J2290
J2290 – Inj, nafcillin sodium, 20 mg · NDC Crosswalk & Billing Units
HCPCS Level II J-code · Medicare Part B drug billing
J-code
● 34 NDCs crosswalked per 20 MG $0.047/unit ASP+6%
📋 J2290 summary
J2290 is a HCPCS Level II J-code used to bill nafcillin sodium, 20 mg, billed per 20 MG. The number of billing units to report depends on the dose administered and the NDC/package billed — use the calculator below.
Brand names associated with J2290: Nafcillin
Code J2290
Billing unit 20 MG Payment limit $0.047/unit NDC-Crosswalk 34
Quarter Q3 2026
RxCUI Atlas Trace the drug concept →
⚠ An NDC↔HCPCS crosswalk and a published payment limit do not guarantee payer coverage or payment. Always verify the current payer policy and claim format before billing.
🗂️ Key billing facts
HCPCS codeJ2290
DescriptorInj, nafcillin sodium, 20 mg
Billing unit20 MG
Payment limit / unit$0.047
Est. ASP / unit$0.044 est.
Mapped NDCs34
Data periodQ3 2026
Last updated2026-08-20
💊 About Nafcillin Injection DRUG GUIDE
NAFCILLIN Injection is used to treat infections caused by staphylococci — specifically strains that produce an enzyme called penicillinase, which makes them resistant to regular penicillin.
Susceptibility testing is performed to confirm the bacteria will respond to nafcillin before or shortly after starting treatment.Nafcillin may also be started right away when a resistant staph infection is strongly suspected, even before test results are available.
It should not be used for infections caused by bacteria that would respond to standard penicillin G, or for infections caused by non-staph organisms.
Clinical overview from our editorial drug guide for Nafcillin Injection. For billing reference, see the sections above.
🧾 Billing & reimbursement HCPCS · CMS · EFF. Q3 2026
📅 Payment limits effective Q3 2026 — from the CMS Medicare Part B Payment Limit File (revised quarterly).
Medicare payment limit / unit
$0.047
Est. ASP / unit
$0.044 est.
Est. after 2% sequester
$0.046
HCPCS dosage
20 MG
The CMS payment limit is the Medicare Part B drug allowance (ASP + 6%, statutory). After the 2% federal sequester the effective payment is ≈ ASP + 4.3%; estimated ASP = payment limit ÷ 1.06. Source: CMS Medicare Part B Payment Limit File (quarterly), Q3 2026.
🧮 Dosing & billing-units calculator HCPCS UNITS
One billing unit of J2290 = 20 mg. Enter a regimen to convert dose → billing units and project a full course.
Billing units = dose ÷ HCPCS unit size. Most payers require whole units — round per the payer's policy. “Est. Medicare pay” uses the current payment limit. For single-dose vials, drug discarded after administration may be separately billable with modifier JW (JZ when none is discarded) where allowed. Always verify payer-specific rounding before billing.
🔁 NDCs that bill under J2290 WITH EST. MEDICARE PAY
34 NDCs map to J2290. Bill units = how many HCPCS units one package represents. Est. pay / pkg = payment limit ($0.047/unit) × that package's bill units.
| NDC (11-digit) | Drug | Labeler | Package | Strength | Bill units | Est. pay / pkg | NADAC / unit | Status | Source |
|---|---|---|---|---|---|---|---|---|---|
| 23155-0906-41 | Nafcillin 1 g/4mL INJECTION, POWDER, FOR SOLUTION | Heritage | 10 VIAL in 1 CARTON (23155-906-41) / 4 mL... | 1 g/4mL | 500 | $23.50 | — | ● Active | CMS + PDAC |
| 23155-0907-41 | Nafcillin 2 g/8mL INJECTION, POWDER, FOR SOLUTION | Heritage | 10 VIAL in 1 CARTON (23155-907-41) / 8 mL... | 2 g/8mL | 1,000 | $47.00 | — | ● Active | CMS + PDAC |
| 25021-0139-10 | Nafcillin Sodium | Sagent | — | — | 500 | $23.50 | — | — | CMS ASP |
| 25021-0140-10 | Nafcillin Sodium | Sagent | — | — | 1,000 | $47.00 | — | — | CMS ASP |
| 25021-0141-99 | Nafcillin Sodium | Sagent | — | — | 5,000 | $235.00 | — | — | CMS ASP |
| 25021-0198-99 | Nafcillin 10 g/100mL INJECTION, POWDER, FOR SOLUTION | Sagent | 1 VIAL in 1 CARTON (25021-198-99) / 100 m... | 10 g/100mL | 500 | $23.50 | — | ● Active | CMS + PDAC |
| 44567-0221-10 | Nafcillin 1 g/1 INJECTION, POWDER, FOR SOLUTION | WG | 10 VIAL in 1 CARTON (44567-221-10) / 1 PO... | 1 g/1 | 500 | $23.50 | — | ● Active | CMS ASP |
| 44567-0222-10 | Nafcillin 2 g/1 INJECTION, POWDER, FOR SOLUTION | WG | 10 VIAL in 1 CARTON (44567-222-10) / 1 PO... | 2 g/1 | 1,000 | $47.00 | — | ● Active | CMS ASP |
| 44567-0223-01 | Nafcillin 10 g/1 INJECTION, POWDER, FOR SOLUTION | WG | 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON... | 10 g/1 | 500 | $23.50 | — | ● Active | CMS + PDAC |
| 55150-0122-15 | Nafcillin 1 g/4mL INJECTION, POWDER, FOR SOLUTION | Eugia | 10 VIAL in 1 BOX (55150-122-15) / 4 mL in... | 1 g/4mL | 500 | $23.50 | — | ● Active | CMS ASP |
| 55150-0123-15 | Nafcillin 2 g/8mL INJECTION, POWDER, FOR SOLUTION | Eugia | 10 VIAL in 1 BOX (55150-123-15) / 8 mL in... | 2 g/8mL | 1,000 | $47.00 | — | ● Active | CMS ASP |
| 55150-0123-16 | Nafcillin 2 g/8mL INJECTION, POWDER, FOR SOLUTION | Eugia | 10 VIAL in 1 BOX (55150-123-16) / 8 mL in... | 2 g/8mL | 1,000 | $47.00 | — | ● Active | CMS + PDAC |
| 55150-0124-09 | Nafcillin 10 g/100mL INJECTION, POWDER, FOR SOLUTION | Eugia | 1 VIAL, PHARMACY BULK PACKAGE in 1 BOX (55... | 10 g/100mL | 500 | $23.50 | — | ● Active | CMS + PDAC |
| 55150-0124-99 | Nafcillin 10 g/100mL INJECTION, POWDER, FOR SOLUTION | Eugia | 1 VIAL, PHARMACY BULK PACKAGE in 1 BOX (55... | 10 g/100mL | 500 | $23.50 | — | ● Active | CMS ASP |
| 63323-0327-10 | Nafcillin 1 g/4mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Fresenius | 10 VIAL in 1 CARTON (63323-327-10) / 4 mL... | 1 g/4mL | 500 | $23.50 | — | ● Active | CMS ASP |
| 63323-0328-20 | Nafcillin 2 g/8mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Fresenius | 10 VIAL in 1 CARTON (63323-328-20) / 8 mL... | 2 g/8mL | 1,000 | $47.00 | — | ● Active | CMS ASP |
| 63323-0328-22 | Nafcillin 2 g/8mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | Fresenius | 10 VIAL in 1 CARTON (63323-328-22) / 8 mL... | 2 g/8mL | 1,000 | $47.00 | — | ● Active | CMS + PDAC |
| 63323-0330-60 | Nafcillin 10 g/100mL INJECTION, POWDER, FOR SOLUTION | Fresenius | 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON... | 10 g/100mL | 500 | $23.50 | — | ● Active | CMS ASP |
| 70860-0116-26 | Nafcillin Sodium | Athenex | — | — | 500 | $23.50 | — | — | CMS ASP |
| 70860-0117-26 | Nafcillin Sodium | Athenex | — | — | 1,000 | $47.00 | — | — | CMS ASP |
| 70860-0119-99 | Nafcillin 10 g/100mL INJECTION, POWDER, FOR SOLUTION | Athenex | 1 BOTTLE in 1 CARTON (70860-119-99) / 100... | 10 g/100mL | 500 | $23.50 | — | Obsolete | CMS + PDAC |
| 72485-0406-10 | NAFCILLIN SODIUM 2 g/1 INJECTION, POWDER, FOR SOLUTION | Armas | 10 VIAL in 1 CARTON (72485-406-10) / 1 IN... | 2 g/1 | 1,000 | $47.00 | — | ● Active | CMS + PDAC |
| 72603-0453-10 | Nafcillin 2 g/8mL INJECTION, POWDER, FOR SOLUTION | NorthStar | 10 VIAL in 1 BOX (72603-453-10) / 8 mL in... | 2 g/8mL | 1,000 | $47.00 | — | ● Active | CMS + PDAC |
| 72603-0567-01 | Nafcillin 10 g/100mL INJECTION, POWDER, FOR SOLUTION | NorthStar | 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON... | 10 g/100mL | 500 | $23.50 | — | ● Active | CMS + PDAC |
| 83634-0101-99 | Nafcillin 10 g/100mL INJECTION, POWDER, FOR SOLUTION | Avenacy | 1 BOTTLE in 1 CARTON (83634-101-99) / 100... | 10 g/100mL | 500 | $23.50 | — | ● Active | CMS ASP |
| 67850-0032-10 | NAFCILLIN 2 GM | Unknown | — | — | 100 | $4.70 | — | — | PDAC |
| 67850-0031-10 | NAFCILLIN 1 GM | Unknown | — | — | 50 | $2.35 | — | — | PDAC |
| 00781-9225-20 | NAFCILLIN NOVAPLUS ADD-VANTAGE 2 GM | Unknown | — | — | 100 | $4.70 | — | — | PDAC |
| 00781-3125-92 | NAFCILLIN SODIUM ADD-VANTAGE VIAL 2 GM | Unknown | — | — | 100 | $4.70 | — | — | PDAC |
| 00338-1019-48 | NAFCILLIN 2 g/100mL INJECTION, SOLUTION | Baxter | 100 mL in 1 BAG (0338-1019-48) | 2 g/100mL | 1 | $0.05 | — | ● Active | PDAC |
| 00781-9224-15 | NAFCILLIN NOVAPLUS ADD-VANTAGE 1 GM | Unknown | — | — | 50 | $2.35 | — | — | PDAC |
| 00781-9126-46 | NAFCILLIN NOVAPLUS 10 GM | Unknown | — | — | 500 | $23.50 | — | — | PDAC |
| 00781-9125-85 | NAFCILLIN NOVAPLUS 2 GM | Unknown | — | — | 100 | $4.70 | — | — | PDAC |
| 00781-9124-85 | NAFCILLIN NOVAPLUS 1 GM | Unknown | — | — | 50 | $2.35 | — | — | PDAC |
NDC→HCPCS mappings come from the CMS ASP NDC-HCPCS crosswalk; additional DME MAC / DMEPOS mappings come from PDAC and are labeled separately. NADAC from CMS (weekly). “Status” reflects the product's marketing / obsolete flag in the NDC directory. Presence or absence here does not determine Medicare coverage. Linked NDCs open the full product page.
📊 Medicare utilization & spend CMS · PART B · 2026 (Q1)
Period
Total Part B spend
$2K
Claims
69
Beneficiaries
—
Spend / beneficiary
—
Spend / claim
$29.70
Trend by period
Where J2290 ranks among Part B drugs · 2026 (Q1) · neighbors ±5
Total spending — #745 of 824
#740
BCG (TICE STRAIN)(90... 90586
$2.4K
#741
DEXTROSE 5%-0.9% NAC... J7042
$2.4K
#742
PELLOGRAFT, PER SQ C... Q4320
$2.2K
#743
HYPERRHO* J2790
$2.2K
#744
POLOCAINE-MPF* J0670
$2.1K
#745
NAFCILLIN SODIUM J2290
$2K
#746
AZACTAM* J0457
$2K
#747
FLUPHENAZINE DECANOA... J2680
$1.9K
#748
ATIVAN* J2060
$1.8K
#749
ACETAMINOPHEN(J0136) J0136
$1.7K
#750
BICILLIN C-R J0558
$1.7K
Total claims — #665 of 824
#660
PRIMATRIX** Q4110
73
#661
HEMOFIL M* J7190
72
#662
EPIEFFECT, PER SQ CM... Q4278
72
#663
CONRAY Q9961
71
#664
ALKERAN* J9245
70
#665
NAFCILLIN SODIUM J2290
69
#666
ENGERIX-B PEDIATRIC-... 90744
68
#667
LUMIZYME J0221
68
#668
BUSULFAN* J0594
68
#669
ARANESP(J0882) J0882
68
#670
POMBILITI J1203
68
Top Medicare Part B drugs by the selected metric. Click any drug to open its J-code page. Source: CMS Medicare Quarterly Part B Spending by Drug.
Full breakdown by period (2)
| Period | Total spend | Beneficiaries | Claims | $/beneficiary | $/claim |
|---|---|---|---|---|---|
| 2026 (Q1) | $2K | — | 69 | — | $29.70 |
| 2025 (Q1-Q4) | $34.2K | — | 66 | — | $517.85 |
Provider-administered (Part B) spend, calculated for the whole HCPCS code (CMS does not publish Medicare spend per individual NDC). Self-administered use is covered under Part D instead. A blank patient count means fewer than 11 people — CMS hides counts that small to protect privacy. Source: CMS Medicare Quarterly Part B Spending by Drug (data.cms.gov), updated quarterly.
📈 Medicare Part B claims detail CMS PSPS · 2024
Calendar-year 2024 Medicare Part B fee-for-service activity for this HCPCS code, summed across all carriers, localities and specialties (CMS Physician/Supplier Procedure Summary). A “service” is one billed line/unit — not one claim — so counts run higher than claim counts.
Allowed charges
$34.7K
Medicare paid
$27.2K
Submitted services
681,859
Denial rate
92.0%
Allowed / service
$0.63
Submitted charges
$689.2K
Source: CMS Physician/Supplier Procedure Summary (PSPS), CY2024 — Medicare Part B carrier + DME fee-for-service claims (excludes Medicare Advantage). Figures are for the whole HCPCS code, which may cover uses beyond this drug. ⚠ CMS hides any figure covering fewer than 11 patients (a privacy rule), so totals — especially denials and low-volume codes — run a little low.
📊 What bills under J2290
J-codes are billing codes often used for drugs billed under the medical benefit. This connects the billing code to the NDC package records it covers, by ingredient and labeler.
NDC products by ingredient
NDC products by labeler
🗃️ Data sources & freshness
Every figure on this page is computed from public datasets. Here's what each section draws on and how current it is.
HCPCS code & descriptor
CMS HCPCS Level II code file
Not available in current dataset
Payment limit & billing unit
CMS Medicare Part B ASP Pricing File (quarterly)
Q3 2026 · as of 2026-08-20
NDC ↔ HCPCS crosswalk
CMS ASP NDC-HCPCS crosswalk + DMEPDAC (PDAC)
34 NDCs mapped
NADAC acquisition cost
CMS National Average Drug Acquisition Cost (weekly)
Not available for mapped NDCs
Utilization & spend
CMS Part B Spending by Drug · PSPS · Physician & Other Practitioners
Latest data year 2026
Figures are estimates for reference and may lag the source files. Always verify against the current CMS files and your payer's policy before submitting claims.
⚠️ Practical billing caveats
- A crosswalk is not coverage. An NDC mapping or a published payment limit does not guarantee a payer will cover or pay this code. Check the specific plan's policy.
- Units ≠ milligrams. Bill the number of HCPCS units (dose ÷ the code's unit size), not the milligram dose. Use the calculator above.
- Discarded drug. For single-dose vials, drug discarded after administration may be separately billable with modifier JW (and JZ when nothing is discarded) where the payer allows.
- Rounding & partial units. Many payers require whole units; round per the payer's policy, not automatically up.
- The code can cover more than this drug. Some HCPCS codes span multiple products or strengths — confirm the exact code for the product administered.
- Figures lag. ASP limits change quarterly and utilization data are released with a delay. Verify against the current CMS files before billing.
❓ J2290 billing FAQ
What is HCPCS code J2290?
J2290 is a HCPCS Level II J-code used to bill Inj, nafcillin sodium, 20 mg under Medicare Part B and most medical (not pharmacy) benefits.
What is the billing unit for J2290?
One unit of J2290 represents 20 MG. Report the number of units equal to the dose administered divided by 20 MG.
How many units of J2290 should I bill?
Divide the dose administered by the code's unit size (20 MG) to get the number of billing units, then round per your payer's policy. The calculator on this page converts a dose into billing units and projects a full course.
How much does Medicare pay for J2290?
The Medicare Part B payment limit is $0.047 per unit (Q3 2026), based on ASP + 6%. After the 2% sequester the effective payment is about $0.046 per unit. Payment limits are revised quarterly.
Which NDCs bill under J2290?
34 NDCs currently map to J2290 in the CMS ASP NDC-HCPCS crosswalk. See the NDC crosswalk table above for each product, package, billing units and estimated reimbursement.
Does a crosswalk mean J2290 is covered?
No. An NDC-to-HCPCS crosswalk and a published payment limit do not guarantee coverage or payment. Coverage depends on the payer, the diagnosis and the site of care — always verify the current policy before billing.
For professional billing reference only — verify against the current CMS files before submitting claims.