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Acetaminophen 325 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 5... — RxCUI 1046751

RxNorm drug concept · Semantic clinical drug
RxCUI 1046751 Semantic clinical drug · SCD ● Current RxNorm concept 3 FDA products 4 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1046751
Official nameAcetaminophen 325 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral Tablet
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asAPAP 325 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral Tablet; acetaminophen 325 MG / diphenhydrAMINE HCl 25 MG / phenylephrine HCl 5 MG Oral Tablet
FDA products mapped3
Package NDCs mapped4
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Diphenhydramine Topical: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • It gives temporary relief of pain and itching on the skin. That includes minor burns, minor cuts or scrapes, insect bites, minor skin irritations, and rashes from poison ivy, oak o...
  • Adults and children 2 and older can apply it to the affected area no more than 3 to 4 times a day. Don't use it more often than directed. For a child under 2, check with a doctor f...
  • No. Don't use it on large areas of the body or on broken, blistered or oozing skin. Also avoid it on chicken pox or sunburn.
  • Can I put it on a large area or on blistered skin?
📖 Read our full Diphenhydramine Topical guide →

🕸️ Concept Web — How Acetaminophen 325 MG / diphenhydramine hydrochlo... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Acetaminophen 325 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral Tablet RxCUI 1046751

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 6

    The active substance itself — no strength, form, or brand attached yet.

    • Acetaminophen 161
    • Diphenhydramine 3498
    • Phenylephrine 8163
    • Acetaminophen / diphenhydramine / phenylephrine 689785
    • Diphenhydramine hydrochloride 1362
    • Phenylephrine hydrochloride 8164
  2. Dose forms 9

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Acetaminophen / diphenhydramine / phenylephrine Oral Tablet 602581
    • Acetaminophen / diphenhydramine hydrochloride / phenylephrine hydrochloride Oral Tablet 2647775
    • Acetaminophen / diphenhydramine / phenylephrine Oral Product 1151196
    • Acetaminophen / diphenhydramine / phenylephrine Pill 1151197
    • Acetaminophen / diphenhydramine hydrochloride / phenylephrine hydrochloride Oral Product 2659765
    • Acetaminophen / diphenhydramine hydrochloride / phenylephrine hydrochloride Pill 2661678
    • Oral Tablet 317541
    • Oral Product 1151131
    • +1 more in this family
  3. Clinical & branded drugs 3

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

    • Acetaminophen 325 MG 315263
    • Diphenhydramine hydrochloride 25 MG 901813
    • Phenylephrine hydrochloride 5 MG 1020198
  4. Packs 2

    Fixed collections of drugs packaged and sold together, like dose packs.

    • {1 (acetaminophen 325 MG / dextromethorphan hydrobromide 10 MG / guaifenesin 100 MG / phenylephrine hydrochloride 5 MG Oral Tablet) / 1 (acetaminophen 325 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral Tablet) } Pack 2634562
    • {1 (acetaminophen 325 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral Tablet) / 1 (acetaminophen 325 MG / guaifenesin 200 MG / phenylephrine hydrochloride 5 MG Oral Tablet) } Pack 2634818

Showing up to 8 concepts per family — 19 of 20 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

  • Acetaminophen 325 MG SCDC · 315263
  • Diphenhydramine hydrochloride 25 MG SCDC · 901813
  • Phenylephrine hydrochloride 5 MG SCDC · 1020198
  • Acetaminophen / diphenhydramine / phenylephrine Oral Tablet SCDF · 602581
  • Acetaminophen / diphenhydramine hydrochloride / phenylephrine hydrochloride Oral Tablet SCDFP · 2647775
  • Acetaminophen / diphenhydramine / phenylephrine Oral Product SCDG · 1151196
  • Acetaminophen / diphenhydramine / phenylephrine Pill SCDG · 1151197
  • Acetaminophen / diphenhydramine hydrochloride / phenylephrine hydrochloride Oral Product SCDGP · 2659765
  • Acetaminophen / diphenhydramine hydrochloride / phenylephrine hydrochloride Pill SCDGP · 2661678
  • {1 (acetaminophen 325 MG / dextromethorphan hydrobromide 10 MG / guaifenesin 100 MG / phenylephrine hydrochloride 5 MG Oral Tablet) / 1 (acetaminophen 325 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral Tablet) } Pack GPCK · 2634562

📦 FDA Products & Package NDCs

3 products · 4 package NDCs
4 package NDCs map to RxCUI 1046751 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
00363-5430-09 2 BLISTER PACK in 1 CARTON (0363-5430-09) / 10 TABLET, FILM... Allergy Relief Walgreen Company 2021-11-04
49035-0543-09 2 BLISTER PACK in 1 CARTON (49035-543-09) / 10 TABLET, FILM... Severe Allergy Plus Sinus Headache Wal-Mart Stores Inc 2007-06-27
49035-0543-41 10 TABLET, FILM COATED in 1 BLISTER PACK (49035-543-41) Severe Allergy Plus Sinus Headache Wal-Mart Stores Inc 2007-06-27
59779-0543-09 2 BLISTER PACK in 1 CARTON (59779-543-09) / 10 TABLET, FILM... Severe Allergy And Sinus Headache Maximum Strength CVS Pharmacy 2007-06-27
Observed labelers: Wal-Mart Stores Inc (2) · CVS Pharmacy (1) · Walgreen Company (1) — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.