Home › NDC Lookup › RxCUI directory › RxCUI 1049630

Diphenhydramine hydrochloride 25 MG Oral Tablet — RxCUI 1049630

RxNorm drug concept · Semantic clinical drug
RxCUI 1049630 Semantic clinical drug · SCD ● Current RxNorm concept 214 FDA products 359 package NDCs Snapshot Jul 14, 2026

This page is curated, coded, and maintained by

Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1049630
Official nameDiphenhydramine hydrochloride 25 MG Oral Tablet
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asdiphenhydrAMINE HCl 25 MG Oral Tablet
FDA products mapped214
Package NDCs mapped359
Reported Medicaid activity (SDUD)150,203 prescriptions · 38 state & territory Medicaid programs · latest period Q4 2025
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Diphenhydramine Topical: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • You can use it for temporary relief of pain and itching from everyday skin problems — things like insect bites, minor burns, minor cuts and scrapes, and general skin irritations. I...
  • What can I actually use this cream or spray for?
  • You can apply it up to 3 to 4 times a day, but no more than that. More frequent use isn't going to help more — and the label is clear that you shouldn't exceed that limit. For kids...
  • This is really important — do not use this topical product at the same time as any other product that contains diphenhydramine, even a pill or capsule. That includes allergy medici...
📖 Read our full Diphenhydramine Topical guide →

🕸️ Concept Web — How Diphenhydramine hydrochloride 25 MG Oral Tablet Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Diphenhydramine hydrochloride 25 MG Oral Tablet RxCUI 1049630

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 2

    The active substance itself — no strength, form, or brand attached yet.

    • Diphenhydramine 3498
    • Diphenhydramine hydrochloride 1362
  2. Brand names 8

    The same medicine's trade names. A brand name alone says nothing about strength or form.

    • Banophen 215558
    • Benadryl 203457
    • Nytol 1092413
    • Rest Simply 1101108
    • Simply Sleep 262241
    • Sominex 152371
    • Wal-Dryl Allergy 1090073
    • Wal-Sleep Z 1363470
  3. Dose forms 41

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Diphenhydramine Oral Tablet 371892
    • Diphenhydramine hydrochloride Oral Tablet 2649122
    • Diphenhydramine Oral Product 1158449
    • Diphenhydramine Pill 1158450
    • Diphenhydramine hydrochloride Oral Product 2659104
    • Diphenhydramine hydrochloride Pill 2659100
    • Diphenhydramine Oral Tablet [Banophen] 369215
    • Diphenhydramine Oral Tablet [Benadryl] 369212
    • +33 more in this family
  4. Clinical & branded drugs 17

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

Showing up to 8 concepts per family — 26 of 68 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

  • Diphenhydramine hydrochloride 25 MG SCDC · 901813
  • Diphenhydramine Oral Tablet SCDF · 371892
  • Diphenhydramine hydrochloride Oral Tablet SCDFP · 2649122
  • Diphenhydramine Oral Product SCDG · 1158449
  • Diphenhydramine Pill SCDG · 1158450
  • Diphenhydramine hydrochloride Oral Product SCDGP · 2659104
  • Diphenhydramine hydrochloride Pill SCDGP · 2659100

Brand-Name Concepts

📦 FDA Products & Package NDCs

214 products · 359 package NDCs
359 package NDCs map to RxCUI 1049630 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
72090-0040-01 1000 TABLET in 1 BOTTLE (72090-040-01) Allergy Relief Pioneer Life Sciences, LLC 2025-03-04
72090-0040-02 600 TABLET in 1 BOTTLE (72090-040-02) Allergy Relief Pioneer Life Sciences, LLC 2025-03-04
72288-0479-78 1 BOTTLE in 1 CARTON (72288-479-78) / 100 TABLET in 1 BOTTL... basic care allergy relief Amazon.com Services LLC 2020-07-28
72288-0479-79 400 TABLET in 1 BOTTLE (72288-479-79) basic care allergy relief Amazon.com Services LLC 2020-11-10
73097-0004-02 1 POUCH in 1 CARTON (73097-004-02) / 2 TABLET, FILM COATED... Benadryl Allergy Ultratab Savings Distributors LLC 2019-07-03
73097-0004-40 20 POUCH in 1 CARTON (73097-004-40) / 2 TABLET, FILM COATED... Benadryl Allergy Ultratab Savings Distributors LLC 2019-07-03
73097-0004-50 25 POUCH in 1 CARTON (73097-004-50) / 2 TABLET, FILM COATED... Benadryl Allergy Ultratab Savings Distributors LLC 2019-07-03
73376-0003-80 1000 mg in 1 BOTTLE (73376-003-80) Diphenhydramine HCl INVAHEALTH INC 2022-07-28
76168-0015-07 1 BOTTLE in 1 CARTON (76168-015-07) / 36 TABLET, FILM COATE... Sleep Aid Velocity Pharma LLC 2018-05-14
76168-0015-12 1 BOTTLE in 1 CARTON (76168-015-12) / 100 TABLET, FILM COAT... Sleep Aid Velocity Pharma LLC 2018-05-14
76168-0121-12 100 CARTON in 1 BOTTLE (76168-121-12) / 1 TABLET in 1 CARTO... Allergy Velocity Pharma LLC 2018-05-14
76457-0002-00 1 BOTTLE in 1 CARTON (76457-002-00) / 100 TABLET in 1 BOTTL... diphenhydramine hydrochloride Simpex Pharma Pvt. Ltd 2018-02-09
79481-0148-04 2 BLISTER PACK in 1 CARTON (79481-0148-4) / 12 TABLET in 1... meijer Allergy Relief Meijer, Inc. 2025-04-25
79481-0148-05 365 TABLET in 1 BOTTLE (79481-0148-5) meijer Allergy Relief Meijer, Inc. 2024-06-27
79481-0148-08 4 BLISTER PACK in 1 CARTON (79481-0148-8) / 12 TABLET in 1... meijer Allergy Relief Meijer, Inc. 2025-04-25
79481-0151-01 1 BOTTLE in 1 CARTON (79481-0151-1) / 100 TABLET in 1 BOTTL... meijer NIGHTTIME Sleep Aid CAPLET Meijer, Inc. 2024-06-27
79903-0056-10 1 BOTTLE in 1 CARTON (79903-056-10) / 100 TABLET, FILM COAT... ALLERGY RELIEF Wal-Mart Stores Inc 2021-01-28
79903-0056-30 365 TABLET, FILM COATED in 1 BOTTLE (79903-056-30) ALLERGY RELIEF Wal-Mart Stores Inc 2021-01-28
79903-0274-36 365 TABLET, FILM COATED in 1 BOTTLE (79903-274-36) equate nighttime sleep aid WALMART INC. 2024-12-10
79903-0297-10 1 BOTTLE in 1 CARTON (79903-297-10) / 100 TABLET in 1 BOTTL... equate allergy relief WALMART INC. 2024-11-19
79903-0491-10 1 BOTTLE in 1 CARTON (79903-491-10) / 100 TABLET, FILM COAT... Allergy Relief Walmart Inc. 2024-08-01
80136-0785-96 96 TABLET in 1 BOTTLE (80136-785-96) Nighttime Sleep-aid NORTHEAST PHARMA 2021-09-01
80267-0431-67 24 BLISTER PACK in 1 CARTON (80267-431-67) / 2 TABLET, FILM... Betr sleep aid Live Betr LLC 2021-01-25
80513-0383-22 220 TABLET in 1 BOTTLE (80513-383-22) NIGHT TIME SLEEP-AID Advanced Rx LLC 2024-08-01
80513-0722-06 600 TABLET in 1 BOTTLE (80513-722-06) Allergy Relief Advanced Rx LLC 2024-08-01
81522-0109-03 1 BOTTLE, PLASTIC in 1 CARTON (81522-109-03) / 100 TABLET,... Allergy Relief FSA STORE INC. 2023-01-11
82706-0021-02 50 POUCH in 1 CARTON (82706-021-02) / 2 TABLET in 1 POUCH AXIV Allergy Relief VIVUNT PHARMA LLC 2024-07-11
82725-1001-01 600 TABLET in 1 BOTTLE (82725-1001-1) Allergy Relief Cabinet Health, Inc 2024-11-01
82725-1101-01 600 TABLET in 1 BOTTLE (82725-1101-1) ValuMeds Allergy Relief Antihistamine Diphenhydramine HCl Cabinet Health P.B.C. 2025-01-01
82725-1101-02 1200 TABLET in 1 BOTTLE (82725-1101-2) ValuMeds Allergy Relief Antihistamine Diphenhydramine HCl Cabinet Health P.B.C. 2025-11-10
82725-3001-02 120 TABLET in 1 POUCH (82725-3001-2) Cabinet Allergy Relief Refill Diphenhydramine HCI Cabinet Health P.B.C. 2025-05-12
82725-4001-01 600 TABLET in 1 BOTTLE (82725-4001-1) Goodmeds Allergy Relief Diphenhydramine HCl Cabinet Health P.B.C. 2026-04-15
82725-4101-01 600 TABLET in 1 BOTTLE (82725-4101-1) Goodmeds Allergy Relief Diphenhydramine HCl Cabinet Health P.B.C. 2026-02-01
82725-4201-01 600 TABLET in 1 BOTTLE (82725-4201-1) Goodmeds Allergy Relief Cabinet Health P.B.C. 2026-05-10
83059-0021-03 1 BOTTLE in 1 CARTON (83059-0021-3) / 36 TABLET, COATED in... Allergy Relief Shield Pharmaceuticals Corp 2024-01-23
83112-0555-59 1 TABLET, FILM COATED in 1 PACKET (83112-555-59) Banophen Health Department, Oklahoma State 2025-01-31
83164-0000-01 1 BOTTLE in 1 BOX (83164-000-01) / 60 TABLET in 1 BOTTLE DORMMY-LON Haendel Farma, S.A. de C.V. 2023-01-04
83324-0088-01 1 BOTTLE, PLASTIC in 1 CARTON (83324-088-01) / 100 TABLET,... Allergy Relief CHAIN DRUG MARKETING ASSOCIATION, INC. 2024-08-12
83324-0088-03 1 BOTTLE, PLASTIC in 1 CARTON (83324-088-03) / 300 TABLET,... Allergy Relief CHAIN DRUG MARKETING ASSOCIATION, INC. 2024-08-12
83324-0088-24 2 BLISTER PACK in 1 CARTON (83324-088-24) / 12 TABLET, COAT... Allergy Relief CHAIN DRUG MARKETING ASSOCIATION, INC. 2024-08-12
83324-0110-32 4 BLISTER PACK in 1 CARTON (83324-110-32) / 8 TABLET in 1 B... Nighttime Sleep Aid CHAIN DRUG MARKETING ASSOCIATION, INC. 2024-08-12
83324-0113-01 1 BOTTLE, PLASTIC in 1 CARTON (83324-113-01) / 100 TABLET,... Rest Simply CHAIN DRUG MARKETING ASSOCIATION, INC. 2024-08-12
83324-0113-24 2 BLISTER PACK in 1 CARTON (83324-113-24) / 12 TABLET, COAT... Rest Simply CHAIN DRUG MARKETING ASSOCIATION, INC. 2024-08-12
83939-0683-01 1 TABLET, COATED in 1 BOTTLE (83939-0683-1) Geri-Dryl allergy relief VerityRx 2025-08-22
83939-0683-02 50 TABLET, COATED in 1 BOTTLE (83939-0683-2) Geri-Dryl allergy relief VerityRx 2025-08-22
83939-0683-03 100 TABLET, COATED in 1 BOTTLE (83939-0683-3) Geri-Dryl allergy relief VerityRx 2025-08-22
84324-0004-01 300 TABLET in 1 BOTTLE (84324-004-01) Allergy Relief NUVICARE LLC 2024-07-17
84324-0016-01 200 TABLET in 1 BOTTLE (84324-016-01) Sleep Aid NUVICARE LLC 2024-07-18
85766-0092-01 100 TABLET, COATED in 1 BOTTLE (85766-092-01) Geri-Dryl allergy relief Sportpharm LLC 2025-10-08
85766-0092-10 10 TABLET, COATED in 1 BOTTLE (85766-092-10) Geri-Dryl allergy relief Sportpharm LLC 2025-10-08
Observed labelers: Lil' Drug Store Products, Inc. (18) · Kenvue Brands LLC (13) · CVS Pharmacy (11) · Walgreen Company (11) · Allegiant Health (10) · DOLGENCORP, LLC (9) · +102 more — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.