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Roflumilast 0.5 MG/ML Topical Cream — RxCUI 2725121

RxNorm drug concept · Semantic clinical drug
RxCUI 2725121 Semantic clinical drug · SCD ● Current RxNorm concept 3 FDA products 6 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI2725121
Official nameRoflumilast 0.5 MG/ML Topical Cream
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asroflumilast 0.05 % Topical Cream
FDA products mapped3
Package NDCs mapped6
Reported Medicaid activity (SDUD)60,925 prescriptions · 38 state & territory Medicaid programs · latest period Q4 2025
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Roflumilast: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • The tablets (Daliresp or generic roflumilast) lower the chance of flare-ups in severe COPD with chronic bronchitis. The Zoryve cream and foam are skin products for conditions such...
  • No. The tablets are not a bronchodilator and don't relieve sudden breathing trouble. Keep using your rescue treatment as your doctor directs.
  • Can I use the tablets for sudden shortness of breath?
  • Take one tablet by mouth once a day, with or without food. Your doctor may start you on a lower dose for the first 4 weeks, but that is not the effective dose. Follow your prescrib...
📖 Read our full Roflumilast guide →

🕸️ Concept Web — How Roflumilast 0.5 MG/ML Topical Cream Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Roflumilast 0.5 MG/ML Topical Cream RxCUI 2725121

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 1

    The active substance itself — no strength, form, or brand attached yet.

    • Roflumilast 1091836
  2. Brand names 1

    The same medicine's trade names. A brand name alone says nothing about strength or form.

    • Zoryve 2608535
  3. Dose forms 6

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Roflumilast Topical Cream 2608533
    • Roflumilast Topical Product 2608532
    • Roflumilast Topical Cream [Zoryve] 2608538
    • Zoryve Topical Product 2608537
    • Topical Cream 316982
    • Topical Product 1151122
  4. Clinical & branded drugs 3

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

Showing up to 8 concepts per family — 11 of 11 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

  • Roflumilast 0.5 MG/ML SCDC · 2725120
  • Roflumilast Topical Cream SCDF · 2608533
  • Roflumilast Topical Product SCDG · 2608532

Brand-Name Concepts

📦 FDA Products & Package NDCs

3 products · 6 package NDCs
6 package NDCs map to RxCUI 2725121 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
80610-0105-60 1 TUBE in 1 CARTON (80610-105-60) / 60 g in 1 TUBE ZORYVE Arcutis Biotherapeutics, Inc. 2025-10-04
80610-0105-96 6 TUBE in 1 CARTON (80610-105-96) / 5 g in 1 TUBE (80610-10... ZORYVE Arcutis Biotherapeutics, Inc. 2025-10-04
80610-0115-60 1 TUBE in 1 CARTON (80610-115-60) / 60 g in 1 TUBE ZORYVE Arcutis Biotherapeutics, Inc. 2024-07-09
80610-0115-96 6 TUBE in 1 CARTON (80610-115-96) / 5 g in 1 TUBE (80610-11... ZORYVE Arcutis Biotherapeutics, Inc. 2024-07-09
80610-0130-60 1 TUBE in 1 CARTON (80610-130-60) / 60 g in 1 TUBE ZORYVE Arcutis Biotherapeutics, Inc. 2022-07-29
80610-0130-96 6 TUBE in 1 CARTON (80610-130-96) / 5 g in 1 TUBE (80610-13... ZORYVE Arcutis Biotherapeutics, Inc. 2022-07-29
Observed labelers: Arcutis Biotherapeutics, Inc. (6) — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.