J1599 NDC Crosswalk, Billing Units, ASP Payment & Medicare Reimbursement

📋 J1599 summary

J1599 is a HCPCS Level II J-code used to bill immune globulin, intravenous, non-lyophilized (e.g., liquid), not otherwise specified, 500.... The number of billing units to report depends on the dose administered and the NDC/package billed — use the calculator below.

Brand names associated with J1599: Qivigy Kthm, Yimmugo, Panzyga

Code J1599 NDC-Crosswalk 23 RxCUI Atlas Trace the drug concept →

⚠ An NDC↔HCPCS crosswalk and a published payment limit do not guarantee payer coverage or payment. Always verify the current payer policy and claim format before billing.

🗂️ Key billing facts

HCPCS codeJ1599

DescriptorInjection, immune globulin, intravenous, non-lyophilized (e.g., liquid), not otherwise specified, 500 mg

Billing unitNot available in current dataset

Payment limit / unit Not available in current dataset

Mapped NDCs23

Data periodNot available in current dataset

Last updatedSource date not available

💊 About Human Immunoglobulin G DRUG GUIDE

Human immunoglobulin G (IgG) is used as replacement therapy for primary humoral immunodeficiency (PI) — a group of conditions where the immune system cannot make enough protective antibodies.

This includes congenital agammaglobulinemia, common variable immunodeficiency (CVID), X-linked agammaglobulinemia, Wiskott-Aldrich syndrome, and severe combined immunodeficiencies.

Privigen, Asceniv, Hizentra, Qivigy, and Gammaplex are all approved for PI, though the specific patient ages and routes differ by product.Privigen (intravenous) is also approved to treat chronic immune thrombocytopenic purpura (ITP), a condition where the immune system attacks platelets, causing dangerously low platelet counts.

The goal in ITP is to raise platelet levels.

Read the full Human Immunoglobulin G drug guide →

Clinical overview from our editorial drug guide for Human Immunoglobulin G. For billing reference, see the sections above.

🧾 Billing & reimbursement HCPCS · CMS

Medicare payment limit / unit

—

Est. ASP / unit

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Est. after 2% sequester

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HCPCS dosage

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The CMS payment limit is the Medicare Part B drug allowance (ASP + 6%, statutory). After the 2% federal sequester the effective payment is ≈ ASP + 4.3%; estimated ASP = payment limit ÷ 1.06. Source: CMS Medicare Part B Payment Limit File (quarterly).

Full HCPCS code details (official CMS record)

Long descriptionInjection, immune globulin, intravenous, non-lyophilized (e.g., liquid), not otherwise specified, 500 mg

CoverageC — Carrier/MAC judgment

Pricing indicator51 — Drug — priced under the ASP methodology

Type of service1 — Medical care

BETOS-2O1E

ASC payment group—

Action codeN — No maintenance this year

Effective date2011-01-01

Date added2011-01-01

Source: CMS HCPCS Level II code file (imported via admin).

🧮 Dosing & billing-units calculator HCPCS UNITS

One billing unit of J1599 = 1 unit. Enter a regimen to convert dose → billing units and project a full course.

Dose per administration (unit) Frequency — every days Number of doses NDC / package billed (optional)

Billing units = dose ÷ HCPCS unit size. Most payers require whole units — round per the payer's policy. “Est. Medicare pay” uses the current payment limit. For single-dose vials, drug discarded after administration may be separately billable with modifier JW (JZ when none is discarded) where allowed. Always verify payer-specific rounding before billing.

🔁 NDCs that bill under J1599 CROSSWALKED NDCs

23 NDCs map to J1599. Bill units = how many HCPCS units one package represents.

NDC (11-digit)	Drug	Labeler	Package	Strength	Bill units	NADAC / unit	Status	Source
76179-0010-04	QIVIGY kthm human immunoglobulin g 5 g/50mL INJECTION, SOLUTION	Kedrion	1 VIAL, GLASS in 1 CARTON (76179-010-04)...	5 g/50mL	0.2	—	● Active	PDAC
76179-0010-02	QIVIGY kthm human immunoglobulin g 5 g/50mL INJECTION, SOLUTION	Kedrion	1 VIAL, GLASS in 1 CARTON (76179-010-02)...	5 g/50mL	0.2	—	● Active	PDAC
83372-0605-21	YIMMUGO immune globulin intravenous, human - dira 10 g/100mL SOLUTION	Biotest	1 VIAL, GLASS in 1 CARTON (83372-605-21)...	10 g/100mL	0.2	—	● Active	PDAC
83372-0605-11	YIMMUGO immune globulin intravenous, human - dira 10 g/100mL SOLUTION	Biotest	1 VIAL, GLASS in 1 CARTON (83372-605-11)...	10 g/100mL	0.2	—	● Active	PDAC
83372-0605-01	YIMMUGO immune globulin intravenous, human - dira 10 g/100mL SOLUTION	Biotest	1 VIAL, GLASS in 1 CARTON (83372-605-01)...	10 g/100mL	0.2	—	● Active	PDAC
68982-0822-06	Panzyga immune globulin intravenous (human) 100 mg/mL SOLUTION	Octapharma	1 BOTTLE, GLASS in 1 CARTON (68982-822-06)...	100 mg/mL	0.2	—	● Active	PDAC
68982-0822-05	Panzyga immune globulin intravenous (human) 100 mg/mL SOLUTION	Octapharma	1 BOTTLE, GLASS in 1 CARTON (68982-822-05)...	100 mg/mL	0.2	—	● Active	PDAC
68982-0822-04	Panzyga immune globulin intravenous (human) 100 mg/mL SOLUTION	Octapharma	1 BOTTLE, GLASS in 1 CARTON (68982-822-04)...	100 mg/mL	0.2	—	● Active	PDAC
68982-0822-03	Panzyga immune globulin intravenous (human) 100 mg/mL SOLUTION	Octapharma	1 BOTTLE, GLASS in 1 CARTON (68982-822-03)...	100 mg/mL	0.2	—	● Active	PDAC
68982-0822-02	Panzyga immune globulin intravenous (human) 100 mg/mL SOLUTION	Octapharma	1 BOTTLE, GLASS in 1 CARTON (68982-822-02)...	100 mg/mL	0.2	—	● Active	PDAC
68982-0822-01	Panzyga immune globulin intravenous (human) 100 mg/mL SOLUTION	Octapharma	1 BOTTLE, GLASS in 1 CARTON (68982-822-01)...	100 mg/mL	0.2	—	● Active	PDAC
00069-1109-02	Panzyga immune globulin intravenous (human) 100 mg/mL SOLUTION	Pfizer	1 BOTTLE, GLASS in 1 CARTON (0069-1109-02)...	100 mg/mL	0.2	—	● Active	PDAC
00069-1558-02	Panzyga immune globulin intravenous (human) 100 mg/mL SOLUTION	Pfizer	1 BOTTLE, GLASS in 1 CARTON (0069-1558-02)...	100 mg/mL	0.2	—	● Active	PDAC
00069-1415-02	Panzyga immune globulin intravenous (human) 100 mg/mL SOLUTION	Pfizer	1 BOTTLE, GLASS in 1 CARTON (0069-1415-02)...	100 mg/mL	0.2	—	● Active	PDAC
00069-1312-02	Panzyga immune globulin intravenous (human) 100 mg/mL SOLUTION	Pfizer	1 BOTTLE, GLASS in 1 CARTON (0069-1312-02)...	100 mg/mL	0.2	—	● Active	PDAC
00069-1224-02	Panzyga immune globulin intravenous (human) 100 mg/mL SOLUTION	Pfizer	1 BOTTLE, GLASS in 1 CARTON (0069-1224-02)...	100 mg/mL	0.2	—	● Active	PDAC
00069-1011-02	Panzyga immune globulin intravenous (human) 100 mg/mL SOLUTION	Pfizer	1 BOTTLE, GLASS in 1 CARTON (0069-1011-02)...	100 mg/mL	0.2	—	● Active	PDAC
68982-0820-06	PANZYGA (PF,LATEX-FREE) 100 MG/1 ML	Unknown	—	—	0.2	—	—	PDAC
68982-0820-05	PANZYGA (PF,LATEX-FREE) 100 MG/1 ML	Unknown	—	—	0.2	—	—	PDAC
68982-0820-04	PANZYGA (PF,LATEX-FREE) 100 MG/1 ML	Unknown	—	—	0.2	—	—	PDAC
68982-0820-03	PANZYGA (PF,LATEX-FREE) 100 MG/1 ML	Unknown	—	—	0.2	—	—	PDAC
68982-0820-02	PANZYGA (PF,LATEX-FREE) 100 MG/1 ML	Unknown	—	—	0.2	—	—	PDAC
68982-0820-01	PANZYGA (PF,LATEX-FREE) 100 MG/1 ML	Unknown	—	—	0.2	—	—	PDAC

NDC→HCPCS mappings come from the CMS ASP NDC-HCPCS crosswalk; additional DME MAC / DMEPOS mappings come from PDAC and are labeled separately. NADAC from CMS (weekly). “Status” reflects the product's marketing / obsolete flag in the NDC directory. Presence or absence here does not determine Medicare coverage. Linked NDCs open the full product page.

⚠️ Don't confuse J1599 with… RELATED CODES

Adjacent HCPCS codes that share an ingredient or formulation with J1599. Billing units and payment limits differ — confirm the exact code, strength and form before billing.

Code	Descriptor	Billing unit	Payment limit / unit	How it differs from J1599
J1561	Gamunex-c/gammaked	500 MG	$49.014	Related ingredient or formulation — confirm strength, form and billing unit before substituting.
J1554	Inj. asceniv	500 MG	$509.139	Related ingredient or formulation — confirm strength, form and billing unit before substituting.
J1558	Inj. xembify, 100 mg	100 MG	$15.243	Related ingredient or formulation — confirm strength, form and billing unit before substituting.
J1552	IMMUNE GLOBULIN,GAMMA(IGG)STWK	500 MG	$121.544	Related ingredient or formulation — confirm strength, form and billing unit before substituting.
J1460	Gamma globulin 1 cc inj	1 CC	$48.874	Related ingredient or formulation — confirm strength, form and billing unit before substituting.

Related codes matched on shared ingredient (CMS Medicare Part B Spending feed). Billing units and payment limits from the CMS ASP Pricing File. Always verify the precise HCPCS code for the product and strength administered.

📈 Medicare Part B claims detail CMS PSPS · 2024

Calendar-year 2024 Medicare Part B fee-for-service activity for this HCPCS code, summed across all carriers, localities and specialties (CMS Physician/Supplier Procedure Summary). A “service” is one billed line/unit — not one claim — so counts run higher than claim counts.

Allowed charges

$156K

Medicare paid

$132K

Submitted services

2,550

Denial rate

24.3%

Allowed / service

$80.83

Submitted charges

$473.8K

Source: CMS Physician/Supplier Procedure Summary (PSPS), CY2024 — Medicare Part B carrier + DME fee-for-service claims (excludes Medicare Advantage). Figures are for the whole HCPCS code, which may cover uses beyond this drug. ⚠ CMS hides any figure covering fewer than 11 patients (a privacy rule), so totals — especially denials and low-volume codes — run a little low.

📊 What bills under J1599

J-codes are billing codes often used for drugs billed under the medical benefit. This connects the billing code to the NDC package records it covers, by ingredient and labeler.

NDC products by ingredient

immune globulin intravenous (human... 7

human immunoglobulin g 2

immune globulin intravenous, human... 1

NDC products by labeler

Pfizer Laboratories Div Pfizer Inc 6

Kedrion S.p.A. 2

Octapharma USA Inc 1

Biotest AG 1

🔗 Related NDC directory pages

🧪 All Immune Globulin Intravenous (Human) NDCsIngredient 🧪 All Human Immunoglobulin G NDCsIngredient 🧪 All Immune Globulin Intravenous, Human - Dira NDCsIngredient 🏭 All Pfizer labeler NDCsLabeler 00069 🏭 All Kedrion labeler NDCsLabeler 76179 🏭 All Octapharma labeler NDCsLabeler 68982 🏭 All Biotest labeler NDCsLabeler 83372 📚 All Human Immunoglobulin G NDCsDrug class

🗃️ Data sources & freshness

Every figure on this page is computed from public datasets. Here's what each section draws on and how current it is.

HCPCS code & descriptor

CMS HCPCS Level II code file

Loaded

Payment limit & billing unit

CMS Medicare Part B ASP Pricing File (quarterly)

Not available

NDC ↔ HCPCS crosswalk

CMS ASP NDC-HCPCS crosswalk + DMEPDAC (PDAC)

23 NDCs mapped

NADAC acquisition cost

CMS National Average Drug Acquisition Cost (weekly)

Not available for mapped NDCs

Utilization & spend

CMS Part B Spending by Drug · PSPS · Physician & Other Practitioners

No reportable utilization

Figures are estimates for reference and may lag the source files. Always verify against the current CMS files and your payer's policy before submitting claims.

⚠️ Practical billing caveats

A crosswalk is not coverage. An NDC mapping or a published payment limit does not guarantee a payer will cover or pay this code. Check the specific plan's policy.
Units ≠ milligrams. Bill the number of HCPCS units (dose ÷ the code's unit size), not the milligram dose. Use the calculator above.
Discarded drug. For single-dose vials, drug discarded after administration may be separately billable with modifier JW (and JZ when nothing is discarded) where the payer allows.
Rounding & partial units. Many payers require whole units; round per the payer's policy, not automatically up.
The code can cover more than this drug. Some HCPCS codes span multiple products or strengths — confirm the exact code for the product administered.
Figures lag. ASP limits change quarterly and utilization data are released with a delay. Verify against the current CMS files before billing.

❓ J1599 billing FAQ

What is HCPCS code J1599?

J1599 is a HCPCS Level II J-code used to bill Injection, immune globulin, intravenous, non-lyophilized (e.g., liquid), not otherwise specified, 500 mg under Medicare Part B and most medical (not pharmacy) benefits.

Which NDCs bill under J1599?

23 NDCs currently map to J1599 in the CMS ASP NDC-HCPCS crosswalk. See the NDC crosswalk table above for each product, package, billing units and estimated reimbursement.

Does a crosswalk mean J1599 is covered?

No. An NDC-to-HCPCS crosswalk and a published payment limit do not guarantee coverage or payment. Coverage depends on the payer, the diagnosis and the site of care — always verify the current policy before billing.

J1599 – Injection, immune globulin, intravenous, non-lyophilized (e.g., liquid), · NDC Crosswalk & Billing Units