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Acetaminophen 325 MG / butalbital 50 MG / caffeine 40 MG Oral Tablet — RxCUI 238154

RxNorm drug concept · Semantic clinical drug
RxCUI 238154 Semantic clinical drug · SCD ● Current RxNorm concept 44 FDA products 167 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI238154
Official nameAcetaminophen 325 MG / butalbital 50 MG / caffeine 40 MG Oral Tablet
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asAPAP 325 MG / butalbital 50 MG / caffeine 40 MG Oral Tablet
FDA products mapped44
Package NDCs mapped167
Reported Medicaid activity (SDUD)365,827 prescriptions · 52 state & territory Medicaid programs · latest period Q4 2025
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Acetaminophen, Butalbital, and Caffeine: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • Yes, that's exactly what it's intended for. This combination of butalbital, acetaminophen, and caffeine is prescribed specifically to relieve tension headaches — the kind caused by...
  • What exactly is this medication for? My doctor prescribed it for headaches — is that normal?
  • This is actually something to be careful about. Butalbital, one of the ingredients, is habit-forming — meaning your body can become physically dependent on it if you take it freque...
  • Can I take this regularly if I get headaches a lot?
📖 Read our full Acetaminophen, Butalbital, and Caffeine guide →

🕸️ Concept Web — How Acetaminophen 325 MG / butalbital 50 MG / caffei... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Acetaminophen 325 MG / butalbital 50 MG / caffeine 40 MG Oral Tablet RxCUI 238154

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 4

    The active substance itself — no strength, form, or brand attached yet.

    • Acetaminophen 161
    • Butalbital 19860
    • Caffeine 1886
    • Acetaminophen / butalbital / caffeine 214130
  2. Brand names 2

    The same medicine's trade names. A brand name alone says nothing about strength or form.

    • Esgic 216971
    • Repan 219624
  3. Dose forms 12

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Acetaminophen / butalbital / caffeine Oral Tablet 374751
    • Acetaminophen / butalbital / caffeine Oral Product 1152255
    • Acetaminophen / butalbital / caffeine Pill 1152256
    • Acetaminophen / butalbital / caffeine Oral Tablet [Esgic] 367776
    • Acetaminophen / butalbital / caffeine Oral Tablet [Repan] 367771
    • Esgic Oral Product 1169698
    • Esgic Pill 1169699
    • Repan Oral Product 1181337
    • +4 more in this family
  4. Clinical & branded drugs 7

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

    • Acetaminophen 325 MG 315263
    • Butalbital 50 MG 317309
    • Caffeine 40 MG 317310
    • Acetaminophen 325 MG / butalbital 50 MG / caffeine 40 MG Oral Tablet [Esgic] 211189
    • Acetaminophen 325 MG / butalbital 50 MG / caffeine 40 MG Oral Tablet [Repan] 211194
    • Acetaminophen 325 MG / butalbital 50 MG / caffeine 40 MG [Esgic] 571621
    • Acetaminophen 325 MG / butalbital 50 MG / caffeine 40 MG [Repan] 571650

Showing up to 8 concepts per family — 21 of 25 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

  • Acetaminophen 325 MG SCDC · 315263
  • Butalbital 50 MG SCDC · 317309
  • Caffeine 40 MG SCDC · 317310
  • Acetaminophen / butalbital / caffeine Oral Tablet SCDF · 374751
  • Acetaminophen / butalbital / caffeine Oral Product SCDG · 1152255
  • Acetaminophen / butalbital / caffeine Pill SCDG · 1152256

Brand-Name Concepts

  • Acetaminophen 325 MG / butalbital 50 MG / caffeine 40 MG Oral Tablet [Esgic] SBD · 211189
  • Acetaminophen 325 MG / butalbital 50 MG / caffeine 40 MG Oral Tablet [Repan] SBD · 211194
  • Acetaminophen 325 MG / butalbital 50 MG / caffeine 40 MG [Esgic] SBDC · 571621
  • Acetaminophen 325 MG / butalbital 50 MG / caffeine 40 MG [Repan] SBDC · 571650
  • Acetaminophen / butalbital / caffeine Oral Tablet [Esgic] SBDF · 367776
  • Acetaminophen / butalbital / caffeine Oral Tablet [Repan] SBDF · 367771
  • Esgic Oral Product SBDG · 1169698
  • Esgic Pill SBDG · 1169699
  • Repan Oral Product SBDG · 1181337
  • Repan Pill SBDG · 1181338

📦 FDA Products & Package NDCs

44 products · 167 package NDCs
167 package NDCs map to RxCUI 238154 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
00527-1695-01 100 TABLET in 1 BOTTLE, PLASTIC (0527-1695-01) Butalbital, Acetaminophen, and Caffeine Lannett Company, Inc. 2012-09-13
00527-1695-05 500 TABLET in 1 BOTTLE, PLASTIC (0527-1695-05) Butalbital, Acetaminophen, and Caffeine Lannett Company, Inc. 2012-09-13
00591-3369-01 100 TABLET in 1 BOTTLE (0591-3369-01) Butalbital, Acetaminophen, and Caffeine Actavis Pharma, Inc. 2007-12-13
00591-3369-05 500 TABLET in 1 BOTTLE (0591-3369-05) Butalbital, Acetaminophen, and Caffeine Actavis Pharma, Inc. 2007-12-13
00904-6938-06 50 BLISTER PACK in 1 CARTON (0904-6938-06) / 1 TABLET in 1... Butalbital, Acetaminophen, and Caffeine Major Pharmaceuticals 2012-09-13
10702-0253-01 100 TABLET in 1 BOTTLE (10702-253-01) Butalbital, Acetaminophen and Caffeine KVK-Tech, Inc. 2018-09-26
10702-0253-50 500 TABLET in 1 BOTTLE (10702-253-50) Butalbital, Acetaminophen and Caffeine KVK-Tech, Inc. 2018-11-29
46672-0053-10 100 TABLET in 1 BOTTLE, PLASTIC (46672-053-10) butalbital, acetaminophen and caffeine Mikart, LLC 1987-01-21
46672-0053-50 500 TABLET in 1 BOTTLE, PLASTIC (46672-053-50) butalbital, acetaminophen and caffeine Mikart, LLC 1987-01-21
50090-7042-00 30 TABLET in 1 BOTTLE (50090-7042-0) Butalbital, Acetaminophen, Caffeine A-S Medication Solutions 2024-01-11
50090-7042-03 100 TABLET in 1 BOTTLE (50090-7042-3) Butalbital, Acetaminophen, Caffeine A-S Medication Solutions 2024-02-05
50090-7519-00 30 TABLET in 1 BOTTLE (50090-7519-0) Butalbital, Acetaminophen and Caffeine A-S Medication Solutions 2025-03-17
50268-0553-13 30 BLISTER PACK in 1 BOX (50268-553-13) / 1 TABLET in 1 BLI... Butalbital, Acetaminophen, Caffeine AvPAK 2022-08-11
51407-0556-01 100 TABLET in 1 BOTTLE (51407-556-01) Butalbital, Acetaminophen and Caffeine Golden State Medical Supply, Inc. 2022-09-12
51407-0556-05 500 TABLET in 1 BOTTLE (51407-556-05) Butalbital, Acetaminophen and Caffeine Golden State Medical Supply, Inc. 2022-11-22
55154-3356-00 10 BLISTER PACK in 1 BAG (55154-3356-0) / 1 TABLET in 1 BLI... Butalbital, Acetaminophen, and Caffeine Cardinal Health 107, LLC 2012-09-13
60687-0672-65 50 BLISTER PACK in 1 CARTON (60687-672-65) / 1 TABLET in 1... Butalbital, Acetaminophen and Caffeine American Health Packaging 2022-10-17
60760-0865-12 12 TABLET in 1 BOTTLE, PLASTIC (60760-865-12) Butalbital, Acetaminophen and Caffeine ST. MARY'S MEDICAL PARK PHARMACY 2025-05-19
62135-0751-01 100 TABLET in 1 BOTTLE (62135-751-01) BUTALBITAL, ACETAMINOPHEN AND CAFFEINE Chartwell RX, LLC 2023-08-25
63187-0520-30 30 TABLET in 1 BOTTLE, PLASTIC (63187-520-30) butalbital, acetaminophen and caffeine Proficient Rx LP 2018-12-01
63187-0520-60 60 TABLET in 1 BOTTLE, PLASTIC (63187-520-60) butalbital, acetaminophen and caffeine Proficient Rx LP 2018-12-01
63187-0520-90 90 TABLET in 1 BOTTLE, PLASTIC (63187-520-90) butalbital, acetaminophen and caffeine Proficient Rx LP 2018-12-01
63187-0933-14 14 TABLET in 1 BOTTLE, PLASTIC (63187-933-14) Butalbital, Acetaminophen, and Caffeine Proficient Rx LP 2020-02-28
63187-0933-30 30 TABLET in 1 BOTTLE, PLASTIC (63187-933-30) Butalbital, Acetaminophen, and Caffeine Proficient Rx LP 2017-11-01
63187-0933-60 60 TABLET in 1 BOTTLE, PLASTIC (63187-933-60) Butalbital, Acetaminophen, and Caffeine Proficient Rx LP 2017-11-01
63187-0933-90 90 TABLET in 1 BOTTLE, PLASTIC (63187-933-90) Butalbital, Acetaminophen, and Caffeine Proficient Rx LP 2017-11-01
63629-8392-00 84 TABLET in 1 BOTTLE (63629-8392-0) Butalbital, Acetaminophen, and Caffeine Bryant Ranch Prepack 2024-10-29
63629-8392-01 20 TABLET in 1 BOTTLE (63629-8392-1) Butalbital, Acetaminophen, and Caffeine Bryant Ranch Prepack 2024-10-29
63629-8392-02 30 TABLET in 1 BOTTLE (63629-8392-2) Butalbital, Acetaminophen, and Caffeine Bryant Ranch Prepack 2020-12-09
63629-8392-03 60 TABLET in 1 BOTTLE (63629-8392-3) Butalbital, Acetaminophen, and Caffeine Bryant Ranch Prepack 2020-12-09
63629-8392-04 90 TABLET in 1 BOTTLE (63629-8392-4) Butalbital, Acetaminophen, and Caffeine Bryant Ranch Prepack 2021-01-20
63629-8392-05 50 TABLET in 1 BOTTLE (63629-8392-5) Butalbital, Acetaminophen, and Caffeine Bryant Ranch Prepack 2024-10-29
63629-8392-06 6 TABLET in 1 BOTTLE (63629-8392-6) Butalbital, Acetaminophen, and Caffeine Bryant Ranch Prepack 2024-10-29
63629-8392-07 120 TABLET in 1 BOTTLE (63629-8392-7) Butalbital, Acetaminophen, and Caffeine Bryant Ranch Prepack 2024-10-29
63629-8392-08 40 TABLET in 1 BOTTLE (63629-8392-8) Butalbital, Acetaminophen, and Caffeine Bryant Ranch Prepack 2024-10-29
63629-8392-09 12 TABLET in 1 BOTTLE (63629-8392-9) Butalbital, Acetaminophen, and Caffeine Bryant Ranch Prepack 2020-12-08
64380-0157-01 100 TABLET in 1 BOTTLE, PLASTIC (64380-157-01) Butalbital, Acetaminophen and Caffeine Strides Pharma Science Limited 2022-04-04
64380-0157-02 500 TABLET in 1 BOTTLE, PLASTIC (64380-157-02) Butalbital, Acetaminophen and Caffeine Strides Pharma Science Limited 2022-04-04
67296-2204-01 20 TABLET in 1 BOTTLE (67296-2204-1) Butalbital, Acetaminophen and Caffeine Redpharm Drug 2018-09-26
68071-3249-00 10 TABLET in 1 BOTTLE (68071-3249-0) Butalbital, Acetaminophen, and Caffeine NuCare Pharmaceuticals, Inc. 2017-08-16
68071-3249-02 20 TABLET in 1 BOTTLE (68071-3249-2) Butalbital, Acetaminophen, and Caffeine NuCare Pharmaceuticals, Inc. 2017-05-05
68071-3249-03 30 TABLET in 1 BOTTLE (68071-3249-3) Butalbital, Acetaminophen, and Caffeine NuCare Pharmaceuticals, Inc. 2017-05-05
68071-3249-06 60 TABLET in 1 BOTTLE (68071-3249-6) Butalbital, Acetaminophen, and Caffeine NuCare Pharmaceuticals, Inc. 2017-05-05
68788-4126-02 20 TABLET in 1 BOTTLE (68788-4126-2) Butalbital, Acetaminophen and Caffeine Preferred Pharmaceuticals Inc. 2026-06-09
68788-4126-03 30 TABLET in 1 BOTTLE (68788-4126-3) Butalbital, Acetaminophen and Caffeine Preferred Pharmaceuticals Inc. 2026-06-09
68788-8137-02 20 TABLET in 1 BOTTLE (68788-8137-2) Butalbital, Acetaminophen, Caffeine Preferred Pharmaceuticals Inc. 2022-02-11
68788-8137-03 30 TABLET in 1 BOTTLE (68788-8137-3) Butalbital, Acetaminophen, Caffeine Preferred Pharmaceuticals Inc. 2022-02-11
68788-8794-02 20 TABLET in 1 BOTTLE, PLASTIC (68788-8794-2) BUTALBITAL, ACETAMINOPHEN AND CAFFEINE Preferred Pharmaceuticals Inc. 2024-12-18
68788-8794-03 30 TABLET in 1 BOTTLE, PLASTIC (68788-8794-3) BUTALBITAL, ACETAMINOPHEN AND CAFFEINE Preferred Pharmaceuticals Inc. 2024-12-18
69367-0203-01 100 TABLET in 1 BOTTLE (69367-203-01) Butalbital, Acetaminophen, Caffeine Westminster Pharmaceuticals, LLC 2019-03-05
Observed labelers: Bryant Ranch Prepack (80) · Proficient Rx LP (17) · REMEDYREPACK INC. (10) · Asclemed USA, Inc. (8) · Advanced Rx of Tennessee, LLC (6) · Direct_Rx (6) · +20 more — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

💲 Pricing (NADAC)

NADAC is CMS's National Average Drug Acquisition Cost — roughly what pharmacies pay to buy the drug. It is an acquisition benchmark, not your copay.
Per ea · median
$0.1218
Range $0.1218–$0.1218 · middle 50% $0.1218–$0.1218 · 20 NDCs
Latest compatible distributions from the CMS NADAC file · dataset watermark 2026-07-10. Prices vary by package and pharmacy; a distribution is shown instead of one misleading number. Rows the dataset is silent on carry no price. No zero-cost conclusion should be drawn.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.