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Diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 10 MG Oral Tablet — RxCUI 1052928

RxNorm drug concept · Semantic clinical drug
RxCUI 1052928 Semantic clinical drug · SCD ● Current RxNorm concept 8 FDA products 8 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1052928
Official nameDiphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 10 MG Oral Tablet
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asdiphenhydrAMINE HCl 25 MG / phenylephrine HCl 10 MG Oral Tablet
FDA products mapped8
Package NDCs mapped8
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Diphenhydramine Topical: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • You can use it for temporary relief of pain and itching from everyday skin problems — things like insect bites, minor burns, minor cuts and scrapes, and general skin irritations. I...
  • What can I actually use this cream or spray for?
  • You can apply it up to 3 to 4 times a day, but no more than that. More frequent use isn't going to help more — and the label is clear that you shouldn't exceed that limit. For kids...
  • This is really important — do not use this topical product at the same time as any other product that contains diphenhydramine, even a pill or capsule. That includes allergy medici...
📖 Read our full Diphenhydramine Topical guide →

🕸️ Concept Web — How Diphenhydramine hydrochloride 25 MG / phenylephr... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 10 MG Oral Tablet RxCUI 1052928

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 5

    The active substance itself — no strength, form, or brand attached yet.

    • Diphenhydramine 3498
    • Phenylephrine 8163
    • Diphenhydramine / phenylephrine 690693
    • Diphenhydramine hydrochloride 1362
    • Phenylephrine hydrochloride 8164
  2. Brand names 2

    The same medicine's trade names. A brand name alone says nothing about strength or form.

    • Benadryl Allergy Plus Congestion 1926216
    • Wal-Dryl-D 1087034
  3. Dose forms 17

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Diphenhydramine / phenylephrine Oral Tablet 656686
    • Diphenhydramine hydrochloride / phenylephrine hydrochloride Oral Tablet 2647614
    • Diphenhydramine / phenylephrine Oral Product 1158429
    • Diphenhydramine / phenylephrine Pill 1158430
    • Diphenhydramine hydrochloride / phenylephrine hydrochloride Oral Product 2662612
    • Diphenhydramine hydrochloride / phenylephrine hydrochloride Pill 2660223
    • Diphenhydramine / phenylephrine Oral Tablet [Benadryl Allergy Plus Congestion] 1926218
    • Diphenhydramine / phenylephrine Oral Tablet [Wal-Dryl-D] 1087036
    • +9 more in this family
  4. Clinical & branded drugs 6

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

  5. Packs 1

    Fixed collections of drugs packaged and sold together, like dose packs.

Showing up to 8 concepts per family — 22 of 31 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

Brand-Name Concepts

  • Diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 10 MG Oral Tablet [Benadryl Allergy Plus Congestion] SBD · 1926221
  • Diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 10 MG Oral Tablet [Wal-Dryl-D] SBD · 1087037
  • Diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 10 MG [Benadryl Allergy Plus Congestion] SBDC · 1926217
  • Diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 10 MG [Wal-Dryl-D] SBDC · 1087035
  • Diphenhydramine / phenylephrine Oral Tablet [Benadryl Allergy Plus Congestion] SBDF · 1926218
  • Diphenhydramine / phenylephrine Oral Tablet [Wal-Dryl-D] SBDF · 1087036
  • Diphenhydramine hydrochloride / phenylephrine hydrochloride Oral Tablet [Benadryl Allergy Plus Congestion] SBDFP · 2657275
  • Diphenhydramine hydrochloride / phenylephrine hydrochloride Oral Tablet [Wal-Dryl-D] SBDFP · 2654640
  • Benadryl Allergy Plus Congestion Oral Product SBDG · 1926219
  • Benadryl Allergy Plus Congestion Pill SBDG · 1926220

📦 FDA Products & Package NDCs

8 products · 8 package NDCs
8 package NDCs map to RxCUI 1052928 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
00363-4534-09 1 KIT in 1 PACKAGE, COMBINATION (0363-4534-09) * 12 TABLET... Sinus PE Congestion Walgreen Company 2022-01-19
00363-4851-08 2 BLISTER PACK in 1 CARTON (0363-4851-08) / 12 TABLET, FILM... Allergy Relief Plus Congestion Walgreen Company 2021-11-01
11822-0485-08 2 BLISTER PACK in 1 CARTON (11822-0485-8) / 12 TABLET, FILM... Allergy Plus Sinus Relief Rite Aid Corporation 2005-08-10
11822-9485-09 1 KIT in 1 CARTON (11822-9485-9) * 12 TABLET, FILM COATED... Sinus Pressure and Congestion Relief Rite Aid Corporation 2019-07-02
50580-0239-01 1 KIT in 1 PACKAGE (50580-239-01) * 2 BLISTER PACK in 1 CA... SUDAFED PE SINUS CONGESTION Kenvue Brands LLC 2019-06-17
50580-0415-01 2 BLISTER PACK in 1 CARTON (50580-415-01) / 12 TABLET, FILM... Benadryl Allergy Plus Congestion Kenvue Brands LLC 2017-06-19
51316-0485-08 2 BLISTER PACK in 1 CARTON (51316-485-08) / 12 TABLET, FILM... Allergy Plus Congestion Relief CVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATED 2022-08-09
79481-4534-01 1 KIT in 1 CARTON (79481-4534-1) * 12 TABLET, FILM COATED... Sinus PE Congestion Daytime Nighttime Meijer Distribution, Inc. 2023-07-05
Observed labelers: Kenvue Brands LLC (2) · Rite Aid Corporation (2) · Walgreen Company (2) · CVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATED (1) · Meijer Distribution, Inc. (1) — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.