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Diphenhydramine hydrochloride 25 MG Oral Tablet — RxCUI 1049630

RxNorm drug concept · Semantic clinical drug
RxCUI 1049630 Semantic clinical drug · SCD ● Current RxNorm concept 214 FDA products 359 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1049630
Official nameDiphenhydramine hydrochloride 25 MG Oral Tablet
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asdiphenhydrAMINE HCl 25 MG Oral Tablet
FDA products mapped214
Package NDCs mapped359
Reported Medicaid activity (SDUD)150,203 prescriptions · 38 state & territory Medicaid programs · latest period Q4 2025
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Diphenhydramine Topical: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • You can use it for temporary relief of pain and itching from everyday skin problems — things like insect bites, minor burns, minor cuts and scrapes, and general skin irritations. I...
  • What can I actually use this cream or spray for?
  • You can apply it up to 3 to 4 times a day, but no more than that. More frequent use isn't going to help more — and the label is clear that you shouldn't exceed that limit. For kids...
  • This is really important — do not use this topical product at the same time as any other product that contains diphenhydramine, even a pill or capsule. That includes allergy medici...
📖 Read our full Diphenhydramine Topical guide →

🕸️ Concept Web — How Diphenhydramine hydrochloride 25 MG Oral Tablet Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Diphenhydramine hydrochloride 25 MG Oral Tablet RxCUI 1049630

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 2

    The active substance itself — no strength, form, or brand attached yet.

    • Diphenhydramine 3498
    • Diphenhydramine hydrochloride 1362
  2. Brand names 8

    The same medicine's trade names. A brand name alone says nothing about strength or form.

    • Banophen 215558
    • Benadryl 203457
    • Nytol 1092413
    • Rest Simply 1101108
    • Simply Sleep 262241
    • Sominex 152371
    • Wal-Dryl Allergy 1090073
    • Wal-Sleep Z 1363470
  3. Dose forms 41

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Diphenhydramine Oral Tablet 371892
    • Diphenhydramine hydrochloride Oral Tablet 2649122
    • Diphenhydramine Oral Product 1158449
    • Diphenhydramine Pill 1158450
    • Diphenhydramine hydrochloride Oral Product 2659104
    • Diphenhydramine hydrochloride Pill 2659100
    • Diphenhydramine Oral Tablet [Banophen] 369215
    • Diphenhydramine Oral Tablet [Benadryl] 369212
    • +33 more in this family
  4. Clinical & branded drugs 17

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

Showing up to 8 concepts per family — 26 of 68 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

  • Diphenhydramine hydrochloride 25 MG SCDC · 901813
  • Diphenhydramine Oral Tablet SCDF · 371892
  • Diphenhydramine hydrochloride Oral Tablet SCDFP · 2649122
  • Diphenhydramine Oral Product SCDG · 1158449
  • Diphenhydramine Pill SCDG · 1158450
  • Diphenhydramine hydrochloride Oral Product SCDGP · 2659104
  • Diphenhydramine hydrochloride Pill SCDGP · 2659100

Brand-Name Concepts

📦 FDA Products & Package NDCs

214 products · 359 package NDCs
359 package NDCs map to RxCUI 1049630 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
69168-0263-30 30 TABLET in 1 BOTTLE (69168-263-30) Sleep Aid Allegiant Health 2015-03-03
69168-0263-54 1 BAG in 1 CARTON (69168-263-54) / 16458 TABLET in 1 BAG Sleep Aid Allegiant Health 2025-05-08
69168-0263-93 24 TABLET in 1 BOX (69168-263-93) Sleep Aid Allegiant Health 2015-03-03
69168-0263-98 200 TABLET in 1 BOTTLE (69168-263-98) Sleep Aid Allegiant Health 2021-07-23
69452-0444-31 600 TABLET in 1 BOTTLE (69452-444-31) Allergy Relief BIONPHARMA INC. 2025-06-24
69517-0003-01 100 TABLET in 1 BOTTLE (69517-003-01) Allergy Relief HealthLife of USA LLC 2025-09-17
69517-0003-03 300 TABLET in 1 BOTTLE (69517-003-03) Allergy Relief HealthLife of USA LLC 2025-09-17
69517-0003-06 600 TABLET in 1 BOTTLE (69517-003-06) Allergy Relief HealthLife of USA LLC 2025-09-17
69517-0003-10 1000 TABLET in 1 BOTTLE (69517-003-10) Allergy Relief HealthLife of USA LLC 2025-09-17
69517-0004-03 300 TABLET, COATED in 1 BOTTLE (69517-004-03) Nighttime Sleep Aid HealthLife of USA LLC 2025-09-25
69517-0004-06 600 TABLET, COATED in 1 BOTTLE (69517-004-06) Nighttime Sleep Aid HealthLife of USA LLC 2025-09-25
69517-0004-10 1000 TABLET, COATED in 1 BOTTLE (69517-004-10) Nighttime Sleep Aid HealthLife of USA LLC 2025-09-25
69618-0025-01 100 TABLET in 1 BOTTLE, PLASTIC (69618-025-01) Diphenhydramine HCL 25 mg Reliable 1 Laboratories LLC 2015-11-01
69842-0672-51 365 TABLET, FILM COATED in 1 BOTTLE, PLASTIC (69842-672-51) Sleep-Aid Nighttime CVS PHARMACY 2015-07-24
69842-0834-51 365 TABLET, FILM COATED in 1 BOTTLE (69842-834-51) DIPHENHYDRAMINE HYDROCHLORIDE CVS Pharmacy, Inc. 2018-07-23
69842-0834-55 500 TABLET, FILM COATED in 1 BOTTLE (69842-834-55) DIPHENHYDRAMINE HYDROCHLORIDE CVS Pharmacy, Inc. 2019-01-22
69842-0981-08 1 BOTTLE in 1 CARTON (69842-981-08) / 200 TABLET, FILM COAT... Diphenhydramine Hydrochloride CVS Pharmacy, Inc 2020-09-23
70000-0136-01 2 BLISTER PACK in 1 CARTON (70000-0136-1) / 12 TABLET, FILM... Allergy Relief Cardinal Health 110, LLC. DBA Leader 1990-03-02
70000-0136-02 4 BLISTER PACK in 1 CARTON (70000-0136-2) / 12 TABLET, FILM... Allergy Relief Cardinal Health 110, LLC. DBA Leader 1990-03-02
70000-0136-03 1 BOTTLE, PLASTIC in 1 CARTON (70000-0136-3) / 100 TABLET,... Allergy Relief Cardinal Health 110, LLC. DBA Leader 1990-03-02
70000-0244-01 2 BLISTER PACK in 1 CARTON (70000-0244-1) / 12 TABLET, FILM... Sleep Aid Cardinal Health 110, LLC. DBA Leader 2000-06-10
70264-0024-01 30 POUCH in 1 CARTON (70264-024-01) / 2 TABLET, FILM COATED... Benadryl Allergy R J General Corporation 2022-12-26
70677-1014-01 2 BLISTER PACK in 1 CARTON (70677-1014-1) / 12 TABLET, FILM... Allergy Relief Strategic Sourcing Services LLC 2023-03-28
70677-1014-02 1 BOTTLE, PLASTIC in 1 CARTON (70677-1014-2) / 100 TABLET,... Allergy Relief Strategic Sourcing Services LLC 2026-03-11
70677-1128-01 2 BLISTER PACK in 1 CARTON (70677-1128-1) / 12 TABLET, FILM... Nighttime Sleep Aid Strategic Sourcing Services LLC 2023-05-18
70677-1238-01 120 TABLET, FILM COATED in 1 BOTTLE (70677-1238-1) Allergy Relief Strategic Sourcing Services, LLC 2024-01-24
70692-0011-06 1 BOTTLE in 1 CARTON (70692-011-06) / 60 TABLET in 1 BOTTLE GOOD REMEDIES Nighttime Sleep Aid Caplets Strive Pharmaceuticals Inc. 2024-10-28
70692-0022-06 1 BOTTLE in 1 CARTON (70692-022-06) / 60 TABLET in 1 BOTTLE GOOD REMEDIES Allergy Relief Strive Pharmaceuticals Inc. 2024-10-28
70692-0148-01 100 TABLET in 1 PACKAGE (70692-148-01) Diphenhydramine Hydrochloride 25mg Strive Pharmaceuticals Inc 2018-12-28
70692-0148-11 1000 TABLET in 1 BOTTLE (70692-148-11) Diphenhydramine Hydrochloride 25mg Strive Pharmaceuticals Inc 2021-06-01
70692-0148-40 400 TABLET in 1 BOTTLE (70692-148-40) Diphenhydramine Hydrochloride 25mg Strive Pharmaceuticals Inc 2021-06-01
70692-0148-46 1 BOTTLE in 1 CARTON (70692-148-46) / 72 TABLET in 1 BOTTLE Diphenhydramine Hydrochloride 25mg Strive Pharmaceuticals Inc 2023-04-06
70692-0148-62 600 TABLET in 1 BOTTLE (70692-148-62) Diphenhydramine Hydrochloride 25mg Strive Pharmaceuticals Inc 2021-06-01
70692-0151-46 1 BOTTLE in 1 CARTON (70692-151-46) / 72 TABLET, COATED in... Nighttime Sleep Aid Strive Pharmaceuticals Inc. 2023-04-06
71141-0177-32 1 BOTTLE, PLASTIC in 1 CARTON (71141-177-32) / 100 TABLET,... Allergy Relief Lidl US LLC 2023-05-15
71205-0521-06 3 POUCH in 1 BAG (71205-521-06) / 2 TABLET, FILM COATED in... Benadryl Proficient Rx LP 2021-01-01
71205-0611-20 20 TABLET, FILM COATED in 1 BOTTLE, PLASTIC (71205-611-20) Banophen Proficient Rx LP 2021-10-11
71205-0611-30 30 TABLET, FILM COATED in 1 BOTTLE, PLASTIC (71205-611-30) Banophen Proficient Rx LP 2021-10-11
71205-0611-60 60 TABLET, FILM COATED in 1 BOTTLE, PLASTIC (71205-611-60) Banophen Proficient Rx LP 2021-10-11
71205-0611-90 90 TABLET, FILM COATED in 1 BOTTLE, PLASTIC (71205-611-90) Banophen Proficient Rx LP 2021-10-11
71679-0308-00 100000 TABLET, FILM COATED in 1 BOTTLE (71679-308-00) Diphenhydramine Hydrochloride Health Pharma USA LLC 2026-06-27
71679-0311-00 100000 TABLET, FILM COATED in 1 BOX (71679-311-00) Diphenhydramine Hydrochloride Health Pharma USA LLC 2024-03-07
72036-0019-02 4 BLISTER PACK in 1 CARTON (72036-019-02) / 8 TABLET in 1 B... Somnitabs HARRIS TEETER 2011-10-06
72036-0090-01 2 BLISTER PACK in 1 CARTON (72036-090-01) / 12 TABLET, COAT... Allergy Relief Harris Teeter 2012-08-06
72036-0091-01 2 BLISTER PACK in 1 CARTON (72036-091-01) / 12 TABLET, COAT... Rest Simply Harris Teeter 2011-10-06
72090-0020-10 100 TABLET in 1 BOTTLE (72090-020-10) Sleep Aid Pioneer Life Sciences, LLC 2020-06-29
72090-0021-10 1000 TABLET in 1 BOTTLE (72090-021-10) Allergy Relief Pioneer Life Sciences, LLC 2024-05-13
72090-0021-60 600 TABLET in 1 BOTTLE (72090-021-60) Allergy Relief Pioneer Life Sciences, LLC 2020-06-29
72090-0029-01 1000 TABLET in 1 BOTTLE (72090-029-01) Allergy Relief Pioneer Life Sciences, LLC 2024-05-13
72090-0029-60 600 TABLET in 1 BOTTLE (72090-029-60) Allergy Relief Pioneer Life Sciences, LLC 2023-10-25
Observed labelers: Lil' Drug Store Products, Inc. (18) · Kenvue Brands LLC (13) · CVS Pharmacy (11) · Walgreen Company (11) · Allegiant Health (10) · DOLGENCORP, LLC (9) · +102 more — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.