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Acetaminophen 65 MG/ML / chlorpheniramine maleate 0.4 MG/ML / dextromethorphan hydrobromid... — RxCUI 2121065

Name: Acetaminophen 65 MG/ML / chlorpheniramine maleate 0.4 MG/ML / dextromethorphan hydrob… (RxCUI 2121065)
Creator: Brian Staiger, PharmD

RxNorm drug concept · Semantic clinical drug

RxCUI 2121065 Semantic clinical drug · SCD ● Current RxNorm concept 2 FDA products 2 package NDCs Snapshot Jul 14, 2026

This page is curated, coded, and maintained by Dr. Brian Staiger, PharmD

Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI2121065

Official nameAcetaminophen 65 MG/ML / chlorpheniramine maleate 0.4 MG/ML / dextromethorphan hydrobromide 1.3 MG/ML / phenylephrine hydrochloride 1 MG/ML Oral Solution

Concept typeSemantic clinical drug (SCD)

RxNorm statusCurrent RxNorm concept

Also known asAPAP 65 MG/ML / Chlorpheniramine Maleate 0.4 MG/ML / Dextromethorphan Hydrobromide 1.3 MG/ML / Phenylephrine Hydrochloride 1 MG/ML Oral Solution; acetaminophen 325 MG / chlorpheniramine maleate 2 MG / dextromethorphan HBr 6.5 MG / phenylephrine HCl 5 MG in 5 mL Oral Solution; acetaminophen 325 MG / chlorpheniramine maleate 2 MG / dextromethorphan hydrobromide 6.5 MG / phenylephrine hydrochloride 5 MG per 5 ML Oral Solution

FDA products mapped2

Package NDCs mapped2

RxNorm release07/06/2026

Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Phenylephrine: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist

It depends on the product. The injection raises low blood pressure during anesthesia and, for some products, septic shock. Eye drops dilate the pupil, nasal products relieve conges...
Be careful. Over-the-counter phenylephrine should not be used with a prescription MAOI or within 2 weeks of stopping one. If you aren't sure whether your medicine is an MAOI, ask m...
With the injection, the most common are nausea, vomiting and headache. Call for help right away if you have chest pain, a very slow heartbeat, or pain or skin changes around the IV...
Stop and talk to a doctor if you get nervousness, dizziness or sleeplessness. Also stop if symptoms last more than 7 days or come with a fever. Don't use more than the label recomm...

📖 Read our full Phenylephrine guide →

🕸️ Concept Web — How Acetaminophen 65 MG/ML / chlorpheniramine maleat... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.

This page's concept Acetaminophen 65 MG/ML / chlorpheniramine maleate 0.4 MG/ML / dextromethorphan hydrobromide 1.3 MG/ML / phenylephrine hydrochloride 1 MG/ML Oral Solution RxCUI 2121065 Semantic clinical drug · SCD

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

Ingredients 8

The active substance itself — no strength, form, or brand attached yet.
- Acetaminophen 161 IN
- Chlorpheniramine 2400 IN
- Dextromethorphan 3289 IN
- Phenylephrine 8163 IN
- Acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine 689580 MIN
- Chlorpheniramine maleate 142429 PIN
- Dextromethorphan hydrobromide 102490 PIN
- Phenylephrine hydrochloride 8164 PIN
Dose forms 9

The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.
- Acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine Oral Solution 728132 SCDF
- Acetaminophen / chlorpheniramine maleate / dextromethorphan hydrobromide / phenylephrine hydrochloride Oral Solution 2649272 SCDFP
- Acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine Oral Liquid Product 1154902 SCDG
- Acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine Oral Product 1154903 SCDG
- Acetaminophen / chlorpheniramine maleate / dextromethorphan hydrobromide / phenylephrine hydrochloride Oral Liquid Product 2661691 SCDGP
- Acetaminophen / chlorpheniramine maleate / dextromethorphan hydrobromide / phenylephrine hydrochloride Oral Product 2659525 SCDGP
- Oral Solution 316968 DF
- Oral Liquid Product 1151137 DFG
- +1 more in this family
Clinical & branded drugs 4

Ingredient + strength + dose form. These are the concepts real FDA products actually carry.
- Acetaminophen 65 MG/ML 317286 SCDC
- Chlorpheniramine maleate 0.4 MG/ML 996986 SCDC
- Dextromethorphan hydrobromide 1.3 MG/ML 2121064 SCDC
- Phenylephrine hydrochloride 1 MG/ML 996578 SCDC

Showing up to 8 concepts per family — 20 of 21 stored related concepts drawn.

These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

Acetaminophen 65 MG/ML SCDC · 317286
Chlorpheniramine maleate 0.4 MG/ML SCDC · 996986
Dextromethorphan hydrobromide 1.3 MG/ML SCDC · 2121064
Phenylephrine hydrochloride 1 MG/ML SCDC · 996578
Acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine Oral Solution SCDF · 728132
Acetaminophen / chlorpheniramine maleate / dextromethorphan hydrobromide / phenylephrine hydrochloride Oral Solution SCDFP · 2649272
Acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine Oral Liquid Product SCDG · 1154902
Acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine Oral Product SCDG · 1154903
Acetaminophen / chlorpheniramine maleate / dextromethorphan hydrobromide / phenylephrine hydrochloride Oral Liquid Product SCDGP · 2661691
Acetaminophen / chlorpheniramine maleate / dextromethorphan hydrobromide / phenylephrine hydrochloride Oral Product SCDGP · 2659525

📦 FDA Products & Package NDCs

2 products · 2 package NDCs

2 package NDCs map to RxCUI 2121065 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.

Package NDC	Package	Brand / generic name	Labeler	Marketing start
58552-0136-04	1 BOTTLE in 1 CARTON (58552-136-04) / 118 mL in 1 BOTTLE	Giltuss MultiSymptom Cold and Flu	Giltuss Pharmaceutical Corp	2018-10-02
58552-0137-04	1 BOTTLE in 1 CARTON (58552-137-04) / 118 mL in 1 BOTTLE	Giltuss Childrens MultiSymptom Cold and Flu	Giltuss Pharmaceutical Corp	2018-10-02

Observed labelers: Giltuss Pharmaceutical Corp (2) — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7

openFDA export observedJul 14, 2026

RxNorm release07/06/2026

Methodology2026-07-full-catalog-v1

A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.

This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.