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Diphenhydramine hydrochloride 25 MG Oral Tablet — RxCUI 1049630

RxNorm drug concept · Semantic clinical drug
RxCUI 1049630 Semantic clinical drug · SCD ● Current RxNorm concept 214 FDA products 359 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1049630
Official nameDiphenhydramine hydrochloride 25 MG Oral Tablet
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asdiphenhydrAMINE HCl 25 MG Oral Tablet
FDA products mapped214
Package NDCs mapped359
Reported Medicaid activity (SDUD)150,203 prescriptions · 38 state & territory Medicaid programs · latest period Q4 2025
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Diphenhydramine Topical: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • You can use it for temporary relief of pain and itching from everyday skin problems — things like insect bites, minor burns, minor cuts and scrapes, and general skin irritations. I...
  • What can I actually use this cream or spray for?
  • You can apply it up to 3 to 4 times a day, but no more than that. More frequent use isn't going to help more — and the label is clear that you shouldn't exceed that limit. For kids...
  • This is really important — do not use this topical product at the same time as any other product that contains diphenhydramine, even a pill or capsule. That includes allergy medici...
📖 Read our full Diphenhydramine Topical guide →

🕸️ Concept Web — How Diphenhydramine hydrochloride 25 MG Oral Tablet Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Diphenhydramine hydrochloride 25 MG Oral Tablet RxCUI 1049630

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 2

    The active substance itself — no strength, form, or brand attached yet.

    • Diphenhydramine 3498
    • Diphenhydramine hydrochloride 1362
  2. Brand names 8

    The same medicine's trade names. A brand name alone says nothing about strength or form.

    • Banophen 215558
    • Benadryl 203457
    • Nytol 1092413
    • Rest Simply 1101108
    • Simply Sleep 262241
    • Sominex 152371
    • Wal-Dryl Allergy 1090073
    • Wal-Sleep Z 1363470
  3. Dose forms 41

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Diphenhydramine Oral Tablet 371892
    • Diphenhydramine hydrochloride Oral Tablet 2649122
    • Diphenhydramine Oral Product 1158449
    • Diphenhydramine Pill 1158450
    • Diphenhydramine hydrochloride Oral Product 2659104
    • Diphenhydramine hydrochloride Pill 2659100
    • Diphenhydramine Oral Tablet [Banophen] 369215
    • Diphenhydramine Oral Tablet [Benadryl] 369212
    • +33 more in this family
  4. Clinical & branded drugs 17

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

Showing up to 8 concepts per family — 26 of 68 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

  • Diphenhydramine hydrochloride 25 MG SCDC · 901813
  • Diphenhydramine Oral Tablet SCDF · 371892
  • Diphenhydramine hydrochloride Oral Tablet SCDFP · 2649122
  • Diphenhydramine Oral Product SCDG · 1158449
  • Diphenhydramine Pill SCDG · 1158450
  • Diphenhydramine hydrochloride Oral Product SCDGP · 2659104
  • Diphenhydramine hydrochloride Pill SCDGP · 2659100

Brand-Name Concepts

📦 FDA Products & Package NDCs

214 products · 359 package NDCs
359 package NDCs map to RxCUI 1049630 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
63868-0492-24 2 BLISTER PACK in 1 CARTON (63868-492-24) / 12 TABLET, COAT... Allergy Relief Chain Drug Marketing Association 2014-06-13
63868-0611-32 4 BLISTER PACK in 1 CARTON (63868-611-32) / 8 TABLET in 1 B... Nighttime Sleep Aid Chain Drug Marketing Association 2007-06-25
63868-0772-10 1 BOTTLE, PLASTIC in 1 CARTON (63868-772-10) / 100 TABLET,... Rest Simply Chain Drug Marketing Association 2014-06-13
63868-0772-24 2 BLISTER PACK in 1 CARTON (63868-772-24) / 12 TABLET, COAT... Rest Simply Chain Drug Marketing Association 2014-06-13
63941-0090-01 2 BLISTER PACK in 1 CARTON (63941-090-01) / 12 TABLET, COAT... Allergy Relief VALU MERCHANDISERS COMPANY 2017-05-19
63941-0090-03 1 BOTTLE, PLASTIC in 1 CARTON (63941-090-03) / 100 TABLET,... Allergy Relief VALU MERCHANDISERS COMPANY 2017-02-27
63941-0091-01 4 BLISTER PACK in 1 CARTON (63941-091-01) / 6 TABLET, COATE... Nighttime Sleep Aid VALU MERCHANDISERS COMPANY 2010-02-25
63941-0219-01 4 BLISTER PACK in 1 CARTON (63941-219-01) / 4 TABLET in 1 B... Nighttime Sleep Aid VALU MERCHANDISERS COMPANY 2017-01-19
63981-0329-78 600 TABLET, FILM COATED in 1 BOTTLE, PLASTIC (63981-329-78) Allergy Medicine COSTCO WHOLESALE CORPORATION 1990-03-02
64024-0479-78 1 BOTTLE in 1 CARTON (64024-479-78) / 100 TABLET in 1 BOTTL... welby allergy relief Aldi Inc 2017-07-14
66715-5154-08 3 BLISTER PACK in 1 CARTON (66715-5154-8) / 12 TABLET, COAT... Allergy, Circle K Lil' Drug Store Products, Inc. 2021-07-12
66715-5503-08 2 BLISTER PACK in 1 CARTON (66715-5503-8) / 12 TABLET, FILM... Sleep-Aid, Circle K Lil' Drug Store Products, Inc. 2021-12-20
66715-5554-03 3 POUCH in 1 CARTON (66715-5554-3) / 2 TABLET, FILM COATED... Circle K Allergy Antihistamine Lil' Drug Store Products, Inc. 2019-10-15
66715-6314-08 3 BLISTER PACK in 1 CARTON (66715-6314-8) / 12 TABLET, COAT... Allergy 36ct, Caseys 4good Lil' Drug Store Products, Inc. 2023-08-01
66715-6406-02 2 POUCH in 1 CARTON (66715-6406-2) / 2 TABLET, FILM COATED... Benadryl Lil' Drug Store Products, Inc. 2022-11-28
66715-6406-07 25 POUCH in 1 BOX, UNIT-DOSE (66715-6406-7) / 2 TABLET, FIL... Benadryl Lil' Drug Store Products, Inc. 2022-04-19
66715-6406-08 30 POUCH in 1 BOX, UNIT-DOSE (66715-6406-8) / 2 TABLET, FIL... Benadryl Lil' Drug Store Products, Inc. 2022-04-19
66715-6506-02 2 POUCH in 1 CARTON (66715-6506-2) / 2 TABLET, FILM COATED... Benadryl Lil' Drug Store Products, Inc. 2022-05-06
66715-6514-08 2 BLISTER PACK in 1 CARTON (66715-6514-8) / 12 TABLET, COAT... Allergy Relief, 24-7 Lift by 7-Eleven Lil' Drug Store products, Inc. 2022-04-19
66715-6643-08 2 BLISTER PACK in 1 CARTON (66715-6643-8) / 12 TABLET, FILM... Sleep-Aid, Lil Drug Store Lil' Drug Store Products, Inc. 2021-12-20
66715-6914-08 3 BLISTER PACK in 1 CARTON (66715-6914-8) / 12 TABLET, COAT... Allergy, Lil Drug Store Lil' Drug Store Products, Inc. 2021-07-12
66715-8157-03 1 BLISTER PACK in 1 CARTON (66715-8157-3) / 6 TABLET, FILM... Allergy Relief, 24-7 Life by 7-Eleven Lil' Drug Store Products, Inc. 2022-05-06
66715-9706-02 2 POUCH in 1 CARTON (66715-9706-2) / 2 TABLET, FILM COATED... Benadryl Lil' Drug Store Products, Inc. 2018-12-14
66715-9706-03 3 POUCH in 1 CARTON (66715-9706-3) / 2 TABLET, FILM COATED... Benadryl Lil' Drug Store Products, Inc. 2018-12-14
66715-9711-07 50 POUCH in 1 BOX, UNIT-DOSE (66715-9711-7) / 2 TABLET in 1... Allergy Lil' Drug Store Products, Inc. 2014-09-12
67091-0115-10 1 BOTTLE, PLASTIC in 1 CARTON (67091-115-10) / 100 TABLET,... Nighttime Sleep Aid WinCo Foods, LLC 2000-06-10
67091-0200-10 1 BOTTLE, PLASTIC in 1 CARTON (67091-200-10) / 100 TABLET,... Allergy Relief Complete WinCo Foods, LLC 1990-03-02
67091-0200-24 2 BLISTER PACK in 1 CARTON (67091-200-24) / 12 TABLET, FILM... Allergy Relief Complete WinCo Foods, LLC 1990-03-02
67091-0339-24 2 BLISTER PACK in 1 CARTON (67091-339-24) / 12 TABLET, FILM... Sleep Aid WinCo Foods, LLC 2019-11-19
67414-0226-00 2500 POUCH in 1 BOX (67414-226-00) / 2 TABLET, FILM COATED... Benadryl Allergy Ultratab Jones Healthcare Group - Packaging Services, Inc 2018-01-24
67414-0226-54 60 POUCH in 1 CARTON (67414-226-54) / 2 TABLET, FILM COATED... Benadryl Allergy Ultratab Jones Healthcare Group - Packaging Services, Inc 2018-01-24
67751-0166-01 1 POUCH in 1 CARTON (67751-166-01) / 2 TABLET, FILM COATED... Benadryl Ultratabs Navajo Manufacturing Company Inc. 2016-09-22
67751-0166-02 1 POUCH in 1 CARTON (67751-166-02) / 4 TABLET, FILM COATED... Benadryl Ultratabs Navajo Manufacturing Company Inc. 2016-09-22
67751-0221-01 1 BLISTER PACK in 1 CARTON (67751-221-01) / 8 TABLET, FILM... Sominex Navajo Manufacturing Company Inc. 2012-06-01
68094-0018-61 10 BLISTER PACK in 1 CARTON (68094-018-61) / 10 TABLET in 1... Diphenhydramine Hydrochloride Precision Dose, Inc. 2019-07-15
68196-0160-60 600 TABLET in 1 BOTTLE (68196-160-60) Allergy Relief SAM'S WEST INC 2024-07-01
68196-0829-78 600 TABLET, FILM COATED in 1 BOTTLE, PLASTIC (68196-829-78) Aller-Ben Sam's West Inc 2020-02-18
68391-0160-33 600 TABLET, FILM COATED in 1 BOTTLE (68391-160-33) Allergy Relief BJWC (Berkley & Jensen / BJ's) 2025-08-20
68391-0200-79 400 TABLET in 1 BOTTLE (68391-200-79) Berkley and Jensen Allergy Relief BJWC 2013-12-10
68788-8104-00 10 TABLET, COATED in 1 BOTTLE (68788-8104-0) Geri-Dryl allergy relief Preferred Pharmaceuticals Inc. 2021-10-21
68788-8104-01 15 TABLET, COATED in 1 BOTTLE (68788-8104-1) Geri-Dryl allergy relief Preferred Pharmaceuticals Inc. 2021-10-21
68788-8104-03 304 TABLET, COATED in 1 BOTTLE (68788-8104-3) Geri-Dryl allergy relief Preferred Pharmaceuticals Inc. 2021-10-21
68998-0090-03 1 BOTTLE, PLASTIC in 1 CARTON (68998-090-03) / 100 TABLET,... Allergy Relief Marc Glassman, Inc. 2008-03-01
68998-0091-01 2 BLISTER PACK in 1 CARTON (68998-091-01) / 12 TABLET, COAT... Rest Simply Marc Glassman, Inc. 2008-12-31
69168-0002-93 24 TABLET, COATED in 1 CARTON (69168-002-93) Diphenhydramine HCl 25mg Allegiant Health 2021-11-23
69168-0048-01 100 TABLET in 1 BOTTLE (69168-048-01) Allergy Allegiant Health 2014-12-15
69168-0048-20 600 TABLET in 1 BOTTLE (69168-048-20) Allergy Allegiant Health 2020-03-22
69168-0048-93 2 BLISTER PACK in 1 BOX (69168-048-93) / 12 TABLET in 1 BLI... Allergy Allegiant Health 2014-12-15
69168-0048-98 200 TABLET in 1 BOTTLE (69168-048-98) Allergy Allegiant Health 2022-05-18
69168-0247-24 24 TABLET in 1 BOTTLE, UNIT-DOSE (69168-247-24) Sleep Tabs For Nighttime use Allegiant Health 2015-04-28
Observed labelers: Lil' Drug Store Products, Inc. (18) · Kenvue Brands LLC (13) · CVS Pharmacy (11) · Walgreen Company (11) · Allegiant Health (10) · DOLGENCORP, LLC (9) · +102 more — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.