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Hydroxyurea 500 MG Oral Capsule — RxCUI 197797

Name: Hydroxyurea 500 MG Oral Capsule (RxCUI 197797)
Creator: Brian Staiger, PharmD

RxNorm drug concept · Semantic clinical drug

RxCUI 197797 Semantic clinical drug · SCD ● Current RxNorm concept 12 FDA products 12 package NDCs Snapshot Jul 14, 2026

This page is curated, coded, and maintained by Dr. Brian Staiger, PharmD

Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI197797

Official nameHydroxyurea 500 MG Oral Capsule

Concept typeSemantic clinical drug (SCD)

RxNorm statusCurrent RxNorm concept

FDA products mapped12

Package NDCs mapped12

Reported Medicaid activity (SDUD)111,994 prescriptions · 50 state & territory Medicaid programs · latest period Q4 2025

RxNorm release07/06/2026

Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Hydroxyurea: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist

It's actually both, depending on the specific product. Droxia, Siklos, and Xromi are each approved to reduce the painful crises and blood transfusion needs in sickle cell anemia. H...
What exactly is hydroxyurea used for — is it a cancer drug or a sickle cell drug?
Very regularly — typically every two weeks while your dose is being adjusted. Hydroxyurea can lower your white blood cell and platelet counts, so monitoring is built into the treat...
How often will I need blood tests while I'm on this medication?

📖 Read our full Hydroxyurea guide →

🕸️ Concept Web — How Hydroxyurea 500 MG Oral Capsule Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.

This page's concept Hydroxyurea 500 MG Oral Capsule RxCUI 197797 Semantic clinical drug · SCD

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

Ingredients 1

The active substance itself — no strength, form, or brand attached yet.
- Hydroxyurea 5552 IN
Brand names 1

The same medicine's trade names. A brand name alone says nothing about strength or form.
- Hydrea 151871 BN
Dose forms 9

The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.
- Hydroxyurea Oral Capsule 370658 SCDF
- Hydroxyurea Oral Product 1160113 SCDG
- Hydroxyurea Pill 1160114 SCDG
- Hydroxyurea Oral Capsule [Hydrea] 366743 SBDF
- Hydrea Oral Product 1174066 SBDG
- Hydrea Pill 1174067 SBDG
- Oral Capsule 316965 DF
- Oral Product 1151131 DFG
- +1 more in this family
Clinical & branded drugs 3

Ingredient + strength + dose form. These are the concepts real FDA products actually carry.
- Hydroxyurea 500 MG 316070 SCDC
- Hydroxyurea 500 MG Oral Capsule [Hydrea] 105602 SBD
- Hydroxyurea 500 MG [Hydrea] 564113 SBDC

Showing up to 8 concepts per family — 13 of 14 stored related concepts drawn.

These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

Hydroxyurea 500 MG SCDC · 316070
Hydroxyurea Oral Capsule SCDF · 370658
Hydroxyurea Oral Product SCDG · 1160113
Hydroxyurea Pill SCDG · 1160114

Brand-Name Concepts

Hydroxyurea 500 MG Oral Capsule [Hydrea] SBD · 105602
Hydroxyurea 500 MG [Hydrea] SBDC · 564113
Hydroxyurea Oral Capsule [Hydrea] SBDF · 366743
Hydrea Oral Product SBDG · 1174066
Hydrea Pill SBDG · 1174067
Hydrea BN · 151871

📦 FDA Products & Package NDCs

12 products · 12 package NDCs

12 package NDCs map to RxCUI 197797 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.

Package NDC	Package	Brand / generic name	Labeler	Marketing start
00555-0882-02	100 CAPSULE in 1 BOTTLE (0555-0882-02)	HYDROXYUREA	Teva Pharmaceuticals USA, Inc.	1998-10-19
00904-6939-61	100 BLISTER PACK in 1 CARTON (0904-6939-61) / 1 CAPSULE in...	Hydroxyurea	Major Pharmaceuticals	1999-02-24
42291-0321-01	100 CAPSULE in 1 BOTTLE (42291-321-01)	HYDROXYUREA	AvKARE	2013-07-23
49884-0724-01	100 CAPSULE in 1 BOTTLE (49884-724-01)	Hydroxyurea	Par Health USA, LLC	1999-02-24
51407-0909-01	100 CAPSULE in 1 BOTTLE, PLASTIC (51407-909-01)	HYDROXYUREA	Golden State Medical Supply, Inc.	2024-04-22
61269-0835-10	100 CAPSULE in 1 BOTTLE (61269-835-10)	HYDREA	H2-Pharma LLC	2009-06-01
67046-1619-03	30 CAPSULE in 1 BLISTER PACK (67046-1619-3)	HYDROXYUREA	Coupler LLC	2025-12-02
67184-0607-01	100 CAPSULE in 1 BOTTLE (67184-0607-1)	HYDROXYUREA	Qilu Pharmaceutical Co., Ltd.	2024-03-06
68084-0284-01	100 BLISTER PACK in 1 BOX, UNIT-DOSE (68084-284-01) / 1 CAP...	Hydroxyurea	American Health Packaging	2008-09-17
69315-0164-01	100 CAPSULE in 1 BOTTLE, PLASTIC (69315-164-01)	HYDROXYUREA	Leading Pharma, LLC	2020-07-09
70069-0820-01	100 CAPSULE in 1 BOTTLE (70069-820-01)	HYDROXYUREA	Somerset Therapeutics, LLC	2024-06-18
80725-0810-10	100 CAPSULE in 1 BOTTLE, PLASTIC (80725-810-10)	HYDREA	Waylis Therapeutics LLC	2025-09-11

Observed labelers: American Health Packaging (1) · AvKARE (1) · Coupler LLC (1) · Golden State Medical Supply, Inc. (1) · H2-Pharma LLC (1) · Leading Pharma, LLC (1) · +6 more — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

💲 Pricing (NADAC)

NADAC is CMS's National Average Drug Acquisition Cost — roughly what pharmacies pay to buy the drug. It is an acquisition benchmark, not your copay.

Per ea · median

$0.1910

Range $0.1910–$0.1910 · middle 50% $0.1910–$0.1910 · 6 NDCs

Latest compatible distributions from the CMS NADAC file · dataset watermark 2026-07-10. Prices vary by package and pharmacy; a distribution is shown instead of one misleading number. Rows the dataset is silent on carry no price. No zero-cost conclusion should be drawn.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7

openFDA export observedJul 14, 2026

RxNorm release07/06/2026

Methodology2026-07-full-catalog-v1

A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.

This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.