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J0281

J0281 – Inj aminocaproic acid 1 gram · NDC Crosswalk & Billing Units

HCPCS Level II J-code · Medicare Part B drug billing
J-code ● 6 NDCs crosswalked per 1 GM $1.866/unit ASP+6%

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

📋 J0281 summary

J0281 is a HCPCS Level II J-code used to bill aminocaproic acid 1 gram, billed per 1 GM. The number of billing units to report depends on the dose administered and the NDC/package billed — use the calculator below.

Brand names associated with J0281: Aminocaproic Acid

Code J0281 Billing unit 1 GM Payment limit $1.866/unit NDC-Crosswalk 6 Quarter Q3 2026 RxCUI Atlas Trace the drug concept →

⚠ An NDC↔HCPCS crosswalk and a published payment limit do not guarantee payer coverage or payment. Always verify the current payer policy and claim format before billing.

🗂️ Key billing facts

HCPCS codeJ0281
DescriptorInj aminocaproic acid 1 gram
Billing unit1 GM
Payment limit / unit$1.866
Est. ASP / unit$1.760 est.
Mapped NDCs6
Data periodQ3 2026
Last updated2026-09-20

💊 About Aminocaproic Acid Injection DRUG GUIDE

Aminocaproic Acid Injection helps blood clot better when excess clot breakdown (fibrinolysis) is contributing to bleeding.

In life-threatening situations, other emergency measures such as blood transfusions may also be needed.This type of bleeding can follow heart surgery, liver disease, certain blood disorders, and some cancers.

It can also occur in the urinary tract after severe trauma, shock, or surgery.

Read the full Aminocaproic Acid Injection drug guide →
Clinical overview from our editorial drug guide for Aminocaproic Acid Injection. For billing reference, see the sections above.

🧾 Billing & reimbursement HCPCS · CMS · EFF. Q3 2026

📅 Payment limits effective Q3 2026 — from the CMS Medicare Part B Payment Limit File (revised quarterly).
Medicare payment limit / unit
$1.866
Est. ASP / unit
$1.760 est.
Est. after 2% sequester
$1.829
HCPCS dosage
1 GM
The CMS payment limit is the Medicare Part B drug allowance (ASP + 6%, statutory). After the 2% federal sequester the effective payment is ≈ ASP + 4.3%; estimated ASP = payment limit ÷ 1.06. Source: CMS Medicare Part B Payment Limit File (quarterly), Q3 2026.

🧮 Dosing & billing-units calculator HCPCS UNITS

One billing unit of J0281 = 1 gm. Enter a regimen to convert dose → billing units and project a full course.
Billing units = dose ÷ HCPCS unit size. Most payers require whole units — round per the payer's policy. “Est. Medicare pay” uses the current payment limit. For single-dose vials, drug discarded after administration may be separately billable with modifier JW (JZ when none is discarded) where allowed. Always verify payer-specific rounding before billing.

🔁 NDCs that bill under J0281 WITH EST. MEDICARE PAY

6 NDCs map to J0281. Bill units = how many HCPCS units one package represents. Est. pay / pkg = payment limit ($1.866/unit) × that package's bill units.
NDC (11-digit)DrugLabelerPackageStrength Bill units Est. pay / pkg NADAC / unit StatusSource
00404-9812-20 AMINOCAPROIC ACID 250 mg/mL INJECTION, SOLUTION Henry 1 VIAL, SINGLE-DOSE in 1 BAG (0404-9812-20... 250 mg/mL 5 $9.33 — ● Active CMS ASP
00409-4346-73 Aminocaproic Acid 250 mg/mL INJECTION, SOLUTION Hospira, 25 VIAL, SINGLE-DOSE in 1 TRAY (0409-4346-... 250 mg/mL 125 $233.25 — ● Active CMS + PDAC
00517-9120-25 Aminocaproic Acid 250 mg/mL INJECTION, SOLUTION American 25 VIAL, MULTI-DOSE in 1 TRAY (0517-9120-2... 250 mg/mL 125 $233.25 — ● Active CMS + PDAC
00517-9191-25 Aminocaproic Acid 250 mg/mL INJECTION, SOLUTION American 25 VIAL, MULTI-DOSE in 1 TRAY (0517-9191-2... 250 mg/mL 125 $233.25 — ● Active CMS + PDAC
72572-0015-25 Aminocaproic Acid 250 mg/mL INJECTION, SOLUTION Civica, 25 VIAL, MULTI-DOSE in 1 TRAY (72572-015-2... 250 mg/mL 125 $233.25 — ● Active CMS + PDAC
00517-9191-01 AMINOCAPROIC ACID NOVAPLUS MDV 250 MG/1 ML Unknown — — 0.25 $0.47 — — PDAC
NDC→HCPCS mappings come from the CMS ASP NDC-HCPCS crosswalk; additional DME MAC / DMEPOS mappings come from PDAC and are labeled separately. NADAC from CMS (weekly). “Status” reflects the product's marketing / obsolete flag in the NDC directory. Presence or absence here does not determine Medicare coverage. Linked NDCs open the full product page.

🗺️ Where J0281 is utilized

⏳
The geographic utilization map is building for this code — it aggregates millions of CMS Part B claim lines, then caches the result. Refresh in a moment; if it doesn’t appear, this code may have no reportable Part B utilization.

📊 What bills under J0281

J-codes are billing codes often used for drugs billed under the medical benefit. This connects the billing code to the NDC package records it covers, by ingredient and labeler.

NDC products by ingredient
Aminocaproic Acid 3
AMINOCAPROIC ACID 1
NDC products by labeler
American Regent, Inc. 2
Hospira, Inc. 1
Civica, Inc. 1

🗃️ Data sources & freshness

Every figure on this page is computed from public datasets. Here's what each section draws on and how current it is.
HCPCS code & descriptor
CMS HCPCS Level II code file
Not available in current dataset
Payment limit & billing unit
CMS Medicare Part B ASP Pricing File (quarterly)
Q3 2026 · as of 2026-09-20
NDC ↔ HCPCS crosswalk
CMS ASP NDC-HCPCS crosswalk + DMEPDAC (PDAC)
6 NDCs mapped
NADAC acquisition cost
CMS National Average Drug Acquisition Cost (weekly)
Not available for mapped NDCs
Utilization & spend
CMS Part B Spending by Drug · PSPS · Physician & Other Practitioners
No reportable utilization
Figures are estimates for reference and may lag the source files. Always verify against the current CMS files and your payer's policy before submitting claims.

⚠️ Practical billing caveats

  • A crosswalk is not coverage. An NDC mapping or a published payment limit does not guarantee a payer will cover or pay this code. Check the specific plan's policy.
  • Units ≠ milligrams. Bill the number of HCPCS units (dose ÷ the code's unit size), not the milligram dose. Use the calculator above.
  • Discarded drug. For single-dose vials, drug discarded after administration may be separately billable with modifier JW (and JZ when nothing is discarded) where the payer allows.
  • Rounding & partial units. Many payers require whole units; round per the payer's policy, not automatically up.
  • The code can cover more than this drug. Some HCPCS codes span multiple products or strengths — confirm the exact code for the product administered.
  • Figures lag. ASP limits change quarterly and utilization data are released with a delay. Verify against the current CMS files before billing.

❓ J0281 billing FAQ

What is HCPCS code J0281?
J0281 is a HCPCS Level II J-code used to bill Inj aminocaproic acid 1 gram under Medicare Part B and most medical (not pharmacy) benefits.
What is the billing unit for J0281?
One unit of J0281 represents 1 GM. Report the number of units equal to the dose administered divided by 1 GM.
How many units of J0281 should I bill?
Divide the dose administered by the code's unit size (1 GM) to get the number of billing units, then round per your payer's policy. The calculator on this page converts a dose into billing units and projects a full course.
How much does Medicare pay for J0281?
The Medicare Part B payment limit is $1.866 per unit (Q3 2026), based on ASP + 6%. After the 2% sequester the effective payment is about $1.829 per unit. Payment limits are revised quarterly.
Which NDCs bill under J0281?
6 NDCs currently map to J0281 in the CMS ASP NDC-HCPCS crosswalk. See the NDC crosswalk table above for each product, package, billing units and estimated reimbursement.
Does a crosswalk mean J0281 is covered?
No. An NDC-to-HCPCS crosswalk and a published payment limit do not guarantee coverage or payment. Coverage depends on the payer, the diagnosis and the site of care — always verify the current policy before billing.
For professional billing reference only — verify against the current CMS files before submitting claims.