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Acetaminophen 32.5 MG/ML / diphenhydramine hydrochloride 1.25 MG/ML Oral Solution — RxCUI 2374554

Name: Acetaminophen 32.5 MG/ML / diphenhydramine hydrochloride 1.25 MG/ML Oral Solution (RxCUI 2374554)
Creator: Brian Staiger, PharmD

RxNorm drug concept · Semantic clinical drug

RxCUI 2374554 Semantic clinical drug · SCD ● Current RxNorm concept 3 FDA products 4 package NDCs Snapshot Jul 14, 2026

This page is curated, coded, and maintained by Dr. Brian Staiger, PharmD

Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI2374554

Official nameAcetaminophen 32.5 MG/ML / diphenhydramine hydrochloride 1.25 MG/ML Oral Solution

Concept typeSemantic clinical drug (SCD)

RxNorm statusCurrent RxNorm concept

Also known asAPAP 32.5 MG/ML / diphenhydramine hydrochloride 1.25 MG/ML Oral Solution; acetaminophen 650 MG / diphenhydrAMINE HCl 25 MG in 20 mL Oral Solution; acetaminophen 650 MG / diphenhydramine HCl 25 MG per 20 mL Oral Solution

FDA products mapped3

Package NDCs mapped4

RxNorm release07/06/2026

Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Diphenhydramine Topical: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist

You can use it for temporary relief of pain and itching from everyday skin problems — things like insect bites, minor burns, minor cuts and scrapes, and general skin irritations. I...
What can I actually use this cream or spray for?
You can apply it up to 3 to 4 times a day, but no more than that. More frequent use isn't going to help more — and the label is clear that you shouldn't exceed that limit. For kids...
This is really important — do not use this topical product at the same time as any other product that contains diphenhydramine, even a pill or capsule. That includes allergy medici...

📖 Read our full Diphenhydramine Topical guide →

🕸️ Concept Web — How Acetaminophen 32.5 MG/ML / diphenhydramine hydro... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.

This page's concept Acetaminophen 32.5 MG/ML / diphenhydramine hydrochloride 1.25 MG/ML Oral Solution RxCUI 2374554 Semantic clinical drug · SCD

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

Ingredients 4

The active substance itself — no strength, form, or brand attached yet.
- Acetaminophen 161 IN
- Diphenhydramine 3498 IN
- Acetaminophen / diphenhydramine 214181 MIN
- Diphenhydramine hydrochloride 1362 PIN
Dose forms 9

The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.
- Acetaminophen / diphenhydramine Oral Solution 371897 SCDF
- Acetaminophen / diphenhydramine hydrochloride Oral Solution 2648062 SCDFP
- Acetaminophen / diphenhydramine Oral Liquid Product 1151203 SCDG
- Acetaminophen / diphenhydramine Oral Product 1151204 SCDG
- Acetaminophen / diphenhydramine hydrochloride Oral Liquid Product 2660960 SCDGP
- Acetaminophen / diphenhydramine hydrochloride Oral Product 2662609 SCDGP
- Oral Solution 316968 DF
- Oral Liquid Product 1151137 DFG
- +1 more in this family
Clinical & branded drugs 2

Ingredient + strength + dose form. These are the concepts real FDA products actually carry.
- Acetaminophen 32.5 MG/ML 336021 SCDC
- Diphenhydramine hydrochloride 1.25 MG/ML 1049883 SCDC

Showing up to 8 concepts per family — 14 of 15 stored related concepts drawn.

These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

Acetaminophen 32.5 MG/ML SCDC · 336021
Diphenhydramine hydrochloride 1.25 MG/ML SCDC · 1049883
Acetaminophen / diphenhydramine Oral Solution SCDF · 371897
Acetaminophen / diphenhydramine hydrochloride Oral Solution SCDFP · 2648062
Acetaminophen / diphenhydramine Oral Liquid Product SCDG · 1151203
Acetaminophen / diphenhydramine Oral Product SCDG · 1151204
Acetaminophen / diphenhydramine hydrochloride Oral Liquid Product SCDGP · 2660960
Acetaminophen / diphenhydramine hydrochloride Oral Product SCDGP · 2662609

📦 FDA Products & Package NDCs

3 products · 4 package NDCs

4 package NDCs map to RxCUI 2374554 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.

Package NDC	Package	Brand / generic name	Labeler	Marketing start
00031-0101-04	1 BOTTLE in 1 CARTON (0031-0101-04) / 118 mL in 1 BOTTLE	Robitussin Maximum Strength Severe Multi-Symptom Cough Cold Flu Nighttime	Haleon US Holdings LLC	2024-02-15
00031-8770-12	1 BOTTLE in 1 CARTON (0031-8770-12) / 118 mL in 1 BOTTLE	Robitussin Honey Severe Cough, Flu Plus Sore Throat Nighttime	Haleon US Holdings LLC	2020-06-15
00031-8770-18	1 BOTTLE in 1 CARTON (0031-8770-18) / 237 mL in 1 BOTTLE	Robitussin Honey Severe Cough, Flu Plus Sore Throat Nighttime	Haleon US Holdings LLC	2020-06-15
11673-0794-01	1 KIT in 1 KIT (11673-794-01) * 177 mL in 1 BOTTLE, PLASTI...	Maximum Strength Daytime Severe and Nighttime Cold and Flu	TARGET Corporation	2024-05-01

Observed labelers: Haleon US Holdings LLC (3) · TARGET Corporation (1) — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7

openFDA export observedJul 14, 2026

RxNorm release07/06/2026

Methodology2026-07-full-catalog-v1

A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.

This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.