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Methotrexate 2.5 MG/ML Oral Solution — RxCUI 1921592

RxNorm drug concept · Semantic clinical drug
RxCUI 1921592 Semantic clinical drug · SCD ● Current RxNorm concept 1 FDA product 2 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1921592
Official nameMethotrexate 2.5 MG/ML Oral Solution
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asmethotrexate 2.5 MG/ML (methotrexate sodium 2.74 MG/ML) Oral Solution
FDA products mapped1
Package NDCs mapped2
Reported Medicaid activity (SDUD)3,656 prescriptions · 27 state & territory Medicaid programs · latest period Q4 2025
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Methotrexate Injection: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • Yes — for rheumatoid arthritis, psoriasis, and juvenile idiopathic arthritis, once weekly is the correct and intended schedule. This is actually one of the most important safety po...
  • Why am I only taking this once a week? Is that really enough?
  • Common things like mild nausea, tiredness, or mouth soreness are expected and your team can help you manage them. But you should call your doctor immediately — or go to the ER — if...
  • What side effects should I just watch for, versus which ones mean I should call someone right away?
📖 Read our full Methotrexate Injection guide →

🕸️ Concept Web — How Methotrexate 2.5 MG/ML Oral Solution Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Methotrexate 2.5 MG/ML Oral Solution RxCUI 1921592

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 1

    The active substance itself — no strength, form, or brand attached yet.

    • Methotrexate 6851
  2. Brand names 1

    The same medicine's trade names. A brand name alone says nothing about strength or form.

    • Xatmep 1921593
  3. Dose forms 9

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Methotrexate Oral Solution 1921591
    • Methotrexate Oral Liquid Product 1921590
    • Methotrexate Oral Product 1162236
    • Methotrexate Oral Solution [Xatmep] 1921595
    • Xatmep Oral Liquid Product 1921596
    • Xatmep Oral Product 1921597
    • Oral Solution 316968
    • Oral Liquid Product 1151137
    • +1 more in this family
  4. Clinical & branded drugs 3

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

Showing up to 8 concepts per family — 13 of 14 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

  • Methotrexate 2.5 MG/ML SCDC · 330028
  • Methotrexate Oral Solution SCDF · 1921591
  • Methotrexate Oral Liquid Product SCDG · 1921590
  • Methotrexate Oral Product SCDG · 1162236

Brand-Name Concepts

  • Methotrexate 2.5 MG/ML Oral Solution [Xatmep] SBD · 1921598
  • Methotrexate 2.5 MG/ML [Xatmep] SBDC · 1921594
  • Methotrexate Oral Solution [Xatmep] SBDF · 1921595
  • Xatmep Oral Liquid Product SBDG · 1921596
  • Xatmep Oral Product SBDG · 1921597
  • Xatmep BN · 1921593

📦 FDA Products & Package NDCs

1 product · 2 package NDCs
2 package NDCs map to RxCUI 1921592 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
52652-2001-01 120 mL in 1 BOTTLE (52652-2001-1) Xatmep Azurity Pharmaceuticals, Inc. 2017-05-01
52652-2001-06 60 mL in 1 BOTTLE (52652-2001-6) Xatmep Azurity Pharmaceuticals, Inc. 2018-08-13
Observed labelers: Azurity Pharmaceuticals, Inc. (2) — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🧾 Billing Codes (HCPCS)

Medical billing codes (HCPCS "J-codes") that connect to this concept's packages — used mostly when a clinic or hospital bills for a drug it administers. Each code links to its full billing page.
CodeDescriptorMapped packagesSources
J8612 Oral methotrexate (xatmep) 2 CMS
⚠ A crosswalk is not coverage: an NDC↔HCPCS mapping does not guarantee any payer covers or pays the code. Always verify the current payer policy before billing.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.