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Diphenhydramine hydrochloride 2.5 MG/ML Oral Solution — RxCUI 1049906

RxNorm drug concept · Semantic clinical drug
RxCUI 1049906 Semantic clinical drug · SCD ● Current RxNorm concept 133 FDA products 174 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1049906
Official nameDiphenhydramine hydrochloride 2.5 MG/ML Oral Solution
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asdiphenhydramine HCl 12.5 MG per 5 ML Oral Solution; diphenhydrAMINE HCl 12.5 MG in 5 mL Oral Solution; diphenhydramine hydrochloride 25 MG per 10 ML Oral Solution; diphenhydramine hydrochloride 50 MG per 20 ML Oral Solution
FDA products mapped133
Package NDCs mapped174
Reported Medicaid activity (SDUD)383,205 prescriptions · 47 state & territory Medicaid programs · latest period Q4 2025
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Diphenhydramine Topical: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • It gives temporary relief of pain and itching on the skin. That includes minor burns, minor cuts or scrapes, insect bites, minor skin irritations, and rashes from poison ivy, oak o...
  • Adults and children 2 and older can apply it to the affected area no more than 3 to 4 times a day. Don't use it more often than directed. For a child under 2, check with a doctor f...
  • No. Don't use it on large areas of the body or on broken, blistered or oozing skin. Also avoid it on chicken pox or sunburn.
  • Can I put it on a large area or on blistered skin?
📖 Read our full Diphenhydramine Topical guide →

🕸️ Concept Web — How Diphenhydramine hydrochloride 2.5 MG/ML Oral Sol... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Diphenhydramine hydrochloride 2.5 MG/ML Oral Solution RxCUI 1049906

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 2

    The active substance itself — no strength, form, or brand attached yet.

    • Diphenhydramine 3498
    • Diphenhydramine hydrochloride 1362
  2. Brand names 6

    The same medicine's trade names. A brand name alone says nothing about strength or form.

    • Banophen 215558
    • Benadryl 203457
    • Diphedryl 216654
    • Scot-Tussin Allergy 1094448
    • Siladryl 219896
    • Wal-Dryl Childrens 1086764
  3. Dose forms 33

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Diphenhydramine Oral Solution 371889
    • Diphenhydramine hydrochloride Oral Solution 2647041
    • Diphenhydramine Oral Liquid Product 1158448
    • Diphenhydramine Oral Product 1158449
    • Diphenhydramine hydrochloride Oral Liquid Product 2663691
    • Diphenhydramine hydrochloride Oral Product 2659104
    • Diphenhydramine Oral Solution [Banophen] 364139
    • Diphenhydramine Oral Solution [Benadryl] 364116
    • +25 more in this family
  4. Clinical & branded drugs 13

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

  5. Packs 1

    Fixed collections of drugs packaged and sold together, like dose packs.

Showing up to 8 concepts per family — 25 of 55 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

Brand-Name Concepts

  • Diphenhydramine hydrochloride 2.5 MG/ML Oral Solution [Benadryl] SBD · 1049908
  • Diphenhydramine hydrochloride 2.5 MG/ML Oral Solution [Wal-Dryl Childrens] SBD · 1086767
  • Diphenhydramine hydrochloride 2.5 MG/ML Oral Solution [Banophen] SBD · 1092424
  • Diphenhydramine hydrochloride 2.5 MG/ML Oral Solution [Diphedryl] SBD · 1094188
  • Diphenhydramine hydrochloride 2.5 MG/ML Oral Solution [Scot-Tussin Allergy] SBD · 1094451
  • Diphenhydramine hydrochloride 2.5 MG/ML Oral Solution [Siladryl] SBD · 1094393
  • Diphenhydramine hydrochloride 2.5 MG/ML [Banophen] SBDC · 1092423
  • Diphenhydramine hydrochloride 2.5 MG/ML [Benadryl] SBDC · 1049907
  • Diphenhydramine hydrochloride 2.5 MG/ML [Diphedryl] SBDC · 1094187
  • Diphenhydramine hydrochloride 2.5 MG/ML [Scot-Tussin Allergy] SBDC · 1094449

📦 FDA Products & Package NDCs

133 products · 174 package NDCs
174 package NDCs map to RxCUI 1049906 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
00113-0379-26 1 BOTTLE in 1 CARTON (0113-0379-26) / 118 mL in 1 BOTTLE good sense allergy L. Perrigo Company 1989-09-15
00121-0489-00 10 TRAY in 1 CASE (0121-0489-00) / 10 CUP, UNIT-DOSE in 1 T... DIPHENHYDRAMINE HYDROCHLORIDE PAI Holdings, LLC dba PAI Pharma 1982-02-10
00121-0865-00 10 TRAY in 1 CASE (0121-0865-00) / 10 CUP, UNIT-DOSE in 1 T... Diphenhydramine HCl PAI Holdings, LLC dba PAI Pharma 2020-06-18
00121-0865-30 3 TRAY in 1 CASE (0121-0865-30) / 10 CUP, UNIT-DOSE in 1 TR... Diphenhydramine HCl PAI Holdings, LLC dba PAI Pharma 2020-06-18
00121-0978-00 10 TRAY in 1 CASE (0121-0978-00) / 10 CUP, UNIT-DOSE in 1 T... DIPHENHYDRAMINE HYDROCHLORIDE PAI Holdings, LLC dba PAI Pharma 1982-02-10
00121-1730-00 10 TRAY in 1 CASE (0121-1730-00) / 10 CUP, UNIT-DOSE in 1 T... Diphenhydramine HCl PAI Holdings, LLC dba PAI Pharma 2020-06-18
00363-0092-08 1 BOTTLE, PLASTIC in 1 BOX (0363-0092-08) / 237 mL in 1 BOT... Wal Dryl Childrens Allergy Walgreens 2015-04-30
00363-0293-04 1 BOTTLE, PLASTIC in 1 BOX (0363-0293-04) / 118 mL in 1 BOT... Dye Free Wal Dryl Allergy childrens Walgreens 2015-03-31
00363-0710-08 1 BOTTLE in 1 CARTON (0363-0710-08) / 236 mL in 1 BOTTLE childrens Allergy Dye Free Wal Dryl WALGREEN CO. 2017-08-31
00363-1236-26 1 BOTTLE in 1 CARTON (0363-1236-26) / 118 mL in 1 BOTTLE childrens allergy relief Walgreen Company 2024-04-29
00363-7100-04 1 BOTTLE in 1 CARTON (0363-7100-04) / 118 mL in 1 BOTTLE Adult Allergy Relief Dye Free WALGREEN COMPANY 2020-01-30
00363-8018-36 1 BOTTLE, PLASTIC in 1 CARTON (0363-8018-36) / 118 mL in 1... Childrens Allergy Relief Walgreen Company 2023-05-18
00904-6985-16 473 mL in 1 BOTTLE, PLASTIC (0904-6985-16) Diphenhydramine HCl Major Pharmaceuticals 2019-08-27
00904-6985-20 118 mL in 1 BOTTLE, PLASTIC (0904-6985-20) Diphenhydramine HCl Major Pharmaceuticals 2019-08-27
00904-7324-72 100 CUP, UNIT-DOSE in 1 BOX, UNIT-DOSE (0904-7324-72) / 10... Diphenhydramine HCl Oral Solution Major Pharmaceuticals 2024-01-22
00904-7533-15 473 mL in 1 BOTTLE, PLASTIC (0904-7533-15) Allergy Relief Childrens Major Pharmaceuticals 2025-03-07
00904-7533-20 1 BOTTLE, PLASTIC in 1 CARTON (0904-7533-20) / 118 mL in 1... Allergy Relief Childrens Major Pharmaceuticals 2025-03-07
00904-7559-72 10 TRAY in 1 CASE (0904-7559-72) / 10 CUP, UNIT-DOSE in 1 T... Diphenhydramine HCl Major Pharmaceuticals 2025-08-01
00904-7560-70 10 TRAY in 1 CASE (0904-7560-70) / 10 CUP, UNIT-DOSE in 1 T... Diphenhydramine HCl Major Pharmaceuticals 2025-08-01
11673-0832-04 1 BOTTLE, PLASTIC in 1 CARTON (11673-832-04) / 118 mL in 1... Children Allergy Relief Bubblegum flavor TARGET CORPORATION 2019-04-17
11673-0832-08 2 BOTTLE, PLASTIC in 1 CARTON (11673-832-08) / 118 mL in 1... Children Allergy Relief Bubblegum flavor TARGET CORPORATION 2025-05-15
11673-0918-36 1 BOTTLE, PLASTIC in 1 CARTON (11673-918-36) / 118 mL in 1... childrens allergy relief dye-free Target Corporation 2018-05-20
11822-0379-00 1 BOTTLE in 1 CARTON (11822-0379-0) / 118 mL in 1 BOTTLE Childrens Allergy Relief Rite Aid Corporation 2023-04-05
11822-0918-01 1 BOTTLE, PLASTIC in 1 CARTON (11822-0918-1) / 118 mL in 1... Childrens Dye Free Allergy Relief Rite Aid Corporation 2023-05-01
21130-0025-04 118 mL in 1 BOTTLE, PLASTIC (21130-025-04) Childrens Allergy Safeway, Inc. 2009-02-03
21130-0563-05 1 BOTTLE in 1 CARTON (21130-563-05) / 118 mL in 1 BOTTLE Childrens Dye Free Allergy Relief BETTER LIVING BRANDS LLC. 2026-05-01
24286-1565-04 1 BOTTLE in 1 CARTON (24286-1565-4) / 118 mL in 1 BOTTLE BACTIMICINA CHILDRENS ALLERGY DLC Laboratories, Inc. 2015-06-17
24385-0379-26 1 BOTTLE in 1 CARTON (24385-379-26) / 118 mL in 1 BOTTLE Good Neighbor Pharmacy Childrens Allergy Amerisource Bergen 1989-08-15
30142-0404-26 1 BOTTLE in 1 CARTON (30142-404-26) / 118 mL in 1 BOTTLE Childrens Allergy Relief Kroger Company 2014-02-04
30142-0651-26 1 BOTTLE in 1 CARTON (30142-651-26) / 118 mL in 1 BOTTLE childrens allergy Kroger Company 2020-06-17
30142-0651-34 1 BOTTLE in 1 CARTON (30142-651-34) / 237 mL in 1 BOTTLE childrens allergy Kroger Company 2020-06-17
36800-0379-26 1 BOTTLE in 1 CARTON (36800-379-26) / 118 mL in 1 BOTTLE Topcare childrens allergy Topco Associates LLC 1987-12-15
36800-0379-34 1 BOTTLE in 1 CARTON (36800-379-34) / 237 mL in 1 BOTTLE Topcare childrens allergy Topco Associates LLC 2003-11-18
37808-0012-08 1 BOTTLE, PLASTIC in 1 BOX (37808-012-08) / 237 mL in 1 BOT... Allergy Childrens H E B 2016-02-29
37808-0379-26 1 BOTTLE in 1 CARTON (37808-379-26) / 118 mL in 1 BOTTLE Allergy H E B 1987-07-15
41163-0379-26 1 BOTTLE in 1 CARTON (41163-379-26) / 118 mL in 1 BOTTLE equaline allergy United Natural Foods, Inc. dba UNFI 2004-08-17
41226-0710-08 1 BOTTLE, PLASTIC in 1 CARTON (41226-710-08) / 236 mL in 1... KROGER Dye Free Childrens Allergy Relief KROGER COMPANY 2024-06-17
41250-0379-26 1 BOTTLE in 1 CARTON (41250-379-26) / 118 mL in 1 BOTTLE allergy childrens Meijer Distribution Inc 1987-11-15
41250-0379-34 1 BOTTLE in 1 CARTON (41250-379-34) / 237 mL in 1 BOTTLE allergy childrens Meijer Distribution Inc 1995-12-12
41250-0710-08 1 BOTTLE, PLASTIC in 1 CARTON (41250-710-08) / 118 mL in 1... Meijer Childrens Allergy Relief Bubblegum flavor MEIJER DISTRIBUTION INC 2017-03-07
41520-0632-26 1 BOTTLE in 1 CARTON (41520-632-26) / 118 mL in 1 BOTTLE CareOne Childrens Allergy Relief American Sales Company 2016-04-12
42507-0379-26 1 BOTTLE in 1 CARTON (42507-379-26) / 118 mL in 1 BOTTLE (4... allergy HyVee Inc 1992-11-11
46122-0685-26 1 BOTTLE, PLASTIC in 1 CARTON (46122-685-26) / 118 mL in 1... Allergy Relief Amerisource Bergen 2021-01-26
46122-0793-29 1 BOTTLE, PLASTIC in 1 CARTON (46122-793-29) / 118 mL in 1... Good NeighborChildrens Allergy Relief Bubblegum flavor AMERISOURCE BERGEN 2024-06-24
49035-0379-26 1 BOTTLE in 1 CARTON (49035-379-26) / 118 mL in 1 BOTTLE equate allergy relief Wal-Mart Stores Inc 1990-08-15
49035-0600-04 1 BOTTLE, PLASTIC in 1 CARTON (49035-600-04) / 118 mL in 1... Dye Free Childrens Allergy Relief WAL-MART STORES INC. 2020-03-09
49580-0292-02 118 mL in 1 BOTTLE, PLASTIC (49580-0292-2) Childrens Allergy P & L Development, LLC 2015-03-31
49580-0292-04 1 BOTTLE, PLASTIC in 1 BOX (49580-0292-4) / 118 mL in 1 BOT... Childrens Allergy P & L Development, LLC 2015-03-31
49580-0293-04 1 BOTTLE, PLASTIC in 1 BOX (49580-0293-4) / 118 mL in 1 BOT... Childrens Dye Free Allergy P & L Development, LLC 2015-02-28
50090-6163-00 1 BOTTLE in 1 CARTON (50090-6163-0) / 118 mL in 1 BOTTLE children allergy relief dye free cherry A-S Medication Solutions 2022-10-11
Observed labelers: VERITYRX, LLC (10) · Kenvue Brands LLC (7) · Major Pharmaceuticals (7) · CVS PHARMACY (5) · PAI Holdings, LLC dba PAI Pharma (5) · Bryant Ranch Prepack (4) · +72 more — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

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