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Acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG Oral Tablet [Exaprin Plus] — RxCUI 2723568

Name: Acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG Oral Tablet [Exaprin Plus] (RxCUI 2723568)
Creator: Brian Staiger, PharmD

RxNorm drug concept · Semantic branded drug

RxCUI 2723568 Semantic branded drug · SBD ● Current RxNorm concept 1 FDA product 2 package NDCs Snapshot Jul 14, 2026

This page is curated, coded, and maintained by Dr. Brian Staiger, PharmD

Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI2723568

Official nameAcetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG Oral Tablet [Exaprin Plus]

Concept typeSemantic branded drug (SBD)

RxNorm statusCurrent RxNorm concept

Also known asAPAP 250 MG / ASA 250 MG / caffeine 65 MG Oral Tablet [Exaprin Plus]; Exaprin Plus 250 MG / 250 MG / 65 MG Oral Tablet

FDA products mapped1

Package NDCs mapped2

RxNorm release07/06/2026

Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Acetaminophen Injection: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist

It treats mild to moderate pain, and moderate to severe pain when used with opioid medicines. It also lowers fever. It is given through a vein in a healthcare setting.
What is Acetaminophen Injection used for?
It is given as an IV infusion over 15 minutes by a healthcare professional. Your dose depends on your age and weight. Your care team follows the label and your prescriber's orders.
The most common are nausea and vomiting. Adults may also get headache or trouble sleeping. Children may have constipation or itching.

📖 Read our full Acetaminophen Injection guide →

🕸️ Concept Web — How Acetaminophen 250 MG / aspirin 250 MG / caffeine... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.

This page's concept Acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG Oral Tablet [Exaprin Plus] RxCUI 2723568 Semantic branded drug · SBD

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

Ingredients 4

The active substance itself — no strength, form, or brand attached yet.
- Acetaminophen 161 IN
- Aspirin 1191 IN
- Caffeine 1886 IN
- Acetaminophen / aspirin / caffeine 466584 MIN
Brand names 1

The same medicine's trade names. A brand name alone says nothing about strength or form.
- Exaprin Plus 2723563 BN
Dose forms 9

The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.
- Acetaminophen / aspirin / caffeine Oral Tablet 238142 SCDF
- Acetaminophen / aspirin / caffeine Oral Product 1154257 SCDG
- Acetaminophen / aspirin / caffeine Pill 1154258 SCDG
- Acetaminophen / aspirin / caffeine Oral Tablet [Exaprin Plus] 2723567 SBDF
- Exaprin Plus Oral Product 2723565 SBDG
- Exaprin Plus Pill 2723566 SBDG
- Oral Tablet 317541 DF
- Oral Product 1151131 DFG
- +1 more in this family
Clinical & branded drugs 5

Ingredient + strength + dose form. These are the concepts real FDA products actually carry.
- Acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG Oral Tablet 308297 SCD
- Acetaminophen 250 MG 315259 SCDC
- Aspirin 250 MG 335953 SCDC
- Caffeine 65 MG 317311 SCDC
- Acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG [Exaprin Plus] 2723564 SBDC
Packs 1

Fixed collections of drugs packaged and sold together, like dose packs.
- {100 (acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG Oral Tablet) / 24 (acetaminophen 250 MG / aspirin 250 MG / diphenhydramine citrate 38 MG Oral Tablet) } Pack 2047427 GPCK

Showing up to 8 concepts per family — 19 of 20 stored related concepts drawn.

These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

Acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG Oral Tablet SCD · 308297
{100 (acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG Oral Tablet) / 24 (acetaminophen 250 MG / aspirin 250 MG / diphenhydramine citrate 38 MG Oral Tablet) } Pack GPCK · 2047427
Acetaminophen 250 MG SCDC · 315259
Aspirin 250 MG SCDC · 335953
Caffeine 65 MG SCDC · 317311
Acetaminophen / aspirin / caffeine Oral Tablet SCDF · 238142
Acetaminophen / aspirin / caffeine Oral Product SCDG · 1154257
Acetaminophen / aspirin / caffeine Pill SCDG · 1154258

Brand-Name Concepts

Acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG [Exaprin Plus] SBDC · 2723564
Acetaminophen / aspirin / caffeine Oral Tablet [Exaprin Plus] SBDF · 2723567
Exaprin Plus Oral Product SBDG · 2723565
Exaprin Plus Pill SBDG · 2723566
Exaprin Plus BN · 2723563

📦 FDA Products & Package NDCs

1 product · 2 package NDCs

2 package NDCs map to RxCUI 2723568 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.

Package NDC	Package	Brand / generic name	Labeler	Marketing start
50332-0144-04	40 PACKET in 1 BOX (50332-0144-4) / 2 TABLET, FILM COATED i...	Exaprin Plus	HART Health	2025-08-04
50332-0144-07	100 PACKET in 1 BOX (50332-0144-7) / 2 TABLET, FILM COATED...	Exaprin Plus	HART Health	2025-08-04

Observed labelers: HART Health (2) — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7

openFDA export observedJul 14, 2026

RxNorm release07/06/2026

Methodology2026-07-full-catalog-v1

A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.

This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.