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12 HR naproxen sodium 220 MG / pseudoephedrine hydrochloride 120 MG Extended Release Oral... — RxCUI 1367426

RxNorm drug concept · Semantic clinical drug
RxCUI 1367426 Semantic clinical drug · SCD ● Current RxNorm concept 12 FDA products 16 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1367426
Official name12 HR naproxen sodium 220 MG / pseudoephedrine hydrochloride 120 MG Extended Release Oral Tablet
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asnaproxen sodium 220 MG / pseudoephedrine HCl 120 MG 12HR Extended Release Oral Tablet
FDA products mapped12
Package NDCs mapped16
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Naproxen: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • They're very similar — naproxen sodium is just the salt form of naproxen, and it dissolves in water more quickly. That means your body absorbs naproxen sodium a bit faster, so it t...
  • What's the difference between naproxen and naproxen sodium — are they the same thing?
  • You can take it either way, but taking it with food, milk, or a full glass of water is a good idea because it helps protect your stomach. Naproxen can irritate the lining of your s...
  • Can I take naproxen on an empty stomach, or do I need to eat first?
📖 Read our full Naproxen guide →

🕸️ Concept Web — How 12 HR naproxen sodium 220 MG / pseudoephedrine h... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept 12 HR naproxen sodium 220 MG / pseudoephedrine hydrochloride 120 MG Extended Release Oral Tablet RxCUI 1367426

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 5

    The active substance itself — no strength, form, or brand attached yet.

    • Naproxen 7258
    • Pseudoephedrine 8896
    • Naproxen / pseudoephedrine 284641
    • Naproxen sodium 142442
    • Pseudoephedrine hydrochloride 91168
  2. Dose forms 9

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Naproxen / pseudoephedrine Extended Release Oral Tablet 374618
    • Naproxen sodium / pseudoephedrine hydrochloride Extended Release Oral Tablet 2648872
    • Naproxen / pseudoephedrine Oral Product 1157003
    • Naproxen / pseudoephedrine Pill 1157004
    • Naproxen sodium / pseudoephedrine hydrochloride Oral Product 2659977
    • Naproxen sodium / pseudoephedrine hydrochloride Pill 2661035
    • Extended Release Oral Tablet 316945
    • Oral Product 1151131
    • +1 more in this family
  3. Clinical & branded drugs 2

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

    • Naproxen sodium 220 MG 849573
    • Pseudoephedrine hydrochloride 120 MG 997405

Showing up to 8 concepts per family — 15 of 16 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

  • Naproxen sodium 220 MG SCDC · 849573
  • Pseudoephedrine hydrochloride 120 MG SCDC · 997405
  • Naproxen / pseudoephedrine Extended Release Oral Tablet SCDF · 374618
  • Naproxen sodium / pseudoephedrine hydrochloride Extended Release Oral Tablet SCDFP · 2648872
  • Naproxen / pseudoephedrine Oral Product SCDG · 1157003
  • Naproxen / pseudoephedrine Pill SCDG · 1157004
  • Naproxen sodium / pseudoephedrine hydrochloride Oral Product SCDGP · 2659977
  • Naproxen sodium / pseudoephedrine hydrochloride Pill SCDGP · 2661035

📦 FDA Products & Package NDCs

12 products · 16 package NDCs
16 package NDCs map to RxCUI 1367426 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
00280-6045-10 1 BLISTER PACK in 1 CARTON (0280-6045-10) / 10 TABLET in 1... Aleve-D Sinus and Headache Bayer HealthCare LLC. 2014-01-01
00280-6090-10 1 BLISTER PACK in 1 CARTON (0280-6090-10) / 10 TABLET in 1... Aleve-D Sinus and Cold Bayer HealthCare LLC. 2014-01-01
00280-6090-20 2 BLISTER PACK in 1 CARTON (0280-6090-20) / 10 TABLET in 1... Aleve-D Sinus and Cold Bayer HealthCare LLC. 2014-01-01
00363-0650-01 20 BLISTER PACK in 1 CARTON (0363-0650-01) / 1 TABLET, FILM... All Day Sinus and Cold D Walgreen Company 2013-05-23
36800-0417-01 20 BLISTER PACK in 1 CARTON (36800-417-01) / 1 TABLET, FILM... Topcare Sinus and Cold D Topco Associates LLC 2013-08-14
41250-0417-01 20 BLISTER PACK in 1 CARTON (41250-417-01) / 1 TABLET, FILM... Sinus and Cold D Meijer Distribution Inc 2013-08-12
50580-0434-01 2 BLISTER PACK in 1 CARTON (50580-434-01) / 8 TABLET, MULTI... Sudafed Sinus 12 Hour Pressure plus Pain Kenvue Brands LLC 2019-06-17
51316-0339-01 20 BLISTER PACK in 1 CARTON (51316-339-01) / 1 TABLET, FILM... Sinus and Cold D CVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATED 2024-05-08
58602-0816-67 2 BLISTER PACK in 1 CARTON (58602-816-67) / 10 TABLET, EXTE... Naproxen Sodium and Pseudoephedrine Hydrochloride Sinus and Cold Aurohealth LLC 2022-06-01
58602-0816-72 3 BLISTER PACK in 1 CARTON (58602-816-72) / 8 TABLET, EXTEN... Naproxen Sodium and Pseudoephedrine Hydrochloride Sinus and Cold Aurohealth LLC 2025-02-12
58602-0816-83 1 BLISTER PACK in 1 CARTON (58602-816-83) / 10 TABLET, EXTE... Naproxen Sodium and Pseudoephedrine Hydrochloride Sinus and Cold Aurohealth LLC 2022-06-01
58602-0832-67 2 BLISTER PACK in 1 CARTON (58602-832-67) / 10 TABLET, EXTE... Naproxen Sodium and Pseudoephedrine Hydrochloride Sinus and Headache Aurohealth LLC 2022-06-01
58602-0832-83 1 BLISTER PACK in 1 CARTON (58602-832-83) / 10 TABLET, EXTE... Naproxen Sodium and Pseudoephedrine Hydrochloride Sinus and Headache Aurohealth LLC 2022-06-01
70000-0605-01 20 BLISTER PACK in 1 CARTON (70000-0605-1) / 1 TABLET, FILM... Leader All Day Sinus and Cold D Cardinal Health 110, LLC. dba Leader 2022-05-19
71179-0816-24 3 BLISTER PACK in 1 CARTON (71179-816-24) / 8 TABLET, EXTEN... NAPROXEN SODIUM AND PSEUDOEPHEDRINE HYDROCHLORIDE COLD AND SINUS VESPYR BRANDS LLC 2024-08-07
72854-0223-20 2 BLISTER PACK in 1 CARTON (72854-223-20) / 10 TABLET, EXTE... Mucinex DS 12HR COLD, FEVER and SINUS Reckitt Benckiser LLC 2026-07-01
Observed labelers: Aurohealth LLC (5) · Bayer HealthCare LLC. (3) · Cardinal Health 110, LLC. dba Leader (1) · CVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATED (1) · Kenvue Brands LLC (1) · Meijer Distribution Inc (1) · +4 more — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.