxidants reverse daily damage and rejuvenate skin Contains Vitamins B, C and E and Natural Soy to improve skin tone and texture Works wonders as a nighttime moisturizer, too Non-greasy light coverage (apply 1 pea-size drop). . . . . . LikewiseSkinCare.com LIKEWISE INCORPORATED 200 COOL SPRINGS BOULEVARD FRANKLIN, TENNESSEE 37067 IN CASE OF ADVERSE REACTION: 877.778.9546

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗
← 76229-0234-02 · Likewise 76229-0456-04 · Likewise →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.