Acetaminophen 325 MG / butalbital 50 MG / caffeine 40 MG Oral Tablet — RxCUI 238154
RxNorm drug concept · Semantic clinical drug
RxCUI 238154
Semantic clinical drug · SCD
● Current RxNorm concept 44 FDA products
167 package NDCs
Snapshot Jul 14, 2026
What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.
🗂️ Key Facts
RxCUI238154
Official nameAcetaminophen 325 MG / butalbital 50 MG / caffeine 40 MG Oral Tablet
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asAPAP 325 MG / butalbital 50 MG / caffeine 40 MG Oral Tablet
FDA products mapped44
Package NDCs mapped167
Reported Medicaid activity (SDUD)365,827 prescriptions · 52 state & territory Medicaid programs · latest period Q4 2025
RxNorm release07/06/2026
Snapshot dataJul 14, 2026
📖 Skip the Codes — Read It in Plain English.
Our pharmacist-built guide to Acetaminophen, Butalbital, and Caffeine: what it is, how it’s used, side effects, and interactions.
📗 Our plain-language guide HelloPharmacist
- Yes, that's exactly what it's intended for. This combination of butalbital, acetaminophen, and caffeine is prescribed specifically to relieve tension headaches — the kind caused by...
- What exactly is this medication for? My doctor prescribed it for headaches — is that normal?
- This is actually something to be careful about. Butalbital, one of the ingredients, is habit-forming — meaning your body can become physically dependent on it if you take it freque...
- Can I take this regularly if I get headaches a lot?
🕸️ Concept Web — How Acetaminophen 325 MG / butalbital 50 MG / caffei... Connects
One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept
Acetaminophen 325 MG / butalbital 50 MG / caffeine 40 MG Oral Tablet
RxCUI 238154 Semantic clinical drug · SCD
Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.
-
Ingredients 4
The active substance itself — no strength, form, or brand attached yet.
-
Acetaminophen
161IN -
Butalbital
19860IN -
Caffeine
1886IN -
Acetaminophen / butalbital / caffeine
214130MIN
-
Acetaminophen
-
Brand names 2
The same medicine's trade names. A brand name alone says nothing about strength or form.
-
Esgic
216971BN -
Repan
219624BN
-
Esgic
-
Dose forms 12
The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.
-
Acetaminophen / butalbital / caffeine Oral Tablet
374751SCDF -
Acetaminophen / butalbital / caffeine Oral Product
1152255SCDG -
Acetaminophen / butalbital / caffeine Pill
1152256SCDG -
Acetaminophen / butalbital / caffeine Oral Tablet [Esgic]
367776SBDF -
Acetaminophen / butalbital / caffeine Oral Tablet [Repan]
367771SBDF -
Esgic Oral Product
1169698SBDG -
Esgic Pill
1169699SBDG -
Repan Oral Product
1181337SBDG - +4 more in this family
-
Acetaminophen / butalbital / caffeine Oral Tablet
-
Clinical & branded drugs 7
Ingredient + strength + dose form. These are the concepts real FDA products actually carry.
-
Acetaminophen 325 MG
315263SCDC -
Butalbital 50 MG
317309SCDC -
Caffeine 40 MG
317310SCDC -
Acetaminophen 325 MG / butalbital 50 MG / caffeine 40 MG Oral Tablet [Esgic]
211189SBD -
Acetaminophen 325 MG / butalbital 50 MG / caffeine 40 MG Oral Tablet [Repan]
211194SBD -
Acetaminophen 325 MG / butalbital 50 MG / caffeine 40 MG [Esgic]
571621SBDC -
Acetaminophen 325 MG / butalbital 50 MG / caffeine 40 MG [Repan]
571650SBDC
-
Acetaminophen 325 MG
Showing up to 8 concepts per family — 21 of 25 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.
🔀 Generic ⇄ Brand Crosswalk
The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.
Generic (Clinical) Concepts
-
Acetaminophen 325 MG
SCDC · 315263 -
Butalbital 50 MG
SCDC · 317309 -
Caffeine 40 MG
SCDC · 317310 -
Acetaminophen / butalbital / caffeine Oral Tablet
SCDF · 374751 -
Acetaminophen / butalbital / caffeine Oral Product
SCDG · 1152255 -
Acetaminophen / butalbital / caffeine Pill
SCDG · 1152256
Brand-Name Concepts
-
Acetaminophen 325 MG / butalbital 50 MG / caffeine 40 MG Oral Tablet [Esgic]
SBD · 211189 -
Acetaminophen 325 MG / butalbital 50 MG / caffeine 40 MG Oral Tablet [Repan]
SBD · 211194 -
Acetaminophen 325 MG / butalbital 50 MG / caffeine 40 MG [Esgic]
SBDC · 571621 -
Acetaminophen 325 MG / butalbital 50 MG / caffeine 40 MG [Repan]
SBDC · 571650 -
Acetaminophen / butalbital / caffeine Oral Tablet [Esgic]
SBDF · 367776 -
Acetaminophen / butalbital / caffeine Oral Tablet [Repan]
SBDF · 367771 -
Esgic Oral Product
SBDG · 1169698 -
Esgic Pill
SBDG · 1169699 -
Repan Oral Product
SBDG · 1181337 -
Repan Pill
SBDG · 1181338
📦 FDA Products & Package NDCs
44 products · 167 package NDCs
167 package NDCs map to RxCUI 238154 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
| Package NDC | Package | Brand / generic name | Labeler | Marketing start |
|---|---|---|---|---|
| 69367-0203-05 | 500 TABLET in 1 BOTTLE (69367-203-05) | Butalbital, Acetaminophen, Caffeine | Westminster Pharmaceuticals, LLC | 2019-03-05 |
| 70010-0149-01 | 100 TABLET in 1 BOTTLE (70010-149-01) | Butalbital, Acetaminophen and Caffeine | Granules Pharmaceuticals Inc. | 2022-06-29 |
| 70010-0149-05 | 500 TABLET in 1 BOTTLE (70010-149-05) | Butalbital, Acetaminophen and Caffeine | Granules Pharmaceuticals Inc. | 2022-06-29 |
| 70518-1134-02 | 60 TABLET in 1 BOTTLE, PLASTIC (70518-1134-2) | Butalbital, Acetaminophen, and Caffeine | REMEDYREPACK INC. | 2023-10-10 |
| 70518-4309-00 | 100 TABLET in 1 BOTTLE, PLASTIC (70518-4309-0) | Butalbital, Acetaminophen, Caffeine | REMEDYREPACK INC. | 2025-03-14 |
| 70518-4309-01 | 60 TABLET in 1 BOTTLE, PLASTIC (70518-4309-1) | Butalbital, Acetaminophen, Caffeine | REMEDYREPACK INC. | 2025-08-04 |
| 70518-4467-00 | 20 TABLET in 1 BOTTLE, PLASTIC (70518-4467-0) | Butalbital, Acetaminophen and Caffeine | REMEDYREPACK INC. | 2025-09-05 |
| 70518-4467-01 | 60 TABLET in 1 BOTTLE, PLASTIC (70518-4467-1) | Butalbital, Acetaminophen and Caffeine | REMEDYREPACK INC. | 2025-12-04 |
| 70518-4467-02 | 60 TABLET in 1 BOTTLE, PLASTIC (70518-4467-2) | Butalbital, Acetaminophen and Caffeine | REMEDYREPACK INC. | 2025-12-10 |
| 70518-4467-03 | 180 TABLET in 1 BOTTLE, PLASTIC (70518-4467-3) | Butalbital, Acetaminophen and Caffeine | REMEDYREPACK INC. | 2026-01-26 |
| 70518-4601-00 | 90 TABLET in 1 BOTTLE, PLASTIC (70518-4601-0) | BUTALBITAL, ACETAMINOPHEN AND CAFFEINE | REMEDYREPACK INC. | 2026-04-16 |
| 70518-4601-01 | 150 TABLET in 1 BOTTLE, PLASTIC (70518-4601-1) | BUTALBITAL, ACETAMINOPHEN AND CAFFEINE | REMEDYREPACK INC. | 2026-05-03 |
| 70518-4601-02 | 120 TABLET in 1 BOTTLE, PLASTIC (70518-4601-2) | BUTALBITAL, ACETAMINOPHEN AND CAFFEINE | REMEDYREPACK INC. | 2026-05-18 |
| 70752-0142-10 | 100 TABLET in 1 BOTTLE, PLASTIC (70752-142-10) | BUTALBITAL, ACETAMINOPHEN AND CAFFEINE | QUAGEN PHARMACEUTICALS LLC | 2024-05-01 |
| 70752-0142-14 | 500 TABLET in 1 BOTTLE, PLASTIC (70752-142-14) | BUTALBITAL, ACETAMINOPHEN AND CAFFEINE | QUAGEN PHARMACEUTICALS LLC | 2024-05-01 |
| 71205-0510-14 | 14 TABLET in 1 BOTTLE (71205-510-14) | Butalbital, Acetaminophen, Caffeine | Proficient Rx LP | 2020-11-25 |
| 71205-0510-30 | 30 TABLET in 1 BOTTLE (71205-510-30) | Butalbital, Acetaminophen, Caffeine | Proficient Rx LP | 2020-11-25 |
| 71205-0510-60 | 60 TABLET in 1 BOTTLE (71205-510-60) | Butalbital, Acetaminophen, Caffeine | Proficient Rx LP | 2020-11-25 |
| 71205-0510-90 | 90 TABLET in 1 BOTTLE (71205-510-90) | Butalbital, Acetaminophen, Caffeine | Proficient Rx LP | 2020-11-25 |
| 71205-0981-00 | 100 TABLET in 1 BOTTLE (71205-981-00) | Butalbital, Acetaminophen, Caffeine | Proficient Rx LP | 2020-05-07 |
| 71205-0981-30 | 30 TABLET in 1 BOTTLE (71205-981-30) | Butalbital, Acetaminophen, Caffeine | Proficient Rx LP | 2020-05-07 |
| 71205-0981-55 | 500 TABLET in 1 BOTTLE (71205-981-55) | Butalbital, Acetaminophen, Caffeine | Proficient Rx LP | 2020-05-07 |
| 71205-0981-60 | 60 TABLET in 1 BOTTLE (71205-981-60) | Butalbital, Acetaminophen, Caffeine | Proficient Rx LP | 2020-05-07 |
| 71205-0981-72 | 120 TABLET in 1 BOTTLE (71205-981-72) | Butalbital, Acetaminophen, Caffeine | Proficient Rx LP | 2020-05-07 |
| 71205-0981-90 | 90 TABLET in 1 BOTTLE (71205-981-90) | Butalbital, Acetaminophen, Caffeine | Proficient Rx LP | 2020-05-07 |
| 71335-1764-00 | 84 TABLET in 1 BOTTLE (71335-1764-0) | Butalbital, Acetaminophen, Caffeine | Bryant Ranch Prepack | 2021-02-02 |
| 71335-1764-01 | 20 TABLET in 1 BOTTLE (71335-1764-1) | Butalbital, Acetaminophen, Caffeine | Bryant Ranch Prepack | 2021-02-02 |
| 71335-1764-02 | 30 TABLET in 1 BOTTLE (71335-1764-2) | Butalbital, Acetaminophen, Caffeine | Bryant Ranch Prepack | 2021-02-02 |
| 71335-1764-03 | 60 TABLET in 1 BOTTLE (71335-1764-3) | Butalbital, Acetaminophen, Caffeine | Bryant Ranch Prepack | 2021-02-02 |
| 71335-1764-04 | 90 TABLET in 1 BOTTLE (71335-1764-4) | Butalbital, Acetaminophen, Caffeine | Bryant Ranch Prepack | 2021-02-02 |
| 71335-1764-05 | 50 TABLET in 1 BOTTLE (71335-1764-5) | Butalbital, Acetaminophen, Caffeine | Bryant Ranch Prepack | 2021-02-02 |
| 71335-1764-06 | 6 TABLET in 1 BOTTLE (71335-1764-6) | Butalbital, Acetaminophen, Caffeine | Bryant Ranch Prepack | 2021-02-02 |
| 71335-1764-07 | 120 TABLET in 1 BOTTLE (71335-1764-7) | Butalbital, Acetaminophen, Caffeine | Bryant Ranch Prepack | 2021-02-02 |
| 71335-1764-08 | 40 TABLET in 1 BOTTLE (71335-1764-8) | Butalbital, Acetaminophen, Caffeine | Bryant Ranch Prepack | 2021-02-02 |
| 71335-1764-09 | 12 TABLET in 1 BOTTLE (71335-1764-9) | Butalbital, Acetaminophen, Caffeine | Bryant Ranch Prepack | 2021-02-02 |
| 71335-1767-00 | 84 TABLET in 1 BOTTLE (71335-1767-0) | Butalbital, Acetaminophen, Caffeine | Bryant Ranch Prepack | 2021-02-18 |
| 71335-1767-01 | 20 TABLET in 1 BOTTLE (71335-1767-1) | Butalbital, Acetaminophen, Caffeine | Bryant Ranch Prepack | 2021-02-18 |
| 71335-1767-02 | 30 TABLET in 1 BOTTLE (71335-1767-2) | Butalbital, Acetaminophen, Caffeine | Bryant Ranch Prepack | 2021-02-18 |
| 71335-1767-03 | 60 TABLET in 1 BOTTLE (71335-1767-3) | Butalbital, Acetaminophen, Caffeine | Bryant Ranch Prepack | 2021-02-18 |
| 71335-1767-04 | 90 TABLET in 1 BOTTLE (71335-1767-4) | Butalbital, Acetaminophen, Caffeine | Bryant Ranch Prepack | 2021-02-18 |
| 71335-1767-05 | 50 TABLET in 1 BOTTLE (71335-1767-5) | Butalbital, Acetaminophen, Caffeine | Bryant Ranch Prepack | 2021-02-18 |
| 71335-1767-06 | 6 TABLET in 1 BOTTLE (71335-1767-6) | Butalbital, Acetaminophen, Caffeine | Bryant Ranch Prepack | 2021-02-18 |
| 71335-1767-07 | 120 TABLET in 1 BOTTLE (71335-1767-7) | Butalbital, Acetaminophen, Caffeine | Bryant Ranch Prepack | 2021-02-18 |
| 71335-1767-08 | 40 TABLET in 1 BOTTLE (71335-1767-8) | Butalbital, Acetaminophen, Caffeine | Bryant Ranch Prepack | 2021-02-18 |
| 71335-1767-09 | 12 TABLET in 1 BOTTLE (71335-1767-9) | Butalbital, Acetaminophen, Caffeine | Bryant Ranch Prepack | 2021-02-18 |
| 71335-2270-00 | 84 TABLET in 1 BOTTLE (71335-2270-0) | Butalbital, Acetaminophen and Caffeine | Bryant Ranch Prepack | 2023-11-30 |
| 71335-2270-01 | 20 TABLET in 1 BOTTLE (71335-2270-1) | Butalbital, Acetaminophen and Caffeine | Bryant Ranch Prepack | 2023-11-30 |
| 71335-2270-02 | 30 TABLET in 1 BOTTLE (71335-2270-2) | Butalbital, Acetaminophen and Caffeine | Bryant Ranch Prepack | 2023-11-30 |
| 71335-2270-03 | 60 TABLET in 1 BOTTLE (71335-2270-3) | Butalbital, Acetaminophen and Caffeine | Bryant Ranch Prepack | 2023-11-30 |
| 71335-2270-04 | 90 TABLET in 1 BOTTLE (71335-2270-4) | Butalbital, Acetaminophen and Caffeine | Bryant Ranch Prepack | 2023-11-30 |
Observed labelers:
Bryant Ranch Prepack (80) ·
Proficient Rx LP (17) ·
REMEDYREPACK INC. (10) ·
Asclemed USA, Inc. (8) ·
Advanced Rx of Tennessee, LLC (6) ·
Direct_Rx (6)
· +20 more — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.
💲 Pricing (NADAC)
NADAC is CMS's National Average Drug Acquisition Cost — roughly what pharmacies pay to buy the drug. It is an acquisition benchmark, not your copay.
Per ea · median
$0.1218
Range $0.1218–$0.1218
· middle 50% $0.1218–$0.1218
· 20 NDCs
Latest compatible distributions from the CMS NADAC file · dataset watermark 2026-07-10. Prices vary by package and pharmacy; a distribution is shown instead of one misleading number. Rows the dataset is silent on carry no price. No zero-cost conclusion should be drawn.
🗃️ Sources & Limits
Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
- A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
- Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
- Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
- Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.
Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.