Methotrexate 2.5 MG Oral Tablet — RxCUI 105585
RxNorm drug concept · Semantic clinical drug
RxCUI 105585
Semantic clinical drug · SCD
● Current RxNorm concept 28 FDA products
73 package NDCs
Snapshot Jul 14, 2026
What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.
🗂️ Key Facts
RxCUI105585
Official nameMethotrexate 2.5 MG Oral Tablet
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asmethotrexate 2.5 MG (as methotrexate sodium) Oral Tablet
FDA products mapped28
Package NDCs mapped73
Reported Medicaid activity (SDUD)447,351 prescriptions · 52 state & territory Medicaid programs · latest period Q4 2025
RxNorm release07/06/2026
Snapshot dataJul 14, 2026
📖 Skip the Codes — Read It in Plain English.
Our pharmacist-built guide to Methotrexate Injection: what it is, how it’s used, side effects, and interactions.
📗 Our plain-language guide HelloPharmacist
- Yes — for rheumatoid arthritis, psoriasis, and juvenile idiopathic arthritis, once weekly is the correct and intended schedule. This is actually one of the most important safety po...
- Why am I only taking this once a week? Is that really enough?
- Common things like mild nausea, tiredness, or mouth soreness are expected and your team can help you manage them. But you should call your doctor immediately — or go to the ER — if...
- What side effects should I just watch for, versus which ones mean I should call someone right away?
🕸️ Concept Web — How Methotrexate 2.5 MG Oral Tablet Connects
One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept
Methotrexate 2.5 MG Oral Tablet
RxCUI 105585 Semantic clinical drug · SCD
Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.
-
Ingredients 1
The active substance itself — no strength, form, or brand attached yet.
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Methotrexate
6851IN
-
Methotrexate
-
Dose forms 6
The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.
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Methotrexate Oral Tablet
372836SCDF -
Methotrexate Oral Product
1162236SCDG -
Methotrexate Pill
1162237SCDG -
Oral Tablet
317541DF -
Oral Product
1151131DFG -
Pill
1151133DFG
-
Methotrexate Oral Tablet
-
Clinical & branded drugs 1
Ingredient + strength + dose form. These are the concepts real FDA products actually carry.
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Methotrexate 2.5 MG
328407SCDC
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Methotrexate 2.5 MG
Showing up to 8 concepts per family — 8 of 8 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.
🔀 Generic ⇄ Brand Crosswalk
The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.
Generic (Clinical) Concepts
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Methotrexate 2.5 MG
SCDC · 328407 -
Methotrexate Oral Tablet
SCDF · 372836 -
Methotrexate Oral Product
SCDG · 1162236 -
Methotrexate Pill
SCDG · 1162237
📦 FDA Products & Package NDCs
28 products · 73 package NDCs
73 package NDCs map to RxCUI 105585 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
| Package NDC | Package | Brand / generic name | Labeler | Marketing start |
|---|---|---|---|---|
| 00054-4550-25 | 100 TABLET in 1 BOTTLE, PLASTIC (0054-4550-25) | Methotrexate Sodium | Hikma Pharmaceuticals USA Inc. | 1994-08-01 |
| 00378-0014-01 | 100 TABLET in 1 BOTTLE, PLASTIC (0378-0014-01) | Methotrexate | Mylan Pharmaceuticals Inc. | 1992-05-18 |
| 00555-0572-02 | 100 TABLET in 1 BOTTLE (0555-0572-02) | Methotrexate | Teva Pharmaceuticals USA, Inc. | 1990-11-01 |
| 00555-0572-35 | 36 TABLET in 1 BOTTLE (0555-0572-35) | Methotrexate | Teva Pharmaceuticals USA, Inc. | 1990-11-01 |
| 00904-7141-10 | 20 BLISTER PACK in 1 CARTON (0904-7141-10) / 1 TABLET in 1... | Methotrexate | Major Pharmaceuticals | 2017-02-09 |
| 16729-0486-01 | 100 TABLET in 1 BOTTLE (16729-486-01) | Methotrexate | Accord Healthcare Inc. | 2020-08-24 |
| 46708-0730-31 | 100 TABLET in 1 BOTTLE (46708-730-31) | METHOTREXATE | Alembic Pharmaceuticals Limited | 2024-06-04 |
| 46708-0730-36 | 36 TABLET in 1 BOTTLE (46708-730-36) | METHOTREXATE | Alembic Pharmaceuticals Limited | 2024-06-04 |
| 47335-0235-83 | 100 TABLET in 1 BOTTLE (47335-235-83) | Methotrexate | Sun Pharmaceutical Industries, Inc. | 2017-11-10 |
| 47335-0235-96 | 36 TABLET in 1 BOTTLE (47335-235-96) | Methotrexate | Sun Pharmaceutical Industries, Inc. | 2017-11-10 |
| 48433-0065-05 | 20 BLISTER PACK in 1 CARTON (48433-065-05) / 1 TABLET in 1... | Methotrexate | Safecor Health LLC | 2026-01-19 |
| 50090-5457-09 | 36 TABLET in 1 BOTTLE (50090-5457-9) | Methotrexate | A-S Medication Solutions | 2021-01-29 |
| 50268-0554-15 | 50 BLISTER PACK in 1 BOX (50268-554-15) / 1 TABLET in 1 BLI... | Methotrexate | AvPAK | 2026-01-29 |
| 51079-0670-05 | 20 BLISTER PACK in 1 CARTON (51079-670-05) / 1 TABLET in 1... | Methotrexate | Mylan Institutional Inc. | 1995-07-13 |
| 51407-0121-01 | 100 TABLET in 1 BOTTLE, PLASTIC (51407-121-01) | Methotrexate | Golden State Medical Supply, Inc. | 2018-06-07 |
| 59651-0182-01 | 100 TABLET in 1 BOTTLE (59651-182-01) | Methotrexate | Aurobindo Pharma Limited | 2020-01-30 |
| 59651-0182-36 | 36 TABLET in 1 BOTTLE (59651-182-36) | Methotrexate | Aurobindo Pharma Limited | 2020-01-30 |
| 62135-0772-35 | 36 TABLET in 1 BOTTLE (62135-772-35) | Methotrexate | Chartwell RX, LLC | 2023-08-29 |
| 62332-0730-31 | 100 TABLET in 1 BOTTLE (62332-730-31) | METHOTREXATE | Alembic Pharmaceuticals Inc. | 2024-06-04 |
| 62332-0730-36 | 36 TABLET in 1 BOTTLE (62332-730-36) | METHOTREXATE | Alembic Pharmaceuticals Inc. | 2024-06-04 |
| 64850-0330-01 | 100 TABLET in 1 BOTTLE, PLASTIC (64850-330-01) | Methotrexate Sodium | Elite Laboratories, Inc. | 2024-05-16 |
| 67046-1524-03 | 30 TABLET in 1 BLISTER PACK (67046-1524-3) | Methotrexate | Coupler LLC | 2025-02-27 |
| 68071-3765-06 | 60 TABLET in 1 BOTTLE (68071-3765-6) | Methotrexate | NuCare Pharmaceuticals, Inc. | 2025-01-14 |
| 68071-3765-09 | 90 TABLET in 1 BOTTLE (68071-3765-9) | Methotrexate | NuCare Pharmaceuticals, Inc. | 2025-01-10 |
| 68071-3991-09 | 90 TABLET in 1 BOTTLE (68071-3991-9) | Methotrexate | NuCare Pharmaceuticals, Inc. | 2026-04-30 |
| 68382-0775-01 | 100 TABLET in 1 BOTTLE (68382-775-01) | Methotrexate | Zydus Pharmaceuticals USA Inc. | 2017-02-09 |
| 68382-0775-05 | 500 TABLET in 1 BOTTLE (68382-775-05) | Methotrexate | Zydus Pharmaceuticals USA Inc. | 2017-02-09 |
| 68382-0775-10 | 1000 TABLET in 1 BOTTLE (68382-775-10) | Methotrexate | Zydus Pharmaceuticals USA Inc. | 2017-02-09 |
| 68382-0775-16 | 90 TABLET in 1 BOTTLE (68382-775-16) | Methotrexate | Zydus Pharmaceuticals USA Inc. | 2017-02-09 |
| 68382-0775-60 | 36 TABLET in 1 BOTTLE (68382-775-60) | Methotrexate | Zydus Pharmaceuticals USA Inc. | 2017-02-09 |
| 68382-0775-77 | 100 BLISTER PACK in 1 CARTON (68382-775-77) / 1 TABLET in 1... | Methotrexate | Zydus Pharmaceuticals USA Inc. | 2017-02-09 |
| 70771-1058-00 | 1000 TABLET in 1 BOTTLE (70771-1058-0) | Methotrexate | Zydus Lifesciences Limited | 2017-02-09 |
| 70771-1058-01 | 100 TABLET in 1 BOTTLE (70771-1058-1) | Methotrexate | Zydus Lifesciences Limited | 2017-02-09 |
| 70771-1058-03 | 36 TABLET in 1 BOTTLE (70771-1058-3) | Methotrexate | Zydus Lifesciences Limited | 2017-02-09 |
| 70771-1058-05 | 500 TABLET in 1 BOTTLE (70771-1058-5) | Methotrexate | Zydus Lifesciences Limited | 2017-02-09 |
| 70771-1058-07 | 100 BLISTER PACK in 1 CARTON (70771-1058-7) / 1 TABLET in 1... | Methotrexate | Zydus Lifesciences Limited | 2017-02-09 |
| 70771-1058-09 | 90 TABLET in 1 BOTTLE (70771-1058-9) | Methotrexate | Zydus Lifesciences Limited | 2017-02-09 |
| 71335-0782-01 | 30 TABLET in 1 BOTTLE (71335-0782-1) | Methotrexate | Bryant Ranch Prepack | 2019-02-25 |
| 71335-0782-02 | 12 TABLET in 1 BOTTLE (71335-0782-2) | Methotrexate | Bryant Ranch Prepack | 2021-04-09 |
| 71335-0782-03 | 20 TABLET in 1 BOTTLE (71335-0782-3) | Methotrexate | Bryant Ranch Prepack | 2021-04-09 |
| 71335-0782-04 | 100 TABLET in 1 BOTTLE (71335-0782-4) | Methotrexate | Bryant Ranch Prepack | 2018-04-19 |
| 71335-0782-05 | 36 TABLET in 1 BOTTLE (71335-0782-5) | Methotrexate | Bryant Ranch Prepack | 2021-04-09 |
| 71335-0782-06 | 24 TABLET in 1 BOTTLE (71335-0782-6) | Methotrexate | Bryant Ranch Prepack | 2021-04-09 |
| 71335-0782-07 | 90 TABLET in 1 BOTTLE (71335-0782-7) | Methotrexate | Bryant Ranch Prepack | 2021-04-09 |
| 71335-0782-08 | 4 TABLET in 1 BOTTLE (71335-0782-8) | Methotrexate | Bryant Ranch Prepack | 2021-04-09 |
| 71335-1118-01 | 30 TABLET in 1 BOTTLE (71335-1118-1) | Methotrexate | Bryant Ranch Prepack | 2019-02-25 |
| 71335-1118-02 | 12 TABLET in 1 BOTTLE (71335-1118-2) | Methotrexate | Bryant Ranch Prepack | 2024-05-17 |
| 71335-1118-03 | 20 TABLET in 1 BOTTLE (71335-1118-3) | Methotrexate | Bryant Ranch Prepack | 2024-05-17 |
| 71335-1118-04 | 100 TABLET in 1 BOTTLE (71335-1118-4) | Methotrexate | Bryant Ranch Prepack | 2024-05-17 |
| 71335-1118-05 | 36 TABLET in 1 BOTTLE (71335-1118-5) | Methotrexate | Bryant Ranch Prepack | 2024-05-17 |
Observed labelers:
Bryant Ranch Prepack (35) ·
Zydus Lifesciences Limited (6) ·
Zydus Pharmaceuticals USA Inc. (6) ·
NuCare Pharmaceuticals, Inc. (3) ·
Alembic Pharmaceuticals Inc. (2) ·
Alembic Pharmaceuticals Limited (2)
· +16 more — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.
🧾 Billing Codes (HCPCS)
Medical billing codes (HCPCS "J-codes") that connect to this concept's packages — used mostly when a clinic or hospital bills for a drug it administers. Each code links to its full billing page.
| Code | Descriptor | Mapped packages | Sources |
|---|---|---|---|
| J8610 | Methotrexate oral 2.5 mg | 11 | CMS |
⚠ A crosswalk is not coverage: an NDC↔HCPCS mapping does not guarantee any payer covers or pays the code. Always verify the current payer policy before billing.
🗃️ Sources & Limits
Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
- A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
- Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
- Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
- Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.
Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.