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Diphenhydramine hydrochloride 2.5 MG/ML Oral Solution [Benadryl] — RxCUI 1049908

RxNorm drug concept · Semantic branded drug
RxCUI 1049908 Semantic branded drug · SBD ● Current RxNorm concept 3 FDA products 7 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1049908
Official nameDiphenhydramine hydrochloride 2.5 MG/ML Oral Solution [Benadryl]
Concept typeSemantic branded drug (SBD)
RxNorm statusCurrent RxNorm concept
Also known asBenadryl 2.5 MG/ML Oral Solution; Benadryl Children's Allergy 12.5 MG in 5 mL Oral Solution; Benadryl Children's Allergy 12.5 MG per 5 ML Oral Solution
FDA products mapped3
Package NDCs mapped7
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Diphenhydramine Topical: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • It gives temporary relief of pain and itching on the skin. That includes minor burns, minor cuts or scrapes, insect bites, minor skin irritations, and rashes from poison ivy, oak o...
  • Adults and children 2 and older can apply it to the affected area no more than 3 to 4 times a day. Don't use it more often than directed. For a child under 2, check with a doctor f...
  • No. Don't use it on large areas of the body or on broken, blistered or oozing skin. Also avoid it on chicken pox or sunburn.
  • Can I put it on a large area or on blistered skin?
📖 Read our full Diphenhydramine Topical guide →

🕸️ Concept Web — How Diphenhydramine hydrochloride 2.5 MG/ML Oral Sol... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Diphenhydramine hydrochloride 2.5 MG/ML Oral Solution [Benadryl] RxCUI 1049908

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 2

    The active substance itself — no strength, form, or brand attached yet.

    • Diphenhydramine 3498
    • Diphenhydramine hydrochloride 1362
  2. Brand names 1

    The same medicine's trade names. A brand name alone says nothing about strength or form.

    • Benadryl 203457
  3. Dose forms 13

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Diphenhydramine Oral Solution 371889
    • Diphenhydramine hydrochloride Oral Solution 2647041
    • Diphenhydramine Oral Liquid Product 1158448
    • Diphenhydramine Oral Product 1158449
    • Diphenhydramine hydrochloride Oral Liquid Product 2663691
    • Diphenhydramine hydrochloride Oral Product 2659104
    • Diphenhydramine Oral Solution [Benadryl] 364116
    • Diphenhydramine hydrochloride Oral Solution [Benadryl] 2656947
    • +5 more in this family
  4. Clinical & branded drugs 3

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

  5. Packs 1

    Fixed collections of drugs packaged and sold together, like dose packs.

Showing up to 8 concepts per family — 15 of 20 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

Brand-Name Concepts

  • Diphenhydramine hydrochloride 2.5 MG/ML [Benadryl] SBDC · 1049907
  • Diphenhydramine Oral Solution [Benadryl] SBDF · 364116
  • Diphenhydramine hydrochloride Oral Solution [Benadryl] SBDFP · 2656947
  • Benadryl Oral Liquid Product SBDG · 1170147
  • Benadryl Oral Product SBDG · 1170148
  • Benadryl BN · 203457

📦 FDA Products & Package NDCs

3 products · 7 package NDCs
7 package NDCs map to RxCUI 1049908 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
50580-0534-04 1 BOTTLE in 1 CARTON (50580-534-04) / 118 mL in 1 BOTTLE Childrens Benadryl ALLERGY Kenvue Brands LLC 2008-07-01
50580-0534-08 1 BOTTLE in 1 CARTON (50580-534-08) / 236 mL in 1 BOTTLE Childrens Benadryl ALLERGY Kenvue Brands LLC 2008-07-01
50580-0534-18 2 CARTON in 1 PACKAGE (50580-534-18) / 1 BOTTLE in 1 CARTON... Childrens Benadryl ALLERGY Kenvue Brands LLC 2021-04-12
50580-0535-01 1 BOTTLE in 1 CARTON (50580-535-01) / 118 mL in 1 BOTTLE Childrens Benadryl DYE-FREE ALLERGY Kenvue Brands LLC 2015-12-01
50580-0535-02 2 CARTON in 1 PACKAGE (50580-535-02) / 1 BOTTLE in 1 CARTON... Childrens Benadryl DYE-FREE ALLERGY Kenvue Brands LLC 2024-11-18
50580-0535-08 1 BOTTLE in 1 CARTON (50580-535-08) / 236 mL in 1 BOTTLE Childrens Benadryl DYE-FREE ALLERGY Kenvue Brands LLC 2022-06-16
50580-0573-04 1 BOTTLE in 1 CARTON (50580-573-04) / 118 mL in 1 BOTTLE BENADRYL Allergy Kenvue Brands LLC 2024-12-02
Observed labelers: Kenvue Brands LLC (7) — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.