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Brimonidine tartrate 2 MG/ML / brinzolamide 10 MG/ML Ophthalmic Suspension [Simbrinza] — RxCUI 1421456

RxNorm drug concept · Semantic branded drug
RxCUI 1421456 Semantic branded drug · SBD ● Current RxNorm concept 1 FDA product 2 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1421456
Official nameBrimonidine tartrate 2 MG/ML / brinzolamide 10 MG/ML Ophthalmic Suspension [Simbrinza]
Concept typeSemantic branded drug (SBD)
RxNorm statusCurrent RxNorm concept
Also known asSimbrinza (brimonidine tartrate 0.2 % / brinzolamide 1 % ) Ophthalmic Suspension; SIMBRINZA 1 % / 0.2 % Ophthalmic Suspension
FDA products mapped1
Package NDCs mapped2
Reported Medicaid activity (SDUD)20,375 prescriptions · 37 state & territory Medicaid programs · latest period Q4 2025
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Brimonidine Ophthalmic: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • It lowers pressure inside your eye. Doctors prescribe it for open-angle glaucoma or ocular hypertension (high eye pressure). Lowering that pressure helps protect your optic nerve a...
  • The 0.15% label describes one drop in the affected eye(s) three times a day, about 8 hours apart. If you use other eye drops, wait at least 5 minutes between them. Always follow wh...
  • Eye redness, itching, burning or stinging, and dry mouth are common. Some people feel tired or notice blurred vision. Call your doctor if you have eye pain, discharge, swelling, a...
  • The 0.2% product contains benzalkonium chloride, which soft lenses can absorb. Wait at least 15 minutes after the drop before putting soft lenses in. Ask me about your specific pro...
📖 Read our full Brimonidine Ophthalmic guide →

🕸️ Concept Web — How Brimonidine tartrate 2 MG/ML / brinzolamide 10 M... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Brimonidine tartrate 2 MG/ML / brinzolamide 10 MG/ML Ophthalmic Suspension [Simbrinza] RxCUI 1421456

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 4

    The active substance itself — no strength, form, or brand attached yet.

    • Brimonidine 134615
    • Brinzolamide 194881
    • Brimonidine / brinzolamide 1421450
    • Brimonidine tartrate 39171
  2. Brand names 1

    The same medicine's trade names. A brand name alone says nothing about strength or form.

    • Simbrinza 1421452
  3. Dose forms 9

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Brimonidine / brinzolamide Ophthalmic Suspension 1421449
    • Brimonidine tartrate / brinzolamide Ophthalmic Suspension 2646325
    • Brimonidine / brinzolamide Ophthalmic Product 1421448
    • Brimonidine tartrate / brinzolamide Ophthalmic Product 2659674
    • Brimonidine / brinzolamide Ophthalmic Suspension [Simbrinza] 1421454
    • Brimonidine tartrate / brinzolamide Ophthalmic Suspension [Simbrinza] 2656733
    • Simbrinza Ophthalmic Product 1421455
    • Ophthalmic Suspension 316964
    • +1 more in this family
  4. Clinical & branded drugs 4

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

Showing up to 8 concepts per family — 17 of 18 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

  • Brimonidine tartrate 2 MG/ML / brinzolamide 10 MG/ML Ophthalmic Suspension SCD · 1421451
  • Brimonidine tartrate 2 MG/ML SCDC · 861199
  • Brinzolamide 10 MG/ML SCDC · 329604
  • Brimonidine / brinzolamide Ophthalmic Suspension SCDF · 1421449
  • Brimonidine tartrate / brinzolamide Ophthalmic Suspension SCDFP · 2646325
  • Brimonidine / brinzolamide Ophthalmic Product SCDG · 1421448
  • Brimonidine tartrate / brinzolamide Ophthalmic Product SCDGP · 2659674

Brand-Name Concepts

  • Brimonidine tartrate 2 MG/ML / brinzolamide 10 MG/ML [Simbrinza] SBDC · 1421453
  • Brimonidine / brinzolamide Ophthalmic Suspension [Simbrinza] SBDF · 1421454
  • Brimonidine tartrate / brinzolamide Ophthalmic Suspension [Simbrinza] SBDFP · 2656733
  • Simbrinza Ophthalmic Product SBDG · 1421455
  • Simbrinza BN · 1421452

📦 FDA Products & Package NDCs

1 product · 2 package NDCs
2 package NDCs map to RxCUI 1421456 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
00065-4147-25 1 BOTTLE, DROPPER in 1 CARTON (0065-4147-25) / 2.5 mL in 1... SIMBRINZA Alcon Laboratories, Inc. 2013-05-06
00065-4147-27 1 BOTTLE, DROPPER in 1 CARTON (0065-4147-27) / 8 mL in 1 BO... SIMBRINZA Alcon Laboratories, Inc. 2013-05-06
Observed labelers: Alcon Laboratories, Inc. (2) — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

💲 Pricing (NADAC)

NADAC is CMS's National Average Drug Acquisition Cost — roughly what pharmacies pay to buy the drug. It is an acquisition benchmark, not your copay.
Per ml · median
$26.0412
Range $26.0412–$26.0412 · middle 50% $26.0412–$26.0412 · 1 NDCs
Latest compatible distributions from the CMS NADAC file · dataset watermark 2026-07-10. Prices vary by package and pharmacy; a distribution is shown instead of one misleading number. Rows the dataset is silent on carry no price. No zero-cost conclusion should be drawn.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.