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Acetaminophen 650 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 1... — RxCUI 1659960

RxNorm drug concept · Semantic clinical drug
RxCUI 1659960 Semantic clinical drug · SCD ● Current RxNorm concept 25 FDA products 27 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1659960
Official nameAcetaminophen 650 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 10 MG Granules for Oral Solution
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asacetaminophen 650 MG / diphenhydramine HCl 25 MG / phenylephrine HCl 10 MG Packet for Oral Solution; acetaminophen 650 MG / diphenhydrAMINE HCl 25 MG / phenylephrine HCl 10 MG Granules for Oral Solution; acetaminophen 650 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 10 MG Powder for Oral Solution; APAP 650 MG / Diphenhydramine Hydrochloride 25 MG / Phenylephrine Hydrochloride 10 MG Granules for Oral Solution
FDA products mapped25
Package NDCs mapped27
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Diphenhydramine Topical: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • You can use it for temporary relief of pain and itching from everyday skin problems — things like insect bites, minor burns, minor cuts and scrapes, and general skin irritations. I...
  • What can I actually use this cream or spray for?
  • You can apply it up to 3 to 4 times a day, but no more than that. More frequent use isn't going to help more — and the label is clear that you shouldn't exceed that limit. For kids...
  • This is really important — do not use this topical product at the same time as any other product that contains diphenhydramine, even a pill or capsule. That includes allergy medici...
📖 Read our full Diphenhydramine Topical guide →

🕸️ Concept Web — How Acetaminophen 650 MG / diphenhydramine hydrochlo... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Acetaminophen 650 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 10 MG Granules for Oral Solution RxCUI 1659960

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 6

    The active substance itself — no strength, form, or brand attached yet.

    • Acetaminophen 161
    • Diphenhydramine 3498
    • Phenylephrine 8163
    • Acetaminophen / diphenhydramine / phenylephrine 689785
    • Diphenhydramine hydrochloride 1362
    • Phenylephrine hydrochloride 8164
  2. Dose forms 9

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Acetaminophen / diphenhydramine / phenylephrine Granules for Oral Solution 1659959
    • Acetaminophen / diphenhydramine hydrochloride / phenylephrine hydrochloride Granules for Oral Solution 2649021
    • Acetaminophen / diphenhydramine / phenylephrine Granule Product 1659958
    • Acetaminophen / diphenhydramine / phenylephrine Oral Product 1151196
    • Acetaminophen / diphenhydramine hydrochloride / phenylephrine hydrochloride Granule Product 2659146
    • Acetaminophen / diphenhydramine hydrochloride / phenylephrine hydrochloride Oral Product 2659765
    • Granules for Oral Solution 1540453
    • Granule Product 1294708
    • +1 more in this family
  3. Clinical & branded drugs 3

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

    • Acetaminophen 650 MG 315268
    • Diphenhydramine hydrochloride 25 MG 901813
    • Phenylephrine hydrochloride 10 MG 996705
  4. Packs 2

    Fixed collections of drugs packaged and sold together, like dose packs.

Showing up to 8 concepts per family — 19 of 20 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

📦 FDA Products & Package NDCs

25 products · 27 package NDCs
27 package NDCs map to RxCUI 1659960 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
00067-6095-01 8 POUCH in 1 CARTON (0067-6095-01) / 1 POWDER, FOR SOLUTION... THERAFLU POWERPODS NIGHTTIME SEVERE COLD Haleon US Holdings LLC 2018-07-28
00067-6095-03 1 POUCH in 1 CARTON (0067-6095-03) / 1 POWDER, FOR SOLUTION... THERAFLU POWERPODS NIGHTTIME SEVERE COLD Haleon US Holdings LLC 2019-01-20
00067-6803-02 6 PACKET in 1 CARTON (0067-6803-02) / 237 mL in 1 PACKET Theraflu Severe Cold Relief Nighttime Haleon US Holdings LLC 2023-01-20
00067-6804-02 1 KIT in 1 PACKAGE, COMBINATION (0067-6804-02) * 6 PACKET... Theraflu Severe Cold Relief Daytime and Theraflu Severe Cold Relief Nighttime Haleon US Holdings LLC 2023-01-20
00067-7918-06 6 PACKET in 1 CARTON (0067-7918-06) / 237 mL in 1 PACKET (0... THERAFLU NIGHTTIME SEVERE COLD AND COUGH Haleon US Holdings LLC 2014-07-01
00067-7919-12 1 KIT in 1 PACKAGE, COMBINATION (0067-7919-12) * 6 PACKET... Theraflu Multi-Symptom Severe Cold and Theraflu Nighttime Severe Cold and Cough Haleon US Holdings LLC 2016-01-01
00067-8200-01 1 KIT in 1 PACKAGE, COMBINATION (0067-8200-01) * 6 PACKET... Theraflu Multi-Symptom Severe Cold and Theraflu Nighttime Severe Cold and Cough Haleon US Holdings LLC 2019-09-01
00067-8212-01 6 PACKET in 1 CARTON (0067-8212-01) / 1 POWDER, FOR SOLUTIO... Theraflu Severe Cold Relief Nighttime with Honey Elderberry Flavor Haleon US Holdings LLC 2023-05-01
00363-5410-06 6 POWDER, FOR SOLUTION in 1 CARTON (0363-5410-06) Nighttime Wal Flu Severe Cold and Cough WALGREEN CO. 2018-05-29
00363-5480-12 1 KIT in 1 CARTON (0363-5480-12) * 6 PACKET in 1 CARTON (0... Multi Symptom Severe Cold and Nighttime Severe Cold and Cough WALGREEN CO. 2018-06-22
11673-0113-07 6 POWDER, FOR SOLUTION in 1 CARTON (11673-113-07) up and up nighttime flu and severe cold and cough Target Corporation 2013-06-28
11673-0542-12 1 KIT in 1 CARTON (11673-542-12) * 6 POWDER, FOR SOLUTION... daytime severe cold and cough and nighttime severe cold and cough Target Corporation 2017-07-31
11673-0877-55 1 KIT in 1 CARTON (11673-877-55) * 1 POWDER, FOR SOLUTION... Up and Up Daytime Multi Symptom Severe Cold Nighttime Severe Cold and Cough Target Corporation 2021-07-16
41226-0541-06 6 POWDER, FOR SOLUTION in 1 CARTON (41226-541-06) Nighttime Severe Cold and Cough KROGER COMPANY 2024-01-15
49035-0948-12 1 KIT in 1 CARTON (49035-948-12) * 6 PACKET in 1 CARTON (7... Multi Symptom Severe Cold and Nighttime Severe Cold and Cough WAL-MART STORES INC 2019-07-01
49035-0964-91 6 PACKET in 1 CARTON (49035-964-91) / 1 POWDER, FOR SOLUTIO... Equate Flu and Severe Cold and Cough Wal-Mart Stores Inc 2011-07-11
55758-0385-06 6 GRANULE, FOR SOLUTION in 1 CARTON (55758-385-06) SanaTos Severe Cold Relief Nighttime Pharmadel LLC 2024-03-31
55910-0964-91 6 POWDER, FOR SOLUTION in 1 CARTON (55910-964-91) dg health flu and severe cold and cough Dolgencorp, LLC 2011-05-24
58933-0542-16 1 KIT in 1 PACKAGE (58933-542-16) * 5 g in 1 PACKET (58933... Vicks DayQuil NyQuil HOT REMEDY RAPID RELIEF MULTI-SYMPTOM Cold and Flu plus Congestion Procter & Gamble Manufactura S de RL de CV 2022-07-20
58933-0551-01 5 g in 1 PACKET (58933-551-01) Vicks NyQuil HOT REMEDY RAPID RELIEF MULTI-SYMPTOM Cold and Flu plus Congestion Procter & Gamble Manufactura S de RL de CV 2023-03-22
58933-0551-08 8 PACKET in 1 PACKAGE (58933-551-08) / 5 g in 1 PACKET Vicks NyQuil HOT REMEDY RAPID RELIEF MULTI-SYMPTOM Cold and Flu plus Congestion Procter & Gamble Manufactura S de RL de CV 2023-03-22
59779-0768-12 1 KIT in 1 CARTON (59779-768-12) * 6 POWDER, FOR SOLUTION... Multi Symptom Severe Cold and Nighttime Severe Cold and Cough CVS Pharmacy,Inc. 2015-09-21
63868-0291-06 6 PACKET in 1 CARTON (63868-291-06) / 1 POWDER, FOR SOLUTIO... Quality Choice Severe Cold and Cough Nighttime Chain Drug Manufacturing Assn 2018-07-16
67091-0323-06 6 PACKET in 1 CARTON (67091-323-06) / 1 POWDER, FOR SOLUTIO... Severe Cold and Cough Nighttime WinCo Foods, LLC 2018-08-01
68163-0541-06 6 PACKET in 1 CARTON (68163-541-06) / 1 POWDER, FOR SOLUTIO... Nighttime Severe Cold and Cough RARITAN PHARMACEUTICALS INC 2019-03-22
72288-0191-55 1 KIT in 1 CARTON (72288-191-55) * 1 POWDER, FOR SOLUTION... basic care daytime severe cold and flu nighttime severe cold cough and flu Amazon.com Services LLC 2023-05-31
72288-0964-91 6 PACKET in 1 CARTON (72288-964-91) / 1 POWDER, FOR SOLUTIO... Basic Care severe cold and cough Amazon.com Services LLC 2021-07-20
Observed labelers: Haleon US Holdings LLC (8) · Procter & Gamble Manufactura S de RL de CV (3) · Target Corporation (3) · Amazon.com Services LLC (2) · Wal-Mart Stores Inc (2) · WALGREEN CO. (2) · +7 more — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.